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Neurobiology of PTSD: A Review of Neuroimaging Findings
Open accessAbstract
Neuroimaging serves as an effec-tive way to investigate the neu-rocircuitry involved in the de-velopment of posttraumatic stress disorder (PTSD).1-3 A number of models describing functional neuroanatomy of PTSD symp-tom development emerged over the past decade, inspired by both basic animal re-search and an increasing number of human neuroimaging studies. These models have traditionally conceptualized PTSD as a state of heightened responsivity to threat-ening stimuli and later as a state of insuf-fi cient inhibitory control over-exaggerated threat-sensitivity. They emphasize the cen-trality of threat-related processing in the pathophysiology of PTSD and therefore
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“we have recently proposed that PTSD is associated with failure to contextualize emotional memory,30,44”
From Altered resting-state amygdala functional connectivity in men with posttraumatic stress disorder (2012) · cites this paper as [44]
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Research works printed but not linked: 1
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Cited by
Sorted by citations
Patel, R., Spreng, R. N., Shin, L. M., & Girard, T. A. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.06.003 · Cited by 546
“In recent years there has been a growing body of narative reviews providing qualitative syntheses of neuroimaging ndings in the PTSD literature (Bremner, 2004; Francati et al., 2007; arfinkel and Liberzon, 2009; Lanius et al., 2006; Rauch et al., 006; Villarreal and King, 2004).”
O'Doherty, D. C. M., Chitty, K. M., Saddiqui, S., Bennett, M. R., & Lagopoulos, J. (2015) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2015.01.002 · Cited by 375
“The pathophysiology of PTSD is characterised by a heightened sensitivity to certain stimuli perceived to be threatening, followed by inability to extinguish the resulting fear (Garfinkel and Liberzon, 2009).”
BackgroundA critical evaluation of the complex PTSD literature: Implications for DSM‐5
Resick, P. A., Bovin, M. J., Calloway, A. L., Dick, A. M., King, M. W., Mitchell, K. S., Suvak, M. K., Wells, S. Y., Stirman, S. W., & Wolf, E. J. (2012) · Journal of Traumatic Stress · doi:10.1002/jts.21699 · Cited by 365
Garfinkel, S. N., Abelson, J. L., King, A. P. J., Sripada, R. K., Wang, X., Gaines, L. M., & Liberzon, I. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4287-13.2014 · Cited by 390
Self-citationFear from the heart: sensitivity to fear stimuli depends on individual heartbeats
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Self-citation
Metadata
- Authors
- Garfinkel, S. N., & Liberzon, I.
- Affiliations
- University of Michigan (US)
- Houston Methodist (US)
- Venue
- Psychiatric Annals
- Publisher
- SLACK, Inc.
- Published
- 2009-06
- Volume
- 39
- Issue
- 6
- Pages
- 370-381
- ISSN
- 0048-5713 (ISSN-L)
- 1938-2456
- OpenAlex
- W2100532508
- Cited by
- 102
- References
- 79
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 3 · 2021: 12 · 2020: 10 · 2019: 6 · 2018: 10 · 2017: 10 · 2016: 9 · 2015: 8 · 2014: 5 · 2013: 4 · 2012: 8
- FWCI
- 4.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Psychiatric Annals (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Social Sciences › Psychology › Clinical Psychology › Psychoanalysis and Psychopathology Research
- Keywords
- post-traumatic stress disorder, neurobiology of PTSD, neuroimaging findings, threat processing, threat sensitivity, inhibitory control, functional neuroanatomy, PTSD pathophysiology
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