Mechanisms of Action of (n-3) Fatty Acids,

Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

Oh, D. Y., Talukdar, S., Bae, E. J., Imamura, T., Morinaga, H., Fan, W., Li, P., Lu, W. J., Watkins, S. M., & Olefsky, J. M. (2010) · Cell · doi:10.1016/j.cell.2010.07.041 · Cited by 2,428

Integrating cell-signalling pathways with NF-κB and IKK function

Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

Forman, B. M., Chen, J., & Evans, R. M. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4312 · Cited by 2,116

Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction: Time-Course Analysis of the Results of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Infarto Miocardico (GISSI)-Prevenzione

Marchioli, R., Barzi, F., Bomba, E., Chieffo, C., Di Gregorio, D., Di Mascio, R., Franzosi, M. G., Geraci, E., Levantesi, G., Maggioni, A. P., et al. (2002) · Circulation · doi:10.1161/01.cir.0000014682.14181.f2 · Cited by 1,311

Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4

Lee, J. Y., Sohn, K. H., Rhee, S. H., & Hwang, D. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011695200 · Cited by 1,299

Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing

Serhan, C. N., Clish, C. B., Brannon, J., Colgan, S. P., Chiang, N., & Gronert, K. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.8.1197 · Cited by 1,189

Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century

Blasbalg, T. L., Hibbeln, J. R., Ramsden, C. E., Majchrzak, S. F., & Rawlings, R. R. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.006643 · Cited by 881

Omega-3 Fatty Acids: Evidence Basis for Treatment and Future Research in Psychiatry

Freeman, M. P., Hibbeln, J. R., Wisner, K. L., Davis, J. M., Mischoulon, D., Peet, M., Keck, P. E., Marangell, L. B., Richardson, A. J., Lake, J., et al. (2006) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v67n1217 · Cited by 709

Very long-chain n -3 fatty acids and human health: fact, fiction and the future

Calder, P. C. (2018) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117003950 · Cited by 419

Fatty Acid Profiles and Production in Marine Phytoplankton

Jónasdóttir, S. H. (2019) · Marine Drugs · doi:10.3390/md17030151 · Cited by 321

Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction

Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14061137 · Cited by 255

Cosmetic and Therapeutic Applications of Fish Oil’s Fatty Acids on the Skin

Huang, T.-H., Wang, P.-W., Yang, S.-C., Chou, W.-L., & Fang, J.-Y. (2018) · Marine Drugs · doi:10.3390/md16080256 · Cited by 210

How polyunsaturated fatty acids modify molecular organization in membranes: insight from NMR studies of model systems

Shaikh, S. R., Kinnun, J. J., Leng, X., Williams, J. A., & Wassall, S. R. (2015) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.04.020 · Cited by 179

Selected in-season nutritional strategies to enhance recovery for team sport athletes: a practical overview

Heaton, L. E., Davis, J. K., Rawson, E. S., Nuccio, R. P., Witard, O. C., Stein, K. W., Baar, K., Carter, J. M., & Baker, L. B. (2017) · Sports Medicine · doi:10.1007/s40279-017-0759-2 · Cited by 158

The Eye, Oxidative Damage and Polyunsaturated Fatty Acids

Saccà, S. C., Cutolo, C. A., Ferrari, D., Corazza, P., & Traverso, C. E. (2018) · Nutrients · doi:10.3390/nu10060668 · Cited by 150

Nutritional strategies for maintaining muscle mass and strength from middle age to later life: A narrative review

Cruz-Jentoft, A. J., Dawson Hughes, B., Scott, D., Sanders, K. M., & Rizzoli, R. (2020) · Maturitas · doi:10.1016/j.maturitas.2019.11.007 · Cited by 144

Temporal changes in human skeletal muscle and blood lipid composition with fish oil supplementation

McGlory, C., Galloway, S. D. R., Hamilton, D. L., McClintock, C., Breen, L., Dick, J. R., Bell, J. G., & Tipton, K. D. (2014) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.03.001 · Cited by 130

Fatty acids as modulators of neutrophil recruitment, function and survival

Rodrigues, H. G., Takeo Sato, F., Curi, R., & Vinolo, M. A. R. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.098 · Cited by 124

Anticolorectal cancer activity of the omega-3 polyunsaturated fatty acid eicosapentaenoic acid.

Cockbain, A. J., Volpato, M., Race, A. D., Munarini, A., Fazio, C., Belluzzi, A., Loadman, P. M., Toogood, G. J., & Hull, M. A. (2014) · Gut · doi:10.1136/gutjnl-2013-306445 · Cited by 115

Effect of supplementation with long-chain ω-3 polyunsaturated fatty acids on behavior and cognition in children with attention deficit/hyperactivity disorder (ADHD): A randomized placebo-controlled intervention trial

Widenhorn-Müller, K., Schwanda, S., Scholz, E., Spitzer, M., & Bode, H. (2014) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2014.04.004 · Cited by 103

Lipids in Parenteral Nutrition: Biological Aspects

Calder, P. C., Waitzberg, D. L., Klek, S., & Martindale, R. G. (2020) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1756 · Cited by 102

Omega-3 Fatty Acid Intake by Age, Gender, and Pregnancy Status in the United States: National Health and Nutrition Examination Survey 2003–2014

Thompson, M., Hein, N., Hanson, C., Smith, L. M., Anderson-Berry, A., Richter, C. K., Stessy Bisselou, K., Kusi Appiah, A., Kris-Etherton, P., Skulas-Ray, A. C., et al. (2019) · Nutrients · doi:10.3390/nu11010177 · Cited by 98

Omega-3 futures in aquaculture: exploring the supply and demands for long-chain Omega-3 essential fatty acids by aquaculture species

Glencross, B. D., Bachis, E., Betancor, M. B., Calder, P., Liland, N., Newton, R., & Ruyter, B. (2025) · Reviews in Fisheries Science & Aquaculture · doi:10.1080/23308249.2024.2388563 · Cited by 89

n-3 Polyunsaturated Fatty Acids and Metabolic Syndrome Risk: A Meta-Analysis

Guo, X.-F., Li, X., Shi, M., & Li, D. (2017) · Nutrients · doi:10.3390/nu9070703 · Cited by 89

Lipid Lowering Drugs: Present Status and Future Developments

Ruscica, M., Ferri, N., Santos, R. D., Sirtori, C. R., & Corsini, A. (2021) · Current Atherosclerosis Reports · doi:10.1007/s11883-021-00918-3 · Cited by 73

Omega-3 Fatty Acids and Adipose Tissue: Inflammation and Browning

Kalupahana, N. S., Goonapienuwala, B. L., & Moustaid-Moussa, N. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-122319-034142 · Cited by 72

Effect of losartan and fish oil on plasma IL-6 and mobility in older persons.The ENRGISe pilot randomized clinical trial

Pahor, M., Anton, S. D., Beavers, D. P., Cauley, J. A., Fielding, R. A., Kritchevsky, S. B., Leeuwenburgh, C., Lewis, K. H., Liu, C. K., Lovato, L. C., et al. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly277 · Cited by 50

Docosahexaenoic acid attenuates Western diet-induced hepatic fibrosis in Ldlr mice by targeting the TGFβ-Smad3 pathway

Lytle, K. A., Depner, C. M., Wong, C. P., & Jump, D. B. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m061275 · Cited by 45

The promise and limitations of anti-inflammatory agents for the treatment of Major Depressive Disorder

Raison, C. L. (2016) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2016_26 · Cited by 36

Administration of eicosapentaenoic and docosahexaenoic acids may improve the remodeling and browning in subcutaneous white adipose tissue and thermogenic markers in brown adipose tissue in mice

Bargut, T. C. L., Martins, F. F., Santos, L. P., Aguila, M. B., & Mandarim-de-Lacerda, C. A. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2018.12.003 · Cited by 34

Fish Oil–Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence

Abbasoglu, O., Hardy, G., Manzanares, W., & Pontes‐Arruda, A. (2019) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607117721907 · Cited by 30

Potential role of omega-3 fatty acids on the myogenic program of satellite cells

Bhullar, A. S., Putman, C. T., & Mazurak, V. C. (2016) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s27481 · Cited by 26

Paucity of evidence for a relationship between long-chain omega-3 fatty acid intake and chronic obstructive pulmonary disease: a systematic review

Fulton, A. S., Hill, A. M., Williams, M. T., Howe, P. R. C., & Coates, A. M. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuv017 · Cited by 26

Targeting neuroinflammation: The therapeutic potential of ω-3 PUFAs in substance abuse

Peng, S., Peng, Z., Qin, M., Huang, L., Zhao, B., Wei, L., Ning, J., Tuo, Q.-H., Yuan, T.-F., Shi, Z., et al. (2021) · Nutrition · doi:10.1016/j.nut.2020.111058 · Cited by 18

Eicosapentaenoic acid and branched-chain amino acids fortified complete nutrition drink improved muscle strength in older individuals with inadequate protein intake

Khoonin, W., Shantavasinkul, P. C., Santivarangkna, C., Praengam, K., & Trachootham, D. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1164469 · Cited by 7