Cited by 307Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsMenopause: Health Impacts and Treatments

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Sex differences in cognitive impairment in Alzheimer’s disease

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Laws, Keith R, Irvine, Karen, Gale, Tim M·2016·World Journal of Psychiatry

DOI 10.5498/wjp.v6.i1.54PMC PMC4804268

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Abstract

Sex differences in neurocognitive abilities have been extensively explored both in the healthy population and in many disorders. Until recently, however, little work has examined such differences in people with Alzheimer's disease (AD). This is despite clear evidence that AD is more prevalent in women, and converging lines of evidence from brain imaging, post-mortem analyses, hormone therapy and genetics suggesting that AD affects men and women differently. We provide an overview of evidence attesting to the poorer cognitive profiles in women than in men at the same stage of AD. Indeed, men significantly outperform women in several cognitive domains, including: Language and semantic abilities, visuospatial abilities and episodic memory. These differences do not appear to be attributable to any differences in age, education, or dementia severity. Reasons posited for this female disadvantage include a reduction of estrogen in postmenopausal women, greater cognitive reserve in men, and the influence of the apolipoprotein E ε4 allele. Assessment of cognitive abilities contributes to the diagnosis of the condition and thus, it is crucial to identify the role of sex differences if potentially more accurate diagnoses and treatments are to emerge.

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[Japanese version of the Neuropsychiatric Inventory--a scoring system for neuropsychiatric disturbance in dementia patients].
Hirono, N., Mori, E., Ikejiri, Y., Imamura, T., Shimomura, T., Hashimoto, M., Yamashita, H., & Ikeda, M. (1997) · PubMed · Cited by 21,012
Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Overdependence on degraded gist memory in Alzheimer's disease.
Gallo, D. A., Shahid, K. R., Olson, M. A., Solomon, T. M., Schacter, D. L., & Budson, A. E. (2006) · Neuropsychology · doi:10.1037/0894-4105.20.6.625 · Cited by 4,757
The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part I. Clinical and neuropsychological assesment of Alzheimer's disease
Moms, J. C., Heyman, A., Mohs, R. C., Hughes, J. P., van Belle, G., Fillenbaum, G., Mellits, E. D., & Clark, C. (1989) · Neurology · doi:10.1212/wnl.39.9.1159 · Cited by 4,130
Emergence and Characterization of Sex Differences in Spatial Ability: A Meta-Analysis
Linn, M. C., & Petersen, A. C. (1985) · Child Development · doi:10.2307/1130467 · Cited by 3,234
Magnitude of sex differences in spatial abilities: a meta-analysis and consideration of critical variables
Voyer, D., Voyer, S., & Bryden, M. P. (1995) · Psychological Bulletin · doi:10.1037/0033-2909.117.2.250 · Cited by 2,868
Gender differences in verbal ability: A meta-analysis.
Hyde, J. S., & Linn, M. C. (1988) · Psychological Bulletin · doi:10.1037/0033-2909.104.1.53 · Cited by 1,405
Sex differences in the structural connectome of the human brain
Ingalhalikar, M., Smith, A., Parker, D., Satterthwaite, T. D., Elliott, M. A., Ruparel, K., Hakonarson, H., Gur, R. E., Gur, R. C., & Verma, R. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316909110 · Cited by 1,223
Education and the prevalence of dementia and Alzheimer's disease
Katzman, R. (1993) · Neurology · doi:10.1212/wnl.43.1_part_1.13 · Cited by 1,186
Physical Activity Improves Verbal and Spatial Memory in Older Adults with Probable Mild Cognitive Impairment: A 6-Month Randomized Controlled Trial
Nagamatsu, L. S., Chan, A., Davis, J. C., Beattie, B. L., Graf, P., Voss, M. W., Sharma, D., & Liu-Ambrose, T. Y. L. (2013) · Journal of Aging Research · doi:10.1155/2013/861893 · Cited by 1,090
Sex modifies the APOE ‐related risk of developing Alzheimer disease
Altmann, A., Tian, L., Henderson, V. W., Greicius, M. D., & Alzheimer's Disease Neuroimaging Initiative Investigators (2014) · Annals of Neurology · doi:10.1002/ana.24135 · Cited by 891
Verbal fluency performance in dementia of the Alzheimer’s type: a meta-analysis
Henry, J. D., Crawford, J. R., & Phillips, L. H. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.02.001 · Cited by 847
Timing of onset of cognitive decline: results from Whitehall II prospective cohort study
Singh-Manoux, A., Kivimaki, M., Glymour, M. M., Elbaz, A., Berr, C., Ebmeier, K. P., Ferrie, J. E., & Dugravot, A. (2012) · BMJ · doi:10.1136/bmj.d7622 · Cited by 836
The question of familial meningiomas and schwannomas:
King, A. A., & Gutmann, D. H. (2000) · Neurology · doi:10.1212/wnl.54.1.4 · Cited by 814
The Relationships Between Age, Sex, and the Incidence of Dementia and Alzheimer Disease
Gao, S., Hendrie, H. C., Hall, K. S., & Hui, S. L. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.9.809 · Cited by 782
Effects of estrogen on memory function in surgically menopausal women
Phillips, S. M. (1992) · Psychoneuroendocrinology · doi:10.1016/0306-4530(92)90007-t · Cited by 737
Estrogen and/or androgen replacement therapy and cognitive functioning in surgically menopausal women
Sherwin, B. B. (1988) · Psychoneuroendocrinology · doi:10.1016/0306-4530(88)90060-1 · Cited by 705
Untitled work
(2000) · PubMed · Cited by 683
Comparisons of Verbal Fluency Tasks in the Detection of Dementia of the Alzheimer Type
Monsch, A. U., Bondi, M. W., Butters, N., Salmon, D. P., Katzman, R., & Thal, L. J. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530360051017 · Cited by 658
Gender differences in the incidence of AD and vascular dementia: The EURODEM Studies
Andersen, K., Launer, L. J., Dewey, M. E., Letenneur, L., Ott, A., Copeland, J. R. M., Dartigues, J.-F., Kragh–Sorensen, P., Baldereschi, M., Brayne, C., et al. (1999) · Neurology · doi:10.1212/wnl.53.9.1992 · Cited by 650
Sex Differences in the Clinical Manifestations of Alzheimer Disease Pathology
Barnes, L. L., Wilson, R. S., Bienias, J. L., Schneider, J. A., Evans, D. A., & Bennett, D. A. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.685 · Cited by 643
Episodic and Semantic Memory: A Comparison of Amnesic and Demented Patients
Butters, N., Granholm, E. L., Salmon, D. P., Grant, I., & Wolfe, J. (1987) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688638708410764 · Cited by 596
Sex differences in cognitive impairment and Alzheimer’s disease
Li, R., & Singh, M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.01.002 · Cited by 527
Neuropsychological Assessment of Dementia
Salmon, D. P., & Bondi, M. W. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.57.102904.190024 · Cited by 491
Gender differences in age effect on brain atrophy measured by magnetic resonance imaging.
Gur, R., Mozley, P., Resnick, S., Gottlieb, G., Kohn, M., Zimmerman, R. A., Herman, G., Atlas, S. J., Grossman, R., & Berretta, D. (1991) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.88.7.2845 · Cited by 467
Sex Differences in Brain Aging
Coffey, C. E., Lucke, J. F., Saxton, J. A., Ratcliff, G. G., Unitas, L. J., Billig, B. K., & Bryan, R. N. (1998) · Archives of Neurology · doi:10.1001/archneur.55.2.169 · Cited by 446
Putative sex differences in verbal abilities and language cortex: A critical review
Wallentin, M. (2008) · Brain and Language · doi:10.1016/j.bandl.2008.07.001 · Cited by 438
Marked gender differences in progression of mild cognitive impairment over 8 years
Lin, K. A., Choudhury, K. R., Rathakrishnan, B. G., Marks, D. M., Petrella, J. R., Doraiswamy, P. M., & Initiative, A. D. N. (2015) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2015.07.001 · Cited by 396
Sex differences in cognitive functions
Weiss, E. M., Kemmler, G., Deisenhammer, E., Fleischhacker, W. W., & Delazer, M. (2002) · Personality and Individual Differences · doi:10.1016/s0191-8869(02)00288-x · Cited by 378
Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease
Gomez‐Isla, T., West, H. L., Rebeck, G. W., Harr, S. D., Growdon, J. H., Locascio, J. J., Perls, T. T., Lipsitz, L. A., & Hyman, B. T. (1996) · Annals of Neurology · doi:10.1002/ana.410390110 · Cited by 378
Cognitive Functioning in Healthy Older Adults Aged 64–81: A Cohort Study into the Effects of Age, Sex, and Education
van Hooren, S., Valentijn, A., Bosma, H., Ponds, R., van Boxtel, M. P. J., & Jolles, J. (2006) · Aging Neuropsychology and Cognition · doi:10.1080/138255890969483 · Cited by 368
Sex differences in aging of the human frontal and temporal lobes
Cowell, P. E., Turetsky, B. I., Gur, R., Grossman, R. I., Shtasel, D. L., & Gur, R. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-08-04748.1994 · Cited by 336
Age and gender predict volume decline in the anterior and posterior hippocampus in early adulthood
Pruessner, J. C., Collins, D. L., Pruessner, M., & Evans, A. C. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-00194.2001 · Cited by 292
Greater cognitive deterioration in women than men with Alzheimer's disease: A meta analysis
Irvine, K., Laws, K. R., Gale, T. M., & Kondel, T. K. (2012) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2012.712676 · Cited by 290
Self-citation
Semantic knowledge in mild cognitive impairment and mild Alzheimer's disease
Adlam, A.-L. R., Bozeat, S., Arnold, R., Watson, P., & Hodges, J. R. (2006) · Cortex · doi:10.1016/s0010-9452(08)70404-0 · Cited by 274
Enhanced Verbal Memory in Nondemented Elderly Women Receiving Hormone-Replacement Therapy
Maki, P. M., Zonderman, A. B., & Resnick, S. M. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.2.227 · Cited by 269
Sex, Apolipoprotein E ε4 Status, and Hippocampal Volume in Mild Cognitive Impairment
Fleisher, A. (2005) · Archives of Neurology · doi:10.1001/archneur.62.6.953 · Cited by 268
Spatial cognition and the human navigation network in AD and MCI
Deipolyi, A. R., Rankin, K. P., Mucke, L., Miller, B. L., & Gorno‐Tempini, M. (2007) · Neurology · doi:10.1212/01.wnl.0000271376.19515.c6 · Cited by 259
Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women.
Payami, H., Zareparsi, S., Montee, K. R., Sexton, G. J., Kaye, J. A., Bird, T. D., Yu, C. E., Wijsman, E. M., Heston, L. L., Litt, M. J., et al. (1996) · PubMed Central · Cited by 248
A review of the impact of pregnancy on memory function
Henry, J. D., & Rendell, P. G. (2007) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390701612209 · Cited by 234
Sex Differences in Cognition are Stable Over a 10-Year Period in Adulthood and Old Age
de Frias, C. M., Nilsson, L., & Herlitz, A. (2006) · Aging Neuropsychology and Cognition · doi:10.1080/13825580600678418 · Cited by 232
Estrogen Replacement Therapy and Memory in Older Women
Robinson, D. S., Friedman, L., Marcus, R., Tinklenberg, J. R., & Yesavage, J. A. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06580.x · Cited by 226
Category and letter verbal fluency across the adult lifespan: relationship to EEG theta power
Brickman, A. M., Paul, R. H., COHEN, R., Williams, L. M., MacGregor, K. L., Jefferson, A. L., Tate, D. F., Gunstad, J., & GORDON, E. (2005) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2004.12.006 · Cited by 222
Sex differences in episodic memory: The impact of verbal and visuospatial ability.
Herlitz, A., Airaksinen, E., & Nordström, E. (1999) · Neuropsychology · doi:10.1037//0894-4105.13.4.590 · Cited by 208
Effects of Age, Education and Gender on Verbal Fluency
Mathuranath, P. S., George, A., Cherian, P. J., Alexander, A., Sarma, S. G., & Sarma, P. S. (2003) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.25.8.1057.16736 · Cited by 207
Apolipoprotein E and cognitive change in an elderly population
Hyman, B. T., Gómez‐Isla, T., Briggs, M. E., Chung, H., Nichols, S., Kohout, F. J., & Wallace, R. B. (1996) · Annals of Neurology · doi:10.1002/ana.410400111 · Cited by 205
Estrogen, Cognition, and a Woman’s Risk of Alzheimer’s Disease
Henderson, V. W. (1997) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00261-1 · Cited by 191
Cognitive skills associated with estrogen replacement in women with Alzheimer's disease
Henderson, V. W., Watt, L., & Buckwalter, J. G. (1996) · Psychoneuroendocrinology · doi:10.1016/0306-4530(95)00060-7 · Cited by 189
The underlying mechanisms of semantic memory loss in Alzheimer's disease and semantic dementia
Rogers, S. L., & Friedman, R. B. (2007) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2007.08.010 · Cited by 184
Evidence for an Interaction between Apolipoprotein E Genotype, Gender, and Alzheimer Disease
Bretsky, P., Buckwalter, J. G., Seeman, T. E., Miller, C. A., Poirier, J., Schellenberg, G. D., Finch, C. E., & Henderson, V. W. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199910000-00007 · Cited by 183
An Empirically Derived Short Form of the Boston Naming Test
Lansing, A. E., Ivnik, R. J., Cullum, C. M., & RANDOLPH, C. C. (1999) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/14.6.481 · Cited by 180
Naming of objects, faces and buildings in mild cognitive impairment
Ahmed, S., Arnold, R. J., Thompson, S., Graham, K. S., & Hodges, J. R. (2007) · Cortex · doi:10.1016/j.cortex.2007.02.002 · Cited by 175
Gender, cognitive decline, and risk of AD in older persons
Barnes, L. L., Wilson, R. S., Schneider, J. A., Bienias, J. L., Evans, D. A., & Bennett, D. A. (2003) · Neurology · doi:10.1212/01.wnl.0000065892.67099.2a · Cited by 173
Hormones and cognitive functioning during late pregnancy and postpartum: A longitudinal study.
Henry, J. F., & Sherwin, B. B. (2011) · Behavioral Neuroscience · doi:10.1037/a0025540 · Cited by 172
Cognitive deficits of men and women with Alzheimer's disease
Henderson, V. W., & Buckwalter, J. G. (1994) · Neurology · doi:10.1212/wnl.44.1.90 · Cited by 170
Sex differences in clustering and switching in verbal fluency tasks
Weiss, E. M., Ragland, J. D., Brensinger, C. M., Bilker, W. B., Deisenhammer, E., & Delazer, M. (2006) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617706060656 · Cited by 168
Effects of Age, Gender and Education on Selected Neuropsychological Tests in an Elderly Community Cohort
Wiederholt, W. C., Cahn, D. A., Butters, N., Salmon, D. P., Kritz‐Silverstein, D. C., & Barrett-Connor, E. L. (1993) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1993.tb06738.x · Cited by 167
Change in Object Naming Ability During Adulthood
Connor, L. T., Spiro, A., Obler, L. K., & Albert, M. L. (2004) · The Journals of Gerontology Series B: Psychological Sciences and Social Sciences · doi:10.1093/geronb/59.5.p203 · Cited by 167
Gender Affects Word Retrieval of Certain Categories in Semantic Fluency Tasks
Capitani, E., Laiacona, M., & Barbarotto, R. (1999) · Cortex · doi:10.1016/s0010-9452(08)70800-1 · Cited by 163
Apolipoprotein E ε4 Prevalence in Alzheimer’s Disease Patients Varies across Global Populations: A Systematic Literature Review and Meta-Analysis
Crean, S., Ward, A., Mercaldi, C. J., Collins, J. M., Cook, M. N., Baker, N. L., & Arrighi, H. M. (2011) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000321984 · Cited by 163
Latent growth curve analyses of accelerating decline in cognitive abilities in late adulthood.
Finkel, D., Reynolds, C. A., McArdle, J. J., Gatz, M., & Pedersen, N. L. (2003) · Developmental Psychology · doi:10.1037/0012-1649.39.3.535 · Cited by 158
Age-Related Differences in Performance of Phonemic Verbal Fluency Measured by Controlled Oral Word Association Task (COWAT): A Meta-Analytic Study
Rodríguez‐Aranda, C., & Martinussen, M. (2006) · Developmental Neuropsychology · doi:10.1207/s15326942dn3002_3 · Cited by 156
Gender and education impact on brain aging: A general cognitive factor approach.
Proust‐Lima, C., Amieva, H., Letenneur, L., Orgogozo, J., Jacqmin‐Gadda, H., & Dartigues, J. (2008) · Psychology and Aging · doi:10.1037/a0012838 · Cited by 151
Hormonal Influences on Cognition and Risk for Alzheimer’s Disease
Janicki, S. C., & Schupf, N. (2010) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-010-0122-6 · Cited by 150
Emotion perception in Alzheimer’s disease and mood disorder in old age.
Phillips, L. H., Scott, C. L., Henry, J. D., Mowat, D., & Bell, J. S. (2010) · Psychology and Aging · doi:10.1037/a0017369 · Cited by 150
Short anxiety screening test—a brief instrument for detecting anxiety in the elderly
Sinoff, G., Ore, L., Zlotogorsky, D., & Tamir, A. (1999) · International Journal of Geriatric Psychiatry · doi:10.1002/(sici)1099-1166(199912)14:12 · Cited by 137
Stability of Sex Differences in Cognition in Advanced Old Age: The Role of Education and Attrition
Gerstorf, D., Herlitz, A., & Smith, J. (2006) · The Journals of Gerontology Series B · doi:10.1093/geronb/61.4.p245 · Cited by 130
Disorders of the visual system in Alzheimer's disease.
Mendez, M. F., Tomsak, R. L., & Remler, B. F. (1990) · PubMed · Cited by 129
Prevalence of Visual Deficits in Alzheimer's Disease
Mendola, J. D., Cronin‐Golomb, A., Corkin, S., & Growdon, J. H. (1995) · Optometry and Vision Science · doi:10.1002/j.1538-9235.1995.tb03842.x · Cited by 126
Semantic error patterns on the Boston Naming Test in normal aging, amnestic mild cognitive impairment, and mild Alzheimer's disease: Is there semantic disruption?
Balthazar, M. L. F., Cendes, F., & Damasceno, B. P. (2008) · Neuropsychology · doi:10.1037/a0012919 · Cited by 123
Educational and Gender Normative Data for the Boston Naming Test in a Group of Older Adults
Welch, L. W., Doineau, D., Johnson, S., & King, D. (1996) · Brain and Language · doi:10.1006/brln.1996.0047 · Cited by 121
Giving birth to a new brain: hormone exposures of pregnancy influence human memory
Glynn, L. M. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.01.015 · Cited by 121
Gender and Sexual Orientation Differences in Cognition Across Adulthood: Age Is Kinder to Women than to Men Regardless of Sexual Orientation
Maylor, E. A., Reimers, S. J., Choi, J., Collaer, M. L., Peters, M., & SILVERMAN, I. W. (2007) · Archives of Sexual Behavior · doi:10.1007/s10508-006-9155-y · Cited by 117
The effect of age and sex on clustering and switching during speeded verbal fluency tasks
Lanting, S. C., Haugrud, N., & Crossley, M. (2009) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617709090237 · Cited by 116
Visuoconstructional problems in dementia: Contribution of executive systems functions.
Freeman, R. Q., Giovannetti, T., Lamar, M., Cloud, B., Stern, R. A., Kaplan, E., & Libon, D. J. (2000) · Neuropsychology · doi:10.1037//0894-4105.14.3.415 · Cited by 114
Gender Differences in Relations of Mental Rotation, Verbal Fluency, and SAT Scores to Finger Length Ratios as Hormonal Indexes
Burton, L. A., Henninger, D. E., & Hafetz, J. S. (2005) · Developmental Neuropsychology · doi:10.1207/s15326942dn2801_3 · Cited by 111
The naming deficit in early Alzheimer's and vascular dementia.
Lukatela, K., Malloy, P. F., Jenkins, M., & Cohen, R. A. (1998) · Neuropsychology · doi:10.1037/0894-4105.12.4.565 · Cited by 110
Gender and age modify the association between APOE and AD-related neuropathology
Ghebremedhin, E., Schultz, C., Thal, D. R., Rüb, U., Ohm, T. G., Braak, E., & Braak, H. (2001) · Neurology · doi:10.1212/wnl.56.12.1696 · Cited by 108
Is age kinder to females than to males?
Meinz, E. J., & Salthouse, T. A. (1998) · Psychonomic Bulletin & Review · doi:10.3758/bf03209457 · Cited by 104
Comparative value of brain perfusion SPECT and [123I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer’s disease
Hanyu, H., Shimizu, S., Hirao, K., Kanetaka, H., Iwamoto, T., Chikamori, T., Usui, Y., Yamashina, A., Koizumi, K., & Abe, K. (2005) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-005-1921-x · Cited by 104
‘Normal’ semantic–phonemic fluency discrepancy in Alzheimer's disease? A meta-analytic study
Laws, K. R., Duncan, A. L., & Gale, T. M. (2009) · Cortex · doi:10.1016/j.cortex.2009.04.009 · Cited by 101
Self-citation
Determinants of Confrontation Naming Performance
RANDOLPH, C. C., Lansing, A. E., Ivnik, R. J., Cullum, C. M., & Hermann, B. P. (1999) · Archives of Clinical Neuropsychology · doi:10.1016/s0887-6177(98)00023-7 · Cited by 101
Visuospatial Deficits in Parkinsons Disease Assessed by Judgment of Line Orientation Test: Error Analyses and Practice Effects
Alegret, M., Vendrell, P., Junqué, C., Francesc, V., & Eduardo, T. (2001) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.23.5.592.1248 · Cited by 97
A Cross-Sectional Study of the Effects of Age, Education, and Gender on the Boston Naming Test
Zec, R. F., Burkett, N. R., Markwell, S. J., & Larsen, D. L. (2007) · The Clinical Neuropsychologist · doi:10.1080/13854040701220028 · Cited by 95
Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease
Cahn, D. A., Sullivan, E. V., Shear, P. K., Fama, R., Lim, K. O., Yesavage, J. A., Tinklenberg, J. R., & Pfefferbaum, A. (1999) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617799566034 · Cited by 95
Neuropsychological data in nondemented oldest old: The 90+ Study
Whittle, C., Corrada, M. M., Dick, M. B., Ziegler, R., Kahle‐Wrobleski, K., Paganini‐Hill, A., & Kawas, C. H. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803390600678038 · Cited by 94
Gender Differences in Cognitive Function with Age: The Rancho Bernardo Study
Barrett-Connor, E. L., & Kritz‐Silverstein, D. C. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb04573.x · Cited by 93
Gender Differences and Cognition Among Older Adults
Parsons, T. D., Rizzo, A. R., van der Zaag, C., McGee, J. S., & Buckwalter, J. G. (2005) · Aging Neuropsychology and Cognition · doi:10.1080/13825580590925125 · Cited by 93
Gender differences in language of AD patients
Ripich, D. N., Petrill, S. A., Whitehouse, P. J., & Ziol, E. W. (1995) · Neurology · doi:10.1212/wnl.45.2.299 · Cited by 93
Gender differences in brain reserve
Perneczky, R., Drzezga, A. E., Diehl‐Schmid, J., Li, Y., & Kurz, A. (2007) · Journal of Neurology · doi:10.1007/s00415-007-0558-z · Cited by 91
Women have Farther to Fall: Gender Differences Between Normal Elderly and Alzheimer's Disease in Verbal Memory Engender Better Detection of Alzheimer's Disease in Women
Chapman, R. M., Mapstone, M. E., Gardner, M. N., Sandoval, T. C., McCrary, J. W., Guillily, M. D., Reilly, L. A., & DeGrush, E. (2011) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711000452 · Cited by 85
Visual and spatial perception in the early phase of Alzheimer's disease.
Binetti, G. G., Cappa, S. F., Magni, E., Padovani, A., Bianchetti, A., & Trabucchi, M. (1998) · Neuropsychology · doi:10.1037//0894-4105.12.1.29 · Cited by 85
Gender Differences on a Brief Measure of Cognitive Functioning in Alzheimer's Disease
Buckwalter, J. G., Sobel, E., Dunn, M. E., Diz, M. M., & Henderson, V. W. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540070069018 · Cited by 85
Neuropsychological Features of Mild Cognitive Impairment and Preclinical Alzheimer’s Disease
Salmon, D. P. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2011_171 · Cited by 83
Visuoconstructional problems in dementia: Contribution of executive systems functions.
Freeman, R. Q., Giovannetti, T., Lamar, M., et al. (2000) · Neuropsychology · doi:10.1037/0894-4105.14.3.415 · Cited by 83
Memory in pregnancy. I: Subjective experiences and objective assessment of implicit, explicit and working memory in primigravid and primiparous women
Janes, C., Casey, P. J., Huntsdale, C., & Angus, G. (1999) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/01674829909075580 · Cited by 79
Gender-specificities in Alzheimer's disease and mild cognitive impairment
Beinhoff, U., Tumani, H., Brettschneider, J., Bittner, D., & Riepe, M. W. (2008) · Journal of Neurology · doi:10.1007/s00415-008-0726-9 · Cited by 79
Semantic category dissociations in naming : is there a gender effect in Alzheimer’s disease?
Laiacona, M., Barbarotto, R., & Capitani, E. (1998) · Neuropsychologia · doi:10.1016/s0028-3932(97)00125-5 · Cited by 74
Memory Performance, but not Information Processing Speed, may be Reduced During Early Pregnancy
de Groot, R. H. M., Hornstra, G., Roozendaal, N., & Jolles, J. (2003) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.25.4.482.13871 · Cited by 74
Effects of age, gender, education and race on two tests of language ability in community-based older adults
Snitz, B. E., Unverzagt, F. W., Chang, C.-C. H., Bilt, J. D. V., Gao, S., Saxton, J. A., Hall, K. S., & Ganguli, M. (2009) · International Psychogeriatrics · doi:10.1017/s1041610209990214 · Cited by 71
Individual differences in 16-year memory changes.
Zelinski, E. M., & Stewart, S. T. (1998) · Psychology and Aging · doi:10.1037//0882-7974.13.4.622 · Cited by 71
Line orientation judgment in normal elderly and subjects with dementia of Alzheimer's type
Ska, B., Poissant, A., & Joanette, Y. (1990) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/01688639008401012 · Cited by 68
Neuropsychological performance in advanced age: Influences of Demographic factors and Apolipoprotein E: Findings from the Cache County Memory Study
Welsh-Bohmer, K. A., Østbye, T., Sanders, L. L., Pieper, C. F., Hayden, K. M., Tschanz, J. T., Norton, M. C., & for the Cache Country Study Group (2008) · The Clinical Neuropsychologist · doi:10.1080/13854040801894730 · Cited by 67
On the Nature of Naming Errors in Aging and Dementia: A Study of Semantic Relatedness
Nicholas, M. L., Obler, L. K., Au, R., & Albert, M. L. (1996) · Brain and Language · doi:10.1006/brln.1996.0070 · Cited by 67
A Review of the Boston Naming Test and Multiple-Occasion Normative Data for Older Adults on 15-Item Versions
Kent, P. S., & Luszcz, M. A. (2002) · The Clinical Neuropsychologist · doi:10.1076/clin.16.4.555.13916 · Cited by 67
Greater relative impairment of object recognition than of visuospatial abilities in Alzheimer's disease.
Kurylo, D. D., Corkin, S., F., I. R. J., & Growdon, J. H. (1996) · Neuropsychology · doi:10.1037/0894-4105.10.1.74 · Cited by 65
Cognitive Functioning in Aging and Dementia: The Kungsholmen Project
Bäckman, L., Wåhlin, Å., Small, B. J., Herlitz, A., Winblad, B. G., & Fratiglioni, L. (2004) · Aging Neuropsychology and Cognition · doi:10.1080/13825580490511099 · Cited by 65
Naming in dementia secondary to Parkinson's, Huntington's, and Alzheimer's diseases
Frank, E. M., McDade, H. L., & Scott, W. K. (1996) · Journal of Communication Disorders · doi:10.1016/0021-9924(95)00021-6 · Cited by 64
Gender Comparisons of Cognitive Performances Among Vascular Dementia, Alzheimer Disease, and Older Adults Without Dementia
Buckwalter, J. G., Rizzo, A., McCleary, R., Shankle, W. R., Dick, M. B., & Henderson, V. W. (1996) · Archives of Neurology · doi:10.1001/archneur.1996.00550050066025 · Cited by 63
Sex Differences After All Those Years? Heritability of Cognitive Abilities in Old Age
Read, S., Pedersen, N. L., Gatz, M., Berg, S., Vuoksimaa, E., Malmberg, B., Johansson, B. E. A., & McClearn, G. E. (2006) · The Journals of Gerontology Series B · doi:10.1093/geronb/61.3.p137 · Cited by 61
Determinants of Functional Abilities in Dementia
Hill, R. D., Bäckman, L., & Fratiglioni, L. (1995) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1995.tb07006.x · Cited by 61
Normative data on the boston naming test for elderly adults in a demographically diverse medical sample
Ross, T. P., Lichtenberg, P. A., & Christensen, B. K. (1995) · The Clinical Neuropsychologist · doi:10.1080/13854049508400496 · Cited by 60
Decline of Language Among Women and Men With Alzheimer's Disease
Hebert, L. E., Wilson, R. S., Gilley, D. W., Beckett, L. A., Scherr, P. A., Bennett, D. A., & Evans, D. A. (2000) · The Journals of Gerontology Series B · doi:10.1093/geronb/55.6.p354 · Cited by 55
Gender-Related Cognitive Deficits in Alzheimer’s Disease
McPherson, S. E., Cummings, J. L., Back, C., & Buckwalter, J. G. (1999) · International Psychogeriatrics · doi:10.1017/s1041610299005670 · Cited by 55
Fundamental sex difference in human brain architecture
Cahill, L. F. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320954111 · Cited by 53
A Longitudinal Study of Quantitative and Qualitative Features of Category Verbal Fluency in Incident Alzheimer’s Disease Subjects: Results from the PAQUID Study
Auriacombe, S., Lechevallier‐Michel, N., Amieva, H., Harston, S., Raoux, N., & Dartigues, J. (2006) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000091407 · Cited by 53
Do men show more rapid age-associated decline in simulated everyday verbal memory than do women?
Larrabee, G. J., & Crook, T. H. (1993) · Psychology and Aging · doi:10.1037//0882-7974.8.1.68 · Cited by 52
The impact of dementia, age and sex on category fluency: Greater deficits in women with Alzheimer's disease
Moreno-Martínez, F. J., Laws, K. R., & Schulz, J. (2008) · Cortex · doi:10.1016/j.cortex.2007.11.008 · Cited by 48
Self-citation
Gender-related dissociations of categorical fluency in normal subjects and in subjects with Alzheimer's disease.
Marra, C., Ferraccioli, M., & Gainotti, G. (2007) · Neuropsychology · doi:10.1037/0894-4105.21.2.207 · Cited by 46
Gender and age differences in measured and self-perceived imaging capacity
Campos, A., Pérez-Fabello, M. J., & Gómez-Juncal, R. (2004) · Personality and Individual Differences · doi:10.1016/j.paid.2004.01.008 · Cited by 46
Male gender is associated with greater cerebral hypometabolism in frontotemporal dementia: evidence for sex‐related cognitive reserve
Perneczky, R., Diehl‐Schmid, J., Förstl, H., Drzezga, A. E., & Kurz, A. (2007) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1803 · Cited by 44
Perception and representation of the Euclidean coordinates in mature and elderly men and women
Robert, M., & Tanguay, M. (1990) · Experimental Aging Research · doi:10.1080/07340669008251539 · Cited by 40
Do men show more rapid age-associated decline in simulated everyday verbal memory than do women?
Larrabee, G. J., & Crook, T. H. (1993) · Psychology and Aging · doi:10.1037/0882-7974.8.1.68 · Cited by 40
Effects of Health Status on Word Finding in Aging
Albert, M. L., Spiro, A., Sayers, K. J., Cohen, J. A., Brady, C. B., Goral, M., & Obler, L. K. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02559.x · Cited by 39
The Relationship Between Signs of Cardiovascular Deficiency and Cognitive Performance in Old Age: A Population-Based Study
Fahlander, K., Wåhlin, Å., Fastbom, J., Grut, M., Forsell, Y., Hill, R. D., Winblad, B. G., & Bäckman, L. (2000) · The Journals of Gerontology Series B · doi:10.1093/geronb/55.5.p259 · Cited by 39
Visuoperceptual-spatial ability and visual memory in vascular dementia and dementia of the Alzheimer type
Ricker, J. H., Keenan, P. A., & Jacobson, M. W. (1994) · Neuropsychologia · doi:10.1016/0028-3932(94)90110-4 · Cited by 38
Category-specific naming effect in non-brain-damaged individuals
Coppens, P., & Frisinger, D. (2005) · Brain and Language · doi:10.1016/j.bandl.2004.11.008 · Cited by 38
Differential effects of Alzheimer's disease and Huntington's disease on the performance of mental rotation
Lineweaver, T. T., Salmon, D. P., Bondi, M. W., & Corey‐Bloom, J. (2005) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617705050034 · Cited by 37
Preclinical Cognitive Trajectories Differ for Alzheimer's Disease and Vascular Dementia
Laukka, E. J., MacDonald, S. W. S., Fratiglioni, L., & Bäckman, L. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617711001718 · Cited by 36
Apolipoprotein E Gender Effects on Cognitive Performance in Age-Associated Memory Impairment
David Bartrés-faz, A., Junqué, C., Moral, P., López‐Alomar, A., Sánchez-Aldeguer, J., & Clemente, I. C. (2002) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.14.1.80 · Cited by 32
Analysis of Visuospatial Errors in Patients with Alzheimer's Disease or Parkinson's Disease
Finton, M. J., Lucas, J. A., Graff‐Radford, N. R., & Uitti, R. J. (1998) · Journal of Clinical and Experimental Neuropsychology · doi:10.1076/jcen.20.2.186.1167 · Cited by 32
Potential role of estrogen in the pathobiology and prevention of Alzheimer's disease.
Wharton, W., Gleason, C. E., Lorenze, K. R., Markgraf, T. S., Ries, M. L., Carlsson, C. M., & Asthana, S. (2009) · PubMed Central · Cited by 31
Lexical semantic memory in amnestic mild cognitive impairment and mild Alzheimer's disease
Balthazar, M. L. F., Martinelli, J. E., Cendes, F., & Damasceno, B. P. (2007) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2007000400014 · Cited by 31
Gender Differences in Language of Alzheimer Disease Patients Revisited
Bayles, K. A., Azuma, T., Cruz, R. F., Tomoeda, C. K., Wood, J. A., & Montgomery, E. B. (1999) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199907000-00005 · Cited by 29
Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment
Bai, F., Zhang, Z., Watson, D. R., Yu, H., Shi, Y., Zhu, W., Wang, L., Yuan, Y., & Qian, Y. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.11.055 · Cited by 28
Gender differences on the Repeatable Battery for the Assessment of Neuropsychological Status subtests in older adults: Baseline and retest data
Duff, K. M., Schoenberg, M. R., Mold, J. W., Scott, J. G., & Adams, R. L. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2010.533156 · Cited by 26
Fiber bundle length and cognition: a length-based tractography MRI study
Behrman-Lay, A. M., Usher, C., Conturo, T. E., Correia, S., Laidlaw, D. H., Lane, E. M., Bolzenius, J., Heaps, J. M., Salminen, L. E., Baker, L. M., et al. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-014-9334-8 · Cited by 26
Women and Alzheimer's Disease
Lerner, A. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.6.5725 · Cited by 24
The Sex Specificity of Navigational Strategies in Alzheimer Disease
Cushman, L., & Duffy, C. J. (2007) · Alzheimer Disease and Associated Disorders · doi:10.1097/wad.0b013e318047df2f · Cited by 24
Gender-related differences in visuospatial memory persist in Alzheimer's disease.
Millet, X., Raoux, N., Carret, N. L., Bouisson, J., Dartigues, J., & Amieva, H. (2009) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acp086 · Cited by 22
Competence in Independently Living Older Adults: Assessment and Correlates
North, A. J., & Ulatowska, H. K. (1981) · Journal of Gerontology · doi:10.1093/geronj/36.5.576 · Cited by 19
Gender differences in the cognitive impairment in Alzheimer's disease
Heun, R., & Kockler, M. (2002) · Archives of Women s Mental Health · doi:10.1007/s007370200011 · Cited by 18
Early Reproductive Experiences in Females Make Differences in Cognitive Function Later in Life
Li, R., Cui, J., Jothishankar, B., Shen, J., He, P., & Shen, Y. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122101 · Cited by 18
Geschlechtsunterschiede kognitiver Leistungen - populärwissenschaftliche Stereotypien oder evidenzbasierte Studienergebnisse?
Weiss, E. M., Deisenhammer, E., Hinterhuber, H., & Marksteiner, J. (2005) · Fortschritte der Neurologie · Psychiatrie · doi:10.1055/s-2004-830296 · Cited by 13
Women and Alzheimer's Disease
Lerner, A. J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.84.6.1830 · Cited by 12
Gender differences in neuropsychological performance in individuals with atherosclerosis: Impact of vascular function
Moore, C. S., Miller, I. N., Andersen, R. L., Arndt, S. V., Haynes, W. G., & Moser, D. J. (2010) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803391003757841 · Cited by 5

Research works printed but not linked: 9

Rowe G, Turcotte J, Hasher L. The effect of age and gender on visuo-spatial working memory. In Poster presented at the 10th Cognitive Aging Conference, Atlanta, GA, 2004. .
10.1037/0882-7974.13.4.622 · DOI · Paper page
10.1111/j.1532-5415.2009.02559 · DOI
10.1093/arclin/14.6.489 · DOI
10.1037/0894-4105.13.4.590 · DOI
10.1097/00006324-199503000-00003 · DOI
10.1037/0894-4105.12.1.29 · DOI
10.1176/jnp.14.1.80 · DOI
10.1093/geronb/55.6 · DOI

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See all 307

Authors: Laws, K. R., Irvine, K., & Gale, T. M.
Affiliations: University of Hertfordshire (GB)
Corresponding author: Laws, Keith R
ORCID: Laws, Keith R
Irvine, Karen
Gale, Tim M
Venue: World Journal of Psychiatry
Publisher: Baishideng Publishing Group Inc.
Published: 2016
Volume: 6
Issue: 1
Pages: 54
ISSN: 2220-3206 (ISSN-L)
DOI: 10.5498/wjp.v6.i1.54
PMC: PMC4804268
OpenAlex: W2328745627
Cited by: 307
References: 145
Citations by year: 2026: 19 · 2025: 34 · 2024: 38 · 2023: 32 · 2022: 40 · 2021: 41 · 2020: 29 · 2019: 26 · 2018: 24 · 2017: 17 · 2016: 7
FWCI: 3.53
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: World Journal of Psychiatry (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
University of Hertfordshire Research Archive (University of Hertfordshire) (acceptedVersion)
University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion, cc-by-nc)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: Alzheimer's disease, sex differences, cognitive impairment, women, estrogen, postmenopausal women, cognitive reserve, APOE ε4, episodic memory, visuospatial ability, dementia diagnosis

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Sex differences in cognitive impairment in Alzheimer’s disease

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