Most cited biochemistry, genetics and molecular biology papers
- Verified
Pooled Association Tests for Rare Variants in Exon-Resequencing Studies
Price, A. L., Kryukov, G. V., de Bakker, P. I. W., Purcell, S. M., Staples, J., Wei, L.-J., & Sunyaev, S. R. (2010) · The American Journal of Human Genetics
Genetic Associations and EpidemiologyGenomics and Rare Diseases
Cited by 755
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Gene regulatory network inference: Data integration in dynamic models—A review
Hecker, M., Lambeck, S., Toepfer, S., van Someren, E., & Guthke, R. (2009) · Biosystems
Gene Regulatory Network AnalysisMicrobial Metabolic Engineering and Bioproduction
Cited by 755
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The BioMart community portal: an innovative alternative to large, centralized data repositories
Smedley, D., Haider, S., Durinck, S., Pandini, L., Provero, P., Allen, J., Arnaiz, O., Awedh, M. H., Baldock, R., Barbiera, G., et al. (2015) · Nucleic Acids Research
Bioinformatics and Genomic NetworksScientific Computing and Data Management
Cited by 755
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Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair
Lee, K., Conboy, M., Park, H. M., Jiang, F., Kim, H. J., Dewitt, M. A., Mackley, V. A., Chang, K., Rao, A., Skinner, C., et al. (2017) · Nature Biomedical Engineering
CRISPR and Genetic EngineeringRNA Interference and Gene Delivery
Cited by 755
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Peroxisome proliferator-activated receptors in inflammation control
Delerive, P., Fruchart, J., & Staels, B. (2001) · Journal of Endocrinology
Peroxisome Proliferator-Activated ReceptorsFatty Acid Research and Health
Cited by 755
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Augmented Wnt signaling in a mammalian model of accelerated aging
Liu, H., Fergusson, M. M., Castilho, R. M., Liu, J., Cao, L., Chen, J., Malide, D., Rovira, I. I., Schimel, D., Kuo, C. J., et al. (2007) · Science
Wnt/β-catenin signaling in development and cancerTelomeres, Telomerase, and Senescence
Cited by 755
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Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
Richter, B., Sliter, D. A., Herhaus, L., Stolz, A., Wang, C., Beli, P., Zaffagnini, G., Wild, P., Martens, S., Wagner, S. A., et al. (2016) · Proceedings of the National Academy of Sciences
Autophagy in Disease and TherapyUbiquitin and proteasome pathways
Cited by 755
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PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome
Kroeze, W. K., Sassano, M. F., Huang, X.-P., Lansu, K., McCorvy, J. D., Giguère, P. M., Sciaky, N., & Roth, B. L. (2015) · Nature Structural & Molecular Biology
Receptor Mechanisms and SignalingComputational Drug Discovery Methods
Cited by 755
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Adaptive evolution of highly mutable loci in pathogenic bacteria
Moxon, E. R., Rainey, P. B., Nowak, M. A., & Lenski, R. E. (1994) · Current Biology
Evolution and Genetic DynamicsBacterial Genetics and Biotechnology
Cited by 755
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Cohesin’s binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins
Ciosk, R., Shirayama, M., Shevchenko, A., Tanaka, T., Toth, A., Shevchenko, A., & Nasmyth, K. (2000) · Molecular Cell
Microtubule and mitosis dynamicsGenomics and Chromatin Dynamics
Cited by 755
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Spatial transcriptome profiling by MERFISH reveals subcellular RNA compartmentalization and cell cycle-dependent gene expression
Xia, C., Fan, J., Emanuel, G., Hao, J., & Zhuang, X. (2019) · Proceedings of the National Academy of Sciences
Single-cell and spatial transcriptomicsRNA Research and Splicing
Cited by 755
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Implications of protein flexibility for drug discovery
Teague, S. J. (2003) · Nature Reviews Drug Discovery
Protein Structure and DynamicsComputational Drug Discovery Methods
Cited by 755
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DNA Replication Fidelity
Kunkel, T. A. (2004) · Journal of Biological Chemistry
DNA Repair MechanismsDNA and Nucleic Acid Chemistry
Cited by 754
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Autophagy as a promoter of longevity: insights from model organisms
Hansen, M., Rubinsztein, D. C., & Walker, D. W. (2018) · Nature Reviews Molecular Cell Biology
Genetics, Aging, and Longevity in Model OrganismsAutophagy in Disease and Therapy
Cited by 754
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Enzymatic Activity Associated with Class II HDACs Is Dependent on a Multiprotein Complex Containing HDAC3 and SMRT/N-CoR
Fischle, W., Dequiedt, F., Hendzel, M. J., Guenther, M. G., Lazar, M. A., Voelter, W., & Verdin, E. (2002) · Molecular Cell
Histone Deacetylase Inhibitors ResearchGenomics and Chromatin Dynamics
Cited by 754
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CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations
Scott, J. W., Hawley, S. A., Green, K. A., Anis, M., Stewart, G., Scullion, G. A., Norman, D. G., & Hardie, D. G. (2004) · Journal of Clinical Investigation
Biochemical and Molecular ResearchMetabolism, Diabetes, and Cancer
Cited by 754
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Telomere dysfunction in ageing and age-related diseases
Rossiello, F., Jurk, D., Passos, J. F., & d’Adda di Fagagna, F. (2022) · Nature Cell Biology
Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms
Cited by 754
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A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis
Taylor, M. J., Perrais, D., & Merrifield, C. J. (2011) · PLoS Biology
Cellular transport and secretionAutophagy in Disease and Therapy
Cited by 754
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Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins
Schaer, D. J., Buehler, P. W., Alayash, A. I., Belcher, J. D., & Vercellotti, G. M. (2013) · Blood
Hemoglobin structure and functionHeme Oxygenase-1 and Carbon Monoxide
Cited by 754
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piRNAs Can Trigger a Multigenerational Epigenetic Memory in the Germline of C. elegans
Ashe, A., Sapetschnig, A., Weick, E.-M., Mitchell, J., Bagijn, M. P., Cording, A. C., Doebley, A.-L., Goldstein, L. D., Lehrbach, N. J., Le Pen, J., et al. (2012) · Cell
Epigenetics and DNA MethylationChromosomal and Genetic Variations
Cited by 754
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Resveratrol Attenuates Trimethylamine- N -Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota
Chen, M.-L., Yi, L., Zhang, Y., Zhou, X., Ran, L., Yang, J., Zhu, J.-D., Zhang, Q.-Y., & Mi, M.-T. (2016) · mBio
Gut microbiota and healthSirtuins and Resveratrol in Medicine
Cited by 754
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Teratogenicity of high vitamin A intake
Rothman, K. J., Moore, L. L., Singer, M. R., Nguyen, U.-S. D. T., Mannino, S., & Milunsky, A. (1995) · New England Journal of Medicine
Retinoids in leukemia and cellular processesPregnancy and Medication Impact
Cited by 754
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Commensal clostridia: Leading players in the maintenance of gut homeostasis
Lopetuso, L. R., Scaldaferri, F., Petito, V., & Gasbarrini, A. (2013) · Gut Pathogens
Gut microbiota and healthClostridium difficile and Clostridium perfringens research
Cited by 753
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Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics
DNA Repair MechanismsGenetic factors in colorectal cancer
Cited by 753
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