Check biochemistry, genetics and molecular biology papers: citations, claims and retractions

Genomic instability — an evolving hallmark of cancer

Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology

DNA Repair MechanismsCancer Genomics and Diagnostics

Cited by 2,397

Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer

Sparano, J. A., Gray, R. J., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E., Dees, E. C., Goetz, M. P., Olson, J. A., et al. (2018) · New England Journal of Medicine

Breast Cancer Treatment StudiesBRCA gene mutations in cancer

Cited by 2,397

agriGO: a GO analysis toolkit for the agricultural community

Du, Z., Zhou, X., Ling, Y., Zhang, Z., & Su, Z. (2010) · Nucleic Acids Research

Bioinformatics and Genomic NetworksGenomics and Phylogenetic Studies

Cited by 2,396

Insights into the phylogeny and coding potential of microbial dark matter

Rinke, C., Schwientek, P., Sczyrba, A., Ivanova, N. N., Anderson, I. J., Cheng, J.-F., Darling, A., Malfatti, S., Swan, B. K., Gies, E. A., et al. (2013) · Nature

Genomics and Phylogenetic StudiesMicrobial Community Ecology and Physiology

Cited by 2,394

Scoring function for automated assessment of protein structure template quality

Zhang, Y., & Skolnick, J. (2004) · Proteins: Structure, Function, and Bioinformatics

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 2,392

Easy quantitative assessment of genome editing by sequence trace decomposition

Brinkman, E. K., Chen, T., Amendola, M., & van Steensel, B. (2014) · Nucleic Acids Research

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 2,390

Immunosuppression by Glucocorticoids: Inhibition of NF-κB Activity Through Induction of IκB Synthesis

Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., & Karin, M. (1995) · Science

NF-κB Signaling PathwaysSignaling Pathways in Disease

Cited by 2,390

The ENCODE (ENCyclopedia Of DNA Elements) Project

(2004) · Science

Genomics and Chromatin DynamicsGenomics and Phylogenetic Studies

Cited by 2,390

CASTp 3.0: computed atlas of surface topography of proteins

Tian, W., Chen, C., Lei, X., Zhao, J., & Liang, J. (2018) · Nucleic Acids Research

Protein Structure and DynamicsEnzyme Structure and Function

Cited by 2,389

Metformin and reduced risk of cancer in diabetic patients

Evans, J. M. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., & Morris, A. D. (2005) · BMJ

Metabolism, Diabetes, and CancerDiabetes Treatment and Management

Cited by 2,388

Gut microbiome and health: mechanistic insights

de Vos, W. M., Tilg, H., Van Hul, M., & Cani, P. D. (2022) · Gut

Gut microbiota and healthOral microbiology and periodontitis research

Cited by 2,388

Human induced pluripotent stem cells free of vector and transgene sequences

Yu, J., Hu, K., Smuga-Otto, K., Tian, S., Stewart, R., Slukvin, I. I., & Thomson, J. A. (2009) · Science

Pluripotent Stem Cells ResearchCRISPR and Genetic Engineering

Cited by 2,386

Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR–Cas gene editing

Cheng, Q., Wei, T., Farbiak, L., Johnson, L. T., Dilliard, S. A., & Siegwart, D. J. (2020) · Nature Nanotechnology

RNA Interference and Gene DeliveryNanoparticle-Based Drug Delivery

Cited by 2,383

Molecular mechanisms of necroptosis: an ordered cellular explosion

Vandenabeele, P., Galluzzi, L., Vanden Berghe, T., & Kroemer, G. (2010) · Nature Reviews Molecular Cell Biology

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 2,382

The role of iron and reactive oxygen species in cell death

Dixon, S. J., & Stockwell, B. R. (2014) · Nature Chemical Biology

Ferroptosis and cancer prognosisCell death mechanisms and regulation

Cited by 2,381

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 2,380

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

Campisi, J. (2005) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 2,379

Expanded encyclopaedias of DNA elements in the human and mouse genomes

The ENCODE Project Consortium, Abascal, F., Acosta, R., Addleman, N. J., Adrian, J., Afzal, V., Ai, R., Aken, B., Akiyama, J. A., Jammal, O. A., et al. (2020) · Nature

Genomics and Chromatin DynamicsEpigenetics and DNA Methylation

Cited by 2,378

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

Bjorkman, P. J., Saper, M. A., Samraoui, B., Bennett, W. S., Strominger, J. L., & Wiley, D. C. (1987) · Nature

vaccines and immunoinformatics approachesImmunotherapy and Immune Responses

Cited by 2,377

Mammalian thioredoxin is a direct inhibitor of apoptosis signal‐regulating kinase (ASK) 1

Saitoh, M., Nishitoh, H., Fujii, M., Takeda, K., Tobiume, K., Sawada, Y., Kawabata, M., Miyazono, K., & Ichijo, H. (1998) · The EMBO Journal

Redox biology and oxidative stressCell death mechanisms and regulation

Cited by 2,377

Role of the gut microbiota in nutrition and health

Valdes, A. M., Walter, J., Segal, E., & Spector, T. D. (2018) · BMJ

Gut microbiota and healthProbiotics and Fermented Foods

Cited by 2,375

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

Ping, X.-L., Sun, B.-F., Wang, L., Xiao, W., Yang, X., Wang, W.-J., Adhikari, S., Shi, Y., Lv, Y., Chen, Y.-S., et al. (2014) · Cell Research

RNA modifications and cancerRNA regulation and disease

Cited by 2,375

Molecular anatomy of a trafficking organelle

Takamori, S., Holt, M., Stenius, K., Lemke, E. A., Grønborg, M., Riedel, D., Urlaub, H., Schenck, S., Brügger, B., Ringler, P., et al. (2006) · Cell

Cellular transport and secretionExtracellular vesicles in disease

Cited by 2,373

Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins

Verhagen, A. M., Ekert, P. G., Pakusch, M., Silke, J., Connolly, L. M., Reid, G. E., Moritz, R. L., Simpson, R. J., & Vaux, D. L. (2000) · Cell

Cell death mechanisms and regulationCancer-related Molecular Pathways

Cited by 2,372