Most cited biochemistry, genetics and molecular biology papers
- Verified
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., & Chen, Z. J. (2000) · Cell
NF-κB Signaling PathwaysUbiquitin and proteasome pathways
Cited by 1,872
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Receptor Specificity of the Fibroblast Growth Factor Family
Ornitz, D. M., Xu, J., Colvin, J. S., McEwen, D. G., MacArthur, C. A., Coulier, F., Gao, G., & Goldfarb, M. (1996) · Journal of Biological Chemistry
Fibroblast Growth Factor ResearchConnective Tissue Growth Factor Research
Cited by 1,871
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Normalization of cDNA microarray data
Smyth, G. K., & Speed, T. (2003) · Methods
Gene expression and cancer classificationGenomics and Phylogenetic Studies
Cited by 1,871
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HIF-1α pathway: role, regulation and intervention for cancer therapy
Masoud, G. N., & Li, W. (2015) · Acta Pharmaceutica Sinica B
Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer
Cited by 1,871
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ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell
Endoplasmic Reticulum Stress and DiseaseIon Channels and Receptors
Cited by 1,871
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Intracellular adenosine triphosphate (ATP) concentration: A switch in the decision between apoptosis and necrosis
Leist, M., Single, B., Castoldi, A. F., Kühnle, S., & Nicotera, P. (1997) · The Journal of Experimental Medicine
Cell death mechanisms and regulationMitochondrial Function and Pathology
Cited by 1,871
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Mammalian Rho GTPases: new insights into their functions from in vivo studies
Heasman, S. J., & Ridley, A. J. (2008) · Nature Reviews Molecular Cell Biology
Protein Kinase Regulation and GTPase SignalingCellular Mechanics and Interactions
Cited by 1,871
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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. (2011) · Nature
Protein Degradation and InhibitorsAcute Myeloid Leukemia Research
Cited by 1,870
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SPECIFICITY AND VERSATILITY IN TGF-β SIGNALING THROUGH SMADS
Feng, X.-H., & Derynck, R. (2005) · Annual Review of Cell and Developmental Biology
TGF-β signaling in diseasesDevelopmental Biology and Gene Regulation
Cited by 1,869
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Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission
Klar, T. A., Jakobs, S., Dyba, M., Egner, A., & Hell, S. W. (2000) · Proceedings of the National Academy of Sciences
Advanced Fluorescence Microscopy TechniquesNear-Field Optical Microscopy
Cited by 1,869
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Oxidative stress in neurodegeneration: Cause or consequence?
Andersen, J. K. (2004) · Nature Medicine
Redox biology and oxidative stressAntioxidant Activity and Oxidative Stress
Cited by 1,869
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The structure of genetic and environmental risk factors for common psychiatric and substance use disorders in men and women
Kendler, K. S., Prescott, C. A., Myers, J., & Neale, M. C. (2003) · Archives of General Psychiatry
Genetic Associations and EpidemiologyChild and Adolescent Psychosocial and Emotional Development
Cited by 1,868
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Physiological concentrations of purines and pyrimidines
Traut, T. W. (1994) · Molecular and Cellular Biochemistry
Biochemical and Molecular ResearchCancer and biochemical research
Cited by 1,867
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A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency
Hacein-Bey-Abina, S., von Kalle, C., Schmidt, M., Le Deist, F., Wulffraat, N., McIntyre, E., Radford, I., Villeval, J.-L., Fraser, C. C., Cavazzana-Calvo, M., et al. (2003) · New England Journal of Medicine
Virus-based gene therapy researchImmunodeficiency and Autoimmune Disorders
Cited by 1,867
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MicroRNA-155 is induced during the macrophage inflammatory response
O'Connell, R. M., Taganov, K. D., Boldin, M. P., Cheng, G., & Baltimore, D. (2007) · Proceedings of the National Academy of Sciences
MicroRNA in disease regulationImmune Response and Inflammation
Cited by 1,866
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Histone deacetylases and cancer: causes and therapies
Marks, P. A., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., & Kelly, W. K. (2001) · Nature reviews. Cancer
Histone Deacetylase Inhibitors ResearchEpigenetics and DNA Methylation
Cited by 1,866
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Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogenics, Schunkert, H., the CARDIoGRAM Consortium, König, I. R., Kathiresan, S., Reilly, M. P., Assimes, T. L., Holm, H., Preuss, M., Stewart, A. F. R., et al. (2011) · Nature Genetics
Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals
Cited by 1,866
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Transgenerational epigenetic inheritance: myths and mechanisms
Heard, E., & Martienssen, R. A. (2014) · Cell
Epigenetics and DNA MethylationBirth, Development, and Health
Cited by 1,864
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Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Wellcome Trust Case Control Consortium, Zeggini, E., Scott, L. J., Saxena, R., Voight, B. F., Marchini, J. L., Hu, T., de Bakker, P. I., Abecasis, G. R., Almgren, P., et al. (2008) · Nature Genetics
Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals
Cited by 1,864
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The Immunological Genome Project: networks of gene expression in immune cells
The Immunological Genome Project Consortium, Heng, T. S. P., Painter, M. W., Elpek, K., Lukacs-Kornek, V., Mauermann, N., Turley, S. J., Koller, D., Kim, F. S., Wagers, A. J., et al. (2008) · Nature Immunology
Bioinformatics and Genomic NetworksGenomics and Chromatin Dynamics
Cited by 1,864
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RAGE Mediates a Novel Proinflammatory Axis
Hofmann, M. A., Drury, S., Fu, C., Qu, W., Taguchi, A., Lu, Y., Avila, C., Kambham, N., Bierhaus, A., Nawroth, P., et al. (1999) · Cell
Advanced Glycation End Products researchS100 Proteins and Annexins
Cited by 1,864
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Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease
Cho, S. W., Kim, S., Kim, J. M., & Kim, J.-S. (2013) · Nature Biotechnology
CRISPR and Genetic EngineeringRNA regulation and disease
Cited by 1,863
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Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
Dixit, A., Parnas, O., Li, B., Chen, J., Fulco, C. P., Jerby-Arnon, L., Marjanovic, N. D., Dionne, D., Burks, T., Raychowdhury, R., et al. (2016) · Cell
Single-cell and spatial transcriptomicsCRISPR and Genetic Engineering
Cited by 1,863
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Differential Ligand Activation of Estrogen Receptors ERα and ERβ at AP1 Sites
Paech, K., Webb, P., Kuiper, G. G. J. M., Nilsson, S., Gustafsson, J.-Å., Kushner, P. J., & Scanlan, T. S. (1997) · Science
Estrogen and related hormone effectsGenomics and Chromatin Dynamics
Cited by 1,861
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