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Cited by 860

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Local Cerebral Glucose Metabolic Rates in Obsessive-Compulsive Disorder: A Comparison With Rates in Unipolar Depression and in Normal Controls

Baxter, Lewis R.·1987·Archives of General Psychiatry
DOI 10.1001/archpsyc.1987.01800150017003
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Abstract

We studied 14 patients with obsessive-compulsive disorder (OCD) by positron emission tomography and the fluorodeoxyglucose method, looking for abnormalities in local cerebral metabolic rates for glucose in brain structures that have been hypothesized to function abnormally in OCD. These patients were compared with 14 normal controls and 14 patients with unipolar depression. The patients with unipolar depression and OCD did not differ in levels of anxiety, tension, or depression. In OCD, metabolic rates were significantly increased in the left orbital gyrus and bilaterally in the caudate nuclei. This was apparent on all statistical comparisons with both controls and unipolar depression. The right orbital gyrus showed at least a trend to an increased metabolic rate in all comparisons. The metabolic rate in the left orbital gyrus, relative to that in the ipsilateral hemisphere (orbital gyrus/hemisphere ratio), was significantly elevated compared to controls and subjects with unipolar depression, and stayed high even with successful drug treatment. Though it was in the normal range in the morbid state, with improvement in OCD symptoms after drug treatment, the caudate/hemisphere metabolic ratio increased uniformly and significantly bilaterally. This ratio did not increase in patients who did not respond to treatment. Thus, OCD showed cerebral glucose metabolic patterns that differed from controls in both the symptomatic and recovered states.

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Metadata

Authors
Baxter, L. R.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1987-03-01
Volume
44
Issue
3
Pages
211
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1987.01800150017003
OpenAlex
W2120599193
Cited by
860
References
6
FWCI
33.69
Type
journal article
Language
en
Open access
closed

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