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The prevalence of dementia and Alzheimer's disease in Shanghai, China: Impact of age, gender, and education
Abstract
We report the prevalence rates for dementia and Alzheimer's disease (AD) obtained from a probability sample survey of 5,055 noninstitutionalized older persons in Shanghai, China. A two‐stage procedure was used for case finding and case identification. A Chinese version of the Mini‐Mental State Examination was used to determine cases of possible dementia. Three different cutoff points on this mental status test were used depending on the respondent's level of education. Clinical evaluations, based on functional assessments and psychiatric inverview, medical and neurological examinations, three standardized mental status tests, and a selected group of psychometric tests, were made in the second stage of the study to ascertain the clinical diagnoses of dementia and AD utilizing the Diagnostic and Statistical Manual for Mental Disorders, edition 3 and National Institute of Neurological and Communicative Disorders and Stroke–Alzheimer's Disease and Related Disorders Association criteria, respectively. The prevalence rate of dementia in persons 65 years and older was 4.6%. Clinically diagnosed AD accounted for 65% of the subjects with dementia. These findings indicate that the prevalence of dementia in Shanghai is very much higher than figures published earlier for China and Japan, and at the lower part of the range of values reported for community residents in the United States and other Western countries, but less than half of that reported in the recently published survey of the elderly in East Boston. Increasing age, gender (female), and low education are each highly significant and independent risk factors for dementia. One hypothesis to explain the increased prevalence in elderly women who had received no formal education invokes the possibility of an effect of early deprivation, perhaps lowering brain %reserve,% allowing the symptoms of dementia to appear at an earlier date during disease progression.
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Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282
Blessed, G., Tomlinson, B. E., & Roth, M. (1968) · British Journal of Psychiatry · doi:10.1192/bjp.114.512.797 · Cited by 4,117
Evans, D. A. (1989) · JAMA · doi:10.1001/jama.1989.03430180093036 · Cited by 1,226
Research works printed but not linked: 31
- Mortimer JA, 1981, The epidemiology of dementia, 3
- 10.1111/j.1600-0447.1986.tb10598.x · DOI
- 10.1016/S0193-953X(18)30884-0 · DOI
- Mortimer JA, 1983, Alzheimer disease, 144
- Chen XS, 1987, A psychiatric epidemiological survey on elderly in Beijing city, Chung Hua Shen Ching Shen Ko Tsa Chih, 20, 145
- Kuang PG, 1984, A sampling survey of geriatric mental disturbances at Wuhan in 1981, Chung Hua Liu Hsing Ping Hsueh Tsa Chih, 5, 95
- Yang JS, 1988, A survey of physical and mental health among 1229 elderly over 65, Chinese J Neurol Syst Mental Dis (Zhonggua Shenjing Jingshen Jiking Zazhi, in Chinese), 14, 85
- Li G, 1988, The test of MMSE in urban community elderly, Chinese J Mental Health (Zhonghua Shenjing Jingshenke Zazhi, in Chinese), 2, 13
- 10.1093/ije/17.4.931-a · DOI
- 10.1093/geronj/44.3.S97 · DOI
- QuGY RenFM YaoCD et al.Data collection in Shanghai survey of the elderly. Paper presented at the Asia–U.S. Conference on Social Services and Aging Policy August 7–11 1988 Pensacola FL
- 10.1016/0895-4356(88)90034-0 · DOI · Paper page
- 10.1016/0021-9681(86)90019-6 · DOI
- ZhangMY QuGY WangZY et al.The CMMSE and its validity. Paper presented at the Asia–U.S. Conference on Social Service and Aging Policy Aug 7–111988 Pensacola FL
- Fuld PA, 1978, Alzheimer's disease: senile dementia and related disorders. Aging, 185
- 10.1037/0882-7974.4.4.471 · DOI
- Fuld PA, 1981, The Fuld Object‐Memory Evaluation
- 10.1080/01688638708410764 · DOI · Paper page
- Wechsler D, 1974, Manual: Wechsler Intelligence Scale for Children‐Revised (WISC‐R)
- Gong YX, 1982, Manual of Modified Wechsler Adult Intelligence Scale (WAIS‐RC) (in Chinese)
- 10.1093/geronj/37.3.323 · DOI
- 1980, Diagnostic and statistical manual of mental disorders
- 10.1212/WNL.34.7.939 · DOI · Paper page
- Hachinski V, 1978, Alzheimer's disease: Senile dementia and related disorders. Aging, 97
- Levy P, 1980, Sampling for health professionals
- 10.1111/j.1600-0447.1975.tb00012.x · DOI
- Essen‐Möller E, 1956, Individual traits and morbidity in a Swedish rural population, Acta Psychiatr Neurol Scand, 31, 1
- Helgason T, 1973, Proceedings of the Fifth Congress of Psychiatry, Mexico, 1971, 350
- 10.1192/bjp.110.465.146 · DOI · Paper page
- Larsson T, 1963, Senile dementia: a clinical, sociomedical and genetic study, Acta Psychiatr Scand, 39, 1
- 10.1111/j.1600-0447.1963.tb07863.x · DOI
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Scarmeas, N., Levy, G., Tang, M.-X., Manly, J., & Stern, Y. (2001) · Neurology · doi:10.1212/wnl.57.12.2236 · Cited by 831
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Ott, A., Breteler, M. M. B., van Harskamp, F., Claus, J. J., van der Cammen, T. J. M., Grobbee, D. E., & Hofman, A. (1995) · BMJ · doi:10.1136/bmj.310.6985.970 · Cited by 792
Beydoun, M. A., Beydoun, H. A., Gamaldo, A. A., Teel, A., Zonderman, A. B., & Wang, Y. (2014) · BMC Public Health · doi:10.1186/1471-2458-14-643 · Cited by 671
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Metadata
- Authors
- Zhang, M., Katzman, R., Salmon, D., Jin, H., Cai, G., Wang, Z., Qu, G., Grant, I., Yu, E., Levy, P., Klauber, M. R., & Liu, W. T.
- Venue
- Annals of Neurology
- Publisher
- Wiley
- Published
- 1990-04
- Volume
- 27
- Issue
- 4
- Pages
- 428-437
- ISSN
- 0364-5134 (ISSN-L)
- 1531-8249
- OpenAlex
- W2063951693
- Cited by
- 1,047
- References
- 3
- FWCI
- 19.95
- Type
- journal article
- Language
- en
- Open access
- closed
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