Cited by 99Attention Deficit Hyperactivity DisorderAdvanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity Studies

Connectomic disturbances in attention-deficit/hyperactivity disorder: a whole-brain tractography analysis

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Hong, Soon-Beom, Zalesky, Andrew, Fornito, Alex, Park, Subin, Yang, Young-Hui, Park, Min-Hyeon, Song, In-Chan, Sohn, Chul-Ho +6 more·2014·Biological Psychiatry

Abstract

Background Few studies have sought to identify, in a regionally unbiased way, the precise cortical and subcortical regions that are affected by white matter abnormalities in attention-deficit/hyperactivity disorder (ADHD). This study aimed to derive a comprehensive, whole-brain characterization of connectomic disturbances in ADHD.Methods Using diffusion tensor imaging, whole-brain tractography, and an imaging connectomics approach, we characterized altered white matter connectivity in 71 children and adolescents with ADHD compared with 26 healthy control subjects. White matter differences were further delineated between patients with (n = 40) and without (n = 26) the predominantly hyperactive/impulsive subtype of ADHD.Results A significant network comprising 25 distinct fiber bundles linking 23 different brain regions spanning frontal, striatal, and cerebellar brain regions showed altered white matter structure in ADHD patients (p < .05, family-wise error-corrected). Moreover, fractional anisotropy in some of these fiber bundles correlated with attentional disturbances. Attention-deficit/hyperactivity disorder subtypes were differentiated by a right-lateralized network (p < .05, family-wise error-corrected) predominantly linking frontal, cingulate, and supplementary motor areas. Fractional anisotropy in this network was also correlated with continuous performance test scores.Conclusions Using an unbiased, whole-brain, data-driven approach, we demonstrated abnormal white matter connectivity in ADHD. The correlations observed with measures of attentional performance underscore the functional importance of these connectomic disturbances for the clinical phenotype of ADHD. A distributed pattern of white matter microstructural integrity separately involving frontal, striatal, and cerebellar brain regions, rather than direct frontostriatal connectivity, appears to be disrupted in children and adolescents with ADHD.

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Crossref · 10.1016/j.biopsych.2013.12.013

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  • In children and adolescents with ADHD, inattention is linked to reduced brain connectivity in the frontal, anterior cingulate, temporal, and parietal regions.

    “In children and adolescents with ADHD, inattention was linked to reduced brain connectivity not only in the frontal but also in the anterior cingulate, temporal, and parietal regions [28].”
  • These DTI findings in young adults with an ADHD diagnosis are in agreement with recent data using whole-brain tractography, which revealed widespread disturbances in WM connectivity of children and adolescents involving frontal, striatal, and cerebellar brain regions.

    “These DTI findings in young adults with an ADHD diagnosis are in agreement with recent data using whole-brain tractography [28], which revealed widespread disturbances in WM connectivity of children and adolescents involving frontal, striatal, and cerebellar brain regions.”

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  1. Hong, S. -B., Zalesky, A., Fornito, A., Park, S., Yang, Y. -H., Park, M. -H., Song, I. -C., Sohn, C. -H., Shin, M. -S., Kim, B. -N., Cho, S. -C., Han, D. H., Cheong, J. H. & Kim, J. -W. (2014). Connectomic Disturbances in Attention-Deficit/Hyperactivity Disorder: A Whole-Brain Tractography Analysis. BIOLOGICAL PSYCHIATRY, 76 (8), pp.656-663. https://doi.org/10.1016/j.biopsych.2013.12.013. Persistent Link: http://hdl.handle.net/11343/44055

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Authors
Hong, S.-B., Zalesky, A., Fornito, A., Park, S., Yang, Y.-H., Park, M.-H., Song, I.-C., Sohn, C.-H., Shin, M.-S., Kim, B.-N., Cho, S.-C., Han, D. H., Cheong, J. H., & Kim, J.-W.
Affiliations
  • Seoul National University (KR)
  • The University of Melbourne (AU)
  • Pusan National University Yangsan Hospital (KR)
  • Seoul National University Hospital (KR)
  • Chung-Ang University (KR)
  • Sahmyook University (KR)
Corresponding author
Kim, Jae-Won
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2014-10
Volume
76
Issue
8
Pages
656-663
ISSN
0006-3223 (ISSN-L)
OpenAlex
W2102695881
Cited by
99
References
57
Citations by year
2026: 2 · 2025: 4 · 2024: 4 · 2023: 13 · 2022: 8 · 2021: 3 · 2020: 7 · 2019: 8 · 2018: 8 · 2017: 12 · 2016: 8 · 2015: 15 · 2014: 7
FWCI
10.68
Type
journal article
Language
en
Open access
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion)
Funders
  • Basic Science Program through the National Research Foundation of Korea (2010-0002283 to J-WK)
  • Korean Health Technology R&D Project, Ministry of Health & Welfare, Republic of Korea (A120013 to B-NK)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
attention deficit hyperactivity disorder, white matter connectivity, connectomics, whole-brain tractography, hyperactive-impulsive subtype, fractional anisotropy, right lateralization, attentional performance, children and adolescents, diffusion tensor imaging
MeSH terms
Adolescent, Attention Deficit Disorder with Hyperactivity, Brain, Child, Female, Humans, Male, Neural Pathways, Anisotropy, Diffusion Tensor Imaging, Connectome

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