Underconnectivity between voice-selective cortex and reward circuitry in children with autism
Open accessAbstract
Individuals with autism spectrum disorders (ASDs) often show insensitivity to the human voice, a deficit that is thought to play a key role in communication deficits in this population. The social motivation theory of ASD predicts that impaired function of reward and emotional systems impedes children with ASD from actively engaging with speech. Here we explore this theory by investigating distributed brain systems underlying human voice perception in children with ASD. Using resting-state functional MRI data acquired from 20 children with ASD and 19 age- and intelligence quotient-matched typically developing children, we examined intrinsic functional connectivity of voice-selective bilateral posterior superior temporal sulcus (pSTS). Children with ASD showed a striking pattern of underconnectivity between left-hemisphere pSTS and distributed nodes of the dopaminergic reward pathway, including bilateral ventral tegmental areas and nucleus accumbens, left-hemisphere insula, orbitofrontal cortex, and ventromedial prefrontal cortex. Children with ASD also showed underconnectivity between right-hemisphere pSTS, a region known for processing speech prosody, and the orbitofrontal cortex and amygdala, brain regions critical for emotion-related associative learning. The degree of underconnectivity between voice-selective cortex and reward pathways predicted symptom severity for communication deficits in children with ASD. Our results suggest that weak connectivity of voice-selective cortex and brain structures involved in reward and emotion may impair the ability of children with ASD to experience speech as a pleasurable stimulus, thereby impacting language and social skill development in this population. Our study provides support for the social motivation theory of ASD.
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Differences in connectivity between distant brain regions in ASD suggest a propensity towards multisensory deficits.
“evidence for differences in connectivity between distant brain regions in children with ASD (Abrams et al., 2013; Assaf et al., 2010; Maximo et al., 2014; Plitt et al., 2015) would also suggest a propensity towards multisensory deficits”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Abrams et al., 2013
Individuals with ASD show reduced connectivity between the pSTS and reward circuitry regions including ventral tegmental areas, nucleus accumbens, insula, and orbitofrontal cortex.
“Studies have also found reduced connectivity between the pSTS and regions implicated in reward circuitry (including ventral tegmental areas, nucleus accumbens, insula, and orbitofrontal cortex)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Abrams et al., 2013
Some kinds of social stimuli do not evoke the same rewarding response in individuals with ASD as in typically developing individuals.
“suggesting that some kinds of social stimuli do not evoke the same rewarding response in individuals with ASD as they do in individuals with typical development (Abrams et al., 2013)”
From Behavioral, Perceptual, and Neural Alterations in Sensory and Multisensory Function in Autism Spectrum Disorder (2015) · cites this paper as Abrams et al., 2013
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- Authors
- Abrams, D. A., Lynch, C. J., Cheng, K. M., Phillips, J., Supekar, K., Ryali, S., Uddin, L. Q., & Menon, V.
- Affiliations
- Departments of aPsychiatry and Behavioral Sciences and
- Stanford Medicine (US)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2013-06-17
- Volume
- 110
- Issue
- 29
- Pages
- 12060-12065
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC3718181
- OpenAlex
- W2028201432
- Cited by
- 250
- References
- 70
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 16 · 2023: 18 · 2022: 27 · 2021: 12 · 2020: 18 · 2019: 17 · 2018: 12 · 2017: 26 · 2016: 19 · 2015: 25 · 2014: 24 · 2013: 9 · 2012: 1
- FWCI
- 14.08
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH084164, K01MH092288, R01MH084164)
- National Institute on Deafness and Other Communication Disorders (R21DC011095, F32DC010322, DC011095)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, posterior superior temporal sulcus, reward systems, functional connectivity, social motivation theory, prosody, dopaminergic reward pathways, nucleus accumbens, ventral tegmental area, insula, orbitofrontal cortex, amygdala, communication difficulties, symptom severity, children
- MeSH terms
- Autistic Disorder, Brain Mapping, Child, Humans, Magnetic Resonance Imaging, Models, Psychological, Motivation, Nerve Net, Neural Pathways, Regression Analysis, Reward, Speech Perception
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