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Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy
Abstract
Exosomes are biological nanocarriers which could be involved in a variety of basic physiological events. They exert their effects via targeting their cargos (i.e., DNAs, messenger RNAs, microRNAs [miRNAs], and proteins) to host cells, which led to change behaviors of recipient cells. One of the important aspects of exosomes is the roles of them in disease conditions. Increasing evidence indicated that exosomes are one of the main players in Alzheimer’s disease (AD) pathogenesis. Hence, it seems that these nanocarriers could be used as diagnostic and therapeutic biomarkers in AD treatment. Another important player in AD pathogenesis is miRNA. MiRNAs are short noncoding RNAs which exert their effects as epigenetic regulators. These molecules involved in different stages of AD. Therefore, miRNAs could be used as prognostic, diagnostic, and therapeutic biomarkers in AD. Here, we summarized various roles of exosomes and application of them in AD pathogenesis. Moreover, we highlighted the utilization of miRNAs as a therapeutic option in AD therapy.
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“Indeed, it has been reported that miRNAs in exosomes are dysregulated in AD patients when compared to healthy people [36,41].”
From MicroRNAs in Extracellular Vesicles of Alzheimer’s Disease (2023) · cites this paper as [41]
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Metadata
- Authors
- Iranifar, E., Seresht, B. M., Momeni, F., Fadaei, E., Mehr, M. H., Ebrahimi, Z., Rahmati, M., Kharazinejad, E., & Mirzaei, H.
- Affiliations
- Torbat Heydariyeh University of Medical Sciences Torbat Heydariyeh Iran
- Department of Genetics Faculty of Biological Science, Shahid Beheshti University (GC) Tehran Iran
- General Practitioner, Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran
- Faculty of Medicine Islamic Azad University of Najafabad Najafabad Iran
- Department of Physiology School of Medicine, Iran University of Medical Sciences Tehran Iran
- Department of Medical Biotechnology and Molecular Sciences School of Medicine, North Khorasan University of Medical Sciences Bojnurd Iran
- Department of Medical Biotechnology School of Medicine, Shahroud University of Medical Sciences Shahroud Iran
- Abadan School of Medical Sciences Abadan Iran
- Department of Biomaterials Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences Isfahan Iran
- ORCID
- Mirzaei, Hamed
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2018-09-07
- Volume
- 234
- Issue
- 3
- Pages
- 2296-2305
- ISSN
- 0021-9541
- 1097-4652
- Cited by
- 93
- References
- 11
- Language
- en
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