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Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy

Iranifar, Elmira, Seresht, Banafsheh Mirzaei, Momeni, Fatemeh, Fadaei, Elyas, Mehr, Maysam Havasi, Ebrahimi, Zahra, Rahmati, Majid, Kharazinejad, Ebrahim, Mirzaei, Hamed·2019·Journal of Cellular Physiology

DOI 10.1002/jcp.27214

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Abstract

Exosomes are biological nanocarriers which could be involved in a variety of basic physiological events. They exert their effects via targeting their cargos (i.e., DNAs, messenger RNAs, microRNAs [miRNAs], and proteins) to host cells, which led to change behaviors of recipient cells. One of the important aspects of exosomes is the roles of them in disease conditions. Increasing evidence indicated that exosomes are one of the main players in Alzheimer’s disease (AD) pathogenesis. Hence, it seems that these nanocarriers could be used as diagnostic and therapeutic biomarkers in AD treatment. Another important player in AD pathogenesis is miRNA. MiRNAs are short noncoding RNAs which exert their effects as epigenetic regulators. These molecules involved in different stages of AD. Therefore, miRNAs could be used as prognostic, diagnostic, and therapeutic biomarkers in AD. Here, we summarized various roles of exosomes and application of them in AD pathogenesis. Moreover, we highlighted the utilization of miRNAs as a therapeutic option in AD therapy.

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See all 93

Authors: Iranifar, E., Seresht, B. M., Momeni, F., Fadaei, E., Mehr, M. H., Ebrahimi, Z., Rahmati, M., Kharazinejad, E., & Mirzaei, H.
Affiliations: Torbat Heydariyeh University of Medical Sciences Torbat Heydariyeh Iran
Department of Genetics Faculty of Biological Science, Shahid Beheshti University (GC) Tehran Iran
General Practitioner, Faculty of Medicine Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran
Faculty of Medicine Islamic Azad University of Najafabad Najafabad Iran
Department of Physiology School of Medicine, Iran University of Medical Sciences Tehran Iran
Department of Medical Biotechnology and Molecular Sciences School of Medicine, North Khorasan University of Medical Sciences Bojnurd Iran
Department of Medical Biotechnology School of Medicine, Shahroud University of Medical Sciences Shahroud Iran
Abadan School of Medical Sciences Abadan Iran
Department of Biomaterials Tissue Engineering and Nanotechnology, School of Advanced Technologies in Medicine, Isfahan University of Medical Sciences Isfahan Iran
ORCID: Mirzaei, Hamed
Venue: Journal of Cellular Physiology
Publisher: Wiley
Published: 2018-09-07
Volume: 234
Issue: 3
Pages: 2296-2305
ISSN: 0021-9541
1097-4652
DOI: 10.1002/jcp.27214
Cited by: 93
References: 11
Language: en
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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Exosomes and microRNAs: New potential therapeutic candidates in Alzheimer disease therapy

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