Amygdala Modulation of Multiple Memory Systems: Hippocampus and Caudate-Putamen
Abstract
A series of five experiments examined the differential mnemonic roles of the hippocampus and caudate-putamen and the modulatory influence of the amygdala on hippocampal and caudate-putamen memory processes. Findings indicate that (a) posttraining intrahippocampal injections of amphetamine selectively enhance memory in a hidden platform water maze task, (b) posttraining intracaudate injections of amphetamine selectively enhance memory in a visible platform water maze task, (c) posttraining intra-amygdala injections of amphetamine enhance memory in both water maze tasks, (d) preretention intrahippocampal lidocaine injections block expression of the memory enhancing effects of posttraining intrahippocampal amphetamine injections in the hidden platform task, (e) preretention intracaudate lidocaine injections block expression of the memory enhancing effects of posttraining intracaudate amphetamine injections in the visible platform task, (f) preretention intra-amygdala lidocaine injections do not block the memory enhancing effect of posttraining intra-amygdala amphetamine injections on either task, (g) in the hidden platform task, posttraining intrahippocampal, but not intracaudate, lidocaine injections block the memory enhancing effects of posttraining intra-amygdala amphetamine, (h) in the visible platform task, posttraining intracaudate, but not intrahippocampal, lidocaine injections block the memory enhancing effects of posttraining intra-amygdala amphetamine. The findings indicate a double dissociation between the roles of the hippocampus and caudate-putamen in memory and suggest that the amygdala exerts a modulatory influence on both the hippocampal and caudate-putamen memory systems.
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Amphetamine-induced activation of the amygdala enhanced hippocampus-dependent spatial memory.
“Packard and Teather [190] demonstrated that the amphetamine-induced activation of the amygdala enhanced hippocampus-dependent spatial memory.”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Packard and Teather [190]
More severe acute stressors impair hippocampal functions but continue to strengthen emotional associations and motor habits carried out by the amygdala and striatum.
“More severe acute stressors impair hippocampal functions38 but continue to strengthen the emotional associations and motor habits carried out by the amygdala and striatum, respectively14,39.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [39]
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- Authors
- Packard, M. G., & Teather, L. A.
- Affiliations
- Louisiana State University (US)
- Venue
- Neurobiology of Learning and Memory
- Publisher
- Elsevier BV
- Published
- 1998-03
- Volume
- 69
- Issue
- 2
- Pages
- 163-203
- ISSN
- 1074-7427 (ISSN-L)
- OpenAlex
- W2005264554
- Cited by
- 287
- References
- 5
- Citations by year
- 2025: 1 · 2024: 9 · 2023: 3 · 2022: 3 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 11 · 2016: 11 · 2015: 5 · 2014: 12 · 2013: 9 · 2012: 12
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Learning and Memory (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (1R2956973-01)
- National Institute of Mental Health (1RO3MH5307-01)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amygdala, hippocampus, caudate-putamen, memory systems, amphetamine, lidocaine, water maze, spatial memory, memory enhancement, memory modulation, double dissociation, intracerebral injection
- MeSH terms
- Amphetamine, Amygdala, Animals, Behavior, Animal, Caudate Nucleus, Corpus Striatum, Hippocampus, Male, Putamen, Retention, Psychology, Adrenergic Uptake Inhibitors, Rats
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