Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus

Guan, Zhiwei; Peng, Xuwen; Fang, Jidong

doi:10.1016/j.brainres.2004.05.032

Cited by 208Sleep and Wakefulness ResearchMemory and Neural MechanismsSleep and Work-Related Fatigue

Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus

Guan, Zhiwei, Peng, Xuwen, Fang, Jidong·2004·Brain Research

DOI 10.1016/j.brainres.2004.05.032

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Abstract

Loss of sleep may result in memory impairment. However, little is known about the biochemical basis for memory deficits induced by sleep deprivation. Extracellular signal-regulated kinase (ERK) is involved in memory consolidation in different tasks. Phosphorylation of ERK is necessary for its activation and is an important step in mediating neuronal responses to synaptic activities. The aim of the present study was to determine the effects of total sleep deprivation (TSD) on memory and ERK phosphorylation in the brain. Rats were trained in Morris water maze to find a hidden platform (a spatial task) or a visible platform (a nonspatial task) after 6 h TSD or spontaneous sleep. TSD had no effect on spatial learning, but significantly impaired spatial memory tested 24 h after training. Nonspatial learning and memory were not impaired by TSD. Phospho-ERK levels in the hippocampus were significantly reduced after 6 h TSD compared to the controls and returned to the control levels after 2 h recovery sleep. Total ERK1 and ERK2 were slightly increased after 6 h TSD and returned to the control levels after 2 h recovery sleep. These alterations were not observed in the cortex after TSD. Protein phosphotase-1 and mitogen-activated protein kinase phosphatase-2, which dephosphorylates phospho-ERK, were also measured, but they were not altered by TSD. The impairments of both spatial memory and ERK phosphorylation indicate that the hippocampus is vulnerable to sleep loss. These results are consistent with the idea that decreased ERK activation in the hippocampus is involved in sleep deprivation-induced spatial memory impairment.

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A 6-hour period of total sleep deprivation by novelty exposure impairs acquisition of a spatial task in the Morris water maze.
“A 6-hour period of total sleep deprivation by novelty exposure impaired acquisition of a spatial task in the Morris water maze.69”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [69]
A 6-hour period of total sleep deprivation by novelty exposure impairs acquisition of a spatial task in the Morris water maze.
“Moreover, a 6-hour period of total sleep deprivation by novelty exposure impaired acquisition of a spatial task in the Morris water maze.35”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [35]

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Authors: Guan, Z., Peng, X., & Fang, J.
Affiliations: Pennsylvania State University (US)
Corresponding author: Fang, Jidong
ORCID: Guan, Zhiwei
Venue: Brain Research
Publisher: Elsevier BV
Published: 2004-08
Volume: 1018
Issue: 1
Pages: 38-47
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2004.05.032
OpenAlex: W1979530444
Cited by: 208
References: 84
Citations by year: 2026: 3 · 2025: 3 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 7 · 2020: 11 · 2019: 13 · 2018: 9 · 2017: 11 · 2016: 11 · 2015: 16 · 2014: 12 · 2013: 16 · 2012: 11
FWCI: 3.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Brain Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (HL 64245, R01HL064245)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
Keywords: sleep deprivation, spatial memory, extracellular signal-regulated kinase, ERK1/2 phosphorylation, hippocampus, memory consolidation, recovery sleep, protein phosphatase 1, Morris water maze
MeSH terms: Animals, Cerebral Cortex, Hippocampus, Male, Memory Disorders, Phosphoprotein Phosphatases, Phosphorylation, Sleep, Sleep Deprivation, Down-Regulation, Protein Tyrosine Phosphatases, Rats, Sprague-Dawley, Maze Learning, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Rats, Dual-Specificity Phosphatases, Mitogen-Activated Protein Kinase Phosphatases, Protein Phosphatase 2

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Sleep deprivation impairs spatial memory and decreases extracellular signal-regulated kinase phosphorylation in the hippocampus

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