Cited by 328Neural and Behavioral Psychology StudiesMemory and Neural MechanismsNeurotransmitter Receptor Influence on Behavior

The role of the striatum in aversive learning and aversive prediction errors

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Delgado, Mauricio R, Li, Jian, Schiller, Daniela, Phelps, Elizabeth A·2008·Philosophical Transactions of the Royal Society B: Biological Sciences

Abstract

Neuroeconomic studies of decision making have emphasized reward learning as critical in the representation of value-driven choice behaviour. However, it is readily apparent that punishment and aversive learning are also significant factors in motivating decisions and actions. In this paper, we review the role of the striatum and amygdala in affective learning and the coding of aversive prediction errors (PEs). We present neuroimaging results showing aversive PE-related signals in the striatum in fear conditioning paradigms with both primary (shock) and secondary (monetary loss) reinforcers. These results and others point to the general role for the striatum in coding PEs across a broad range of learning paradigms and reinforcer types.

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Research works printed but not linked: 2

  1. Schiller, D., Levy, I., Niv, Y., Ledoux, J. E. & Phelps, E. A. In press. Reversal of fear in the human brain. J. Neurosci [DOI] [PMC free article] [PubMed]
  2. Talairach J, Tournoux P. G. Thieme; Thieme Medical Publishers; Stuttgart, Germany; New York, NY: 1988. Co-planar stereotaxic atlas of the human brain: an approach to medical cerebral imaging. [Google Scholar]

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Authors
Delgado, M. R., Li, J., Schiller, D., & Phelps, E. A.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • New York University (US)
Corresponding author
Phelps, Elizabeth A
Venue
Philosophical Transactions of the Royal Society B: Biological Sciences
Published
2008-10
Volume
363
Issue
1511
Pages
3787-3800
ISSN
  • 0962-8436 (ISSN-L)
  • 1471-2970
OpenAlex
W2167551262
Cited by
328
References
166
Citations by year
2026: 7 · 2025: 14 · 2024: 10 · 2023: 9 · 2022: 7 · 2021: 14 · 2020: 46 · 2019: 11 · 2018: 17 · 2017: 11 · 2016: 30 · 2015: 18 · 2014: 27 · 2013: 24 · 2012: 30
FWCI
1.27
Type
journal article
Language
en
Open access
Locations
  • Philosophical Transactions of the Royal Society B Biological Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
James S. McDonnell Foundation
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
striatum, aversive learning, amygdala, fear conditioning, punishment, affective learning, reward learning, decision-making, financial losses, shock, reinforcement learning
MeSH terms
Affect, Animals, Corpus Striatum, Decision Making, Humans, Learning, Rats

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