CRF antagonist reverses the “anxiogenic” response to ethanol withdrawal in the rat

Characterization of a 41-Residue Ovine Hypothalamic Peptide That Stimulates Secretion of Corticotropin and β-Endorphin

Vale, W., Spiess, J., Rivier, C., & Rivier, J. (1981) · Science · doi:10.1126/science.6267699 · Cited by 3,965

Neurocircuitry of Addiction

Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340

Addiction and the brain antireward system

Koob, G. F., & Le Moal, M. (2008) · Annual Review of Psychology · doi:10.1146/annurev.psych.59.103006.093548 · Cited by 1,457

CRF and CRF receptors: role in stress responsivity and other behaviors

Bale, T. L., & Vale, W. W. (2004) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.44.101802.121410 · Cited by 1,270

A Role for Brain Stress Systems in Addiction

Koob, G. F. (2008) · Neuron · doi:10.1016/j.neuron.2008.06.012 · Cited by 1,056

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

HOLSBOER, F., & BARDEN, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 852

The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety

Holsboer, F. (1999) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)90056-5 · Cited by 654

Corticotropin-releasing factor, norepinephrine, and stress

Koob, G. F. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00164-x · Cited by 629

The role of dopamine in drug abuse viewed from the perspective of its role in motivation

Di Chiara, G. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01118-i · Cited by 629

Increase of extracellular corticotropin-releasing factor-like immunoreactivity levels in the amygdala of awake rats during restraint stress and ethanol withdrawal as measured by microdialysis

Pich, E., Lorang, M., Yeganeh, M., Rodriguez de Fonseca, F., Raber, J., Koob, G., & Weiss, F. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-08-05439.1995 · Cited by 565

Appetite-Suppressing Effects of Urocortin, a CRF-Related Neuropeptide

Spina, M., Merlo-Pich, E., Chan, R. K. W., Basso, A. M., Rivier, J., Vale, W., & Koob, G. F. (1996) · Science · doi:10.1126/science.273.5281.1561 · Cited by 564

A role for corticotropin releasing factor and urocortin in behavioral responses to stressors

Koob, G. F., & Heinrichs, S. C. (1999) · Brain Research · doi:10.1016/s0006-8993(99)01991-5 · Cited by 531

Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary.

Potter, E., Sutton, S., Donaldson, C., Chen, R., Perrin, M., Lewis, K., Sawchenko, P. E., & Vale, W. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.19.8777 · Cited by 514

A key role for corticotropin-releasing factor in alcohol dependence

Heilig, M., & Koob, G. F. (2007) · Trends in Neurosciences · doi:10.1016/j.tins.2007.06.006 · Cited by 503

Deletion of Crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2

Kishimoto, T., Radulovic, J., Radulovic, M., Lin, C. R., Schrick, C., Hooshmand, F., Hermanson, O., Rosenfeld, M. G., & Spiess, J. (2000) · Nature Genetics · doi:10.1038/74271 · Cited by 502

Addiction as a stress surfeit disorder

Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.05.024 · Cited by 483

Role of Corticotropin-Releasing Factor in Drug Addiction: Potential for Pharmacological Intervention

Logrip, M. L., Koob, G. F., & Zorrilla, E. P. (2011) · CNS Drugs · doi:10.2165/11587790-000000000-00000 · Cited by 476

Ethanol self-administration restores withdrawal-associated deficiencies in accumbal dopamine and 5-hydroxytryptamine release in dependent rats

Weiss, F., Parsons, L. H., Schulteis, G., Hyytiä, P., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03474.1996 · Cited by 457

Neurobiological substrates for the dark side of compulsivity in addiction

Koob, G. F. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.043 · Cited by 458

REVIEW: Acute withdrawal, protracted abstinence and negative affect in alcoholism: are they linked?

Heilig, M., Egli, M., Crabbe, J. C., & Becker, H. C. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2009.00194.x · Cited by 435

The dark side of emotion: the addiction perspective

Koob, G. F. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2014.11.044 · Cited by 433

Neural mechanisms underlying nicotine addiction: acute positive reinforcement and withdrawal

S. Watkins, G. F. K. (2000) · Nicotine & Tobacco Research · doi:10.1080/14622200050011277 · Cited by 424

Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal

Rassnick, S., Heinrichs, S. C., Britton, K. T., & Koob, G. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)91352-s · Cited by 407

Addiction is a Reward Deficit and Stress Surfeit Disorder

Koob, G. F. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00072 · Cited by 397

Corticotropin-releasing factor within the central nucleus of the amygdala mediates enhanced ethanol self-administration in withdrawn, ethanol-dependent rats

Funk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3096-06.2006 · Cited by 381

Brain stress systems in the amygdala and addiction

Koob, G. F. (2009) · Brain Research · doi:10.1016/j.brainres.2009.03.038 · Cited by 388

Increased ethanol self-administration and anxiety-like behavior during acute ethanol withdrawal and protracted abstinence: regulation by corticotropin-releasing factor

Valdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02448.x · Cited by 387

Pharmacological treatment of alcohol dependence: Target symptoms and target mechanisms

HEILIG, M., & EGLI, M. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.02.001 · Cited by 377

Corticotropin releasing factor-induced amygdala gamma-aminobutyric Acid release plays a key role in alcohol dependence

Roberto, M., Cruz, M. T., Gilpin, N. W., Sabino, V., Schweitzer, P., Bajo, M., Cottone, P., Madamba, S. G., Stouffer, D. G., Zorrilla, E. P., et al. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.11.007 · Cited by 336

Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action

Heinrichs, S. C., Pich, E. M., Miczek, K. A., Britton, K. T., & Koob, G. F. (1992) · Brain Research · doi:10.1016/0006-8993(92)90708-h · Cited by 329

Corticotropin-releasing factor and neuropeptide y: role in emotional integration

Heilig, M., Koob, G. F., Ekman, R., & Britton, K. T. (1994) · Trends in Neurosciences · doi:10.1016/0166-2236(94)90079-5 · Cited by 324

Neurobiology of the nicotine withdrawal syndrome

Kenny, P. J., & Markou, A. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00651-7 · Cited by 310

Upregulation of voluntary alcohol intake, behavioral sensitivity to stress, and amygdala crhr1 expression following a history of dependence

Sommer, W. H., Rimondini, R., Hansson, A. C., Hipskind, P. A., Gehlert, D. R., Barr, C. S., & Heilig, M. A. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.01.010 · Cited by 309

Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state

Richardson, H. N., Lee, S. Y., O’Dell, L. E., Koob, G. F., & Rivier, C. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06455.x · Cited by 294

The role of CRF and CRF-related peptides in the dark side of addiction

Koob, G. F. (2010) · Brain Research · doi:10.1016/j.brainres.2009.11.008 · Cited by 290

Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats

Funk, C. K., Zorrilla, E. P., Lee, M.-J., Rice, K. C., & Koob, G. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.063 · Cited by 276

Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse

Breese, G. R., Sinha, R., & Heilig, M. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 261

Emotional stress induced by parachute jumping enhances blood nerve growth factor levels and the distribution of nerve growth factor receptors in lymphocytes.

Aloe, L., Bracci-Laudiero, L., Alleva, E., Lambiase, A., Micera, A., & Tirassa, P. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10440 · Cited by 258

Elevated extracellular CRF levels in the bed nucleus of the stria terminalis during ethanol withdrawal and reduction by subsequent ethanol intake

Olive, M. F., Koenig, H. N., Nannini, M. A., & Hodge, C. W. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00748-1 · Cited by 237

Decreased experimental anxiety and voluntary ethanol consumption in rats following central but not basolateral amygdala lesions

Möller, C., Wiklund, L., Sommer, W., Thorsell, A., & Heilig, M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00308-9 · Cited by 229

Corticotropin-releasing factor: long-lasting facilitation of the acoustic startle reflex

Liang, K., Melia, K., Miserendino, M., Falls, W., Campeau, S., & Davis, M. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-06-02303.1992 · Cited by 203

Glucocorticoids, chronic stress, and obesity

Dallman, M. F., Pecoraro, N. C., La Fleur, S. E., Warne, J. P., Ginsberg, A. B., Akana, S. F., Laugero, K. C., Houshyar, H., Strack, A. M., Bhatnagar, S., et al. (2006) · Progress in Brain Research · doi:10.1016/s0079-6123(06)53004-3 · Cited by 198

High-priority communication I Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

Valdez, G. R., Zorrilla, E. P., Roberts, A. J., & Koob, G. F. (2003) · Alcohol · doi:10.1016/s0741-8329(03)00020-x · Cited by 186

Influence of stress associated with chronic alcohol exposure on drinking

Becker, H. C. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.028 · Cited by 191

Neurobiology of dysregulated motivational systems in drug addiction

Edwards, S., & Koob, G. F. (2010) · Future Neurology · doi:10.2217/fnl.10.14 · Cited by 157

Development of pharmacotherapies for drug addiction: a Rosetta stone approach

Koob, G. F., Kenneth Lloyd, G., & Mason, B. J. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2828 · Cited by 154

Anti-Stress Action of a Corticotropin-Releasing Factor Antagonist on Behavioral Reactivity to Stressors of Varying Type and Intensity

Heinrichs, S. C., Menzaghi, F., Pich, E. M., Baldwin, H. A., Rassnick, S., Britton, K. T., & Koob, G. F. (1994) · Neuropsychopharmacology · doi:10.1038/sj.npp.1380104 · Cited by 143

Increased Anxiety‐Like Behavior and Ethanol Self‐Administration in Dependent Rats: Reversal via Corticotropin‐Releasing Factor‐2 Receptor Activation

Valdez, G. R., Sabino, V., & Koob, G. F. (2004) · Alcoholism: Clinical and Experimental Research · doi:10.1097/01.alc.0000128222.29875.40 · Cited by 131

SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats

Knapp, D. J., Overstreet, D. H., Moy, S. S., & Breese, G. R. (2004) · Alcohol · doi:10.1016/j.alcohol.2003.08.007 · Cited by 130

CRH: the link between hormonal-, metabolic- and behavioral responses to stress

Kovács, K. J. (2013) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2013.05.003 · Cited by 126

Translating the neuroscience of alcoholism into clinical treatments: From blocking the buzz to curing the blues

Heilig, M., Thorsell, A., Sommer, W. H., Hansson, A. C., Ramchandani, V. A., George, D. T., Hommer, D., & Barr, C. S. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.018 · Cited by 117

Effects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats

Gilpin, N. W., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1967-8 · Cited by 99

Corticotropin-releasing hormone (CRH) as a regulator of waking

Chang, F.-C., & Opp, M. R. (2001) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(01)00024-0 · Cited by 99

Repeated Stimulation of CRF Receptors in the BNST of Rats Selectively Induces Social but not Panic-Like Anxiety

Lee, Y., Fitz, S., Johnson, P. L., & Shekhar, A. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301674 · Cited by 89

CRF and urocortin decreased brain stimulation reward in the rat: reversal by a CRF receptor antagonist

Macey, D. J., Koob, G. F., & Markou, A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02229-0 · Cited by 69

Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors

Somkuwar, S. S., Vendruscolo, L. F., Fannon, M. J., Schmeichel, B. E., Nguyen, T. B., Guevara, J., Sidhu, H., Contet, C., Zorrilla, E. P., & Mandyam, C. D. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.06.006 · Cited by 64

Mouse strain differences in the behavioral effects of Corticotropin-Releasing Factor (CRF) and the CRF antagonist α-helical CRF9–41

Conti, L. H., Costello, D. G., Martin, L. A., White, M. F., & Abreu, M. E. (1994) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(94)90559-2 · Cited by 49

Corticotropin releasing factor antagonist, α-helical CRF9–41, reverses nicotine-induced conditioned, but not unconditioned, anxiety

Tucci, S., Cheeta, S., Seth, P., & File, S. E. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1403-4 · Cited by 38