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Microglia and inflammation: conspiracy, controversy or control?

Fernandes, Adelaide, Miller-Fleming, Leonor, Pais, Teresa F.·2014·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-014-1670-8
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Research works printed but not linked: 144

  1. Aloisi F, Ria F, Adorini L (2000) Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. Immunol Today 21(3):141–147 · DOI
  2. Eichhoff G, Brawek B, Garaschuk O (2011) Microglial calcium signal acts as a rapid sensor of single neuron damage in vivo. Biochim Biophys Acta 1813(5):1014–1024 · DOI
  3. Nimmerjahn A, Kirchhoff F, Helmchen F (2005) Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science 308(5726):1314–1318 · DOI · Paper page
  4. Davalos D et al (2012) Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation. Nat Commun 3:1227 · DOI · Paper page
  5. Ginhoux F et al (2010) Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330(6005):841–845 · DOI · Paper page
  6. Wake H et al (2009) Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J Neurosci 29(13):3974–3980 · DOI · Paper page
  7. Parkhurst CN et al (2013) Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell 155(7):1596–1609 · DOI · Paper page
  8. Yrjanheikki J et al (1998) Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 95(26):15769–15774 · DOI · Paper page
  9. Frank-Cannon TC et al (2009) Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 4:47 · DOI · Paper page
  10. Blank T, Prinz M (2013) Microglia as modulators of cognition and neuropsychiatric disorders. Glia 61(1):62–70 · DOI
  11. Hume DA (2006) The mononuclear phagocyte system. Curr Opin Immunol 18(1):49–53 · DOI
  12. Simard AR, Rivest S (2004) Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia. FASEB J 18(9):998–1000 · DOI
  13. Ajami B et al (2007) Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci 10(12):1538–1543 · DOI · Paper page
  14. Wang Y et al (2012) IL-34 is a tissue-restricted ligand of CSF1R required for the development of Langerhans cells and microglia. Nat Immunol 13(8):753–760 · DOI · Paper page
  15. Wirenfeldt M et al (2005) Reactive microgliosis engages distinct responses by microglial subpopulations after minor central nervous system injury. J Neurosci Res 82(4):507–514 · DOI
  16. Pais TF, Chatterjee S (2005) Brain macrophage activation in murine cerebral malaria precedes accumulation of leukocytes and CD8+ T cell proliferation. J Neuroimmunol 163(1–2):73–83 · DOI
  17. Logan TT, Villapol S, Symes AJ (2013) TGF-beta superfamily gene expression and induction of the Runx1 transcription factor in adult neurogenic regions after brain injury. PLoS ONE 8(3):e59250 · DOI
  18. Hanisch UK, Kettenmann H (2007) Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci 10(11):1387–1394 · DOI · Paper page
  19. Schwartz M et al (2006) Microglial phenotype: is the commitment reversible? Trends Neurosci 29(2):68–74 · DOI · Paper page
  20. Martinez FO, Helming L, Gordon S (2009) Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 27:451–483 · DOI · Paper page
  21. Chao CC et al (1992) Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J Immunol 149(8):2736–2741 · DOI
  22. Bhat NR et al (1998) Extracellular signal-regulated kinase and p38 subgroups of mitogen-activated protein kinases regulate inducible nitric oxide synthase and tumor necrosis factor-alpha gene expression in endotoxin-stimulated primary glial cultures. J Neurosci 18(5):1633–1641 · DOI
  23. Pais TF et al (2008) Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway. J Neuroinflammation 5:43 · DOI
  24. Maezawa I et al (2011) Amyloid-beta protein oligomer at low nanomolar concentrations activates microglia and induces microglial neurotoxicity. J Biol Chem 286(5):3693–3706 · DOI
  25. Tufekci KU, Genc S, Genc K (2011) The endotoxin-induced neuroinflammation model of Parkinson’s disease. Parkinsons Dis 2011:487450
  26. Freilich RW, Woodbury ME, Ikezu T (2013) Integrated expression profiles of mRNA and miRNA in polarized primary murine microglia. PLoS ONE 8(11):e79416 · DOI · Paper page
  27. Zhao W et al (2006) Protective effects of an anti-inflammatory cytokine, interleukin-4, on motoneuron toxicity induced by activated microglia. J Neurochem 99(4):1176–1187 · DOI
  28. Chao CC, Molitor TW, Hu S (1993) Neuroprotective role of IL-4 against activated microglia. J Immunol 151(3):1473–1481 · DOI
  29. Ponomarev ED et al (2007) CNS-derived interleukin-4 is essential for the regulation of autoimmune inflammation and induces a state of alternative activation in microglial cells. J Neurosci 27(40):10714–10721 · DOI · Paper page
  30. Hanamsagar R, Hanke ML, Kielian T (2012) Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol 33(7):333–342 · DOI · Paper page
  31. Klesney-Tait J, Turnbull IR, Colonna M (2006) The TREM receptor family and signal integration. Nat Immunol 7(12):1266–1273 · DOI
  32. Stefano L et al (2009) The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem 110(1):284–294 · DOI
  33. Chouery E et al (2008) Mutations in TREM2 lead to pure early-onset dementia without bone cysts. Hum Mutat 29(9):E194–E204 · DOI
  34. Kondo T et al (2002) Heterogeneity of presenile dementia with bone cysts (Nasu-Hakola disease): three genetic forms. Neurology 59(7):1105–1107 · DOI
  35. Jiang T et al (2013) TREM2 in Alzheimer’s disease. Mol Neurobiol 48(1):180–185 · DOI
  36. Napoli I, Neumann H (2010) Protective effects of microglia in multiple sclerosis. Exp Neurol 225(1):24–28 · DOI
  37. Crocker PR, Paulson JC, Varki A (2007) Siglecs and their roles in the immune system. Nat Rev Immunol 7(4):255–266 · DOI
  38. Pillai S et al (2012) Siglecs and immune regulation. Annu Rev Immunol 30:357–392 · DOI
  39. Angata T et al (2002) Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia. J Biol Chem 277(27):24466–24474 · DOI
  40. Wang Y, Neumann H (2010) Alleviation of neurotoxicity by microglial human Siglec-11. J Neurosci 30(9):3482–3488 · DOI
  41. Mihrshahi R, Barclay AN, Brown MH (2009) Essential roles for Dok2 and RasGAP in CD200 receptor-mediated regulation of human myeloid cells. J Immunol 183(8):4879–4886 · DOI
  42. Wright GJ et al (2000) Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 13(2):233–242 · DOI
  43. Dentesano G et al (2012) Inhibition of CD200R1 expression by C/EBP beta in reactive microglial cells. J Neuroinflammation 9:165 · DOI
  44. Lyons A et al (2012) Dok2 mediates the CD200Fc attenuation of Abeta-induced changes in glia. J Neuroinflammation 9:107 · DOI
  45. Hoek RM et al (2000) Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 290(5497):1768–1771 · DOI · Paper page
  46. Hernangomez M et al (2012) CD200–CD200R1 interaction contributes to neuroprotective effects of anandamide on experimentally induced inflammation. Glia 60(9):1437–1450 · DOI
  47. Chitnis T et al (2007) Elevated neuronal expression of CD200 protects Wlds mice from inflammation-mediated neurodegeneration. Am J Pathol 170(5):1695–1712 · DOI
  48. Koning N et al (2009) Distribution of the immune inhibitory molecules CD200 and CD200R in the normal central nervous system and multiple sclerosis lesions suggests neuron–glia and glia–glia interactions. J Neuropathol Exp Neurol 68(2):159–167 · DOI
  49. Walker DG et al (2009) Decreased expression of CD200 and CD200 receptor in Alzheimer’s disease: a potential mechanism leading to chronic inflammation. Exp Neurol 215(1):5–19 · DOI
  50. Harrison JK et al (1998) Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia. Proc Natl Acad Sci USA 95(18):10896–10901 · DOI · Paper page
  51. Garton KJ et al (2001) Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1). J Biol Chem 276(41):37993–38001 · DOI
  52. Maciejewski-Lenoir D et al (1999) Characterization of fractalkine in rat brain cells: migratory and activation signals for CX3CR-1-expressing microglia. J Immunol 163(3):1628–1635 · DOI
  53. Zujovic V et al (2000) Fractalkine modulates TNF-alpha secretion and neurotoxicity induced by microglial activation. Glia 29(4):305–315 · DOI
  54. Noda M et al (2011) Fractalkine attenuates excito-neurotoxicity via microglial clearance of damaged neurons and antioxidant enzyme heme oxygenase-1 expression. J Biol Chem 286(3):2308–2319 · DOI
  55. Rogers JT et al (2011) CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. J Neurosci 31(45):16241–16250 · DOI · Paper page
  56. Garcia JA et al (2013) Regulation of adaptive immunity by the fractalkine receptor during autoimmune inflammation. J Immunol 191(3):1063–1072 · DOI
  57. Zhu W et al (2013) Elevated expression of fractalkine (CX3CL1) and fractalkine receptor (CX3CR1) in the dorsal root ganglia and spinal cord in experimental autoimmune encephalomyelitis: implications in multiple sclerosis-induced neuropathic pain. Biomed Res Int 2013:480702
  58. Wu J et al (2013) Suppression of central chemokine fractalkine receptor signaling alleviates amyloid-induced memory deficiency. Neurobiol Aging 34(12):2843–2852 · DOI
  59. Saunders AE, Johnson P (2010) Modulation of immune cell signalling by the leukocyte common tyrosine phosphatase, CD45. Cell Signal 22(3):339–348 · DOI
  60. Ford AL et al (1995) Normal adult ramified microglia separated from other central nervous system macrophages by flow cytometric sorting. Phenotypic differences defined and direct ex vivo antigen presentation to myelin basic protein-reactive CD4+ T cells compared. J Immunol 154(9):4309–4321 · DOI · Paper page
  61. Sedgwick JD et al (1991) Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system. Proc Natl Acad Sci USA 88(16):7438–7442 · DOI
  62. Tan J et al (2000) CD45 opposes beta-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. J Neurosci 20(20):7587–7594 · DOI
  63. Zhu Y et al (2008) CD45RB is a novel molecular therapeutic target to inhibit Abeta peptide-induced microglial MAPK activation. PLoS ONE 3(5):e2135 · DOI
  64. Mott RT et al (2004) Neuronal expression of CD22: novel mechanism for inhibiting microglial proinflammatory cytokine production. Glia 46(4):369–379 · DOI
  65. Mason LH et al (2006) Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45. J Immunol 176(11):6615–6623 · DOI
  66. Taylor DL, Diemel LT, Pocock JM (2003) Activation of microglial group III metabotropic glutamate receptors protects neurons against microglial neurotoxicity. J Neurosci 23(6):2150–2160 · DOI
  67. Lee M, Schwab C, McGeer PL (2011) Astrocytes are GABAergic cells that modulate microglial activity. Glia 59(1):152–165 · DOI
  68. Lee M (2013) Neurotransmitters and microglial-mediated neuroinflammation. Curr Protein Pept Sci 14(1):21–32 · DOI
  69. Chan-Palay V, Asan E (1989) Alterations in catecholamine neurons of the locus coeruleus in senile dementia of the Alzheimer type and in Parkinson’s disease with and without dementia and depression. J Comp Neurol 287(3):373–392 · DOI
  70. Albuquerque EX et al (2009) Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev 89(1):73–120 · DOI · Paper page
  71. Zhang L et al (1998) Cholinergic agonists increase intracellular Ca2+ in cultured human microglia. Neurosci Lett 255(1):33–36 · DOI
  72. Shytle RD et al (2004) Cholinergic modulation of microglial activation by alpha 7 nicotinic receptors. J Neurochem 89(2):337–343 · DOI
  73. De Simone R et al (2005) Activation of alpha7 nicotinic acetylcholine receptor by nicotine selectively up-regulates cyclooxygenase-2 and prostaglandin E2 in rat microglial cultures. J Neuroinflammation 2(1):4 · DOI
  74. Mori K et al (2002) Effects of norepinephrine on rat cultured microglial cells that express alpha1, alpha2, beta1 and beta2 adrenergic receptors. Neuropharmacology 43(6):1026–1034 · DOI · Paper page
  75. Dello Russo C et al (2004) Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1beta production. J Neuroinflammation 1(1):9 · DOI
  76. Waschek JA (2013) VIP and PACAP: neuropeptide modulators of CNS inflammation, injury, and repair. Br J Pharmacol 169(3):512–523 · DOI
  77. Kim WK et al (2000) Vasoactive intestinal peptide and pituitary adenylyl cyclase-activating polypeptide inhibit tumor necrosis factor-alpha production in injured spinal cord and in activated microglia via a cAMP-dependent pathway. J Neurosci 20(10):3622–3630 · DOI
  78. Delgado M, Leceta J, Ganea D (2003) Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the production of inflammatory mediators by activated microglia. J Leukoc Biol 73(1):155–164 · DOI
  79. Delgado M, Varela N, Gonzalez-Rey E (2008) Vasoactive intestinal peptide protects against beta-amyloid-induced neurodegeneration by inhibiting microglia activation at multiple levels. Glia 56(10):1091–1103 · DOI
  80. Heese K, Hock C, Otten U (1998) Inflammatory signals induce neurotrophin expression in human microglial cells. J Neurochem 70(2):699–707 · DOI
  81. Neumann H et al (1998) Neurotrophins inhibit major histocompatibility class II inducibility of microglia: involvement of the p75 neurotrophin receptor. Proc Natl Acad Sci USA 95(10):5779–5784 · DOI
  82. Mizoguchi Y et al (2009) Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia. J Immunol 183(12):7778–7786 · DOI
  83. Nakajima K et al (1998) Neurotrophins regulate the function of cultured microglia. Glia 24(3):272–289 · DOI
  84. Tzeng SF, Huang HY (2003) Downregulation of inducible nitric oxide synthetase by neurotrophin-3 in microglia. J Cell Biochem 90(2):227–233 · DOI
  85. Yamashita H et al (1994) Formation of hetero-oligomeric complexes of type I and type II receptors for transforming growth factor-beta. J Biol Chem 269(31):20172–20178 · DOI
  86. Spittau B et al (2013) Endogenous transforming growth factor-beta promotes quiescence of primary microglia in vitro. Glia 61(2):287–300 · DOI
  87. Qian L et al (2008) Potent anti-inflammatory and neuroprotective effects of TGF-beta1 are mediated through the inhibition of ERK and p47phox-Ser345 phosphorylation and translocation in microglia. J Immunol 181(1):660–668 · DOI
  88. Chen S et al (2002) TGF-beta1 upregulates CX3CR1 expression and inhibits fractalkine-stimulated signaling in rat microglia. J Neuroimmunol 133(1–2):46–55 · DOI
  89. Makwana M et al (2007) Endogenous transforming growth factor beta 1 suppresses inflammation and promotes survival in adult CNS. J Neurosci 27(42):11201–11213 · DOI
  90. Brionne TC et al (2003) Loss of TGF-beta 1 leads to increased neuronal cell death and microgliosis in mouse brain. Neuron 40(6):1133–1145 · DOI · Paper page
  91. Hu X et al (2007) Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J Leukoc Biol 82(2):237–243 · DOI
  92. Milatovic D et al (2003) Pharmacologic suppression of neuronal oxidative damage and dendritic degeneration following direct activation of glial innate immunity in mouse cerebrum. J Neurochem 87(6):1518–1526 · DOI
  93. Hayden MS, Ghosh S (2012) NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 26(3):203–234 · DOI · Paper page
  94. Cho IH et al (2008) Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death. Brain 131(Pt 11):3019–3033 · DOI
  95. Frakes AE et al (2014) Microglia induce motor neuron death via the classical NF-kappaB pathway in amyotrophic lateral sclerosis. Neuron 81(5):1009–1023 · DOI · Paper page
  96. Pawate S et al (2004) Redox regulation of glial inflammatory response to lipopolysaccharide and interferongamma. J Neurosci Res 77(4):540–551 · DOI · Paper page
  97. Innamorato NG et al (2008) The transcription factor Nrf2 is a therapeutic target against brain inflammation. J Immunol 181(1):680–689 · DOI
  98. Koh K et al (2011) Transcription factor Nrf2 suppresses LPS-induced hyperactivation of BV-2 microglial cells. J Neuroimmunol 233(1–2):160–167 · DOI
  99. Ponomarev ED, Veremeyko T, Weiner HL (2013) MicroRNAs are universal regulators of differentiation, activation, and polarization of microglia and macrophages in normal and diseased CNS. Glia 61(1):91–103 · DOI · Paper page
  100. Parisi C et al (2013) Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation. Cell Death Dis 4:e959 · DOI
  101. Jenuwein T, Allis CD (2001) Translating the histone code. Science 293(5532):1074–1080 · DOI · Paper page
  102. Glozak MA et al (2005) Acetylation and deacetylation of non-histone proteins. Gene 363:15–23 · DOI · Paper page
  103. Faraco G et al (2009) Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo. Neurobiol Dis 36(2):269–279 · DOI
  104. Giorgini F et al (2008) Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. J Biol Chem 283(12):7390–7400 · DOI
  105. Martinez-Redondo P, Vaquero A (2013) The diversity of histone versus nonhistone sirtuin substrates. Genes Cancer 4(3–4):148–163 · DOI
  106. Kawahara TL et al (2009) SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 136(1):62–74 · DOI · Paper page
  107. Rothgiesser KM et al (2010) SIRT2 regulates NF-kappaB dependent gene expression through deacetylation of p65 Lys310. J Cell Sci 123(Pt 24):4251–4258 · DOI · Paper page
  108. Pandithage R et al (2008) The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility. J Cell Biol 180(5):915–929 · DOI
  109. Pais TF et al (2013) The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. EMBO J 32(19):2603–2616 · DOI
  110. Beutner C et al (2013) Engineered stem cell-derived microglia as therapeutic vehicle for experimental autoimmune encephalomyelitis. Gene Ther 20(8):797–806 · DOI
  111. Yasojima K et al (1999) Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res 830(2):226–236 · DOI
  112. Fan LW et al (2013) Celecoxib attenuates systemic lipopolysaccharide-induced brain inflammation and white matter injury in the neonatal rats. Neuroscience 240:27–38 · DOI
  113. Lim GP et al (2000) Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer’s disease. J Neurosci 20(15):5709–5714 · DOI
  114. Szekely CA et al (2004) Nonsteroidal anti-inflammatory drugs for the prevention of Alzheimer’s disease: a systematic review. Neuroepidemiology 23(4):159–169 · DOI
  115. Klegeris A, McGeer PL (2005) Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Curr Alzheimer Res 2(3):355–365 · DOI
  116. Aisen PS et al (2003) Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: a randomized controlled trial. JAMA 289(21):2819–2826 · DOI · Paper page
  117. Reines SA et al (2004) Rofecoxib: no effect on Alzheimer’s disease in a 1-year, randomized, blinded, controlled study. Neurology 62(1):66–71 · DOI
  118. Good ML, Hussey DL (2003) Minocycline: stain devil? Br J Dermatol 149(2):237–239 · DOI
  119. Aronson AL (1980) Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 176(10):1061–1068 · DOI
  120. Blum D et al (2004) Clinical potential of minocycline for neurodegenerative disorders. Neurobiol Dis 17(3):359–366 · DOI · Paper page
  121. Ryan ME, Greenwald RA, Golub LM (1996) Potential of tetracyclines to modify cartilage breakdown in osteoarthritis. Curr Opin Rheumatol 8(3):238–247 · DOI
  122. Lin S et al (2001) Minocycline blocks nitric oxide-induced neurotoxicity by inhibition p38 MAP kinase in rat cerebellar granule neurons. Neurosci Lett 315(1–2):61–64 · DOI
  123. Pi R et al (2004) Minocycline prevents glutamate-induced apoptosis of cerebellar granule neurons by differential regulation of p38 and Akt pathways. J Neurochem 91(5):1219–1230 · DOI
  124. Yrjanheikki J et al (1999) A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window. Proc Natl Acad Sci USA 96(23):13496–13500 · DOI
  125. Ferretti MT et al (2012) Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer’s disease-like amyloid pathology. J Neuroinflammation 9:62 · DOI
  126. Seabrook TJ et al (2006) Minocycline affects microglia activation, Abeta deposition, and behavior in APP-tg mice. Glia 53(7):776–782 · DOI
  127. Nikodemova M et al (2007) Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC)alpha/betaII. J Biol Chem 282(20):15208–15216 · DOI
  128. Plane JM et al (2010) Prospects for minocycline neuroprotection. Arch Neurol 67(12):1442–1448 · DOI
  129. Metz LM et al (2004) Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol 55(5):756 · DOI
  130. Zabad RK et al (2007) The clinical response to minocycline in multiple sclerosis is accompanied by beneficial immune changes: a pilot study. Mult Scler 13(4):517–526 · DOI · Paper page
  131. Zhang Y et al (2008) Pilot study of minocycline in relapsing–remitting multiple sclerosis. Can J Neurol Sci 35(2):185–191 · DOI
  132. Liu Y et al (2006) Suppression of microglial inflammatory activity by myelin phagocytosis: role of p47-PHOX-mediated generation of reactive oxygen species. J Neurosci 26(50):12904–12913 · DOI
  133. Akerblom M et al (2013) Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9. Nat Commun 4:1770 · DOI · Paper page
  134. Tabas I, Glass CK (2013) Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 339(6116):166–172 · DOI · Paper page
  135. Liu T et al (1994) Tumor necrosis factor-alpha expression in ischemic neurons. Stroke 25(7):1481–1488 · DOI
  136. Rieckmann P et al (1995) Tumor necrosis factor-alpha messenger RNA expression in patients with relapsing–remitting multiple sclerosis is associated with disease activity. Ann Neurol 37(1):82–88 · DOI
  137. Alvarez A et al (2007) Serum TNF-alpha levels are increased and correlate negatively with free IGF-I in Alzheimer disease. Neurobiol Aging 28(4):533–536 · DOI
  138. McCoy MK, Tansey MG (2008) TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J Neuroinflammation 5:45 · DOI
  139. McCoy MK et al (2006) Blocking soluble tumor necrosis factor signaling with dominant-negative tumor necrosis factor inhibitor attenuates loss of dopaminergic neurons in models of Parkinson’s disease. J Neurosci 26(37):9365–9375 · DOI
  140. McCoy MK et al (2008) Intranigral lentiviral delivery of dominant-negative TNF attenuates neurodegeneration and behavioral deficits in hemiparkinsonian rats. Mol Ther 16(9):1572–1579 · DOI
  141. Cox FF et al (2012) CD200 fusion protein decreases microglial activation in the hippocampus of aged rats. Brain Behav Immun 26(5):789–796 · DOI
  142. Minami SS et al (2012) Selective targeting of microglia by quantum dots. J Neuroinflammation 9:22 · DOI
  143. Priller J et al (2001) Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat Med 7(12):1356–1361 · DOI · Paper page
  144. Sawada M et al (1998) Brain-specific gene expression by immortalized microglial cell-mediated gene transfer in the mammalian brain. FEBS Lett 433(1–2):37–40 · DOI

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Metadata

Authors
Fernandes, A., Miller-Fleming, L., & Pais, T. F.
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2014-07-10
Volume
71
Issue
20
Pages
3969-3985
ISSN
  • 1420-682X
  • 1420-9071
DOI
10.1007/s00018-014-1670-8
Cited by
103
References
43
Language
en
Licence
www.springer.com/tdm (tdm)

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