The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study
Open accessAbstract
Recent muscle biopsy studies have shown a relation between intramuscular lipid content and insulin resistance. The aim of this study was to test this relation in humans by using a novel proton nuclear magnetic resonance (1H NMR) spectroscopy technique, which enables non-invasive and rapid (approximately 45 min) determination of intramyocellular lipid (IMCL) content. Normal weight non-diabetic adults (n = 23, age 29+/-2 years. BMI = 24.1+/-0.5 kg/m2) were studied using cross-sectional analysis. Insulin sensitivity was assessed by a 2-h hyperinsulinaemic (approximately 450 pmol/l)-euglycaemic (approximately 5 mmol/l) clamp test. Intramyocellular lipid concentrations were determined by using localized 1H NMR spectroscopy of soleus muscle. Simple linear regression analysis showed an inverse correlation (r = -0.579, p = 0.0037) [corrected] between intramyocellular lipid content and M-value (100-120 min of clamp) as well as between fasting plasma non-esterified fatty acid concentration and M-value (r = -0.54, p = 0.0267). Intramyocellular lipid content was not related to BMI, age and fasting plasma concentrations of triglycerides, non-esterified fatty acids, glucose or insulin. These results show that intramyocellular lipid concentration, as assessed non invasively by localized 1H NMR spectroscopy, is a good indicator of whole body insulin sensitivity in non-diabetic, non-obese humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Even small amounts of weight loss induced by a negative energy balance affects many variables pertaining to body-fat composition and lipid metabolism -variables that probably contribute to the metabolic abnormalities associated with obesity.[22][23][24][25]”
From Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease (2004) · cites this paper as [23]
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“Even small amounts of weight loss induced by a negative energy balance affects many variables pertaining to body-fat composition and lipid metabolism -variables that probably contribute to the metabolic abnormalities associated with obesity.[22][23][24][25]”
From Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease (2004) · cites this paper as [23]
Experimental — accuracy not yet measuredIn the citing paper
“More recent studies [55, 56] using magnetic resonance spectroscopy have demonstrated that although IMCL fat content contributes only a small fraction (~1%) to the total muscle fat content, it plays a key role in the development of insulin resistance in skeletal muscle compared to EMCL.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [56]
In the citing paper
“Muscle insulin resistance strongly correlates with IMCL, independent of total body fat mass and diabetes status [56], while the correlation between EMCL and insulin ressitance is not significant.”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [56]
In the citing paper
“(i) in insulin resistant individuals, insulin-stimulated glucose disposal correlates more strongly with intramyocellar fat content than with the extramtocellar fat [55, 56];”
From Pathogenesis of insulin resistance in skeletal muscle (2010) · cites this paper as [56]
In the citing paper
“Using 1H magnetic resonance spectroscopy (MRS) to noninvasively assess IMCL content revealed that IMCL was an excellent predictor for muscle insulin resistance in sedentary individuals (Krssak et al., 1999)”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Krssak et al., 1999
In the citing paper
“and disrupt metabolism (insulin resistance, diabetes)”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Krssak et al., 1999
In the citing paper
“Myosteatosis is also linked to insulin resistance.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Krssak et al., 1999
In the citing paper
“IMCL is a strong predictor of insulin resistance in sedentary individuals (Krssak et al., 1999) and muscle insulin resistance can be induced within 5-hours of a lipid infusion in healthy individuals (Dresner et al., 1999), and a fatty acid derived-metabolite (e.g., DAG) has been suggested to be responsible for mediating reduced insulin signaling and insulin action.”
From Myosteatosis in the Context of Skeletal Muscle Function Deficit: An Interdisciplinary Workshop at the National Institute on Aging (2020) · cites this paper as Krssak et al., 1999
In the citing paper
“These lipids interfere with insulin signaling and represent one of the key aspects that could contribute to insulin resistance in situations of high-fat feeding or lipid infusion (Pan et al, 1997; Krssak et al, 1999; Goodpaster et al, 2000).”
From Mitochondrial response to nutrient availability and its role in metabolic disease (2014) · cites this paper as Krssak et al, 1999
In the citing paper
“Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [9]
In the citing paper
“and that insulin resistance is strongly associated with increases in hepatic (HTG) and ∕ or intramyocellular lipid content”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [9]
In the citing paper
“In support of this notion, intramyocellular lipids represent a better predictor of muscle insulin resistance compared to adiposity in young, sedentary, lean subjects (Krssak et al., 1999).”
From Mitochondrial (Dys)function and Insulin Resistance: From Pathophysiological Molecular Mechanisms to the Impact of Diet (2019) · cites this paper as Krssak et al., 1999
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Banting lecture 1988. Role of insulin resistance in human disease.
Reaven, G. (1988) · Diabetes · doi:10.2337/diabetes.37.12.1595 · Cited by 3,801
Mechanism of free fatty acid-induced insulin resistance in humans.
Roden, M., Price, T. B., Perseghin, G., Petersen, K. F., Rothman, D. L., Cline, G. W., & Shulman, G. I. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118742 · Cited by 1,539
Self-citationSkeletal Muscle Triglyceride Levels Are Inversely Related to Insulin Action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diab.46.6.983 · Cited by 1,179
Skeletal muscle triglyceride levels are inversely related to insulin action
Pan, D. A., Lillioja, S., Kriketos, A. D., Milner, M. R., Baur, L. A., Bogardus, C., Jenkins, A. B., & Storlien, L. H. (1997) · Diabetes · doi:10.2337/diabetes.46.6.983 · Cited by 1,179
Storlien, L. H., Jenkins, A. B., Chisholm, D. J., Pascoe, W. S., Khouri, S., & Kraegen, E. W. (1991) · Diabetes · doi:10.2337/diab.40.2.280 · Cited by 967
Frahm, J., Bruhn, H., Gyngell, M. L., Merboldt, K. D., Hänicke, W., & Sauter, R. (1989) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910090110 · Cited by 711
Boesch, C., Slotboom, J., Hoppeler, H. H., & Kreis, R. (1997) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910370403 · Cited by 420
Phillips, D. I. W., Caddy, S., Ilic, V., Fielding, B. A., Frayn, K. N., Borthwick, A. C., & Taylor, R. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90260-7 · Cited by 390
Flagged first, then by citations
Cited by
Sorted by citations
Items 201–300 of 998
Coll, T., Jové, M., Rodríguez‐Calvo, R., Eyre, E., Palomer, X., Sánchez, R. M., Merlos, M., Laguna, J. C., & Vázquez‐Carrera, M. (2006) · Diabetes · doi:10.2337/db05-1494 · Cited by 152
Kautzky-Willer, A., Krssak, M., Winzer, C., Pacini, G., Tura, A., Farhan, S., Wagner, O., Brabant, G., Horn, R., Stingl, H., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.2.244 · Cited by 150
Self-citationRoden, M. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0803102 · Cited by 149
Self-citationMoro, C., Galgani, J. E., Luu, L. C. T., Pasarica, M., Mairal, A., Bajpeyi, S., Schmitz, G., Langin, D., Liebisch, G., & Smith, S. R. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0053 · Cited by 162
Mitochondrial response to nutrient availability and its role in metabolic disease
Gao, A. W., Cantó, C., & Houtkooper, R. H. (2014) · EMBO Molecular Medicine · doi:10.1002/emmm.201303782 · Cited by 148
Gan, S. K., Samaras, K., Thompson, C. H., Kraegen, E. W., Carr, A. D., Cooper, D. A., & Chisholm, D. J. (2002) · Diabetes · doi:10.2337/diabetes.51.11.3163 · Cited by 148
Zhou, Q. G., Hou, F. F., Guo, Z. J., Liang, M., Wang, G. B., & Zhang, X. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.873 · Cited by 145
Excess of free fatty acids as a cause of metabolic dysfunction in skeletal muscle
TUMOVA, J., ANDEL, M., & TRNKA, J. (2016) · Physiological Research · doi:10.33549/physiolres.932993 · Cited by 143
“…accumulation of lipid metabolites, impaired insulin signaling and inflammation A number of studies in both animals and humans reported that an accumulation of IMTG in skeletal muscle strongly correlates with IR (Pan et al. 1997, Krssak et al. 1999); but this is true mainly in untrained individuals.”
BackgroundWatt, M. J., & Hoy, A. J. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00561.2011 · Cited by 142
Freda, P. U., Shen, W., Heymsfield, S. B., Reyes-Vidal, C. M., Geer, E. B., Bruce, J. N., & Gallagher, D. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-2780 · Cited by 141
Skeletal muscle energy metabolism in obesity
Mengeste, A. M., Rustan, A. C., & Lund, J. (2021) · Obesity · doi:10.1002/oby.23227 · Cited by 141
Abdul-Ghani, M. A., Muller, F. L., Liu, Y., Chavez, A. O., Balas, B., Zuo, P., Chang, Z., Tripathy, D., Jani, R., Molina-Carrion, M., et al. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90287.2008 · Cited by 140
Physical inactivity and obesity: links with insulin resistance and type 2 diabetes mellitus
Venables, M. C., & Jeukendrup, A. E. (2009) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.983 · Cited by 137
Adipose tissue as an endocrine organ: impact on insulin resistance.
Im, J., Pijl, H., & Ae, M. (2003) · PubMed · Cited by 137
Hwang, J.-H., Pan, J. W., Heydari, S., Hetherington, H. P., & Stein, D. T. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.4.1267 · Cited by 137
Cardiac fatty acid oxidation in heart failure associated with obesity and diabetes
Fukushima, A., & Lopaschuk, G. D. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2016.03.020 · Cited by 140
Resveratrol and obesity: can resveratrol relieve metabolic disturbances?
de Ligt, M., Timmers, S., & Schrauwen, P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.11.012 · Cited by 135
Muscle Long‐Chain Acyl CoA Esters and Insulin Resistance
Cooney, G. J., Thompson, A. L., Furler, S. M., Ye, J.-M., & Kraegen, E. W. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04276.x · Cited by 131
The Increase in Intramyocellular Lipid Content Is a Very Early Response to Training
Schrauwen‐Hinderling, V. B., Schrauwen, P., Hesselink, M. K. C., van Engelshoven, J. M. A., Nicolay, K., Saris, W. H. M., Kessels, A. G. H., & Kooi, M. E. (2003) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-021464 · Cited by 138
Pirinen, E., Kuulasmaa, T., Pietilä, M., Heikkinen, S., Tusa, M., Itkonen, P., Boman, S., Skommer, J., Virkamäki, A., Hohtola, E., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.02034-06 · Cited by 132
Lysophosphatidylcholine as an effector of fatty acid-induced insulin resistance
Han, M. S., Lim, Y.-M., Quan, W., Kim, J. R., Chung, K. W., Kang, M., Kim, S., Park, S. Y., Han, J., Park, S., et al. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m014787 · Cited by 136
Effect of a short-term diet and exercise intervention on metabolic syndrome in overweight children
Chen, A. K., Roberts, C. K., & Barnard, R. J. (2006) · Metabolism · doi:10.1016/j.metabol.2006.03.001 · Cited by 134
The Role of Impaired Mitochondrial Lipid Oxidation in Obesity
Rogge, M. M. (2009) · Biological Research For Nursing · doi:10.1177/1099800408329408 · Cited by 142
Gan, S. K., Kriketos, A. D., Ellis, B. A., Thompson, C. H., Kraegen, E. W., & Chisholm, D. J. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1706 · Cited by 134
Hip abductor muscle volume in hip osteoarthritis and matched controls
Zacharias, A., Pizzari, T., English, D. J., Kapakoulakis, T., & Green, R. A. (2016) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2016.05.002 · Cited by 133
Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans
Badin, P.-M., Louche, K., Mairal, A., Liebisch, G., Schmitz, G., Rustan, A. C., Smith, S. R., Langin, D., & Moro, C. (2011) · Diabetes · doi:10.2337/db10-1364 · Cited by 132
“Briefly, 1(3)-mono[(3)H]oleyl-2-O-mono-oleylglycerol (MOME)”
Dyslipidemia in Achilles Tendinopathy Is Characteristic of Insulin Resistance
Gaida, J. E., Alfredson, L., KISS, Z. S., Wilson, A., Alfredson, H., & Cook, J. L. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31819794c3 · Cited by 131
Mechanisms of enhanced insulin secretion and sensitivity with n-3 unsaturated fatty acids
Bhaswant, M., Poudyal, H., & Brown, L. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.02.001 · Cited by 133
Intramyocellular Lipid and Insulin Resistance
Kuhlmann, J., Neumann‐Haefelin, C., Belz, U., Kalisch, J., Juretschke, H., Stein, M., Kleinschmidt, E., Kramer, W., & Herling, A. W. (2003) · Diabetes · doi:10.2337/diabetes.52.1.138 · Cited by 130
Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults
Johnson, M. L., Distelmaier, K., Lanza, I. R., Irving, B. A., Robinson, M. M., Konopka, A. R., Shulman, G. I., & Nair, K. S. (2016) · Diabetes · doi:10.2337/db15-0675 · Cited by 129
Self-citationBoden, G., Homko, C., Mozzoli, M., Showe, L. C., Nichols, C., & Cheung, P. (2005) · Diabetes · doi:10.2337/diabetes.54.3.880 · Cited by 129
Koska, J., Stefan, N., Permana, P. A., Weyer, C., Sonoda, M., Bogardus, C., Smith, S. R., Joanisse, D. R., Funahashi, T., Krakoff, J., et al. (2008) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.2.295 · Cited by 129
Corpeleijn, E., Feskens, E. J. M., Jansen, E. H. J. M., Mensink, M., Saris, W. H. M., de Bruin, T. W., & Blaak, E. E. (2006) · Diabetologia · doi:10.1007/s00125-006-0383-4 · Cited by 132
Molecular mechanisms of lipid‐induced insulin resistance in muscle, liver and vasculature
Krebs, M., & Roden, M. (2004) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2004.00439.x · Cited by 130
Self-citationKeung, W., Ussher, J. R., Jaswal, J. S., Raubenheimer, M., Lam, V. H., Wagg, C. S., & Lopaschuk, G. D. (2012) · Diabetes · doi:10.2337/db12-0259 · Cited by 129
Stannard, S. R., & Johnson, N. A. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.053926 · Cited by 127
Kotronen, A., Seppälä-Lindroos, A., Bergholm, R., & Yki-Järvinen, H. (2007) · Diabetologia · doi:10.1007/s00125-007-0867-x · Cited by 126
Jornayvaz, F. R., Samuel, V. T., & Shulman, G. I. (2010) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.012809.104726 · Cited by 132
Self-citationMorino, K., Neschen, S., Bilz, S., Sono, S., Tsirigotis, D., Reznick, R. M., Moore, I., Nagai, Y., Samuel, V., Sebastian, D., et al. (2008) · Diabetes · doi:10.2337/db06-0454 · Cited by 125
Self-citationQuantitative Proton Magnetic Resonance Techniques for Measuring Fat
Harry, H., & Kan, H. E. (2013) · NMR in Biomedicine · doi:10.1002/nbm.3025 · Cited by 121
Hulett, N. A., Scalzo, R. L., & Reusch, J. E. B. (2022) · Nutrients · doi:10.3390/nu14030647 · Cited by 140
Mulder, H., Sörhede‐Winzell, M., Contreras, J. A., Fex, M., Ström, K., Ploug, T., Galbo, H., Arner, P., Lundberg, C., Sundler, F., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m213032200 · Cited by 125
gp130 receptor ligands as potential therapeutic targets for obesity
Febbraio, M. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30453 · Cited by 124
Simha, V., Szczepaniak, L. S., Wagner, A. J., DePaoli, A. M., & Garg, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.1.30 · Cited by 121
A potential role for insulin resistance in experimental pulmonary hypertension
West, J. D., Niswender, K. D., Johnson, J. A., Pugh, M. E., Gleaves, L. A., Fessel, J. P., & Hemnes, A. R. (2012) · European Respiratory Journal · doi:10.1183/09031936.00030312 · Cited by 123
Larson‐Meyer, D. E., Newcomer, B. R., & Hunter, G. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2002.282.1.e95 · Cited by 123
Radin, M. S., Sinha, S., Bhatt, B. A., Dedousis, N. L., & O'Doherty, R. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0861-3 · Cited by 125
Glycosphingolipids and insulin resistance
Langeveld, M., & Aerts, J. M. F. G. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.03.002 · Cited by 127
Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview
Holloway, G. P., Luiken, J. J. F. P., Glatz, J. F. C., Spriet, L. L., & Bonen, A. (2008) · Acta Physiologica · doi:10.1111/j.1748-1716.2008.01878.x · Cited by 127
Epidemiology and treatment of the metabolic syndrome
Laaksonen, D. E., NISKANEN, L. K., Lakka, H., Lakka, T. A., & Uusitupa, M. I. J. (2004) · Annals of Medicine · doi:10.1080/07853890410031849 · Cited by 121
García‐Ruiz, C., Baulies, A., Marí, M., García-Rovés, P. M., & Fernández-Checa, J. C. (2013) · Free Radical Research · doi:10.3109/10715762.2013.830717 · Cited by 119
Impaired protein metabolism: interlinks between obesity, insulin resistance and inflammation
Guillet, C., Masgrau, A., Walrand, S., & Boirie, Y. (2012) · Obesity Reviews · doi:10.1111/j.1467-789x.2012.01037.x · Cited by 118
Hoy, A. J., Bruce, C. R., Turpin-Nolan, S. M., Morris, A. J., Febbraio, M. A., & Watt, M. J. (2010) · Endocrinology · doi:10.1210/en.2010-0661 · Cited by 123
Inflamed adipose tissue, insulin resistance and vascular injury
Andersson, C. X., Gustafson, B., Hammarstedt, A., Hedjazifar, S., & Smith, U. (2008) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.889 · Cited by 118
Machann, J., Thamer, C., Stefan, N., Schwenzer, N. F., Kantartzis, K., Häring, H., Claussen, C. D., Fritsche, A., & Schick, F. (2010) · Radiology · doi:10.1148/radiol.10092284 · Cited by 117
Comparison of the effects of sucrose and fructose on insulin action and glucose tolerance
Thresher, J. S., Podolin, D. A., Wei, Y., Mazzeo, R. S., & Pagliassotti, M. J. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.4.r1334 · Cited by 117
De Feyter, H. M., van den Broek, N. M. A., Praet, S. F. E., Nicolay, K., van Loon, L. J. C., & Prompers, J. J. (2008) · European Journal of Endocrinology · doi:10.1530/eje-07-0756 · Cited by 116
Mitchell, C. S., Savage, D. B., Dufour, S., Schoenmakers, N. A., Murgatroyd, P. R., Befroy, D. E., Halsall, D. J., Northcott, S., Raymond‐Barker, P., Curran, S., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci38793 · Cited by 118
Self-citationPLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle
Mason, R. R., Mokhtar, R. A. M., Matzaris, M., Selathurai, A., Kowalski, G. M., Mokbel, N., Meikle, P. J., Bruce, C. R., & Watt, M. J. (2014) · Molecular Metabolism · doi:10.1016/j.molmet.2014.06.002 · Cited by 118
Cefalu, W. T., Rood, J. C., Pinsonat, P., Qin, J., Sereda, O., de Jonge, L., Anderson, R. A., Zhang, X. H., Martin, J., Martin, C. K., et al. (2009) · Metabolism · doi:10.1016/j.metabol.2009.09.023 · Cited by 117
Boesch, C. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20806 · Cited by 118
Daemen, S., Gemmink, A., Brouwers, B., Meex, R. C. R., Huntjens, P. R., Schaart, G., Moonen‐Kornips, E., Jörgensen, J. A., Joris Hoeks, J., Schrauwen, P., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.08.004 · Cited by 113
Effect of thiazolidinediones on glucose and fatty acid metabolism in patients with type 2 diabetes
Boden, G. H., Cheung, P., Mozzoli, M. A., & Fried, S. K. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00055-6 · Cited by 113
Pancreatic adipose tissue infiltration, parenchymal steatosis and beta cell function in humans
Begovatz, P., Koliaki, C. C., Weber, K. S., Straßburger, K., Nowotny, B., Nowotny, P., Müssig, K., Bunke, J., Pacini, G., Szendrödi, J., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3544-5 · Cited by 117
Self-citationMitochondrial oxidative function and type 2 diabetes
Rabøl, R., Boushel, R., & Dela, F. (2006) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h06-071 · Cited by 113
Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
Larson‐Meyer, D. E., Smith, S. R., Heilbronn, L. K., Kelley, D. E., Ravussin, E., Newcomer, B. R., & The Look AHEAD Adipose Research Group (2006) · Obesity · doi:10.1038/oby.2006.10 · Cited by 111
Kinetics of intramuscular triglyceride fatty acids in exercising humans
Guo, Z., Burguera, B., & Jensen, M. D. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.89.5.2057 · Cited by 110
Using Drosophila to discover mechanisms underlying type 2 diabetes
Alfa, R. W., & Kim, S. K. (2016) · Disease Models & Mechanisms · doi:10.1242/dmm.023887 · Cited by 111
Brøns, C., & Grunnet, L. G. (2016) · European Journal of Endocrinology · doi:10.1530/eje-16-0488 · Cited by 114
Observation of intramyocellular lipids by means of1H magnetic resonance spectroscopy
Boesch, C., Décombaz, J., Slotboom, J., & Kreis, R. (1999) · Proceedings of The Nutrition Society · doi:10.1017/s0029665199001147 · Cited by 109
Fasting for 72 h increases intramyocellular lipid content in nondiabetic, physically fit men
Stannard, S. R., Thompson, M. W., Fairbairn, K., Huard, B., Sachinwalla, T., & Thompson, C. H. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00108.2002 · Cited by 108
Differential Utilization of Saturated Palmitate and Unsaturated Oleate
Gaster, M., Rustan, A. C., & Beck‐Nielsen, H. (2005) · Diabetes · doi:10.2337/diabetes.54.3.648 · Cited by 110
Oliphant, T. E., Manduca, A., Ehman, R. L., & Greenleaf, J. F. (2001) · Magnetic Resonance in Medicine · doi:10.1002/1522-2594(200102)45:2 · Cited by 361
Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro
Thompson, A. L., Lim-Fraser, M. Y.-C., Kraegen, E. W., & Cooney, G. J. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.3.e577 · Cited by 107
Nicolson, G. L. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21247 · Cited by 108
Johannsen, D. L., Conley, K. E., Bajpeyi, S., Punyanitya, M., Gallagher, D., Zhang, Z., Covington, J. D., Smith, S. R., & Ravussin, É. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1798 · Cited by 107
Perseghin, G., Scifo, P., Pagliato, E., Battezzati, A., Benedini, S., Soldini, L., Testolin, G., Del Maschio, A., & Luzi, L. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.7.7666 · Cited by 112
Park, S., Kim, H., Wang, S., Higashimori, T., Dong, J., Kim, Y. J., Cline, G. W., Li, H., Prentki, M., Shulman, G. I., et al. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00251.2004 · Cited by 112
Self-citationEctopic fat and insulin resistance
Lettner, A., & Roden, M. (2008) · Current Diabetes Reports · doi:10.1007/s11892-008-0032-z · Cited by 106
Self-citationLo, J., Bernstein, L. E., Hron, B. M., Torriani, M., Jackson, M. B., Ahima, R. S., & Grinspoon, S. K. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00089.2007 · Cited by 108
Brain‐derived neurotrophic factor ameliorates lipid metabolism in diabetic mice
Tsuchida, A., Nonomura, T., Nakagawa, T., Itakura, Y., Ono‐Kishino, M., Yamanaka, M., Sugaru, E., Taiji, M., & Noguchi, H. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00206.x · Cited by 105
Prats, C., Donsmark, M., Qvortrup, K., Londos, C., Sztalryd, C., Holm, C., Galbo, H., & Ploug, T. (2006) · Journal of Lipid Research · doi:10.1194/jlr.m600247-jlr200 · Cited by 105
Impaired skeletal muscle substrate oxidation in glucose-intolerant men improves after weight loss
Corpeleijn, E., Mensink, M., Kooi, M. E., Roekaerts, P. M. H. J., Saris, W. H. M., & Blaak, E. E. (2008) · Obesity · doi:10.1038/oby.2008.24 · Cited by 104
Poynten, A. M., Gan, S. K., Kriketos, A. D., O’Sullivan, A., Kelly, J. J., Ellis, B. A., Chisholm, D. J., & Campbell, L. V. (2003) · Metabolism · doi:10.1016/s0026-0495(03)00030-1 · Cited by 104
Beck‐Nielsen, H., ALFORD, F. P., Levin, K., & Schroeder, H. D. (2001) · Diabetologia · doi:10.1007/s001250100545 · Cited by 105
Minnaard, R., Schrauwen, P., Schaart, G., Jörgensen, J. A., Lenaers, E., Mensink, M., & Hesselink, M. K. C. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0352 · Cited by 104
Thomas, E. L. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i36.5813 · Cited by 102
Li, Y., Zhao, S., Zhang, W., Zhao, P., He, B., Wu, N., & Han, P. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.03.036 · Cited by 105
Blachnio‐Zabielska, A. U., Persson, X. T., Koutsari, C., Zabielski, P., & Jensen, M. D. (2012) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.6216 · Cited by 102
Martin, S., Cule, M., Basty, N., Tyrrell, J., Beaumont, R. N., Wood, A. R., Frayling, T. M., Sorokin, E. P., Whitcher, B. J., Liu, Y., et al. (2021) · Diabetes · doi:10.2337/db21-0129 · Cited by 105
Fat distribution and storage: how much, where, and how?
Weiss, R. (2007) · European Journal of Endocrinology · doi:10.1530/eje-07-0125 · Cited by 102
Ectopic fat accumulation: an important cause of insulin resistance in humans.
Yki‐Järvinen, H. (2002) · Europe PMC (PubMed Central) · Cited by 101
Krag, M. B., Gormsen, L. C., Guo, Z., Christiansen, J. S., Jensen, M. D., Nielsen, S., & Jørgensen, J. O. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00374.2006 · Cited by 101
1H MR spectroscopy of skeletal muscle, liver and bone marrow
Machann, J., Stefan, N., & Schick, F. (2008) · European Journal of Radiology · doi:10.1016/j.ejrad.2008.02.032 · Cited by 101
Imaging methods for analyzing body composition in human obesity and cardiometabolic disease
Seabolt, L., Welch, E., & Silver, H. (2015) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12842 · Cited by 87
Rates of skeletal muscle and adipose tissue glycerol release in nonobese and obese subjects.
Bolinder, J., Kerckhoffs, D. A. J. M., Moberg, E., Toft, E., & Arner, P. (2000) · Diabetes · doi:10.2337/diabetes.49.5.797 · Cited by 100
High Oxidative Capacity Due to Chronic Exercise Training Attenuates Lipid-Induced Insulin Resistance
Phielix, E., Meex, R., Ouwens, D. M., Sparks, L., Hoeks, J., Schaart, G., Moonen-Kornips, E., Hesselink, M. K. C., & Schrauwen, P. (2012) · Diabetes · doi:10.2337/db11-1832 · Cited by 99
Pinnamaneni, S. K., Southgate, R. J., Febbraio, M. A., & Watt, M. J. (2006) · Diabetologia · doi:10.1007/s00125-006-0427-9 · Cited by 100
Imbeault, P., Tremblay, A., Simoneau, J., & Joanisse, D. R. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00394.2001 · Cited by 99
Insulin Stimulation of Hepatic Triacylglycerol Secretion and the Etiology of Insulin Resistance
Zammit, V. A., Waterman, I. J., McKay, G. A., & Topping, D. L. (2001) · Journal of Nutrition · doi:10.1093/jn/131.8.2074 · Cited by 99
Metadata
- Authors
- Krssak, M., Falk Petersen, K., Dresner, A., DiPietro, L., Vogel, S. M., Rothman, D. L., Shulman, G. I., & Roden, M.
- Affiliations
- Yale University (US)
- Howard Hughes Medical Institute (US)
- University of Vienna (AT)
- Venue
- Diabetologia
- Published
- 1999-01-11
- Volume
- 42
- Issue
- 1
- Pages
- 113-116
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2092441434
- Semantic Scholar
- a27e69dd8a054c7932e6da0a27f4f67ad769f76a
- Cited by
- 1,264
- References
- 13
- Citations by year
- 2026: 10 · 2025: 17 · 2024: 19 · 2023: 19 · 2022: 21 · 2021: 38 · 2020: 40 · 2019: 39 · 2018: 49 · 2017: 51 · 2016: 51 · 2015: 64 · 2014: 51 · 2013: 52 · 2012: 59
- FWCI
- 22.58
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- Yale University
- Universität Wien
- Oesterreichische Nationalbank
- National Institutes of Health (P30 DK)
- U.S. Public Health Service
- National Institute on Aging (5 P60 AG 10469, P60AG010469)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK45735, R01DK049230, R01 DK-49230, P30DK045735)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- intramyocellular lipid, insulin sensitivity, insulin resistance, hyperinsulinemic-euglycemic clamp, free fatty acids, soleus muscle, whole-body insulin sensitivity
- MeSH terms
- Adult, Blood Glucose, Fasting, Fatty Acids, Nonesterified, Female, Humans, Hydrogen, Infusions, Intravenous, Insulin, Male, Magnetic Resonance Spectroscopy, Regression Analysis, Triglycerides, Glucose Clamp Technique, Muscle, Skeletal, Lipid Metabolism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
