Identification of Intermediates and Enzymes Involved in the Early Steps of Artemisinin Biosynthesis in Artemisia annua

March's Advanced Organic Chemistry

Smith, M. B., & March, J. (2006) · Wiley eBooks · doi:10.1002/0470084960 · Cited by 1,842 · see citing works

Engineering a mevalonate pathway in Escherichia coli for production of terpenoids

Martin, V. J. J., Pitera, D. J., Withers, S. T., Newman, J. D., & Keasling, J. D. (2003) · Nature Biotechnology · doi:10.1038/nbt833 · Cited by 1,720 · see citing works

Probing essential oil biosynthesis and secretion by functional evaluation of expressed sequence tags from mint glandular trichomes

Lange, B. M., Wildung, M. R., Stauber, E. J., Sanchez, C., Pouchnik, D. J., & Croteau, R. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2934 · Cited by 311 · see citing works

Molecular Cloning, Expression, and Characterization of Amorpha-4,11-diene Synthase, a Key Enzyme of Artemisinin Biosynthesis in Artemisia annua L.

Mercke, P., Bengtsson, M., Bouwmeester, H. J., Posthumus, M. A., & Brodelius, P. E. (2000) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.2000.1962 · Cited by 283 · see citing works

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H. A., van Loo, B., Jansen, B. J. M., Posthumus, M. A., Schmidt, C. O., De Kraker, J.-W., König, W. A., & Franssen, M. C. R. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00206-x · Cited by 266 · see citing works

Artemisinin, a Novel Antimalarial Drug: Biochemical and Molecular Approaches for Enhanced Production

Abdin, M. Z., Israr, M., Rehman, R. U., & Jain, S. K. (2003) · Planta Medica · doi:10.1055/s-2003-38871 · Cited by 252 · see citing works

In vivo transformations of dihydroartemisinic acid in Artemisia annua plants

Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183 · see citing works

Biosynthesis of Costunolide, Dihydrocostunolide, and Leucodin. Demonstration of Cytochrome P450-Catalyzed Formation of the Lactone Ring Present in Sesquiterpene Lactones of Chicory

de Kraker, J., Franssen, M. C. R., Joerink, M., de Groot, C. P. G. M., & Bouwmeester, H. J. (2002) · PLANT PHYSIOLOGY · doi:10.1104/pp.010957 · Cited by 139 · see citing works

Isolation and Identification of Dihydroartemisinic Acid from <i>Artemisia annua</i> and Its Possible Role in the Biosynthesis of Artemisinin

Wallaart, T. E., van Uden, W., Lubberink, H. G. M., Woerdenbag, H. J., Pras, N., & Quax, W. J. (1999) · Journal of Natural Products · doi:10.1021/np980370p · Cited by 129 · see citing works

Biosynthesis of Germacrene A Carboxylic Acid in Chicory Roots. Demonstration of a Cytochrome P450 (+)-Germacrene A Hydroxylase and NADP+-Dependent Sesquiterpenoid Dehydrogenase(s) Involved in Sesquiterpene Lactone Biosynthesis

de Kraker, J., Franssen, M. C. R., Dalm, M. C. F., de Groot, C. P. G. M., & Bouwmeester, H. J. (2001) · PLANT PHYSIOLOGY · doi:10.1104/pp.125.4.1930 · Cited by 91 · see citing works

Reactivity-selectivity in the Swern oxidation of alcohols using dimethyl sulfoxide-oxalyl chloride

Marx, M., & Tidwell, T. T. (1984) · The Journal of Organic Chemistry · doi:10.1021/jo00179a009 · Cited by 76 · see citing works

Hydroxylation of sesquiterpenes by enzymes from chicory (Cichorium intybus L.) roots

de Kraker, J., Schurink, M., Franssen, M. C. R., König, W. Α., de Groot, C. P. G. M., & Bouwmeester, H. J. (2003) · Tetrahedron · doi:10.1016/s0040-4020(02)01479-5 · Cited by 52 · see citing works

Isolation and identification of dihydroartemisinic acid from Artemisia annua and its possible role in the biosynthesis of artemisinin

Wallaart, T. E., van Uden, W., Lubberink, H. G. M., et al. (1999) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 6 · see citing works

Isolation and identification of dihydroartemisinic acid hydroperoxide from Artemisia annua: A novel biosynthetic precursor of artemisinin

Wallaart, T., Pras, N., & Quax, W. I. 0.-0.-5.-9. (1999) · University of Groningen research database (University of Groningen / Centre for Information Technology) · Cited by 6 · see citing works

Production of the antimalarial drug precursor artemisinic acid in engineered yeast

Ro, D.-K., Paradise, E. M., Ouellet, M., Fisher, K. J., Newman, K. L., Ndungu, J. M., Ho, K. A., Eachus, R. A., Ham, T. S., Kirby, J., et al. (2006) · Nature · doi:10.1038/nature04640 · Cited by 2,805 · see citing works

High-level semi-synthetic production of the potent antimalarial artemisinin

Paddon, C. J., Westfall, P. J., Pitera, D. J., Benjamin, K., Fisher, K., McPhee, D., Leavell, M. D., Tai, A., Main, A., Eng, D., et al. (2013) · Nature · doi:10.1038/nature12051 · Cited by 2,060 · see citing works

Plant Secondary Metabolite Biosynthesis and Transcriptional Regulation in Response to Biotic and Abiotic Stress Conditions

Jan, R., Asaf, S., Numan, M., Lubna, & Kim, K. (2021) · Agronomy · doi:10.3390/agronomy11050968 · Cited by 864 · see citing works

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Westfall, P. J., Pitera, D. J., Lenihan, J. R., Eng, D., Woolard, F. X., Regentin, R., Horning, T., Tsuruta, H., Melis, D. J., Owens, A. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110740109 · Cited by 726 · see citing works

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

Paddon, C. J., & Keasling, J. D. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3240 · Cited by 675 · see citing works

Terpenoid biomaterials

Bohlmann, J., & Keeling, C. I. (2008) · The Plant Journal · doi:10.1111/j.1365-313x.2008.03449.x · Cited by 524 · see citing works

Volatile science? Metabolic engineering of terpenoids in plants

Aharoni, A., Jongsma, M. A., & Bouwmeester, H. J. (2005) · Trends in Plant Science · doi:10.1016/j.tplants.2005.10.005 · Cited by 428 · see citing works

Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action

Bergman, M. E., Davis, B. B., & Phillips, M. A. (2019) · Molecules · doi:10.3390/molecules24213961 · Cited by 413 · see citing works

<i>Artemisia annua</i> L. (Asteraceae) trichome‐specific cDNAs reveal CYP71AV1, a cytochrome P450 with a key role in the biosynthesis of the antimalarial sesquiterpene lactone artemisinin

Teoh, K. H., Polichuk, D. R., Reed, D. W., Nowak, G., & Covello, P. S. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.01.065 · Cited by 409 · see citing works

Production of isoprenoid pharmaceuticals by engineered microbes

Chang, M. C. Y., & Keasling, J. D. (2006) · Nature Chemical Biology · doi:10.1038/nchembio836 · Cited by 388 · see citing works

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

Brown, G. D. (2010) · Molecules · doi:10.3390/molecules15117603 · Cited by 363 · see citing works

The Genetic Map of <i>Artemisia annua</i> L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

Graham, I. A., Besser, K., Blumer, S., Branigan, C. A., Czechowski, T., Elias, L., Guterman, I., Harvey, D., Isaac, P. G., Khan, A. M., et al. (2010) · Science · doi:10.1126/science.1182612 · Cited by 348 · see citing works

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

Ma, D., Pu, G., Lei, C., Ma, L., Wang, H., Guo, Y., Chen, J., Du, Z., Wang, H., Li, G., et al. (2009) · Plant and Cell Physiology · doi:10.1093/pcp/pcp149 · Cited by 333 · see citing works

Volatile terpenoids: multiple functions, biosynthesis, modulation and manipulation by genetic engineering

Abbas, F., Ke, Y., Yu, R., Yue, Y., Amanullah, S., Jahangir, M., & Fan, Y. (2017) · Planta · doi:10.1007/s00425-017-2749-x · Cited by 318 · see citing works

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin in Artemisia annua

Zhang, Y., Teoh, K. H., Reed, D. W., Maes, L., Goossens, A., Olson, D. J. H., Ross, A. R. S., & Covello, P. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803090200 · Cited by 312 · see citing works

Biosynthesis and engineering of isoprenoid small molecules

Withers, S. T., & Keasling, J. D. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0593-1 · Cited by 297 · see citing works

Willmar Schwabe Award 2006: Antiplasmodial and Antitumor Activity of Artemisinin - From Bench to Bedside

Efferth, T. (2007) · Planta Medica · doi:10.1055/s-2007-967138 · Cited by 269 · see citing works

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in <i>Artemisia annua</i> This paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

Teoh, K. H., Polichuk, D. R., Reed, D. W., & Covello, P. S. (2009) · Botany · doi:10.1139/b09-032 · Cited by 251 · see citing works

Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.

Olsson, M. E., Olofsson, L. M., Lindahl, A.-L., Lundgren, A., Brodelius, M., & Brodelius, P. E. (2009) · Phytochemistry · doi:10.1016/j.phytochem.2009.07.009 · Cited by 241 · see citing works

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in <i>Artemisia annua</i> plants

Maes, L., Van Nieuwerburgh, F. C. W., Zhang, Y., Reed, D. W., Pollier, J., Vande Casteele, S. R. F., Inzé, D., Covello, P. S., Deforce, D. L. D., & Goossens, A. (2011) · New Phytologist · doi:10.1111/j.1469-8137.2010.03466.x · Cited by 240 · see citing works

Biosynthesis Investigations of Terpenoid, Alkaloid, and Flavonoid Antimicrobial Agents Derived from Medicinal Plants

Huang, W., Wang, Y., Tian, W., Cui, X., Tu, P., Li, J., Shi, S., & Liu, X. (2022) · Antibiotics · doi:10.3390/antibiotics11101380 · Cited by 256 · see citing works

Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing

Wang, W., Wang, Y., Zhang, Q., Qi, Y., & Guo, D. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-465 · Cited by 224 · see citing works

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors

van Herpen, T. W. J. M., Cankar, K., Nogueira, M., Bosch, D., Bouwmeester, H. J., & Beekwilder, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014222 · Cited by 209 · see citing works

Development of transgenic <i>Artemisia annua</i> (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti‐malarial drug, by hairpin‐RNA‐mediated gene silencing

Zhang, L., Jing, F., Li, F., Li, M., Wang, Y., Wang, G., Sun, X., & Tang, K. (2009) · Biotechnology and Applied Biochemistry · doi:10.1042/ba20080068 · Cited by 206 · see citing works

In vivo transformations of dihydroartemisinic acid in Artemisia annua plants

Brown, G. D., & Sy, L.-K. (2004) · Tetrahedron · doi:10.1016/j.tet.2003.11.070 · Cited by 183 · see citing works

A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450 _BM3

Dietrich, J. A., Yoshikuni, Y., Fisher, K. J., Woolard, F. X., Ockey, D., McPhee, D. J., Renninger, N. S., Chang, M. C. Y., Baker, D., & Keasling, J. D. (2009) · ACS Chemical Biology · doi:10.1021/cb900006h · Cited by 186 · see citing works

Cloning and Characterization of AabHLH1, a bHLH Transcription Factor that Positively Regulates Artemisinin Biosynthesis in Artemisia annua

Ji, Y., Xiao, J., Shen, Y., Ma, D., Li, Z., Pu, G., Li, X., Huang, L., Liu, B., Ye, H., et al. (2014) · Plant and Cell Physiology · doi:10.1093/pcp/pcu090 · Cited by 171 · see citing works

Salicylic acid activates artemisinin biosynthesis in Artemisia annua L.

Pu, G., Ma, D., Chen, J.-L., Ma, L., Wang, H., Li, G., Ye, H., & Liu, B. (2009) · Plant Cell Reports · doi:10.1007/s00299-009-0713-3 · Cited by 172 · see citing works

Artemisinin: current state and perspectives for biotechnological production of an antimalarial drug

Liu, C., Zhao, Y., & Wang, Y. (2006) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-006-0452-0 · Cited by 158 · see citing works

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

Schramek, N., Wang, H., Römisch-Margl, W., Keil, B., Radykewicz, T., Winzenhörlein, B., Beerhues, L., Bacher, A., Rohdich, F., Gershenzon, J., et al. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2009.10.015 · Cited by 150 · see citing works

Functional genomics and the biosynthesis of artemisinin

Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., & Nowak, G. (2007) · Phytochemistry · doi:10.1016/j.phytochem.2007.02.016 · Cited by 152 · see citing works

Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution

Nett, R. S., Montanares, M., Marcassa, A., Lu, X., Nagel, R., Charles, T. C., Hedden, P., Rojas, M. C., & Peters, R. J. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.2232 · Cited by 141 · see citing works

Isoprenoid biosynthesis in Artemisia annua: cloning and heterologous expression of a germacrene A synthase from a glandular trichome cDNA library

Bertea, C. M., Voster, A., Verstappen, F. W. A., Maffei, M., Beekwilder, J., & Bouwmeester, H. J. (2006) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2006.02.026 · Cited by 134 · see citing works

Cytochromes P450 for Terpene Functionalisation and Metabolic Engineering

Pateraki, I., Heskes, A. M., & Hamberger, B. R. (2015) · Advances in biochemical engineering, biotechnology · doi:10.1007/10_2014_301 · Cited by 133 · see citing works

Plant single-cell and single-cell-type metabolomics

Misra, B. B., Assmann, S. M., & Chen, S. (2014) · Trends in Plant Science · doi:10.1016/j.tplants.2014.05.005 · Cited by 120 · see citing works

Functional Genomics and the Biosynthesis of Artemisinin

Covello, P. S., Teoh, K. H., Polichuk, D. R., Reed, D. W., & Nowak, G. (2007) · ChemInform · doi:10.1002/chin.200742266 · Cited by 121 · see citing works

Combinatorial biosynthesis of medicinal plant secondary metabolites

Julsing, M. K., Koulman, A., Woerdenbag, H. J., Quax, W. J., & Kayser, O. (2006) · Biomolecular Engineering · doi:10.1016/j.bioeng.2006.08.001 · Cited by 116 · see citing works

Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells

Malhotra, K., Subramani, M., Rawat, K., Kalamuddin, M., Qureshi, M. I., Malhotra, P., Mohmmed, A., Cornish, K., Daniell, H., & Kumar, S. B. (2016) · Molecular Plant · doi:10.1016/j.molp.2016.09.013 · Cited by 114 · see citing works

Differential transcriptome analysis of glandular and filamentous trichomes in Artemisia annua

Soetaert, S. S., Van Neste, C. M., Vandewoestyne, M. L., Head, S. R., Goossens, A., Van Nieuwerburgh, F. C., & Deforce, D. L. (2013) · BMC Plant Biology · doi:10.1186/1471-2229-13-220 · Cited by 109 · see citing works

Cytochrome P450-enzymes involved in the biosynthesis of mono- and sesquiterpenes

Weitzel, C., & Simonsen, H. T. (2013) · Phytochemistry Reviews · doi:10.1007/s11101-013-9280-x · Cited by 109 · see citing works

The Yin and Yang of traditional Chinese and Western medicine

Fu, R., Li, J., Yu, H., Zhang, Y., Xu, Z., & Martin, C. R. (2021) · Medicinal Research Reviews · doi:10.1002/med.21793 · Cited by 108 · see citing works

Metabolic fingerprinting investigation of Artemisia annua L. in different stages of development by gas chromatography and gas chromatography–mass spectrometry

Ma, C., Wang, H., Lu, X., Xu, G., & Liu, B. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.09.023 · Cited by 103 · see citing works

In vivo transformations of artemisinic acid in Artemisia annua plants

Brown, G. D., & Sy, L.-K. (2007) · Tetrahedron · doi:10.1016/j.tet.2007.06.062 · Cited by 100 · see citing works

Effects of exogenous methyl jasmonate on artemisinin biosynthesis and secondary metabolites in Artemisia annua L.

Wang, H., Ma, C., Li, Z., Ma, L., Wang, H., Ye, H., Xu, G., & Liu, B. (2009) · Industrial Crops and Products · doi:10.1016/j.indcrop.2009.10.008 · Cited by 98 · see citing works

Artemisinin: the biosynthetic pathway and its regulation in Artemisia annua, a terpenoid-rich species

Weathers, P. J., Elkholy, S., & Wobbe, K. K. (2006) · In Vitro Cellular &amp; Developmental Biology - Plant · doi:10.1079/ivp2006782 · Cited by 97 · see citing works

Biosynthesis of fungal terpenoids

Luo, P., Huang, J.-H., Lv, J., Wang, G., Hu, D., & Gao, H. (2024) · Natural Product Reports · doi:10.1039/d3np00052d · Cited by 96 · see citing works

Antimicrobial Activity of Artemisinin and Precursor Derived fromIn VitroPlantlets ofArtemisia annuaL.

Appalasamy, S., Lo, K. Y., Ch’ng, S., Nornadia, K., Othman, A. S., & Keng, C. L. (2014) · BioMed Research International · doi:10.1155/2014/215872 · Cited by 92 · see citing works

Production of artemisinin by genetically-modified microbes

Zeng, Q.-P., Qiu, F., & Yuan, L. (2007) · Biotechnology Letters · doi:10.1007/s10529-007-9596-y · Cited by 87 · see citing works

Enhancement of artemisinin content and biomass in Artemisia annua by exogenous GA3 treatment

Banyai, W., Mii, M., & Supaibulwatana, K. (2010) · Plant Growth Regulation · doi:10.1007/s10725-010-9510-9 · Cited by 89 · see citing works

Metabolic engineering of artemisinin biosynthesis in Artemisia annua L.

Liu, B., Wang, H., Du, Z., Li, G., & Ye, H. (2010) · Plant Cell Reports · doi:10.1007/s00299-010-0967-9 · Cited by 82 · see citing works

Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae

Lindahl, A.-L., Olsson, M. E., Mercke, P., Tollbom, Ö., Schelin, J., Brodelius, M., & Brodelius, P. E. (2006) · Biotechnology Letters · doi:10.1007/s10529-006-0015-6 · Cited by 82 · see citing works

The production of artemisinin precursors in tobacco

Zhang, Y., Nowak, G., Reed, D. W., & Covello, P. S. (2010) · Plant Biotechnology Journal · doi:10.1111/j.1467-7652.2010.00556.x · Cited by 81 · see citing works

Analysis of Artemisia annua L. volatile oil by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry

Ma, C., Wang, H., Lu, X., Li, H., Liu, B., & Xu, G. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2006.08.080 · Cited by 80 · see citing works

Plant Single-Cell Metabolomics—Challenges and Perspectives

de Souza, L. P., Borghi, M., & Fernie, A. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21238987 · Cited by 79 · see citing works

Modulation of artemisinin biosynthesis by elicitors, inhibitor, and precursor in hairy root cultures of Artemisia annua L.

Ahlawat, S., Saxena, P., Alam, P., Wajid, S., & Abdin, M. Z. (2014) · Journal of Plant Interactions · doi:10.1080/17429145.2014.949885 · Cited by 78 · see citing works

Terpenoid metabolic profiling analysis of transgenic Artemisia annua L. by comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry

Ma, C., Wang, H., Lu, X., Wang, H., Xu, G., & Liu, B. (2009) · Metabolomics · doi:10.1007/s11306-009-0170-6 · Cited by 76 · see citing works

The metabolite chemotype of N icotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP 71 AV 1 type and relative gene dosage

Ting, H., Wang, B., Rydén, A., Woittiez, L. S., van Herpen, T. W. J. M., Verstappen, F. W. A., Ruyter-Spira, C. P., Beekwilder, J., Bouwmeester, H. J., & van der Krol, A. R. (2013) · New Phytologist · doi:10.1111/nph.12274 · Cited by 73 · see citing works

An Efficient Chemoenzymatic Synthesis of Dihydroartemisinic Aldehyde

Demiray, M., Tang, X., Wirth, T., Faraldos, J. A., & Allemann, R. K. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201609557 · Cited by 68 · see citing works

Metabolic engineering and in vitro biosynthesis of phytochemicals and non-natural analogues

Mora‐Pale, M., Sánchez-Rodríguez, S. P., Linhardt, R. J., Dordick, J. S., & Koffas, M. A. G. (2013) · Plant Science · doi:10.1016/j.plantsci.2013.05.005 · Cited by 67 · see citing works

Salicylic acid and methyl jasmonate but not Rose Bengal enhance artemisinin production through invoking burst of endogenous singlet oxygen

Guo, X.-X., Yang, X., Yang, R., & Zeng, Q.-P. (2010) · Plant Science · doi:10.1016/j.plantsci.2010.01.014 · Cited by 66 · see citing works

Plant cytochrome P450s: nomenclature and involvement in natural product biosynthesis

Rasool, S., & Mohamed, R. (2015) · PROTOPLASMA · doi:10.1007/s00709-015-0884-4 · Cited by 63 · see citing works

Natural sesquiterpenoids

Fraga, B. M. (2006) · Natural Product Reports · doi:10.1039/b507870a · Cited by 61 · see citing works

Yeast-based genome mining, production and mechanistic studies of the biosynthesis of fungal polyketide and peptide natural products

Tsunematsu, Y., Ishiuchi, K., Hotta, K., & Watanabe, K. (2013) · Natural Product Reports · doi:10.1039/c3np70037b · Cited by 59 · see citing works

Secondary Metabolites Isolated from Artemisia afra and Artemisia annua and Their Anti-Malarial, Anti-Inflammatory and Immunomodulating Properties—Pharmacokinetics and Pharmacodynamics: A Review

Shinyuy, L. M., Loe, G. E., Jansen, O., Mamede, L., Ledoux, A., Noukimi, S. F., Abenwie, S. N., Ghogomu, S. M., Souopgui, J., Robert, A. R., et al. (2023) · Metabolites · doi:10.3390/metabo13050613 · Cited by 58 · see citing works

A glandular trichome-specific monoterpene alcohol dehydrogenase from Artemisia annua

Polichuk, D. R., Zhang, Y., Reed, D. W., Schmidt, J. F., & Covello, P. S. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.04.026 · Cited by 57 · see citing works

Perspectives and limits of engineering the isoprenoid metabolism in heterologous hosts

Muntendam, R., Melillo, E., Rydén, A., & Kayser, O. (2009) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-009-2150-1 · Cited by 56 · see citing works

Effects of sesquiterpene, flavonoid and coumarin types of compounds from Artemisia annua L. on production of mediators of angiogenesis

Zhu, X., Yang, L., Li, Y. J., Zhang, D., Chen, Y., Kostecká, P., Kmonı́èková, E., & Zídek, Z. (2013) · Pharmacological Reports · doi:10.1016/s1734-1140(13)71016-8 · Cited by 55 · see citing works

Research progress relating to the role of cytochrome P450 in the biosynthesis of terpenoids in medicinal plants

Zhao, Y., Cheng, Q., Su, P., Chen, X., Wang, X., Gao, W., & Huang, L. (2014) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-013-5496-3 · Cited by 54 · see citing works

Molecular Farming in Artemisia annua, a Promising Approach to Improve Anti-malarial Drug Production

Pulice, G., Pelaz, S., & Matías-Hernández, L. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00329 · Cited by 53 · see citing works

Sesquiterpene lactones with unusual structure. Their biogenesis and biological activity

Adekenov, S. M. (2017) · Fitoterapia · doi:10.1016/j.fitote.2017.05.017 · Cited by 52 · see citing works

The activity of the artemisinic aldehyde Δ11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L.

Yang, K., Monafared, R. S., Wang, H., Lundgren, A., & Brodelius, P. E. (2015) · Plant Molecular Biology · doi:10.1007/s11103-015-0284-3 · Cited by 50 · see citing works

Metabolic engineering for the production of clinically important molecules: Omega‐3 fatty acids, artemisinin, and taxol

Ye, V. M., & Bhatia, S. K. (2011) · Biotechnology Journal · doi:10.1002/biot.201100289 · Cited by 47 · see citing works

Effect of Gibberellic Acid on Production of Biomass, Polyphenolics and Steviol Glycosides in Adventitious Root Cultures of Stevia rebaudiana (Bert.)

Ahmad, A., Ali, H., Khan, H., Begam, A., Khan, S., Ali, S. S., Ahmad, N., Fazal, H., Ali, M., Hano, C., et al. (2020) · Plants · doi:10.3390/plants9040420 · Cited by 44 · see citing works

Advanced metabolic engineering strategies for increasing artemisinin yield in Artemisia annua L.

Li, Y., Yang, Y., Li, L., Tang, K., Hao, X., & Kai, G. (2024) · Horticulture Research · doi:10.1093/hr/uhad292 · Cited by 42 · see citing works

Variation in the primary and secondary metabolites derived from the isoprenoid pathway in the Perovskia species in response to different wavelengths generated by light emitting diodes (LEDs)

Ghaffari, Z., Rahimmalek, M., & Sabzalian, M. R. (2019) · Industrial Crops and Products · doi:10.1016/j.indcrop.2019.111592 · Cited by 42 · see citing works

Quantitative Transcript Profiling Reveals Down-Regulation of A Sterol Pathway Relevant Gene and Overexpression of Artemisinin Biogenetic Genes in Transgenic<i>Artemisia annua</i>Plants

Yang, R.-Y., Feng, L.-L., Yang, X.-Q., Yin, L.-L., Xu, X.-L., & Zeng, Q.-P. (2008) · Planta Medica · doi:10.1055/s-2008-1081333 · Cited by 41 · see citing works

Senescent Leaves of<i>Artemisia annua</i>are One of the Most Active Organs for Overexpression of Artemisinin Biosynthesis Responsible Genes upon Burst of Singlet Oxygen

Yang, R.-Y., Zeng, X.-M., Lu, Y.-Y., Lu, W.-J., Feng, L.-L., Yang, X.-Q., & Zeng, Q.-P. (2010) · Planta Medica · doi:10.1055/s-0029-1240620 · Cited by 40 · see citing works

Synergistic re-channeling of mevalonate pathway for enhanced artemisinin production in transgenic Artemisia annua

Feng, L.-L., Yang, R.-Y., Yang, X.-Q., Zeng, X.-M., Lu, W.-J., & Zeng, Q.-P. (2009) · Plant Science · doi:10.1016/j.plantsci.2009.03.014 · Cited by 39 · see citing works

Artemisinins in Combating Viral Infections Like SARS-CoV-2, Inflammation and Cancers and Options to Meet Increased Global Demand

Kalalagh, K. F., Kashkooli, A. B., Babaei, A., Rezaei, A., & van der Krol, A. R. (2022) · Frontiers in Plant Science · doi:10.3389/fpls.2022.780257 · Cited by 39 · see citing works

Trichome Specific Expression: Promoters and Their Applications

Tissier, A. F. (2012) · InTech eBooks · doi:10.5772/32101 · Cited by 36 · see citing works

Variation in the essential oil composition of Artemisia annua L. of different growth stages cultivated in Iran

Verdian-rizi, M. (2008) · African Journal of Plant Science · doi:10.5897/ajps.9000256 · Cited by 33 · see citing works

Essential oils of petal, leaf and stem of the antimalarial plant Artemisia annua

Goel, D., Singh, V., Ali, M., Mallavarupu, G. R., & Kumar, S. (2007) · Journal of Natural Medicines · doi:10.1007/s11418-006-0112-9 · Cited by 32 · see citing works

Biosynthesis of Terpenoid–Pyrrolobenzoxazine Hybrid Natural Product CJ‐12662

Cheng, W., Chen, M., Ōhashi, M., & Tang, Y. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202116928 · Cited by 30 · see citing works

Biochemical characterization and identification of a cinnamyl alcohol dehydrogenase from Artemisia annua

Li, X., Ma, D., Chen, J., Pu, G., Ji, Y., Lei, C., Du, Z., Liu, B., Ye, H., & Wang, H. (2012) · Plant Science · doi:10.1016/j.plantsci.2012.05.011 · Cited by 30 · see citing works

Chemical Compositionand Anti-acetyl cholinesterase Activity of Flower Essential Oils of Artemisiaannuaat Different Flowering Stage.

Yu, Z., Wang, B., Yang, F., Sun, Q., Zhan-nan, Y., & Zhu, L. (2011) · Europe PMC (PubMed Central) · Cited by 29 · see citing works

Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L.

Wang, Y., Yang, K., Jing, F., Li, M., Deng, T., Huang, R.-Z., Wang, B., Wang, G., Sun, X., & Tang, K. (2011) · Molecular Biology · doi:10.1134/s0026893311040145 · Cited by 28 · see citing works

A survey of artemisinic and dihydroartemisinic acid contents in glasshouse and global field-grown populations of the artemisinin-producing plant Artemisia annua L.

Larson, T. R., Branigan, C., Harvey, D., Penfield, T., Bowles, D., & Graham, I. A. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2012.12.004 · Cited by 27 · see citing works

Investigation of Glandular Trichome Proteins in Artemisia annua L. Using Comparative Proteomics

Wu, T., Wang, Y., & Guo, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041822 · Cited by 27 · see citing works

Co-overexpression of the HMGR and FPS genes enhances artemisinin content in Artemisia annua L.

Wang, Y., Jing, F., Yu, S., Chen, Y., Wang, T., Pin, L., Wang, G., Sun, X., & Tang, K. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000369 · Cited by 27 · see citing works

Heterologous biosynthesis of artemisinic acid in Saccharomyces cerevisiae

Li, C., Li, J., Wang, G., & Li, X. (2016) · Journal of Applied Microbiology · doi:10.1111/jam.13044 · Cited by 28 · see citing works

Cellular engineering of Artemisia annua and Artemisia dubia with the rol ABC genes for enhanced production of potent anti-malarial drug artemisinin

Kiani, B. H., Suberu, J., & Mirza, B. (2016) · Malaria Journal · doi:10.1186/s12936-016-1312-8 · Cited by 27 · see citing works

Overexpression of the gibberellin 20-oxidase gene from Torenia fournieri resulted in modified trichome formation and terpenoid metabolities of Artemisia annua L.

Inthima, P., Nakano, M., Otani, M., Niki, T., Nishijima, T., Koshioka, M., & Supaibulwatana, K. (2017) · Plant Cell, Tissue and Organ Culture (PCTOC) · doi:10.1007/s11240-017-1171-1 · Cited by 26 · see citing works

Secondary Metabolic Profiling and Artemisinin Biosynthesis of Two Genotypes ofArtemisia annua

Wang, H., Ma, C., Ma, L., Du, Z., Wang, H., Ye, H., Li, G., Liu, B., & Xu, G. (2009) · Planta Medica · doi:10.1055/s-0029-1185814 · Cited by 26 · see citing works

Genetic engineering of artemisinin biosynthesis: prospects to improve its production

Abdin, M. Z., & Alam, P. (2015) · Acta Physiologiae Plantarum · doi:10.1007/s11738-015-1771-5 · Cited by 25 · see citing works

Molecular cloning and functional identification of a novel borneol dehydrogenase from Artemisia annua L.

Tian, N., Tang, Y., Xiong, S., Tian, D., Chen, Y., Wu, D., Liu, Z., & Liu, S. (2015) · Industrial Crops and Products · doi:10.1016/j.indcrop.2015.08.049 · Cited by 25 · see citing works

Artemisinic acid: A promising molecule potentially suitable for the semi-synthesis of artemisinin

Kong, J., Yang, Y., Wang, W., Cheng, K.-D., & Zhu, P. (2013) · RSC Advances · doi:10.1039/c3ra40525g · Cited by 24 · see citing works

Chemical Composition of the Volatile Oils from the Aerial Parts ofArtemisia annuaL. (Asteraceae) by Using Head Space Solid Phase Microextraction and Hydrodistillation Methods Prior to Gas Chromatographic-Mass Spectrometric Determination: A Comparative Investigation

Nekoei, M., Mohammadhosseini, M., & Akhlaghi, H. (2012) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2012.10662595 · Cited by 24 · see citing works

Advancing the scale of synthetic biology via cross-species transfer of cellular functions enabled by iModulon engraftment

Choe, D., Olson, C. A., Szubin, R., Yang, H., Sung, J., Feist, A. M., & Palsson, B. Ø. (2024) · Nature Communications · doi:10.1038/s41467-024-46486-3 · Cited by 24 · see citing works

Chemotype-dependent Metabolic Response to Methyl Jasmonate Elicitation inArtemisia annua

Wu, W., Yuan, M., Zhang, Q., Zhu, Y., Li, Y., Wang, W., Yan, Q., & Guo, D. (2011) · Planta Medica · doi:10.1055/s-0030-1250744 · Cited by 24 · see citing works

Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha‐4,11‐diene

Komori, A., Suzuki, M., Seki, H., Nishizawa, T., Meyer, J. J. M., Shimizu, H., Yokoyama, S., & Muranaka, T. (2013) · FEBS Letters · doi:10.1016/j.febslet.2012.11.031 · Cited by 24 · see citing works

Amorpha-4,11-diene synthase catalyses the first probable step in artemisinin biosynthesis

Bouwmeester, H. J., Wallaart, T. E., Janssen, M. H. A., van Loo, B., Jansen, B. J. M., Posthumus, M. A., Schmidt, C. O., De Kraker, J.-W., König, W. A., & Franssen, M. C. R. (1999) · Phytochemistry · doi:10.1016/s0031-9422(99)00206-x · Cited by 266 · see citing works

Research to Improve Artemisinin Production for use in the Preparation of Anti-Malarial Drugs

Bouwmeester, H. J., Bertea, C. M., Jan-Willem, K. D., Verstappen, F. W. A., & Franssen, M. C. R. (2007) · Springer eBooks · doi:10.1007/1-4020-5449-1_20 · Cited by 6 · see citing works

[Advances in molecular regulation of artemisinin biosynthesis].

Wang, H., Ye, H., Liu, B., Li, Z., & Li, G. (2003) · PubMed · Cited by 5 · see citing works

Biosynthetic Pathway of Artemisinin

Kiani, B. H. (2017) · CRC Press eBooks · doi:10.1201/b22102-6

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in <i>Artemisia annua</i> This paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

Teoh, K. H., Polichuk, D. R., Reed, D. W., & Covello, P. S. (2009) · Botany · doi:10.1139/b09-032 · Cited by 251 · see citing works