Roles of tau protein in health and disease
Guo, Tong, Noble, Wendy, Hanger, Diane P.·2017·Acta Neuropathologica
Cites (550)
Items 201–400 of 550
- Inhibition of Calpain Cleavage of Huntingtin Reduces ToxicityJuliette Gafni, Evan Hermel, Jessica E. Young, Cheryl Lea Wellington, Michael R. Hayden, Lisa Ellerby · 2004 · Journal of Biological Chemistry
- Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) ConformationJeganathan, Sadasivam, Hascher, Antje, Chinnathambi, Subashchandrabose, Biernat, Jacek, Mandelkow, Eva-Maria, Mandelkow, Eckhard · 2008 · Journal of Biological Chemistry
- Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory LossTracy, Tara E., Sohn, Peter Dongmin, Minami, S. Sakura, Wang, Chao, Min, Sang-Won, Li, Yaqiao, Zhou, Yungui, Le, David, Lo, Iris, Ponnusamy, Ravikumar et al. · 2016 · Neuron
- Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degenerationAlan Michael Pittman, A J Myers, Patrick M. Abou‐Sleiman, Hon‐Chung Fung, M Kaleem, Lauren Marlowe, Jaime Duckworth, Doris G. Leung, David R. Williams, Linda Kilford et al. · 2005 · Journal of Medical Genetics
- Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathiesWenjie Luo, Fei Dou, Anna Rodina, Sophorn Chip, Joungnam Kim, Qi Zhao, Kamalika Moulick, Julia Aguirre, Nian Fen Wu, Paul Greengard et al. · 2007 · Proceedings of the National Academy of Sciences
- Pathogenic Forms of Tau Inhibit Kinesin-Dependent Axonal Transport through a Mechanism Involving Activation of Axonal PhosphotransferasesNicholas M. Kanaan, Gerardo A. Morfini, Nichole E. LaPointe, Gustavo F. Pigino, Kristina R. Patterson, Yuyu Song, Athena Andreadis, Yifan Fu, Scott T. Brady, Lester I. Binder · 2011 · Journal of Neuroscience
- Tau Accumulation Causes Mitochondrial Distribution Deficits in Neurons in a Mouse Model of Tauopathy and in Human Alzheimer's Disease BrainKatherine J. Kopeikina, George A. Carlson, Rose Pitstick, Adam E. Ludvigson, Alan Peters, Jennifer Irene Luebke, Robert M. Koffie, Matthew P. Frosch, Bradley T. Hyman, Tara L. Spires‐Jones · 2011 · American Journal Of Pathology
- Activity-Dependent Tau Protein Translocation to Excitatory Synapse Is Disrupted by Exposure to Amyloid-Beta OligomersFrandemiche, Marie Lise, De Seranno, Sandrine, Rush, Travis, Borel, Eve, Elie, Auréliane, Arnal, Isabelle, Lanté, Fabien, Buisson, Alain · 2014 · The Journal of Neuroscience
- Interaction of Endogenous Tau Protein with Synaptic Proteins Is Regulated by N-Methyl-d-aspartate Receptor-dependent Tau Phosphorylation*Mondragón-Rodríguez, Siddhartha, Trillaud-Doppia, Emilie, Dudilot, Anthony, Bourgeois, Catherine, Lauzon, Michel, Leclerc, Nicole, Boehm, Jannic · 2012 · Journal of Biological Chemistry
- Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent MannerJuan Carlos Polanco, Benjamin James Scicluna, Andrew Francis Hill, Jürgen Götz · 2016 · Journal of Biological Chemistry
- Tau and α‐synuclein in susceptibility to, and dementia in, Parkinson's diseaseAn Goris, Caroline H. Williams‐Gray, Graeme R. Clark, Thomas Foltynie, Simon J.G. Lewis, Joanne Brown, Maria Ban, Maria Grazia Spillantini, Alastair Compston, David John Burn et al. · 2007 · Annals of Neurology
- Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated DegradationJose Francisco Abisambra, Umesh K. Jinwal, Laura J. Blair, John C. O’Leary, Qingyou Li, Sarah Brady, Li Wang, Chantal Guidi, Bo Zhang, Bryce A. Nordhues et al. · 2013 · Journal of Neuroscience
- Graded Control of Microtubule Severing by Tubulin GlutamylationMax L. Valenstein, Antonina Roll‐Mecak · 2016 · Cell
- Loss of Bin1 Promotes the Propagation of Tau PathologyCalafate, Sara, Flavin, William, Verstreken, Patrik, Moechars, Diederik · 2016 · Cell Reports
- Site-specific phosphorylation of tau inhibits amyloid-β toxicity in Alzheimer’s miceIttner, Arne, Chua, Sook Wern, Bertz, Josefine, Volkerling, Alexander, van der Hoven, Julia, Gladbach, Amadeus, Przybyla, Magdalena, Bi, Mian, van Hummel, Annika, Stevens, Claire H. et al. · 2016 · Science
- The Generation of a 17 kDa Neurotoxic Fragment: An Alternative Mechanism by which Tau Mediates β-Amyloid-Induced NeurodegenerationPark, So-Young, Ferreira, Adriana · 2005 · The Journal of Neuroscience
- Interface between tauopathies and synucleinopathies: A tale of two proteinsWendy R. Galpern, Anthony Edward Lang · 2006 · Annals of Neurology
- Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer’s disease or corticobasal degeneration brainsSusana Boluda, Michiyo Iba, Bin Zhang, Kevin M. Raible, Virginia M.‐Y. Lee, John Q. Trojanowski · 2014 · Acta Neuropathologica
- Synaptic Contacts Enhance Cell-to-Cell Tau Pathology PropagationSara Calafate, Arjan Buist, Katarzyna Miśkiewicz, V. A. Vijayan, Guy Daneels, Bart De Strooper, Joris de Wit, Patrik Verstreken, Diederik Moechars · 2015 · Cell Reports
- Single-molecule investigation of the interference between kinesin, tau and MAP2cSeitz, Arne, Kojima, Hiroaki, Oiwa, Kazuhiro, Mandelkow, Eva-Maria, Song, Young-Hwa, Mandelkow, Eckhard · 2002 · The EMBO Journal
- Central Role of Glycogen Synthase Kinase-3β in Endoplasmic Reticulum Stress-induced Caspase-3 ActivationLing Song, Patrizia De Sarno, Richard Scott Jope · 2002 · Journal of Biological Chemistry
- Tau truncation during neurofibrillary tangle evolution in Alzheimer’s diseaseGuillozet-Bongaarts, Angela L., Garcia-Sierra, Francisco, Reynolds, Matthew R., Horowitz, Peleg M., Fu, Yifan, Wang, Tianyi, Cahill, Michael E., Bigio, Eileen H., Berry, Robert W., Binder, Lester I. · 2005 · Neurobiology of Aging
- MINOR GROOVE-BINDING ARCHITECTURAL PROTEINS: Structure, Function, and DNA RecognitionCarole A. Bewley, Angela M. Gronenborn, G. Marius Clore · 1998 · Annual Review of Biophysics and Biomolecular Structure
- Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivoNorbert Žilka, Peter Filipčík, Peter Koson, Ľubica Fialová, Rostislav Škrabana, Monika Žilková, Gabriela Rolkova, Eva Kontseková, Michal Novák · 2006 · FEBS Letters
- A major role for Tau in neuronal DNA and RNA protection in vivo under physiological and hyperthermic conditionsViolet, Marie, Delattre, Lucie, Tardivel, Meryem, Sultan, Audrey, Chauderlier, Alban, Caillierez, Raphaelle, Talahari, Smail, Nesslany, Fabrice, Lefebvre, Bruno, Bonnefoy, Eliette et al. · 2014 · Frontiers in Cellular Neuroscience
- Process Outgrowth of Oligodendrocytes Is Promoted by Interaction of Fyn Kinase with the Cytoskeletal Protein TauKlein, Corinna, Krämer, Eva-Maria, Cardine, Anne-Marie, Schraven, Burkhardt, Brandt, Roland, Trotter, Jacqueline · 2002 · The Journal of Neuroscience
- Altered Machinery of Protein Synthesis in Alzheimer's: From the Nucleolus to the RibosomeHernández‐Ortega, Karina, Garcia‐Esparcia, Paula, Gil, Laura, Lucas, José J., Ferrer, Isidre · 2016 · Brain Pathology
- How IRE1 Reacts to ER StressDavid Ron, Stevan R. Hubbard · 2008 · Cell
- Tau oligomers and tau toxicity in neurodegenerative diseaseSarah Ward, Diana S. Himmelstein, Jody K. Lancia, Lester I. Binder · 2012 · Biochemical Society Transactions
- Caspase-9 Activation and Caspase Cleavage of tau in the Alzheimer's Disease BrainTroy T. Rohn, Robert A. Rissman, Michael C. Davis, Young‐Eun Kim, Carl W. Cotman, Elizabeth Head · 2002 · Neurobiology of Disease
- Endoplasmic reticulum stress features are prominent in Alzheimer disease but not in prion diseases in vivoUnterberger, Ursula, Höftberger, Romana, Gelpi, Ellen, Flicker, Helga, Budka, Herbert, Voigtländer, Till · 2006 · Journal of Neuropathology and Experimental Neurology
- Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementiasMelissa Erin Murray, Naomi Kouri, Wen-Lang Lin, Clifford R. Jack, Dennis W. Dickson, Prashanthi Vemuri · 2014 · Alzheimer s Research & Therapy
- SUMOylation at K340 inhibits tau degradation through deregulating its phosphorylation and ubiquitinationLuo, Hong-Bin, Xia, Yi-Yuan, Shu, Xi-Ji, Liu, Zan-Chao, Feng, Ye, Liu, Xing-Hua, Yu, Guang, Yin, Gang, Xiong, Yan-Si, Zeng, Kuan et al. · 2014 · Proceedings of the National Academy of Sciences
- Is calpain activity regulated by membranes and autolysis or by calcium and calpastatin?Darrel E. Goll, Valery F. Thompson, Richard G. Taylor · 1992 · BioEssays
- Valproate protects cells from ER stress-induced lipid accumulation and apoptosis by inhibiting glycogen synthase kinase-3Anna J. Kim, Yuanyuan Shi, Richard C. Austin, Geoff H. Werstuck · 2004 · Journal of Cell Science
- Tau Cleavage and Dephosphorylation in Cerebellar Granule Neurons Undergoing ApoptosisCanu, Nadia, Dus, Laura, Barbato, Christian, Ciotti, Maria T., Brancolini, Claudio, Rinaldi, Anna M., Novak, Michal, Cattaneo, Antonino, Bradbury, Andrew, Calissano, Pietro · 1998 · The Journal of Neuroscience
- Huntington's disease is a four-repeat tauopathy with tau nuclear rodsFernández-Nogales, Marta, Cabrera, Jorge R, Santos-Galindo, María, Hoozemans, Jeroen J M, Ferrer, Isidro, Rozemuller, Annemieke J M, Hernández, Félix, Avila, Jesús, Lucas, José J · 2014 · Nature Medicine
- Phosphorylation Regulates Tau Interactions with Src Homology 3 Domains of Phosphatidylinositol 3-Kinase, Phospholipase Cγ1, Grb2, and Src Family KinasesC. Hugh Reynolds, Claire J. Garwood, Selina Wray, Caroline Price, Stuart Kellie, Timothy Pietro Suren Perera, Marketa Zvelebil, Alice Yang, Paul W. Sheppard, Ian M. Varndell et al. · 2008 · Journal of Biological Chemistry
- Interaction of Tau with the Neural Membrane Cortex Is Regulated by Phosphorylation at Sites That Are Modified in Paired Helical FilamentsMaas, Thorsten, Eidenmüller, Jochen, Brandt, Roland · 2000 · Journal of Biological Chemistry
- CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activityManu Sharma, Jacqueline Burré, Thomas Christian Südhof · 2010 · Nature Cell Biology
- Proteomic Identification of Novel Proteins in Cortical Lewy BodiesJames B. Leverenz, Imran Umar, Qing Wang, Thomas Jude Montine, Pamela J. McMillan, Debby W. Tsuang, Jinghua Jin, Catherine Pan, Jenny Shin, David C. Zhu et al. · 2007 · Brain Pathology
- Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation ChangeFrost, Bess, Ollesch, Julian, Wille, Holger, Diamond, Marc I. · 2009 · Journal of Biological Chemistry
- Constitutive secretion of tau protein by an unconventional mechanismXiyun Chai, Jeffrey L. Dage, Martin Citron · 2012 · Neurobiology of Disease
- Defective ubiquitination of cerebral proteins in Alzheimer's diseaseM. Lopez Salon, Laura Morelli, Eduardo M. Casta�o, Eduardo F. Soto, Juana Maria Pasquini · 2000 · Journal of Neuroscience Research
- 14-3-3ζ Is an Effector of Tau Protein PhosphorylationMitsuko Hashiguchi, Kazuya Sobue, Hemant K. Paudel · 2000 · Journal of Biological Chemistry
- Disease-related Modifications in Tau Affect the Interaction between Fyn and TauKiran Bhaskar, Shu-Hui C. Yen, Gloria S. Lee · 2005 · Journal of Biological Chemistry
- cAMP-induced phosphorylation of 26S proteasomes on Rpn6/PSMD11 enhances their activity and the degradation of misfolded proteinsSudarsanareddy Lokireddy, Nikolay Vadimovich Kukushkin, Alfred Lewis Goldberg · 2015 · Proceedings of the National Academy of Sciences
- Autophagy in aging and neurodegenerative diseases: implications for pathogenesis and therapyChen‐Chen Tan, Jin‐Tai Yu, Meng‐Shan Tan, Teng Jiang, Xi‐Chen Zhu, Lan Tan · 2013 · Neurobiology of Aging
- Parkinsonism and impaired axonal transport in a mouse model of frontotemporal dementiaLars Matthias Ittner, Thomas Fath, Yazi Diana Ke, Mian Bi, Janet van Eersel, Kong M. Li, Peter William Gunning, Jürgen Götz · 2008 · Proceedings of the National Academy of Sciences
- Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegenerationXiaoyu Li, Yatender Kumar, Hans Zempel, Eva‐Maria Mandelkow, Jacek Biernat, Eckhard Mandelkow · 2011 · The EMBO Journal
- Lithium Reduces Tau Phosphorylation but Not Aβ or Working Memory Deficits in a Transgenic Model with Both Plaques and TanglesAntonella Caccamo, Salvatore Oddo, Lana X. Tran, Frank M. LaFerla · 2007 · American Journal Of Pathology
- Identification of nuclear tau isoforms in human neuroblastoma cells.P A Loomis, Thomas H. Howard, R P Castleberry, Lester I. Binder · 1990 · Proceedings of the National Academy of Sciences
- Ectosomes: A New Mechanism for Non-Exosomal Secretion of Tau ProteinSimon Dujardin, Séverine Bégard, Raphaëlle Caillierez, Cédrick Lachaud, Lucie Delattre, Sébastien Carrier, Anne Loyens, Marie‐Christine Galas, Luc Bousset, Ronald Melki et al. · 2014 · PLoS ONE
- Tau Trimers Are the Minimal Propagation Unit Spontaneously Internalized to Seed Intracellular AggregationMirbaha, Hilda, Holmes, Brandon B., Sanders, David W., Bieschke, Jan, Diamond, Marc I. · 2015 · Journal of Biological Chemistry
- Implications of the serine protease HtrA1 in amyloid precursor protein processingGrau, Sandra, Baldi, Alfonso, Bussani, Rossana, Tian, Xiaodan, Stefanescu, Raluca, Przybylski, Michael, Richards, Peter, Jones, Simon A., Shridhar, Viji, Clausen, Tim et al. · 2005 · Proceedings of the National Academy of Sciences
- Early N-Terminal Changes and Caspase-6 Cleavage of Tau in Alzheimer's DiseaseHorowitz, Peleg M., Patterson, Kristina R., Guillozet-Bongaarts, Angela L., Reynolds, Matthew R., Carroll, Christopher A., Weintraub, Susan T., Bennett, David A., Cryns, Vincent L., Berry, Robert W., Binder, Lester I. · 2004 · The Journal of Neuroscience
- Are tau aggregates toxic or protective in tauopathies?Cowan, Catherine M., Mudher, Amrit · 2013 · Frontiers in Neurology
- Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic micePeeraer, Eve, Bottelbergs, Astrid, Van Kolen, Kristof, Stancu, Ilie-Cosmin, Vasconcelos, Bruno, Mahieu, Michel, Duytschaever, Hilde, Ver Donck, Luc, Torremans, An, Sluydts, Ellen et al. · 2015 · Neurobiology of Disease
- Tau phosphorylation by GSK-3β promotes tangle-like filament morphologyCarolyn A. Rankin, Qian Sun, T.C. Gamblin · 2007 · Molecular Neurodegeneration
- Nerve growth factor and galantamine ameliorate early signs of neurodegeneration in anti-nerve growth factor miceSimona Capsoni, Sabina Giannotta, Antonino Cattaneo · 2002 · Proceedings of the National Academy of Sciences
- Loss of
<i>O</i>
-GlcNAc glycosylation in forebrain excitatory neurons induces neurodegenerationWang, Andrew C., Jensen, Elizabeth H., Rexach, Jessica E., Vinters, Harry V., Hsieh-Wilson, Linda C. · 2016 · Proceedings of the National Academy of Sciences
- Evidence of a balance between phosphorylation and O-GlcNAc glycosylation of Tau proteins—a role in nuclear localizationTony Lefebvre, Stéphanie Ferreira, L. Dupont-Wallois, Thierry Bussière, Marie-Joëlle Dupire, André Delacourte, Jean‐Claude Michalski, Marie‐Laure Caillet‐Boudin · 2003 · Biochimica et Biophysica Acta (BBA) - General Subjects
- The Ambiguous Relationship of Oxidative Stress, Tau Hyperphosphorylation, and Autophagy Dysfunction in Alzheimer’s DiseaseZhenzhen Liu, Tao Li, Ping Li, Nannan Wei, Zhiquan Zhao, Huimin Liang, Xin‐Ying Ji, Wenwu Chen, Mengzhou Xue, Jianshe Wei · 2015 · Oxidative Medicine and Cellular Longevity
- Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregationLiu, Fei, Li, Bin, Tung, E‐Jan, Grundke‐Iqbal, Inge, Iqbal, Khalid, Gong, Cheng‐Xin · 2007 · European Journal of Neuroscience
- Stepwise proteolysis liberates tau fragments that nucleate the Alzheimer-like aggregation of full-length tau in a neuronal cell modelY. P. Wang, Jacek Biernat, Marcus Pickhardt, Eckhard Mandelkow�, Eckhard Mandelkow� · 2007 · Proceedings of the National Academy of Sciences
- DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative‐associated proteinsSarah N. Fontaine, Dali Zheng, Jonathan J. Sabbagh, Mackenzie D. Martin, Dale Chaput, April L. Darling, Justin H. Trotter, Andrew R. Stothert, Bryce A. Nordhues, April L. Lussier et al. · 2016 · The EMBO Journal
- Phosphorylation by cAMP-dependent protein kinase inhibits the degradation of tau by calpain.Litersky, J M, Johnson, G V · 1992 · Journal of Biological Chemistry
- Tau co-organizes dynamic microtubule and actin networksElie, Auréliane, Prezel, Elea, Guérin, Christophe, Denarier, Eric, Ramirez-Rios, Sacnicte, Serre, Laurence, Andrieux, Annie, Fourest-Lieuvin, Anne, Blanchoin, Laurent, Arnal, Isabelle · 2015 · Scientific Reports
- Tau phosphorylation affects its axonal transport and degradationTeresa Rodríguez-Martín, Inmaculada Cuchillo‐Ibáñez, Wendy J. Noble, Fanon Nyenya, Brian H. Anderton, Diane P. Hanger · 2013 · Neurobiology of Aging
- The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathiesDiana A.T. Nijholt, Elise S. van Haastert, Annemieke J.M. Rozemüller, Wiep Scheper, Jeroen J.M. Hoozemans · 2011 · The Journal of Pathology
- Inhibition of Protein Phosphatase 2A Overrides Tau Protein Kinase I/Glycogen Synthase Kinase 3β and Cyclin-dependent Kinase 5 Inhibition and Results in Tau Hyperphosphorylation in the Hippocampus of Starved MouseEmmanuel Planel, Kaori Yasutake, Shinobu C. Fujita, Koichi Ishiguro · 2001 · Journal of Biological Chemistry
- The “Jaws” of the Tau-Microtubule InteractionMarco D. Mukrasch, Martin von Bergen�, Jacek Biernat, Daniela Fischer, Christian Griesinger, Eckhard Mandelkow�, Markus Zweckstetter · 2007 · Journal of Biological Chemistry
- The Neuronal Microtubule‐Associated Protein Tau Is a Substrate for Caspase‐3 and an Effector of ApoptosisLuisa Fasulo, Gabriele Ugolini, Michela Visintin, Andrew M. Bradbury, Claudio Brancolini, Vittorio Verzillo, Michal Novák, Antonino Cattaneo · 2000 · Journal of Neurochemistry
- Tau oligomers and aggregation in Alzheimer’s diseaseMarco Antonio Meraz‐Ríos, Karla Isabel Lira-de León, Victoria Campos‐Peña, Martha A. De Anda-Hernández, Raúl Mena‐López · 2009 · Journal of Neurochemistry
- Degradation of Tau by Lysosomal Enzyme Cathepsin D: Implication for Alzheimer Neurofibrillary DegenerationÁ. Kenessey, P. Nacharaju, L. Ko, S. Yen · 1997 · Journal of Neurochemistry
- Thrombin and Prothrombin Are Expressed by Neurons and Glial Cells and Accumulate in Neurofibrillary Tangles in Alzheimer Disease BrainTetsuaki Arai, Judith Miklossy A, Andis Klegeris, Jian‐Ping Guo, Patrick L. McGeer · 2006 · Journal of Neuropathology & Experimental Neurology
- ThrombinaJohn W. Fenton · 1986 · Annals of the New York Academy of Sciences
- Caspase-2 cleavage of tau reversibly impairs memoryZhao, Xiaohui, Kotilinek, Linda A, Smith, Benjamin, Hlynialuk, Chris, Zahs, Kathleen, Ramsden, Martin, Cleary, James, Ashe, Karen H · 2016 · Nature Medicine
- The active form of glycogen synthase kinase-3? is associated with granulovacuolar degeneration in neurons in Alzheimer's diseaseAllal Boutajangout, Karelle Leroy, M. Authelet, Brian H. Anderton, Jean‐Pierre Brion, James Robert Woodgett · 2002 · Acta Neuropathologica
- Identification of amino‐terminally cleaved tau fragments that distinguish progressive supranuclear palsy from corticobasal degenerationTetsuaki Arai, Kenji Ikeda, Haruhiko Akiyama, Takashi Nonaka, Masato Hasegawa, Koichi Ishiguro, Shuji Iritani, Kuniaki Tsuchiya, Eizo Iseki, Saburo Yagishita et al. · 2003 · Annals of Neurology
- Interaction of tau protein with the dynactin complexEnrico Magnani, Juan Fan, Laura Gasparini, Matthew Golding, Meredith Williams, Giampietro Schiavo, Michel Goedert, Linda Amos, Maria Grazia Spillantini · 2007 · The EMBO Journal
- Tyrosine 394 Is Phosphorylated in Alzheimer's Paired Helical Filament Tau and in Fetal Tau with c-Abl as the Candidate Tyrosine KinasePascal Derkinderen, Timothy M.E. Scales, Diane P. Hanger, Kit‐Yi Leung, Helen L. Byers, Malcolm Andrew Ward, Christof Lenz, Caroline Price, Ian N. Bird, Timothy Pietro Suren Perera et al. · 2005 · Journal of Neuroscience
- Tau – an inhibitor of deacetylase HDAC6 functionPerez, Mar, Santa‐Maria, Ismael, De Barreda, Elena Gomez, Zhu, Xiongwei, Cuadros, Raquel, Cabrero, Jose Roman, Sanchez‐Madrid, Francisco, Dawson, Hana N., Vitek, Michael P., Perry, George et al. · 2009 · Journal of Neurochemistry
- Substantia nigra tangles are related to gait impairment in older personsJulie A. Schneider, Jialiang Li, Yan Li, Robert S. Wilson, Jeffrey H. Kordower, David Alan Bennett · 2005 · Annals of Neurology
- Tau isoform regulation is region‐ and cell‐specific in mouse brainMcMillan, Pamela, Korvatska, Elena, Poorkaj, Parvoneh, Evstafjeva, Zana, Robinson, Linda, Greenup, Lynne, Leverenz, James, Schellenberg, Gerard D., D'Souza, Ian · 2008 · Journal of Comparative Neurology
- Tau protein and tau aggregation inhibitorsBruno Bulic, Marcus Pickhardt, Eva‐Maria Mandelkow, Eckhard Mandelkow� · 2010 · Neuropharmacology
- Reduction of acetylated alpha-tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease.Bart Hempen, J. Brion · 1996 · Journal of Neuropathology and Experimental Neurology
- Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: evidence for a neuronal originAnne M. Cataldo, C.Y. Thayer, Edward D. Bird, Timothy R. Wheelock, Ralph A. Nixon · 1990 · Brain Research
- Structural Impact of Heparin Binding to Full-Length Tau As Studied by NMR SpectroscopyNathalie Sibille, Alain Sillen, Arnaud Leroy, Jean‐Michel Wieruszeski, Barbara Mulloy, Isabelle Landrieu, Guy M. Lippens · 2006 · Biochemistry
- Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degenerationSanchez-Mejias, Elisabeth, Navarro, Victoria, Jimenez, Sebastian, Sanchez-Mico, Maria, Sanchez-Varo, Raquel, Nuñez-Diaz, Cristina, Trujillo-Estrada, Laura, Davila, Jose Carlos, Vizuete, Marisa, Gutierrez, Antonia et al. · 2016 · Acta Neuropathologica
- The role of tau kinases in Alzheimer's disease.Philip J. Dolan, Gail V.W. Johnson · 2010 · PubMed
- Caspase-cleaved Tau Expression Induces Mitochondrial Dysfunction in Immortalized Cortical NeuronsQuintanilla, Rodrigo A., Matthews-Roberson, Tori A., Dolan, Philip J., Johnson, Gail V.W. · 2009 · Journal of Biological Chemistry
- Thrombin accumulation in brains of patients with Alzheimer's diseaseHaruhiko Akiyama, Kenji Ikeda, Hiromi Kondo, Patrick L. McGeer · 1992 · Neuroscience Letters
- Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer's diseaseMatthew E. Seward, Eric Swanson, Andrés Norambuena, Anja Reimann, J. Nicholas Cochran, Rong Li, Erik D. Roberson, George S. Bloom · 2013 · Journal of Cell Science
- Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivoAngela L. Guillozet-Bongaarts, Michael E. Cahill, Vincent L. Cryns, Matthew R. Reynolds, Robert W. Berry, Lester I. Binder · 2006 · Journal of Neurochemistry
- Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathwayInoue, Keiichi, Rispoli, Joanne, Kaphzan, Hanoch, Klann, Eric, Chen, Emily I, Kim, Jongpil, Komatsu, Masaaki, Abeliovich, Asa · 2012 · Molecular Neurodegeneration
- Untitled work1995 · PubMed
- Tau protein binds to pericentromeric DNA: a putative role for nuclear tau in nucleolar organizationSjöberg, Marcela K., Shestakova, Elena, Mansuroglu, Zeyni, Maccioni, Ricardo B., Bonnefoy, Eliette · 2006 · Journal of Cell Science
- Degradation of tau protein by autophagy and proteasomal pathwaysWang, Yipeng, Mandelkow, Eckhard · 2012 · Biochemical Society Transactions
- Axonal Tau mRNA Localization Coincides with Tau Protein in Living Neuronal Cells and Depends on Axonal Targeting SignalStella Aronov, Gonzalo Aranda, Leah Behar, Irith Ginzburg · 2001 · Journal of Neuroscience
- Human wild-type full-length tau accumulation disrupts mitochondrial dynamics and the functions via increasing mitofusinsXia‐Chun Li, Yu Hu, Zhi-Hao Wang, Yu Luo, Yao Zhang, Xiuping Liu, Qiong Feng, Qun Wang, Keqiang Ye, Gong‐Ping Liu et al. · 2016 · Scientific Reports
- Proteolysis of tau by calpainJohnson, Gail V.W., Jope, Richard S., Binder, Lester I. · 1989 · Biochemical and Biophysical Research Communications
- Nuclear Tau and Its Potential Role in Alzheimer’s DiseaseBukar Maina, Mahmoud, Al-Hilaly, Youssra, Serpell, Louise · 2016 · Biomolecules
- Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartmentSohn, Peter Dongmin, Tracy, Tara E., Son, Hye-In, Zhou, Yungui, Leite, Renata E. P., Miller, Bruce L., Seeley, William W., Grinberg, Lea T., Gan, Li · 2016 · Molecular Neurodegeneration
- A distinct familial presenile dementia with a novel missense mutation in the tau geneMasaaki Iijima, Takeshi Tabira, Parvoneh Poorkaj, Gerard D. Schellenberg, John Q. Trojanowski, Virginia M.‐Y. Lee, Marie Luise Schmidt, Keikichi Takahashi, Toru Nabika, Takahisa Matsumoto et al. · 1999 · Neuroreport
- Molecular motors implicated in the axonal transport of tau and α-synucleinMichelle A. Utton, Wendy J. Noble, Josephine E. Hill, Brian H. Anderton, Diane P. Hanger · 2005 · Journal of Cell Science
- Swimming against the Tide: Mobility of the Microtubule-Associated Protein Tau in NeuronsSven Konzack, Edda Thies, Alexander Marx, Eva‐Maria Mandelkow, Eckhard Mandelkow� · 2007 · Journal of Neuroscience
- Phosphorylated Tau Interacts with c-Jun N-terminal Kinase-interacting Protein 1 (JIP1) in Alzheimer DiseaseLars Matthias Ittner, Yazi Diana Ke, Jürgen Götz · 2009 · Journal of Biological Chemistry
- Profiling Murine Tau with 0N, 1N and 2N Isoform-Specific Antibodies in Brain and Peripheral Organs Reveals Distinct Subcellular Localization, with the 1N Isoform Being Enriched in the NucleusChang Liu, Jürgen Götz · 2013 · PLoS ONE
- Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s DiseaseSiddhartha Mondragón‐Rodríguez, George L. Perry, Xiongwei Zhu, Paula Isabel Moreira, Mariana Acevedo, Sylvain Williams · 2013 · Oxidative Medicine and Cellular Longevity
- Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic MiceBi, Mian, Ittner, Arne, Ke, Yazi D., Götz, Jürgen, Ittner, Lars M. · 2011 · PLoS ONE
- Short Fibrils Constitute the Major Species of Seed-Competent Tau in the Brains of Mice Transgenic for Human P301S TauSamuel J. Jackson, Caroline Kerridge, Jane Cooper, Annalisa Cavallini, Benjamin Falcon, Claire V. Cella, Alessia Landi, Philip G. Szekeres, Tracey K. Murray, Zeshan Ahmed et al. · 2016 · Journal of Neuroscience
- Tau Enhances α-Synuclein Aggregation and Toxicity in Cellular Models of SynucleinopathyNahuai Badiola, Rita Machado de Oliveira, Federico Herrera, Cristina Guardia‐Laguarta, Susana A. Gonçalves, Marta Pera, Marc Suárez‐Calvet, Jordi Clarimón, Tiago F. Outeiro, Alberto Lleó · 2011 · PLoS ONE
- Accumulation of Aspartic Acid 421 - and Glutamic Acid 391 -Cleaved Tau in Neurofibrillary Tangles Correlates With Progression in Alzheimer DiseaseGustavo Basurto‐Islas, José Luna‐Muñoz, Angela L. Guillozet-Bongaarts, Lester I. Binder, Raúl Mena, Francisco García‐Sierra · 2008 · Journal of Neuropathology & Experimental Neurology
- TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tauMaxime W.C. Rousseaux, María de Haro, Cristian A. Lasagna‐Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar‐Nejad, Ismael Al‐Ramahi, Ajay Sharma, Lauren See, Nan Lü et al. · 2016 · eLife
- The microtubule-associated tau protein has intrinsic acetyltransferase activityCohen, Todd J, Friedmann, Dave, Hwang, Andrew W, Marmorstein, Ronen, Lee, Virginia M Y · 2013 · Nature Structural & Molecular Biology
- Casein kinase 1 delta is associated with pathological accumulation of tau in several neurodegenerative diseasesClaudia Schwab, Anthony J. DeMaggio, Nupur Ghoshal, Lester I. Binder, Jeff Kuret, Patrick L. McGeer · 2000 · Neurobiology of Aging
- Dynamic association of tau with neuronal membranes is regulated by phosphorylationPooler, Amy M., Usardi, Alessia, Evans, Catherine J., Philpott, Karen L., Noble, Wendy, Hanger, Diane P. · 2012 · Neurobiology of Aging
- Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In VivoVikram Khurana, Ilan Elson‐Schwab, Tudor A. Fulga, Katherine A. Sharp, Carin A. Loewen, Erin E. Mulkearns-Hubert, Jaana Tyynelä, Clemens R. Scherzer, Mel Β. Feany · 2010 · PLoS Genetics
- Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathwaysNorbert Žilka, Zuzana Kazmerova, Santosh Jadhav, Peter Neradil, Aladár Maďari, Dominika Obetkova, Ondrej Bugos, Michal Novák · 2012 · Journal of Neuroinflammation
- A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced NeurodegenerationKarsten, Stanislav L., Sang, Tzu-Kang, Gehman, Lauren T., Chatterjee, Shreyasi, Liu, Jiankai, Lawless, George M., Sengupta, Soma, Berry, Robert W., Pomakian, Justine, Oh, Hyun S. et al. · 2006 · Neuron
- Hyperphosphorylated tau causes reduced hippocampal CA1 excitability by relocating the axon initial segmentRobert John Hatch, Wei Yan, Di Xia, Jürgen Götz · 2017 · Acta Neuropathologica
- Loss of Tau protein affects the structure, transcription and repair of neuronal pericentromeric heterochromatinMansuroglu, Zeyni, Benhelli-Mokrani, Houda, Marcato, Vasco, Sultan, Audrey, Violet, Marie, Chauderlier, Alban, Delattre, Lucie, Loyens, Anne, Talahari, Smail, Bégard, Séverine et al. · 2016 · Scientific Reports
- Interaction of Tau Protein with Model Lipid Membranes Induces Tau Structural Compaction and Membrane DisruptionEmmalee M. Jones, Manish Kant Dubey, Phillip J Camp, Briana C. Vernon, Jacek Biernat, Eckhard Mandelkow�, Jaroslaw P. Majewski, Eva Y. Chi · 2012 · Biochemistry
- Co-immunoprecipitation with Tau Isoform-specific Antibodies Reveals Distinct Protein Interactions and Highlights a Putative Role for 2N Tau in DiseaseChang Liu, Xiaomin Song, Rebecca M. Nisbet, Jürgen Götz · 2016 · Journal of Biological Chemistry
- O-GlcNAc Modification of tau Directly Inhibits Its Aggregation without Perturbing the Conformational Properties of tau MonomersScott A. Yuzwa, Adrienne H. Cheung, Mark Okon, Lawrence P. McIntosh, David J. Vocadlo · 2014 · Journal of Molecular Biology
- Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesisRamesh J. L. Kandimalla, P. Hemachandra Reddy · 2015 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- The tubulin-binding sequence of brain microtubule-associated proteins, tau and MAP-2, is also involved in actin bindingCorreas, I, Padilla, R, Avila, J · 1990 · Biochemical Journal
- CSPα knockout causes neurodegeneration by impairing SNAP‐25 functionManu Sharma, Jacqueline Burré, Peter Bronk, Yingsha Zhang, Wei Xu, Thomas Christian Südhof · 2011 · The EMBO Journal
- Phosphorylation of tau and α-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer’s disease, and in Parkinson’s disease and related α-synucleinopathiesGerard Muntané, Esther Dalfó, Ana Martı́nez, Isidró Ferrer · 2008 · Neuroscience
- Tau‐tubulin kinase 1 (TTBK1), a neuron‐specific tau kinase candidate, is involved in tau phosphorylation and aggregationShinji Sato, Ronald L. Cerny, James L. Buescher, Tsuneya Ikezu · 2006 · Journal of Neurochemistry
- The proline-rich domain of tau plays a role in interactions with actinHe, Hai Jin, Wang, Xing Sheng, Pan, Rong, Wang, Dong Liang, Liu, Ming Nan, He, Rong Qiao · 2009 · BMC Cell Biology
- Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensityFunk, Kristen E., Thomas, Stefani N., Schafer, Kelsey N., Cooper, Grace L., Liao, Zhongping, Clark, David J., Yang, Austin J., Kuret, Jeff · 2014 · Biochemical Journal
- ER stress is involved in Aβ‐induced GSK‐3β activation and tau phosphorylationRosa Resende, Elisabete B. Ferreiro, Cláudia Pereira, Catarina Resende Oliveira · 2008 · Journal of Neuroscience Research
- Inhibition of Tau Polymerization by Its Carboxy-Terminal Caspase Cleavage FragmentBerry, R. W., Abraha, A., Lagalwar, S., LaPointe, N., Gamblin, T. C., Cryns, V. L., Binder, L. I. · 2003 · Biochemistry
- Tau protein diffuses along the microtubule latticeHinrichs, Maike H., Jalal, Avesta, Brenner, Bernhard, Mandelkow, Eckhard, Kumar, Satish, Scholz, Tim · 2012 · Journal of Biological Chemistry
- Paired Helical Filaments from Alzheimer Disease Brain Induce Intracellular Accumulation of Tau Protein in AggresomesIsmael Santa‐María, Merina Varghese, Hanna Ksiȩżak-Reding, Anastasiya Dzhun, Jun Wang, Giulio Maria Pasinetti · 2012 · Journal of Biological Chemistry
- Tau StructuresAvila, Jesus, Jiménez, Juan S., Sayas, Carmen L., Bolós, Marta, Zabala, Juan C., Rivas, Germán, Hernández, Felix · 2016 · Frontiers in Aging Neuroscience
- The role of tau in the pathological process and clinical expression of Huntington’s diseaseRomina Vuono, Sophie Winder‐Rhodes, Rohan de Silva, Giulia Cisbani, Janelle Drouin‐Ouellet, REGISTRY Investigators of the European Huntington’s Disease Network, Maria Grazia Spillantini, Francesca Cicchetti, Roger A. Barker · 2015 · Brain
- Proteolytic processing of tauYipeng Wang, Sarika Garg, Eva‐Maria Mandelkow, Eckhard Mandelkow� · 2010 · Biochemical Society Transactions
- Endoplasmic Reticulum Stress Induces Tau Pathology and Forms a Vicious Cycle: Implication in Alzheimer's Disease PathogenesisJanice Yuen Shan Ho, Xifei Yang, Jeffery Chi-Fai Lau, Clara Hiu-Ling Hung, Suthicha Wuwongse, Qishan Zhang, Jian‐Zhi Wang, Larry Baum, Kwok‐Fai So, Raymond Chuen‐Chung Chang · 2012 · Journal of Alzheimer s Disease
- Specification of Neuronal Polarity Regulated by Local Translation of CRMP2 and Tau via the mTOR-p70S6K PathwayTsuyoshi Morita, Kenji Sobue · 2009 · Journal of Biological Chemistry
- Staging the pathological assembly of truncated tau protein into paired helical filaments in Alzheimer's diseaseR. Mena, Patricia C. Edwards, Charles R. Harrington, Elizabeta B. Mukaetova‐Ladinska, Claude M. Wischik · 1996 · Acta Neuropathologica
- Cognition and hippocampal synaptic plasticity in mice with a homozygous tau deletionAhmed, Tariq, Van der Jeugd, Ann, Blum, David, Galas, Marie-Christine, D’Hooge, Rudi, Buee, Luc, Balschun, Detlef · 2014 · Neurobiology of Aging
- The frontotemporal dementia mutation R406W blocks tau’s interaction with the membrane in an annexin A2–dependent mannerAnne Gauthier‐Kemper, Carina Weissmann, Nataliya Golovyashkina, Zsofia Sebö-Lemke, Gerard Drewes, Volker Gerke, Jürgen J. Heinisch, Roland Brandt · 2011 · The Journal of Cell Biology
- Phosphorylation in the amino terminus of tau prevents inhibition of anterograde axonal transportKanaan, Nicholas M., Morfini, Gerardo, Pigino, Gustavo, LaPointe, Nichole E., Andreadis, Athena, Song, Yuyu, Leitman, Ellen, Binder, Lester I., Brady, Scott T. · 2012 · Neurobiology of Aging
- Role of the Tau N-terminal region in microtubule stabilization revealed by newendogenous truncated formsMaxime J. Derisbourg, Coline Leghay, Giovanni Chiappetta, Francisco-José Fernández-Gómez, Cyril Laurent, Dominique Demeyer, Sébastien Carrier, Valérie Buée‐Scherrer, David L Blum, Joëlle Vinh et al. · 2015 · Scientific Reports
- Amyloid-β Toxicity and Tau Hyperphosphorylation are Linked Via RCAN1 in Alzheimer's DiseaseAna Lloret, Mari-Carmen Badía, Esther Giraldo, Gennady Ermak, Maria-Dolores Alonso, Federico Vicente Pallardó, Kelvin J.A. Davies, José Viña · 2011 · Journal of Alzheimer s Disease
- Identification of O-GlcNAc sites within peptides of the Tau protein and their impact on phosphorylationCaroline Smet‐Nocca, Malgorzata Broncel, Jean‐Michel Wieruszeski, Caroline Tokarski, Xavier Hanoulle, Arnaud Leroy, Isabelle Landrieu, Christian H. Rolando, Guy M. Lippens, Christian P. R. Hackenberger · 2011 · Molecular BioSystems
- Pre‐synaptic C‐terminal truncated tau is released from cortical synapses in Alzheimer's diseaseSokolow, Sophie, Henkins, Kristen M., Bilousova, Tina, Gonzalez, Bianca, Vinters, Harry V., Miller, Carol A., Cornwell, Lindsey, Poon, Wayne W., Gylys, Karen H. · 2015 · Journal of Neurochemistry
- Microtubules in health and degenerative disease of the nervous systemAndrew J. Matamoros, Peter W. Baas · 2016 · Brain Research Bulletin
- Dephosphorylation of Tau by Protein Phosphatase 5Fei Liu, Khalid Iqbal, Inge Grundke, Sandra S. Rossie, Cheng‐Xin Gong · 2004 · Journal of Biological Chemistry
- A novel tau transcript in cultured human neuroblastoma cells expressing nuclear tau.Yu Wang, P A Loomis, Raymond P. Zinkowski, Lester I. Binder · 1993 · The Journal of Cell Biology
- Tau phosphorylation and tau mislocalization mediate soluble Aβ oligomer‐induced
<scp>AMPA</scp>
glutamate receptor signaling deficitsMiller, Eric C., Teravskis, Peter J., Dummer, Benjamin W., Zhao, Xiaohui, Huganir, Richard L., Liao, Dezhi · 2014 · European Journal of Neuroscience
- Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau proteinJochen Eidenmüller, Thomas Fath, Thorsten Maas, Madeline Pool, Estelle Sontag, Roland Brandt · 2001 · Biochemical Journal
- NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's diseaseCorsetti, V., Florenzano, F., Atlante, A., Bobba, A., Ciotti, M.T., Natale, F., Della Valle, F., Borreca, A., Manca, A., Meli, G. et al. · 2015 · Human Molecular Genetics
- Tau‐targeted treatment strategies in Alzheimer's diseaseJürgen Götz, Arne Ittner, Lars Matthias Ittner · 2011 · British Journal of Pharmacology
- Expression of microtubule-associated proteins MAP2 and tau in cultured rat brain oligodendrocytesMüller, Reinhold, Heinrich, Michael, Heck, Susanne, Blohm, Dietmar, Richter-Landsberg, Christiane · 1997 · Cell and Tissue Research
- Akt/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitroHanna Ksiȩżak-Reding, Han Kyoung Pyo, Boris Feinstein, Giulio Maria Pasinetti · 2003 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Determination of Peptide Substrate Specificity for μ-Calpain by a Peptide Library-based ApproachDominic Cuerrier, Tudor Moldoveanu, Peter L. Davies · 2005 · Journal of Biological Chemistry
- Acetylated Tau Neuropathology in Sporadic and Hereditary TauopathiesIrwin, David J., Cohen, Todd J., Grossman, Murray, Arnold, Steven E., McCarty-Wood, Elisabeth, Van Deerlin, Vivianna M., Lee, Virginia M.-Y., Trojanowski, John Q. · 2013 · The American Journal of Pathology
- Antibody-Mediated Targeting of Tau In Vivo Does Not Require Effector Function and Microglial EngagementLee, Seung-Hye, Le Pichon, Claire E., Adolfsson, Oskar, Gafner, Valérie, Pihlgren, Maria, Lin, Han, Solanoy, Hilda, Brendza, Robert, Ngu, Hai, Foreman, Oded et al. · 2016 · Cell Reports
- Pathways of tau fibrillizationJeff Kuret, Carmen N. Chirita, Erin E. Congdon, Theresa Joseph Kannanayakal, Guibin Li, Mihaela Necula, Haishan Yin, Qi Zhong · 2004 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Minocycline reduces the development of abnormal tau species in models of Alzheimer's diseaseW. Noble, C. Garwood, J. Stephenson, Anna M. Kinsey, D. Hanger, B. Anderton · 2009 · The FASEB Journal
- Soluble Aβ Promotes Wild-Type Tau Pathology<i>In Vivo</i>Chabrier, Meredith A., Blurton-Jones, Mathew, Agazaryan, Andranik A., Nerhus, Joy L., Martinez-Coria, Hilda, LaFerla, Frank M. · 2012 · The Journal of Neuroscience
- Competition for Microtubule-binding with Dual Expression of Tau Missense and Splice IsoformsMei Lü, Kenneth S. Kosik · 2001 · Molecular Biology of the Cell
- Tau isoform composition influences rate and extent of filament formationZhong, Qi, Congdon, Erin E., Nagaraja, Haikady N., Kuret, Jeff · 2012 · Journal of Biological Chemistry
- A novel DYRK1A (Dual specificity tyrosine phosphorylation‐regulated kinase 1A) inhibitor for the treatment of Alzheimer's disease: effect on Tau and amyloid pathologies in vitroSéverine Coutadeur, Hélène Benyamine, Laurence Delalonde, C. de Oliveira, Bertrand Leblond, Alicia Foucourt, Thierry Besson, Anne-Sophie Casagrande, Thierry Taverne, Angélique Girard et al. · 2014 · Journal of Neurochemistry
- NMR Investigation of the Interaction between the Neuronal Protein Tau and the MicrotubulesAlain Sillen, Pascale Barbier, Isabelle Landrieu, Sylvie Lefebvre, Jean‐Michel Wieruszeski, Arnaud Leroy, Vincent Peyrot, Guy M. Lippens · 2007 · Biochemistry
- Tau Binds to Lipid Membrane Surfaces via Short Amphipathic Helices Located in Its Microtubule-Binding RepeatsElka R. Georgieva, Shifeng Xiao, Peter P. Borbat, Jack H. Freed, David Eliezer · 2014 · Biophysical Journal
- The Human Tau Interactome: Binding to the Ribonucleoproteome, and Impaired Binding of the Proline-to-Leucine Mutant at Position 301 (P301L) to Chaperones and the ProteasomeC. Geeth Gunawardana, Mohadeseh Mehrabian, Xinzhu Wang, Iris Mueller, Isabela Lubambo, James E. N. Jonkman, Hansen Wang, Gerold Schmitt‐Ulms · 2015 · Molecular & Cellular Proteomics
- Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivoPeng Wang, Gérard Joberty, Arjan Buist, Alexandre Vanoosthuyse, Ilie‐Cosmin Stancu, Bruno Vasconcelos, Nathalie Pierrot, Maria Faelth-Savitski, Pascal Kienlen‐Campard, Jean‐Noël Octave et al. · 2017 · Acta Neuropathologica
- Age-Dependent Effects of A53T Alpha-Synuclein on Behavior and Dopaminergic FunctionAdam W. Oaks, Maya Frankfurt, David Isaac Finkelstein, Anita Sidhu · 2013 · PLoS ONE
- Glycogen Synthase Kinase 3β Induces Caspase-cleaved Tau Aggregation in SituJae‐Hyeon Cho, Gail V.W. Johnson · 2004 · Journal of Biological Chemistry
- Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disordersCatharine L. Joachim, James H. Morris, K S Kosik, Dennis J. Selkoe · 1987 · Annals of Neurology
- The dendritic hypothesis for Alzheimer's disease pathophysiologyCochran, J. Nicholas, Hall, Alicia M., Roberson, Erik D. · 2014 · Brain Research Bulletin
- A new function of microtubule-associated protein tau: Involvement in chromosome stabilityGiacomina Rossi, Leda Dalprà, Francesca Crosti, Sara Lissoni, Francesca L. Sciacca, Marcella Catania, Michela Mangieri, Giorgio Giaccone, Danilo Croci, Fabrizio Tagliavini · 2008 · Cell Cycle
- Presence of tau in isolated nuclei from human brainRoseann M. Rady, Raymond P. Zinkowski, Lester I. Binder · 1995 · Neurobiology of Aging
- CSF tau and tau/Aβ42 predict cognitive decline in Parkinson's diseaseChangqin Liu, Brenna Cholerton, Min Yan Shi, Carmen Ginghină, Kevin C. Cain, Peggy Auinger, Jing Zhang · 2015 · Parkinsonism & Related Disorders
- Calpain-Mediated Tau Cleavage: A Mechanism Leading to Neurodegeneration Shared by Multiple TauopathiesFerreira, Adriana, Bigio, Eileen H · 2011 · Molecular Medicine
- Tau and src family tyrosine kinasesGloria S. Lee · 2004 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Are Tangles as Toxic as They Look?Tara L. Spires‐Jones, Katherine J. Kopeikina, Robert M. Koffie, Alix de Calignon, Bradley T. Hyman · 2011 · Journal of Molecular Neuroscience
- Glial Tau Pathology in Neurodegenerative Diseases: Their Nature and Comparison with Neuronal TanglesKenji Ikeda, Haruhiko Akiyama, Tetsuaki Arai, T. Nishimura · 1998 · Neurobiology of Aging
- Cytosolic Proteolysis of τ by Cathepsin D in Hippocampus Following Suppression of Cathepsins B and LEric Bednarski, GARY S. LYNCH · 1996 · Journal of Neurochemistry
- Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortexKen Tashiro, Masato Hasegawa, Yasuo Ihara, Takeshi Iwatsubo · 1997 · Neuroreport
- τ Protein from Alzheimer's Disease Patients Is Glycated at Its Tubulin‐Binding DomainLedesma, M. Dolores, Bonay, Pedro, Avila, Jesús · 1995 · Journal of Neurochemistry
- Determinants of amyloid fibril degradation by the PDZ protease HTRA1Simon Poepsel, Andreas Sprengel, Barbara Saccà, Farnusch Kaschani, Markus Kaiser, Christos Gatsogiannis, Stefan Raunser, Tim Clausen, Michael Ehrmann · 2015 · Nature Chemical Biology
- An immunohistochemical study of cases of sporadic and inherited frontotemporal lobar degeneration using 3R- and 4R-specific tau monoclonal antibodiesRohan de Silva, Tammaryn Lashley, Catherine Strand, Anna-Maria Shiarli, Jing Shi, Jinzhou Tian, Kathryn L. Bailey, Peter Davies, Eileen H. Bigio, Kunimasa Arima et al. · 2006 · Acta Neuropathologica
- Interneuronal Transfer of Human Tau Between Lamprey Central Neurons in situWonHee Kim, Sangmook Lee, Cheolwha Jung, Ambar Ahmed, Gloria S. Lee, Garth F. Hall · 2010 · Journal of Alzheimer s Disease
- Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST OverexpressionMala V. Rao, Panaiyur S. Mohan, Corrinne M. Peterhoff, Dun‐Sheng Yang, Stephen Schmidt, Philip H. Stavrides, Jabbar Campbell, Yuanxin Chen, Ying Jiang, Peter A. Paskevich et al. · 2008 · Journal of Neuroscience
- Argyrophilic grain disease differs from other tauopathies by lacking tau acetylationLea T. Grinberg, Xuehua Wang, Chao Wang, Peter Sohn, Panos Theofilas, Manu Sidhu, John Benjamin Arevalo, Helmut Heinsen, Eric Jinsheng Huang, Howard J. Rosen et al. · 2013 · Acta Neuropathologica
- Structural Insight into Tau Protein’s Paradox of Intrinsically Disordered Behavior, Self-Acetylation Activity, and AggregationYin Luo, Buyong Ma, Ruth Nussinov, Guanghong Wei · 2014 · The Journal of Physical Chemistry Letters
- α-Synuclein and its disease-related mutants interact differentially with the microtubule protein tau and associate with the actin cytoskeletonAlessandro Esposito, Christoph Peter Dohm, Pawel Kermer, Mathias Bähr, Fred Silvester Wouters · 2007 · Neurobiology of Disease
- Aberrant glycosylation modulates phosphorylation of tau by protein kinase A and dephosphorylation of tau by protein phosphatase 2A and 5F Liu, Tanweer Zaidi, Khalid Iqbal, Inge Grundke, Cheng‐Xin Gong · 2002 · Neuroscience
- Tau Accumulation, Altered Phosphorylation, and Missorting Promote Neurodegeneration in GlaucomaMarius Chiasseu, Jorge L. Cueva Vargas, Laurie Destroismaisons, Christine Vande Velde, Nicole M. Leclerc, Adriana Di Polo · 2016 · Journal of Neuroscience
- Lithium treatment arrests the development of neurofibrillary tangles in mutant tau transgenic mice with advanced neurofibrillary pathology.Leroy, Karelle, Ando, Kunie, Héraud, Céline, Yilmaz, Zehra, Authelet, Michèle, Boeynaems, Jean-Marie, Buée, Luc, De Decker, Robert, Brion, Jean-Pierre · 2010 · Journal of Alzheimer's Disease
- Tau phosphorylation increases in symptomatic mice overexpressing A30P α-synucleinMark A. Frasier, Mark Walzer, L. McCarthy, Debra J. Magnuson, J.M. Lee, Carola A. Haas, Philipp J. Kahle, Benjamin L. Wolozin · 2004 · Experimental Neurology
- A critical role for the PAR-1/MARK-tau axis in mediating the toxic effects of Aβ on synapses and dendritic spinesYu, Wendou, Polepalli, Jai, Wagh, Dhananjay, Rajadas, Jayakumar, Malenka, Robert, Lu, Bingwei · 2012 · Human Molecular Genetics
- Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragmentGarg, Sarika, Timm, Thomas, Mandelkow, Eva-Maria, Mandelkow, Eckhard, Wang, Yipeng · 2011 · Neurobiology of Aging
- Novel function of Tau in regulating the effects of external stimuli on adult hippocampal neurogenesisPallas‐Bazarra, Noemí, Jurado‐Arjona, Jerónimo, Navarrete, Marta, Esteban, Jose A, Hernández, Félix, Ávila, Jesús, Llorens‐Martín, María · 2016 · The EMBO Journal