The SLC16 gene family?from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond

Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past

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A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with δ-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses

Bergersen, L., Wærhaug, O., Helm, J., Thomas, M., Laake, P., Davies, A. J., Wilson, M. C., Halestrap, A. P., & Ottersen, O. P. (2001) · Experimental Brain Research · doi:10.1007/s002210000600 · Cited by 155 · cited 3×

The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism

den Besten, G., van Eunen, K., Groen, A. K., Venema, K., Reijngoud, D.-J., & Bakker, B. M. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r036012 · Cited by 5,048

The role of short-chain fatty acids in microbiota–gut–brain communication

Dalile, B., Van Oudenhove, L., Vervliet, B., & Verbeke, K. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0157-3 · Cited by 3,357

Sensors and regulators of intracellular pH

Casey, J. R., Grinstein, S., & Orlowski, J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2820 · Cited by 2,218

Hypoxia signalling in cancer and approaches to enforce tumour regression

Pouysségur, J., Dayan, F., & Mazure, N. M. (2006) · Nature · doi:10.1038/nature04871 · Cited by 1,676

Short chain fatty acids in human gut and metabolic health

Blaak, E. E., Canfora, E. E., Theis, S., Frost, G., Groen, A. K., Mithieux, G., Nauta, A., Scott, K., Stahl, B., van Harsselaar, J., et al. (2020) · Beneficial Microbes · doi:10.3920/bm2020.0057 · Cited by 1,103

Supply and demand in cerebral energy metabolism: the role of nutrient transporters

Simpson, I. A., Carruthers, A., & Vannucci, S. J. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600521 · Cited by 812

Monocarboxylate transporters in the central nervous system: distribution, regulation and function

Pierre, K., & Pellerin, L. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03168.x · Cited by 744

A Novel Syndrome Combining Thyroid and Neurological Abnormalities Is Associated with Mutations in a Monocarboxylate Transporter Gene

Dumitrescu, A. M., Liao, X.-H., Best, T. B., Brockmann, K., & Refetoff, S. (2004) · The American Journal of Human Genetics · doi:10.1086/380999 · Cited by 706

Regulation of tumor pH and the role of carbonic anhydrase 9

Swietach, P., Vaughan-Jones, R. D., & Harris, A. L. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9064-0 · Cited by 539

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

Cox, P. J., Kirk, T., Ashmore, T., Willerton, K., Evans, R., Smith, A., Murray, A. J., Stubbs, B., West, J., McLure, S. W., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.07.010 · Cited by 530

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

Sonveaux, P., Copetti, T., De Saedeleer, C. J., Végran, F., Verrax, J., Kennedy, K. M., Moon, E. J., Dhup, S., Danhier, P., Frérart, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033418 · Cited by 536

Systemic availability and metabolism of colonic‐derived short‐chain fatty acids in healthy subjects: a stable isotope study

Boets, E., Gomand, S. V., Deroover, L., Preston, T., Vermeulen, K., De Preter, V., Hamer, H. M., Van den Mooter, G., De Vuyst, L., Courtin, C. M., et al. (2017) · The Journal of Physiology · doi:10.1113/jp272613 · Cited by 443

Role of Monocarboxylate Transporters in Drug Delivery to the Brain

Vijay, N., & Morris, M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990462 · Cited by 408

Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth

Martinez-Outschoorn, U. E., Lisanti, M. P., & Sotgia, F. (2014) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2014.01.005 · Cited by 423

Role of Ion Channels and Transporters in Cell Migration

Schwab, A., Fabian, A., Hanley, P. J., & Stock, C. (2012) · Physiological Reviews · doi:10.1152/physrev.00018.2011 · Cited by 420

Minireview: Thyroid Hormone Transporters: The Knowns and the Unknowns

Visser, W. E., Friesema, E. C. H., & Visser, T. J. (2011) · Molecular Endocrinology · doi:10.1210/me.2010-0095 · Cited by 390

Regulation of Oligodendrocyte Development and Myelination by Glucose and Lactate

Rinholm, J. E., Hamilton, N. B., Kessaris, N., Richardson, W. D., Bergersen, L. H., & Attwell, D. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3516-10.2011 · Cited by 383

Role of monocarboxylate transporters in human cancers: state of the art

Pinheiro, C., Longatto-Filho, A., Azevedo-Silva, J., Casal, M., Schmitt, F. C., & Baltazar, F. (2012) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-012-9428-1 · Cited by 368

A Diet High in Resistant Starch Modulates Microbiota Composition, SCFA Concentrations, and Gene Expression in Pig Intestine

Haenen, D., Zhang, J., Souza da Silva, C., Bosch, G., van der Meer, I. M., van Arkel, J., van den Borne, J. J. G. C., Pérez Gutiérrez, O., Smidt, H., Kemp, B., et al. (2013) · The Journal of Nutrition · doi:10.3945/jn.112.169672 · Cited by 341

Effective cellular uptake and efflux of thyroid hormone by human monocarboxylate transporter 10

Friesema, E. C. H., Jansen, J., Jachtenberg, J.-W., Visser, W. E., Kester, M. H. A., & Visser, T. J. (2008) · Molecular Endocrinology · doi:10.1210/me.2007-0112 · Cited by 285

Histone Acetylation Regulates Intracellular pH

McBrian, M. A., Behbahan, I. S., Ferrari, R., Su, T., Huang, T.-W., Li, K., Hong, C. S., Christofk, H. R., Vogelauer, M., Seligson, D. B., et al. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.10.025 · Cited by 272

miR-29a and miR-29b Contribute to Pancreatic β-Cell-Specific Silencing of Monocarboxylate Transporter 1 (Mct1)

Pullen, T. J., da Silva Xavier, G., Kelsey, G., & Rutter, G. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.01433-10 · Cited by 258

The syndromes of reduced sensitivity to thyroid hormone

Dumitrescu, A. M., & Refetoff, S. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.08.005 · Cited by 253

Thyroid Hormone Transporters

Groeneweg, S., van Geest, F. S., Peeters, R. P., Heuer, H., & Visser, W. E. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz008 · Cited by 216

Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment

Rattigan, Y. I., Patel, B. B., Ackerstaff, E., Sukenick, G., Koutcher, J. A., Glod, J. W., & Banerjee, D. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.11.014 · Cited by 196

Hypoxia and Adipocyte Physiology: Implications for Adipose Tissue Dysfunction in Obesity

Trayhurn, P. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161156 · Cited by 194

Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer

Kennedy, K. M., Scarbrough, P. M., Ribeiro, A., Richardson, R., Yuan, H., Sonveaux, P., Landon, C. D., Chi, J.-T., Pizzo, S., Schroeder, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0075154 · Cited by 190

H + ‐coupled nutrient, micronutrient and drug transporters in the mammalian small intestine

Thwaites, D. T., & Anderson, C. M. H. (2007) · Experimental Physiology · doi:10.1113/expphysiol.2005.029959 · Cited by 188

Transport of carboxylic acids in yeasts.

Casal, M., Paiva, S., Queirós, O., & Soares-Silva, I. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00128.x · Cited by 185

Thyroid hormone transporters in health and disease

Jansen, J., Friesema, E. C. H., Milici, C., & Visser, T. J. (2005) · Thyroid · doi:10.1089/thy.2005.15.757 · Cited by 181

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons

Halim, N. D., Mcfate, T., Mohyeldin, A., Okagaki, P., Korotchkina, L. G., Patel, M. S., Jeoung, N. H., Harris, R. A., Schell, M. J., & Verma, A. (2010) · Glia · doi:10.1002/glia.20996 · Cited by 177

The redox switch/redox coupling hypothesis

Cerdán, S., Rodrigues, T. B., Sierra, A., Benito, M., Fonseca, L. L., Fonseca, C. P., & García-Martín, M. L. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2005.12.036 · Cited by 146

Molecular aspects of thyroid hormone transporters, including MCT8, MCT10, and OATPs, and the effects of genetic variation in these transporters

van der Deure, W. M., Peeters, R. P., & Visser, T. J. (2010) · Journal of Molecular Endocrinology · doi:10.1677/jme-09-0042 · Cited by 130

Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse

Zhang, Y., Xue, Y., Meng, S., Luo, Y., Liang, J., Li, J., Ai, S., Sun, C., Shen, H., Zhu, W., et al. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.07.007 · Cited by 106

Lactate Is a Key Mediator That Links Obesity to Insulin Resistance via Modulating Cytokine Production From Adipose Tissue

Lin, Y., Bai, M., Wang, S., Chen, L., Li, Z., Li, C., Cao, P., & Chen, Y. (2022) · Diabetes · doi:10.2337/db21-0535 · Cited by 99

Metabolic reprogramming in tumors: Contributions of the tumor microenvironment

Lane, A. N., Higashi, R. M., & Fan, T. W.-M. (2020) · Genes & Diseases · doi:10.1016/j.gendis.2019.10.007 · Cited by 91

Short-Chain Fatty Acids Suppress Inflammatory Reactions in Caco-2 Cells and Mouse Colons

Hung, T. V., & Suzuki, T. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.7b04233 · Cited by 90

Fasting induces a highly resilient deep quiescent state in muscle stem cells via ketone body signaling

Benjamin, D. I., Both, P., Benjamin, J. S., Nutter, C. W., Tan, J. H., Kang, J., Machado, L. A., Klein, J. D. D., de Morree, A., Kim, S., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.012 · Cited by 79

Evolving new-age strategies to transport therapeutics across the blood-brain-barrier

Choudhari, M., Hejmady, S., Narayan Saha, R., Damle, S., Singhvi, G., Alexander, A., Kesharwani, P., & Kumar Dubey, S. (2021) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2021.120351 · Cited by 74

Monocarboxylate 4 mediated butyrate transport in a rat intestinal epithelial cell line

Kekuda, R., Manoharan, P., Baseler, W., & Sundaram, U. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-012-2407-x · Cited by 68

Uptake and Metabolism of the Short-Chain Fatty Acid Butyrate, a Critical Review of the Literature

M. Astbury, S., & M. Corfe, B. (2012) · Current Drug Metabolism · doi:10.2174/138920012800840428 · Cited by 67

The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy

Puris, E., Fricker, G., & Gynther, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020364 · Cited by 58

Excretion of biliary compounds during intrauterine life

Macias, R. I., Marin, J. J., & Serrano, M. A. (2009) · World Journal of Gastroenterology · doi:10.3748/wjg.15.817 · Cited by 54

Proteome Analysis and Conditional Deletion of the EAAT2 Glutamate Transporter Provide Evidence against a Role of EAAT2 in Pancreatic Insulin Secretion in Mice

Zhou, Y., Waanders, L. F., Holmseth, S., Guo, C., Berger, U. V., Li, Y., Lehre, A.-C., Lehre, K. P., & Danbolt, N. C. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.529065 · Cited by 49

Characterization of Monocarboxylate Transport in Human Kidney HK-2 Cells

Wang, Q., Lu, Y., Yuan, M., Darling, I. M., Repasky, E. A., & Morris, M. E. (2006) · Molecular Pharmaceutics · doi:10.1021/mp060037b · Cited by 49

Ciprofloxacin and Rifampin have opposite effects on levothyroxine absorption

Goldberg, A. S., Tirona, R. G., Asher, L. J., Kim, R. B., & Van Uum, S. H. M. (2013) · Thyroid · doi:10.1089/thy.2013.0014 · Cited by 25