Biomedical soft contact-lens sensor for in situ ocular biomonitoring of tear contents
Abstract
A soft contact-lens biosensor (SCL-biosensor) for novel non-invasive biomonitoring of tear fluids was fabricated and tested. Wearing a biosensor on eye enabled the in situ monitoring of tear contents. The biosensor has an enzyme immobilized electrode on the surface of a polydimethyl siloxane (PDMS) contact lens. The SCL-biosensor was fabricated using microfabrication techniques for functional polymers (PDMS and 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer). In investigation of in vitro characterization, the SCL-biosensor showed excellent relationship between the output current and glucose concentration from 0.03 to 5.0 mmol·L(-1), with a correlation coefficient of 0.994. The calibration range covered the reported tear glucose concentrations (0.14 mmol·L(-1)). Based on the result, ocular biomonitoring with the SCL-biosensor was carried out. The SCL-biosensor well worked both in the static state and the dynamic state. The tear glucose level of rabbit was estimated to 0.12 mmol·L(-1) at first and then the tear turnover was successfully calculated to be 29.6 ± 8.42% min(-1). The result indicated that SCL-biosensor is useful for advanced biomonitoring on eye.
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Tear glucose concentrations have been demonstrated to exhibit good correlation with blood glucose levels, reflecting diffusion from the lachrymal artery when tears are sampled without eye irritation or stimulation, which can compromise the relationship.
“In particular, tear glucose concentrations have been demonstrated to exhibit good correlation with blood glucose levels, reflecting the diffusion from the lachrymal artery when the tears are sampled without any eye irritation or stimulation, which can compromise the relationship94, 95, 99-101.”
From Wearable biosensors for healthcare monitoring (2019) · cites this paper as [101]
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Kajisa, T., & Sakata, T. (2017) · Japanese Journal of Applied Physics · doi:10.7567/jjap.56.04cm07 · Cited by 1 · see citing works
Future Perspective of Nanobiomaterials in Human Health Care
Ravikumar, C. H., Muangphrom, P., Pataranutaporn, P., & Surareungchai, W. (2023) · Springer eBooks · doi:10.1007/978-981-19-9437-1_34 · Cited by 1 · see citing works
Zwitterionic Polymeric Materials
Damodaran, V. B., Leszczak, V., Reynolds, M. M., & Popat, K. C. (2017) · CRC Press eBooks · doi:10.1081/e-ebppc-120050037 · Cited by 1 · see citing works
Physical Bio-monitoring in Unconsciousness with Biomedical Sensors
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Jordan, C. T. (2016) · CommonKnowledge Research Repository (Pacific University Oregon)
生体化学情報モニタリングを目指した着脱可能なキャビタス（体腔）センサ ～ソフトコンタクトレンズ型バイオセンサとマウスガード型バイオセンサ～
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Mitsubayashi, K. (2017) · Journal of The Japan Institute of Electronics Packaging · doi:10.5104/jiep.20.98
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Paliwal, G., & Bunglowala, A. (2018) · Advances in medical diagnosis, treatment, and care (AMDTC) book series · doi:10.4018/978-1-5225-7131-5.ch007
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Self-citationChakraborty, M., Shrivastava, A., Sanwaria, S., & Singh, A. K. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-21658-9.00019-x
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- Authors
- Chu, M., Shirai, T., Takahashi, D., Arakawa, T., Kudo, H., Sano, K., Sawada, S.-I., Yano, K., Iwasaki, Y., Akiyoshi, K., Mochizuki, M., & Mitsubayashi, K.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Tokyo University of Technology (JP)
- Kansai University (JP)
- Corresponding author
- Mitsubayashi, Kohji
- ORCID
- Venue
- Biomedical Microdevices
- Published
- 2011-04-08
- Volume
- 13
- Issue
- 4
- Pages
- 603-611
- ISSN
- 1387-2176 (ISSN-L)
- 1572-8781
- OpenAlex
- W2043624863
- Cited by
- 85
- References
- 39
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 9 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 9 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 8 · 2015: 4 · 2014: 6 · 2013: 1 · 2012: 3
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biomedical Microdevices (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (21650041)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ocular Surface and Contact Lens
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Keywords
- non-invasive biomonitoring, 2-methacryloyloxyethyl phosphorylcholine, rabbit eye
- MeSH terms
- Animals, Calibration, Contact Lenses, Hydrophilic, Dimethylpolysiloxanes, Eye, Glucose, Methacrylates, Phosphorylcholine, Rabbits, Tears, Vision, Ocular, Biosensing Techniques, Biomedical Technology, Microtechnology
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