Improving Working Memory in Children with Attention-Deficit/Hyperactivity Disorder: The Separate and Combined Effects of Incentives and Stimulant Medication
Open accessAbstract
Working memory (WM) is considered a core deficit in Attention-Deficit/ Hyperactivity Disorder (ADHD), with numerous studies demonstrating impaired WM among children with ADHD. We tested the degree to which WM in children with ADHD was improved by performance-based incentives, an analog of behavioral intervention. In two studies, WM performance was assessed using a visuo-spatial n-back task. Study 1 compared children (ages 9-12 years) with ADHD-Combined type (n = 24) to a group of typically developing (TD) children (n = 32). Study 1 replicated WM deficits among children with ADHD. Incentives improved WM, particularly among children with ADHD. The provision of incentives reduced the ADHD-control group difference by approximately half but did not normalize WM. Study 2 examined the separate and combined effects of incentives and stimulant medication among 17 children with ADHD-Combined type. Both incentives and a moderate dose of long-acting methylphenidate (MPH; ~0.3 mg/kg t.i.d. equivalent) robustly improved WM relative to the no-incentive, placebo condition. The combination of incentives and medication improved WM significantly more than either incentives or MPH alone. These studies indicate that contingencies markedly improve WM among children with ADHD-Combined type, with effect sizes comparable to a moderate dose of stimulant medication. More broadly, this work calls attention to the role of motivation in studying cognitive deficits in ADHD and in testing multifactorial models of ADHD.
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- Findingown data
In Study 2, the amount of improvement from medication did not differ between the 1-back and 2-back conditions.
“the amount of improvement with medication did not differ between the 1- and 2-back, F<1.”
Quote in the paperNot a substantial claim - Findingown data
Compared with no treatment, incentives alone improved accuracy.
“Compared to no treatment, both incentives alone and MPH alone improved accuracy, F = 19.9, ps = .001, .002, ds = 1.04, 0.88.”
Quote in the paperSubstantial claim - Findingown data
In Study 1's baseline session, performance did not differ between the 1-back and 2-back conditions.
“however, performance did not vary between WM manipulation conditions, Group × 1- v. 2-back, F(1,52) = 1.6, p= .21, d = .31.”
Quote in the paperNot a substantial claim - Findingown data
Incentives improved working memory more in children with ADHD than in controls.
“As hypothesized, incentives facilitated working memory more among children with ADHD than among controls.”
Quote in the paperSubstantial claim - Findingown data
The separate effects of incentives and methylphenidate on accuracy did not differ.
“The separate effects of incentives and MPH on accuracy did not differ, F = 19.9, p = .87, d = .04.”
Quote in the paperSubstantial claim
- Findingown data
In Study 1's incentive session, the improvement from incentives was consistent across load conditions.
“However, improvement with incentives was consistent across load conditions, Group × Incentive × 0- v. 1- and 2-back and Group × Incentive × 1- v. 2-back Fs(1,52) = .68 and 2.3, ps = .41 and .14.”
Quote in the paperNot a substantial claim - Findingown data
In Study 1's incentive session, the group and load effects replicated those seen at baseline.
“As can be seen, the pattern of group and load effects for the incentive task replicated those observed for the baseline task (Figure 2a).”
Quote in the paperNot a substantial claim - Findingown data
The same patterns were present when each working memory load was examined separately.
“(These same patterns were evident when examining each load individually.)”
Quote in the paperNot a substantial claim - Findingown data
In Study 1's baseline session, the ADHD-TD difference was larger during working memory manipulation conditions (1- and 2-back) than during the 0-back.
“This group difference was greater during the WM manipulation conditions (i.e., 1- and 2-back), F(1, 52) = 11.3, p < .001, d = 1.15, than during the 0-back, F(1,52) = 6.25, p = .016, d = .63, Group × 0- v. 1- and 2-back F(1,52) = 5.38, p= .024, d = .7”
Quote in the paperNot a substantial claim - Findingown data
In Study 1's incentive session, incentives produced greater accuracy improvement in children with ADHD than in typically developing children.
“Most importantly, incentives led to greater improvement in accuracy among children with ADHD, F(1,52) = 77.1, p <.001, d = 1.28, compared to the TD control group, F(1,52) = 17.9, p < .001, d = 1.1, Group × Incentive F(1,52) = 14.9, p < .001, d = .9.”
Quote in the paperSubstantial claim - Findingown data
In Study 1's incentive session, the incentive effect did not differ between the 1-back and 2-back conditions.
“The effect of incentives did not differ between WM manipulation conditions, Incentive × 1- v. 2-back, F < 1, p = .59, d = .11.”
Quote in the paperNot a substantial claim - Findingreasoning
In the present work, incentive effects were stronger in the 1-back and 2-back conditions than in the 0-back condition.
“In the present work, incentive effects were stronger in the 1- and 2-back conditions, which require mental manipulation of visuo-spatial information, than in the 0-back condition, which does not.”
Quote in the paperSubstantial claim - Findingown data
In Study 2, accuracy fell further as working memory manipulation demands increased from 1-back to 2-back.
“and declined further as the WM manipulation demands increased, 1- v. 2-back, F(1,16) = 10.9, p < .01, d = .8”
Quote in the paperNot a substantial claim - Findingown data
In Study 2, accuracy fell when working memory manipulation was required (0-back versus 1- and 2-back).
“As expected, accuracy (%) significantly declined when working memory manipulation was required, 0-back v. 1- and 2-back, F(1,16) = 26.87, p < .001, d = 1.26”
Quote in the paperNot a substantial claim - Findingown data
Compared with no treatment, methylphenidate alone improved accuracy.
“Compared to no treatment, both incentives alone and MPH alone improved accuracy, F = 19.9, ps = .001, .002, ds = 1.04, 0.88.”
Quote in the paperSubstantial claim - Findingown data
In Study 2, the incentive effect did not differ between the 1-back and 2-back conditions.
“Also as in Study 1, the incentive effect did not vary between 1- and 2-back conditions, F < 1.”
Quote in the paperNot a substantial claim - Findingown data
In Study 1's baseline session, accuracy fell when working memory manipulation was required (0-back versus 1- and 2-back).
“As expected, accuracy significantly declined when working memory manipulation was required, 0-back v. 1- and 2-back, F(1,52) = 101.9, p < .001, d = 1.28”
Quote in the paperNot a substantial claim - Findingown data
Study 1 replicated the robust working memory deficits commonly found among children with ADHD.
“the study replicated the robust working memory deficits commonly identified among children with ADHD (e.g., Martinussen, Hayden Hogg-Johnson, & Tannock, 2005; Nigg, Willcutt, Doyle, & Sonuga- Barke, 2005; Willcutt et al., 2005)”
Quote in the paperSubstantial claim0 of 3 sources checked - Findingown data
The ADHD-control group difference was consistently larger under loads requiring manipulation than under the 0-back load.
“Paralleling the effect of incentives, this group difference was consistently greater under loads requiring manipulation, compared to the 0-back.”
Quote in the paperNot a substantial claim - Findingown data
Incentives reduced the ADHD group's performance deficit.
“incentives reduced the ADHD group performance deficit”
- Also stated in: § Discussion · plain
“incentives markedly attenuated the ADHD deficit in working memory.”
Quote in the paperSubstantial claim - Also stated in: § Discussion · plain
- Findingown data
In Study 2, combining incentives with medication improved working memory more than either incentives alone or methylphenidate alone.
“The combination of incentives and medication improved WM significantly more than either incentives or MPH alone.”
Quote in the paperSubstantial claim - Findingown data
In Study 1's incentive session, the improvement from incentives was larger during working memory manipulation conditions than during the 0-back.
“Improvement with incentives was more pronounced during WM manipulation conditions, F(1,52) = 100.2, p < .001, d = 1.17, compared to the 0-back, F(1, 52) = 24.6, p < .001, d = .53, Incentive × 0-back v. 1- and 2-back, F(1,52) = 5.0, p = .03, d = .3.”
Quote in the paperNot a substantial claim - Findingown data
The combination of incentives and methylphenidate produced greater accuracy than either treatment alone.
“The combined effect of incentives and MPH resulted in greater accuracy than did either incentives or MPH alone, F = 19.9, ps ≤ .001, ds = 1.02, 1.06.”
Quote in the paperSubstantial claim - Findingown data
In the study, incentives and methylphenidate did not interact in their effects on accuracy.
“Notably, the effects of incentives and MPH on accuracy did not interact, Incentive × MPH, Incentive × MPH × 0- vs. 1- and 2-back, and Incentive × MPH × 1- vs. 2-back Fs <1.2, ps > .3.”
Quote in the paperSubstantial claim - Findingown data
In Study 2, the improvement from incentives was larger during working memory manipulation conditions than during the 0-back.
“and improvement with incentives was more pronounced during WM manipulation conditions (1- and 2-back), F(1,16) = 31.1, p < .001, d = 1.35, than during the 0-back, F(1,16) = 12.2, p = .003, d = .85, Incentive × 0- v. 1- and 2-back F (1,16) = 4.6, p < .05, d = .68.”
Quote in the paperSubstantial claim - Findingown data
In Study 1's baseline session, accuracy fell further as working memory demands increased from 1-back to 2-back.
“with further decline as working memory task demands increased, 1- v. 2-back, F(1,52) = 37.5, p < .001, d = .8.”
Quote in the paperNot a substantial claim - Findingown data
In Study 2, a moderate dose of long-acting methylphenidate improved working memory relative to placebo.
“Both incentives and a moderate dose of long-acting methylphenidate (MPH; ~0.3 mg/kg t.i.d. equivalent) robustly improved WM relative to the no-incentive, placebo condition.”
- Also stated in: § Study 2 Results · plain
“Similar to the observed incentive effects, accuracy improved with MPH compared to placebo, F(1,16) = 22.9, < .001, d = 1.16.”
Quote in the paperSubstantial claim - Also stated in: § Study 2 Results · plain
- Findingown data
In Study 1's normalization analysis, accuracy remained lower in the ADHD group under incentives than in the control group without incentives.
“On average, accuracy remained lower among the ADHD group during incentive conditions than among the control group during no incentive conditions, group F = 4.5, p < .05, d = .55.”
Quote in the paperSubstantial claim - Findingown data
In Study 1, children with ADHD showed the expected working memory deficits compared with typically developing children.
“Study 1 replicated WM deficits among children with ADHD.”
- Also stated in: § Baseline visit · boosted
“Also as predicted, children in the ADHD group demonstrated lower accuracy than the TD control group, F(1,52) = 12.6, p = .001, d = .85.”
Quote in the paperSubstantial claim - Also stated in: § Baseline visit · boosted
- Findingown data
In Study 2, incentives improved working memory relative to the no-incentive condition.
“Both incentives and a moderate dose of long-acting methylphenidate (MPH; ~0.3 mg/kg t.i.d. equivalent) robustly improved WM relative to the no-incentive, placebo condition.”
- Also stated in: § Study 2 Results · plain
“As observed in Study 1, accuracy was greater under incentive compared to no-incentive conditions, F(1,16) = 33.1, p < .001, d = 1.4”
Quote in the paperSubstantial claim - Also stated in: § Study 2 Results · plain
- Findingown data
In Study 1's incentive session, accuracy was higher in incentive blocks than in no-incentive blocks.
“On average, accuracy was greater during incentive compared to no-incentive conditions, F(1,52) = 88.5, p < .001, d = 1.02.”
Quote in the paperSubstantial claim - Findingown data
In Study 1, no group, incentive, or load interaction changed significantly across the two 50-trial repetitions.
“No interactions with group, incentive, or load significantly changed across the two 50-trial repetitions of each condition, all block Fs< 3.1, ps > .08.4”
Quote in the paperNot a substantial claim - Findingown data
In Study 2, the effects of methylphenidate were marginally larger during working memory manipulation conditions than during the 0-back.
“The effects of MPH were marginally greater during the WM manipulation conditions, MPH × 1- and 2-back F(1,16) = 23.1, p < .001, d = 1.17, compared to the 0-back, MPH × 0-back F(1, 16) = 7.4, p = .015, d = .66, MPH × 0- v. 1- and 2-back F(1,16) = 3.8, p = .07, d = .47”
Quote in the paperNot a substantial claim - Findingown data
Without reward, the ADHD group's performance remained significantly below that of typically developing peers.
“the ADHD group performance remained significantly below that of their TD peers without reward”
Quote in the paperSubstantial claim - Findingown data
Study 2 found that incentives were as effective as a moderate dose of methylphenidate in improving working memory in an ADHD sample.
“Study 2 revealed that incentives were just as effective as a moderate dose of methylphenidate in improving working memory among an ADHD sample.”
Quote in the paperSubstantial claim - Findingown data
The combination of stimulants and incentives produced better working memory than either alone.
“The combination of stimulants and incentives yielded better working memory than either alone.”
Quote in the paperSubstantial claim - Interpretationcitation
The replicated working memory deficit pattern is consistent with models that treat working memory as a core deficit in ADHD.
“a pattern consistent with models implicating WM as a core deficit in the disorder (e.g., Rapport et al., 2008).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Rapport et al., 2008 source
Not checked in the free run.
- Premisecitation
Very little published research has examined how incentives affect working memory in ADHD.
“Despite the interest in motivation-cognition, there is very little published research examining incentive effects on working memory in ADHD (in contrast to response inhibition, another putative core process in ADHD, e.g., Oosterlaan and Sergeant, 1998; Scheres et al., 2001; Slusarek et al, 2001).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Oosterlaan and Sergeant, 1998; Scheres et al., 2001; Slusarek et al, 2001
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Premisecitation
Motivational processes may influence or moderate cognitive processing in ADHD.
“Specifically, a growing number of studies provide evidence that motivational processes may influence, or moderate, cognitive processing in ADHD (see reviews by Luman et al., 2005, 2010).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Luman et al., 2005, 2010
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Premisecitation
The analogue of combination treatment is rarely studied in the extensive literature on cognitive processes in ADHD.
“the analogue of combination treatment is rarely examined (c.f., Epstein et al., 2011a; Solanto et al., 2001) in the otherwise extensive literature (e.g., Nigg et al., 2005; Willcutt et al., 2005) on cognitive processes in ADHD.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Epstein et al., 2011a; Solanto et al., 2001; Nigg et al., 2005
Not checked in the free run.
- Premisecitation
Several studies show that methylphenidate improves aspects of working memory in ADHD.
“Moreover, because several studies demonstrate beneficial effects of methylphenidate on aspects of working memory in ADHD (e.g., Bedard & Tannock, 2008; Bedard, Jain, Johnson, & Tannock, 2007; Bedard, Martinussen, Ickowicz, & Tannock, 2004, Tannock, Ickowicz, & Schachar, 1995)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Bedard & Tannock, 2008; Bedard, Jain, Johnson, & Tannock, 2007; Bedard, Martinussen, Ickowicz, & Tannock, 2004
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
- Interpretationcitation
The pattern of stronger incentive effects under higher manipulation demands is broadly consistent with Shiels et al.'s evidence that incentive effects are stronger when active manipulation and updating are required or when task difficulty is moderate-to-high.
“This is broadly consistent with Shiels and colleagues’ (2008) evidence from the spatial span task that incentive effects are stronger when active manipulation and updating of material in working memory is required or, more generally, when task difficulty is moderate-to-high.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Shiels and colleagues’ (2008)
Not checked in the free run.
- Premisecitation
Contingency management has clear efficacy for ADHD.
“The clinical parallel is the clear efficacy of contingency management for ADHD (Fabiano et al., 2009).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Fabiano et al., 2009 source
Not checked in the free run.
- Study design and conductreasoning
In Study 1's baseline session, the fixed ascending order confounded time on task with working memory load.
“Although this order confounds time on task and working memory load, pilot testing suggested that an ascending difficulty sequence was necessary on first exposure to the task to ensure children in this age range could reasonably understand the task.”
Quote in the paperNot a substantial claim - Premisecitation
Working memory has ecological validity for predicting observable inattentive behavior in ADHD.
“However, working memory does have ecological validity in predicting observable inattentive behavior in ADHD (Kofler, Rapport, Bolden, Sarver, & Raiker, 2010)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Kofler, Rapport, Bolden, Sarver, & Raiker, 2010 source
Not checked in the free run.
- Interpretationown data
Studies 1 and 2 provide clear evidence that incentives improve visuo-spatial working memory in children with ADHD.
“Studies 1 and 2 provide clear evidence that incentives improve visuo-spatial working memory in an ADHD sample.”
Quote in the paperSubstantial claim - Interpretationown data
A core motivational deficit is unlikely to fully explain the working memory deficits commonly seen in clinically referred children with ADHD.
“This finding suggests that a core deficit in motivation is not likely to fully account for the working memory deficits commonly observed among clinically referred children with ADHD.”
Quote in the paperSubstantial claim - Premisecitation
In Dovis et al., none of the enhanced motivation conditions normalized working memory.
“However, none of these enhanced motivation conditions normalized working memory.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Dovis et al.
Not checked in the free run.
- Premisecitation
A very similar pattern was observed in the Dovis et al. study.
“A very similar pattern was observed in a recent study by Dovis, Van der Oord, Wiers, and Prins (in press).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Dovis, Van der Oord, Wiers, and Prins (in press)
Not checked in the free run.
- Interpretationown data
Incentives did not normalize the ADHD group's working memory performance.
“incentives did not normalize ADHD group performance”
Quote in the paperSubstantial claim - Premisecitation
In Dovis et al., control children's performance did not vary across motivational contexts.
“Performance among controls did not vary across motivational contexts.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Dovis et al.
Not checked in the free run.
- Premisecitation
In Dovis et al., relative to a feedback-only condition, children with ADHD improved equally with 1-euro rewards, 10-euro rewards, and a videogame-like context.
“Relative to a feedback-only condition (trial-by-trial auditory and visual stimuli), performance was improved among children with ADHD equally by the addition of 1 or 10 euro rewards for performing “well enough” (in reality, all children were given the reward, regardless of performance) and a videogame-like context.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Dovis et al.
Not checked in the free run.
- May combine two claims. 24
- Classified as probably not a substantial claim. 19
- The quote only partly states this claim. 1
May combine two claims.
Findingown dataIn Study 1, incentives cut the ADHD-control difference by about half but did not bring working memory to normal levels.
“The provision of incentives reduced the ADHD-control group difference by approximately half but did not normalize WM.”
- Also stated in: § Normalization · plain
“On average, accuracy remained lower among the ADHD group during incentive conditions than among the control group during no incentive conditions, group F = 4.5, p < .05, d = .55.”
Quote in the paperSubstantial claim- Also stated in: § Normalization · plain
May combine two claims.
Findingown dataIn Study 1, incentives improved working memory, and the improvement was larger in children with ADHD than in typically developing children.
“Incentives improved WM, particularly among children with ADHD.”
- Also stated in: § Incentive visit · plain
“Most importantly, incentives led to greater improvement in accuracy among children with ADHD, F(1,52) = 77.1, p <.001, d = 1.28, compared to the TD control group, F(1,52) = 17.9, p < .001, d = 1.1, Group × Incentive F(1,52) = 14.9, p < .001, d = .9.”
Quote in the paperSubstantial claim- Also stated in: § Incentive visit · plain
May combine two claims.
Findingown dataIn Study 1's normalization analysis, incentives normalized average performance on the 0-back but not on the working memory manipulation conditions.
“However, a marginal Group (ADHD-Incentive v. TD-No-incentive) × 0-back v. 1- and 2-back interaction, F(1,52) = 3.1, p = .08, suggested that incentives normalized average performance during the 0-back, F(1, 52) = 1.5, p = .23 , d = .33, but not during the WM manipulation conditions, F(1,52) = 5.0, p = .03, d = .58, Group × 1- and 2-back, F(1,52) = .4, p = .52.”
Quote in the paperNot a substantial claimMay combine two claims.
Findingown dataPerformance incentives did not normalize working memory, but they roughly halved the ADHD-control performance difference at the present reinforcement dose.
“Though performance-based incentives did not normalize working memory, the ADHD-control difference in performance was roughly cut in half with the present “dose” of reinforcement.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataThe present studies show that both stimulant treatment and performance incentives acutely improve visuo-spatial working memory.
“The present studies demonstrate that both stimulant treatment and incentives for better performance each acutely improve visuo-spatial working memory.”
Quote in the paperSubstantial claimMay combine two claims.
Findingown dataBoth incentive and methylphenidate effects on working memory were large and easily detected despite the small sample.
“Both incentive and methylphenidate effects on working memory were large and easily detected despite the small sample.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
Study design and conductown dataIn Study 2, medication condition varied between days and incentive condition alternated within day, with medication and incentive orders counterbalanced across participants.
“Medication condition varied between days and incentive condition alternated within day. Medication order and incentive order were counterbalanced between subjects.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationNo single cognitive process, including working memory, is highly specific or sensitive to ADHD.
“Of course, no single cognitive process, including working memory, is highly specific or sensitive to ADHD (Pennington et al., 2005; Willcutt et al., 2005).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Pennington et al., 2005; Willcutt et al., 2005
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Classified as probably not a substantial claim.
Study design and conductown dataIn Study 2, children taking stimulant medication stopped it at least 24 hours before participation.
“Children who were currently taking stimulant medication discontinued medication use for at least 24 hours prior participation.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationADHD may be associated with an altered reward threshold.
“Specifically, ADHD may be associated with problems in the reward threshold (e.g., Haenlein & Caul, 1987)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Haenlein & Caul, 1987 source
Not checked in the free run.
May combine two claims.
Study design and conductown dataChildren in the control group had fewer than four symptoms of inattention and hyperactivity/impulsivity on the DBD-RS, no significant impairment on the IRS, and no DISC-IV diagnosis of ADHD or another behavioral disorder.
“Children included in the control group exhibited less than 4 symptoms of inattention and hyperactivity/impulsivity on the DBD-RS, were free of significant impairment on the IRS (all scores < 3 on the 0-6 scale), and did not meet diagnostic criteria for ADHD or any other behavioral disorder on the DISC-IV.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim. May combine two claims.
PremisecitationCombining contingency management with stimulant therapy may yield more improvement than either alone and is a recommended standard of care.
“Though the combination of contingency management and stimulant therapy may produce more improvement than either modality alone (e.g., Carlson et al., 1992; Pelham et al., 1993; 2005; Fabiano et al., 2007) and is a recommended standard of care (AAP, 2011)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Carlson et al., 1992; Pelham et al., 1993; 2005
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Classified as probably not a substantial claim.
Study design and conductown dataIn Study 2, active medication or placebo was administered double-blind.
“Children were administered active medication or placebo in a double-blind fashion shortly after their 7:30 a.m. arrival (medication order was counterbalanced), and cognitive testing began 90 minutes after administration.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataThe present data replicate and extend Shiels et al.'s preliminary finding that incentives improve performance when working memory manipulation is required.
“These data replicate and extend Shiels and colleagues’ (2008) preliminary finding that incentives enhance task performance when working memory manipulation was required (i.e., backward span).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Shiels and colleagues’ (2008)
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationADHD may involve general discounting of delayed consequences.
“or general discounting of delayed consequences (e.g., Luman, Tripp, & Scheres, 2010; Shiels et al., 2009; Sonuga-Barke, 2005)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Luman, Tripp, & Scheres, 2010; Shiels et al., 2009; Sonuga-Barke, 2005
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Classified as probably not a substantial claim.
PremisecitationADHD may be characterized by a steeper reinforcement gradient.
“and may be characterized by a steeper reinforcement gradient (e.g., Sagvolden et al., 2005)”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Sagvolden et al., 2005 source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Study design and conductcitationIn Study 1's incentive version, the order of incentive and no-incentive blocks was counterbalanced across participants.
“Incentive order (whether a child received an incentive block 1st or a no-incentive block 1st) was counterbalanced between subjects, since incentive order may influence working memory task performance in children with ADHD (see Shiels et al., 2008).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Shiels et al., 2008 source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataIn Study 2, each child completed the task during one of several possible testing periods, and this timing was counterbalanced across children.
“Each child completed the task during one of several possible testing periods throughout the day, and this timing was counterbalanced across children.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataAcross the two studies, contingencies substantially improve working memory in children with ADHD-Combined type, with effect sizes similar to those of a moderate stimulant dose.
“These studies indicate that contingencies markedly improve WM among children with ADHD–Combined type, with effect sizes comparable to a moderate dose of stimulant medication.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataIn Study 1's incentive session, load order was randomized and counterbalanced, and incentive and no-incentive blocks alternated within each load.
“Load order was randomized and counterbalanced across participants, and incentive and no-incentive conditions alternated within load.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationThe Shiels et al. (2008) study had no control group, so it is unclear whether a working memory deficit was present or whether incentive-related improvement represented normalization.
“However, this prior study did not include a control group, and without comparison to typically developing peers, it remains unclear whether or not a working memory deficit was present in this sample, or if improved performance in response to incentives constituted working memory normalization.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Shiels and colleagues (2008)
Not checked in the free run.
May combine two claims.
PremisecitationThe few published n-back studies in children with ADHD have generally found working memory deficits, often larger as n-back load increases.
“Indeed, the few published studies of the n-back among children with ADHD (e.g., Karatekin Bingham & White, 2009; Klein et al., 2006; Shallice et al., 2002) have generally demonstrated working memory deficits among children with ADHD, with greater deficits often apparent as n-back load is increased (see also the work of Ehlis et al., 2008, in adults).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Karatekin Bingham & White, 2009; Klein et al., 2006; Shallice et al., 2002
Not checked in the free run.
May combine two claims.
PremisecitationWorking memory deficits in ADHD are robust, and the largest impairments occur on tasks that require executive control of visuo-spatial information.
“Deficits in working memory among children with ADHD are robust, with the largest impairments on tasks that require executive control in dealing with visual and spatial information (i.e., visuo-spatial working memory; e.g., meta-analytic reviews of Martinussen, Hayden Hogg-Johnson, & Tannock, 2005; Nigg, Willcutt, Doyle, & Sonuga-Barke, 2002; Willcutt et al., 2005).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Martinussen, Hayden Hogg-Johnson, & Tannock, 2005; Nigg, Willcutt, Doyle, & Sonuga-Barke, 2002; Willcutt et al., 2005
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Interpretationown dataStudy 1's results suggest that performance-based incentives substantially reduced group differences in working memory but did not fully normalize it at the group level.
“Study 1 suggested that performance-based incentives markedly attenuated the group differences in working memory but did not fully normalize the process at the group level.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
Study design and conductnone givenParticipants who were taking stimulant medication stopped it at least 24 hours before each testing day.
“All participants who were actively taking stimulant medication (n = 12) discontinued use at least 24 hours prior to each testing day.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
InterpretationcitationThe finding of larger ADHD-control differences at higher n-back loads is consistent with some prior studies, while other studies have found only a general deficit across loads.
“This finding is consistent with previous studies demonstrating greater ADHD performance deficits, relative to controls, during larger n-back loads (e.g., Klein et al., 2006; Kobel 2008), though other studies have observed only a general deficit across n-back loads (e.g., Karatekin, Bingham, & White, 2009; Shallice, et al., 2002).”
Quote in the paperNot a substantial claim0 of 3 sources checkedClassified as probably not a substantial claim.
Study design and conductreasoningIn Study 2, identical opaque capsules were used to keep medication condition blinded.
“In order to maintain blinding to medication condition, children received identical opaque capsules on each day of testing.”
Quote in the paperSubstantial claimThe quote only partly states this claim.
Study design and conductown dataChildren in the ADHD group met DSM-IV criteria for ADHD-Combined type, confirmed by DBD-RS, IRS, and DISC-IV assessments.
“All children in the ADHD group met Diagnostic and Statistical Manual of Mental Disorders (4th ed., or DSM–IV; American Psychiatric Association, 2000) criteria for ADHD– Combined type.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationPreliminary evidence suggests that working memory training may be an effective treatment for ADHD.
“and preliminary evidence suggests that training working memory may be an effective treatment for the disorder (e.g., Klingberg et al., 2005).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Klingberg et al., 2005 source
Not checked in the free run.
May combine two claims.
PremisecitationKobel et al. (2008) found that methylphenidate normalized working memory differences between children with ADHD and typically developing children on an n-back task, although the effect did not vary with load.
“Kobel et al. (2008) have also demonstrated that methylphenidate normalized group differences in working memory performance among children with ADHD in comparison to TD children on an n-back task, although this effect did not vary across n-back load.”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Kobel et al. (2008) source
Not checked in the free run.
May combine two claims.
PremisecitationWorking memory is regarded as a core deficit in ADHD, and many studies have found impaired working memory in children with ADHD.
“Working memory (WM) is considered a core deficit in Attention-Deficit/ Hyperactivity Disorder (ADHD), with numerous studies demonstrating impaired WM among children with ADHD.”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Martinussen, Hayden Hogg-Johnson, & Tannock, 2005; Nigg, Willcutt, Doyle, & Sonuga-Barke, 2002; Willcutt et al., 2005
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
May combine two claims.
Interpretationown dataThe equivalence of incentives and methylphenidate was not due to a ceiling effect, because the combination produced greater improvement than either alone.
“the equivalence of incentives and methylphenidate was not due to a ceiling effect on performance, as the combination of incentives and methylphenidate yielded greater improvement than either alone”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationMethylphenidate effects on spatial working memory can be dose-dependent, but the exact dose-response function appears inconsistent across tasks.
“The effects of methylphenidate on spatial working memory can be dose-dependent, though the exact nature of that dose-response function appears to be inconsistent across tasks (e.g., Bedard et al., 2004).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites Bedard et al., 2004 source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing).
Interpretationown dataThe present data are broadly consistent with treatment guidelines that recommend both pharmacotherapy and behavioral intervention for school-age children with ADHD.
“These novel data are broadly consistent with treatment guidelines recommending that school-age children with ADHD receive both pharmacotherapy and behavioral intervention (AAP, 2011).”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites AAP, 2011
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationStimulant medication is a well-studied and empirically supported treatment for ADHD.
“stimulant medication, a well-studied and empirically supported treatment for ADHD (Greenhill et al., 2002; Plizska 2007).”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Greenhill et al., 2002 source
Not checked in the free run.
- cites Plizska 2007
Not checked in the free run.
May combine two claims.
InterpretationreasoningThe present work and Dovis et al. complement each other and highlight the importance of considering or manipulating motivational context when assessing working memory in ADHD.
“the two studies generally complement one another and indicate the importance explicitly considering, or even manipulating, the motivational context in which working memory is assessed in ADHD (see also Luman et al., 2005, 2010).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites Luman et al., 2005, 2010
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
Probably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationStudies of incentives on cognition are even less likely to examine a dose-response function.
“Studies of incentives on cognition are even less likely to examine a dose-response function (c.f., Dovis et al., in press; Luman et al., 2007).”
Quote in the paperNot a substantial claim0 of 2 sources checked- cites Dovis et al., in press
Not checked in the free run.
- cites Luman et al., 2007 source
Not checked in the free run.
The authors state this as an assumption.
Performance-based incentives in the laboratory serve as an analogue of behavioral intervention in clinical settings.
“performance-based incentives, an analog of behavioral intervention”
The paper relies on this without support.
A 24-hour washout is sufficient to remove the effects of prior stimulant medication.
“discontinued use at least 24 hours prior to each testing day.”
The paper relies on this without support.
The fixed ascending order in the baseline session does not differentially bias ADHD versus typically developing group comparisons.
“Although this order confounds time on task and working memory load, pilot testing suggested that an ascending difficulty sequence was necessary on first exposure to the task to ensure children in this age range could reasonably understand the task.”
The authors state this as an assumption.
The combination of incentives and stimulants in the laboratory is an analogue of combination treatment in real-world settings.
“the combination of incentives and stimulants provides an analogue of combination treatment in real-world settings.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Children with ADHD, in contrast to TD peers, show suboptimal performance on visuospatial WM- and STM tasks under regular reinforcement conditions, and require relatively high incentives to perform to their full abilities.
“Research indeed shows that children with ADHD, in contrast to their TD peers, show suboptimal performance on visuospatial WM- and visuospatial STM tasks under regular reinforcement conditions (e.g., feedback-only), and require relatively high incentives (e.g., feedback ? 10 euros) to perform to their full abilities [13, 33, 34].”
From Prevalence and diagnostic validity of motivational impairments and deficits in visuospatial short-term memory and working memory in ADHD subtypes (2015) · cites this paper as [34]
Study 1 and the Discussion report poorer visuospatial working-memory performance in children with ADHD than in typically developing peers, and improvement with incentives. But the paper does not establish the claim for separate visuospatial short-term-memory tasks or show that high incentives are required for children to perform to their full abilities: its incentives did not normalize working memory, and its Discussion reports improvement with both 1- and 10-euro rewards in another study. The Study 1 Methods also describe a no-incentive condition with non-informative signals, not feedback-only reinforcement. (LLM, conf=0.89)
Experimental — accuracy not yet measuredAbnormal sensitivity to reinforcement is characteristic of children with ADHD on a group level.
“Although both theory [e.g. 28, 29] and research [39, 40; also see 13, 33, 34] suggest that an abnormal sensitivity to reinforcement is characteristic of children with ADHD on a group level,”
From Prevalence and diagnostic validity of motivational impairments and deficits in visuospatial short-term memory and working memory in ADHD subtypes (2015) · cites this paper as [34]
Preliminary evidence suggests that strong, immediate rewards for task performance that improve spatial working memory to the same extent as stimulant medication are similarly effective in reinforcing fast, consistent responses in children with ADHD.
“Indeed, preliminary evidence suggests that the strong, immediate rewards for task performance that improve spatial working memory to the same extent as stimulant medication [95] are similarly effective in reinforcing fast, consistent responses in children with ADHD [96].”
From Reaction Time Variability in ADHD: A Review (2012) · cites this paper as [95]
Statistics that don’t add up
Each reported p-value recomputed from its test statistic and degrees of freedom.
p-value fits an unstated one-tailed test: F(1, 52) = 11.3, p < .001
MinorThe paper reports p < .001 here; recomputing from the test statistic and its degrees of freedom gives p = .001. The reported value is what a one-tailed test gives, but the paper does not say near this result that a one-tailed test was used.
Reported p < .001 · recomputed p = .001
“F(1, 52) = 11.3, p < .001”
Statistics recomputed
Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.
- Doesn’t add upF(1, 52) = 11.3reported p < .001 · recomputed p = .001
“F(1, 52) = 11.3, p < .001”
- ConsistentF(1, 52) = 101.9reported p < .001 · recomputed p < .001
“F(1,52) = 101.9, p < .001”
- ConsistentF(1, 52) = 37.5reported p < .001 · recomputed p < .001
“F(1,52) = 37.5, p < .001”
- ConsistentF(1, 52) = 12.6reported p = .001 · recomputed p < .001
“F(1,52) = 12.6, p = .001”
- ConsistentF(1, 52) = 6.25reported p = .016 · recomputed p = .016
“F(1,52) = 6.25, p = .016”
- ConsistentF(1, 52) = 5.38reported p = .024 · recomputed p = .024
“F(1,52) = 5.38, p = .024”
- ConsistentF(1, 52) = 1.6reported p = .21 · recomputed p = .212
“F(1,52) = 1.6, p = .21”
- ConsistentF(1, 52) = 80.9reported p < .001 · recomputed p < .001
“F(1,52) = 80.9, p < .001”
- ConsistentF(1, 52) = 53reported p < .001 · recomputed p < .001
“F(1,52) = 53, p < .001”
- ConsistentF(1, 52) = 24reported p < .001 · recomputed p < .001
“F(1,52) = 24, p < .001”
- ConsistentF(1, 52) = 24.8reported p < .001 · recomputed p < .001
“F(1, 52) = 24.8, p < .001”
- ConsistentF(1, 52) = 7.8reported p < .01 · recomputed p = .007
“F(1,52) = 7.8, p < .01”
- ConsistentF(1, 52) = 0.9reported p = .34 · recomputed p = .347
“F(1,52) = .9, p = .34”
- ConsistentF(1, 52) = 88.5reported p < .001 · recomputed p < .001
“F(1,52) = 88.5, p < .001”
- ConsistentF(1, 52) = 100.2reported p < .001 · recomputed p < .001
“F(1,52) = 100.2, p < .001”
- ConsistentF(1, 52) = 24.6reported p < .001 · recomputed p < .001
“F(1, 52) = 24.6, p < .001”
- ConsistentF(1, 52) = 5reported p = .03 · recomputed p = .030
“F(1,52) = 5.0, p = .03”
- ConsistentF(1, 52) = 77.1reported p < .001 · recomputed p < .001
“F(1,52) = 77.1, p < .001”
- ConsistentF(1, 52) = 17.9reported p < .001 · recomputed p < .001
“F(1,52) = 17.9, p < .001”
- ConsistentF(1, 52) = 14.9reported p < .001 · recomputed p < .001
“F(1,52) = 14.9, p < .001”
- ConsistentF(1, 52) = 3.1reported p = .08 · recomputed p = .084
“F(1,52) = 3.1, p = .08”
- ConsistentF(1, 52) = 1.5reported p = .23 · recomputed p = .226
“F(1, 52) = 1.5, p = .23”
- ConsistentF(1, 52) = 0.4reported p = .52 · recomputed p = .530
“F(1,52) = .4, p = .52”
- ConsistentF(1, 16) = 26.87reported p < .001 · recomputed p < .001
“F(1,16) = 26.87, p < .001”
- ConsistentF(1, 16) = 10.9reported p < .01 · recomputed p = .005
“F(1,16) = 10.9, p < .01”
- ConsistentF(1, 16) = 33.1reported p < .001 · recomputed p < .001
“F(1,16) = 33.1, p < .001”
- ConsistentF(1, 16) = 31.1reported p < .001 · recomputed p < .001
“F(1,16) = 31.1, p < .001”
- ConsistentF(1, 16) = 12.2reported p = .003 · recomputed p = .003
“F(1,16) = 12.2, p = .003”
- ConsistentF(1, 16) = 4.6reported p < .05 · recomputed p = .048
“F (1,16) = 4.6, p < .05”
- ConsistentF(1, 16) = 23.1reported p < .001 · recomputed p < .001
“F(1,16) = 23.1, p < .001”
- ConsistentF(1, 16) = 7.4reported p = .015 · recomputed p = .015
“F(1, 16) = 7.4, p = .015”
- ConsistentF(1, 16) = 3.8reported p = .07 · recomputed p = .069
“F(1,16) = 3.8, p = .07”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Self-check results appear here once an independent check has confirmed them.
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“Extending independent demonstrations that incentives (Dovis et al. 2012; Shiels et al. 2008; Study 1) and stimulants (e.g., Bedard and Tannock 2008; Bedard et al. 2007) improve aspects of working memory, Study 2 revealed that incentives were just as effective as a moderate dose of methylphenidate…”
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- Authors
- Strand, M. T., Hawk, L. W., Bubnik, M., Shiels, K., Pelham, W. E., & Waxmonsky, J. G.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Hawk, Larry W.
- Venue
- Journal of Abnormal Child Psychology
- Published
- 2012-04-03
- Volume
- 40
- Issue
- 7
- Pages
- 1193-1207
- ISSN
- 0091-0627 (ISSN-L)
- 1573-2835
- PMC
- PMC3422611
- OpenAlex
- W2156915655
- Cited by
- 67
- References
- 68
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 5 · 2018: 5 · 2017: 4 · 2016: 12 · 2015: 11 · 2014: 8 · 2013: 5 · 2012: 1
- FWCI
- 5.71
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Research on Child and Adolescent Psychopathology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Mental Health (R01MH069434)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Developmental and Educational Neuropsychology
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- working memory, attention deficit hyperactivity disorder, combined type ADHD, performance-based incentives, behavioral interventions, stimulant medication, methylphenidate, motivation, children
- MeSH terms
- Central Nervous System Stimulants, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Child, Combined Modality Therapy, Female, Humans, Male, Memory Disorders, Memory, Short-Term, Methylphenidate, Motivation, Reinforcement, Psychology
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