The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Where Is Dopamine and how do Immune Cells See it?: Dopamine-Mediated Immune Cell Function in Health and Disease
Open accessAbstract
Dopamine is well recognized as a neurotransmitter in the brain, and regulates critical functions in a variety of peripheral systems. Growing research has also shown that dopamine acts as an important regulator of immune function. Many immune cells express dopamine receptors and other dopamine related proteins, enabling them to actively respond to dopamine and suggesting that dopaminergic immunoregulation is an important part of proper immune function. A detailed understanding of the physiological concentrations of dopamine in specific regions of the human body, particularly in peripheral systems, is critical to the development of hypotheses and experiments examining the effects of physiologically relevant dopamine concentrations on immune cells. Unfortunately, the dopamine concentrations to which these immune cells would be exposed in different anatomical regions are not clear. To address this issue, this comprehensive review details the current information regarding concentrations of dopamine found in both the central nervous system and in many regions of the periphery. In addition, we discuss the immune cells present in each region, and how these could interact with dopamine in each compartment described. Finally, the review briefly addresses how changes in these dopamine concentrations could influence immune cell dysfunction in several disease states including Parkinson’s disease, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, as well as the collection of pathologies, cognitive and motor symptoms associated with HIV infection in the central nervous system, known as NeuroHIV. These data will improve our understanding of the interactions between the dopaminergic and immune systems during both homeostatic function and in disease, clarify the effects of existing dopaminergic drugs and promote the creation of new therapeutic strategies based on manipulating immune function through dopaminergic signaling. Graphical Abstract Graphical Abstract
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · cited 1×
“Both the mesolimbic pathway and mesocortical pathways are associated with the reward system (Wise 2004).”
Normal gut microbiota modulates brain development and behavior
Heijtz, R. D., Wang, S., Anuar, F., Qian, Y., Björkholm, B., Samuelsson, A., Hibberd, M. L., Forssberg, H., & Pettersson, S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010529108 · Cited by 3,228
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
Antipsychotic drug doses and neuroleptic/dopamine receptors
SEEMAN, P., LEE, T., CHAU-WONG, M., & WONG, K. (1976) · Nature · doi:10.1038/261717a0 · Cited by 1,622
Microglial interactions with synapses are modulated by visual experience
Tremblay, M.-È., Lowery, R. L., & Majewska, A. K. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000527 · Cited by 1,542
Neurotransmitter modulation by the gut microbiota
Strandwitz, P. (2018) · Brain Research · doi:10.1016/j.brainres.2018.03.015 · Cited by 1,527
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494
Alveolar macrophages: plasticity in a tissue-specific context
Hussell, T., & Bell, T. J. (2014) · Nature Reviews Immunology · doi:10.1038/nri3600 · Cited by 1,377
The brain on drugs: from reward to addiction
Volkow, N. D., & Morales, M. (2015) · Cell · doi:10.1016/j.cell.2015.07.046 · Cited by 1,306
Brochard, V., Combadière, B., Prigent, A., Laouar, Y., Perrin, A., Beray-Berthat, V., Bonduelle, O., Alvarez-Fischer, D., Callebert, J., Launay, J.-M., et al. (2008) · Journal of Clinical Investigation · doi:10.1172/jci36470 · Cited by 1,172
Subsecond dopamine release promotes cocaine seeking
Phillips, P. E. M., Stuber, G. D., Heien, M. L. A. V., Wightman, R. M., & Carelli, R. M. (2003) · Nature · doi:10.1038/nature01476 · Cited by 1,113
Floresco, S. B., West, A. R., Ash, B., Moore, H., & Grace, A. A. (2003) · Nature Neuroscience · doi:10.1038/nn1103 · Cited by 1,106
Noradrenergic and peptidergic innervation of lymphoid tissue
Felten, D. L., Felten, S. Y., Carlson, S. L., Olschowka, J. A., & Livnat, S. (1985) · The Journal of Immunology · doi:10.4049/jimmunol.135.2.755 · Cited by 1,025 · cited 1×
“Further, in the splenic white pulp, sympathetic nerve terminals are in direct apposition to T-cells and adjacent to both dendritic cells and B-cells, with a neuroimmune junction approximately 6 nm wide (Felten et al. 1987; Felten et al. 1985).”
Macrophages Facilitate Electrical Conduction in the Heart
Hulsmans, M., Clauss, S., Xiao, L., Aguirre, A. D., King, K. R., Hanley, A., Hucker, W. J., Wülfers, E. M., Seemann, G., Courties, G., et al. (2017) · Cell · doi:10.1016/j.cell.2017.03.050 · Cited by 1,011
Dopamine as a Prolactin (PRL) Inhibitor
Ben-Jonathan, N., & Hnasko, R. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.6.0451 · Cited by 983
Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system
Lammel, S., Hetzel, A., Häckel, O., Jones, I., Liss, B., & Roeper, J. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.022 · Cited by 976
Wightman, R. M., Jankowski, J. A., Kennedy, R. T., Kawagoe, K. T., Schroeder, T. J., Leszczyszyn, D. J., Near, J. A., Diliberto, E. J., & Viveros, O. H. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10754 · Cited by 893
T cells from patients with Parkinson’s disease recognize α-synuclein peptides
Sulzer, D., Alcalay, R. N., Garretti, F., Cote, L., Kanter, E., Agin-Liebes, J., Liong, C., McMurtrey, C., Hildebrand, W. H., Mao, X., et al. (2017) · Nature · doi:10.1038/nature22815 · Cited by 866
Autonomic innervation and regulation of the immune system (1987–2007)
Nance, D. M., & Sanders, V. M. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.008 · Cited by 855
Liu, J., Divoux, A., Sun, J., Zhang, J., Clément, K., Glickman, J. N., Sukhova, G. K., Wolters, P. J., Du, J., Gorgun, C. Z., et al. (2009) · Nature Medicine · doi:10.1038/nm.1994 · Cited by 796
Revisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682
Morón, J. A., Brockington, A., Wise, R. A., Rocha, B. A., & Hope, B. T. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-02-00389.2002 · Cited by 681
Kempadoo, K. A., Mosharov, E. V., Choi, S. J., Sulzer, D., & Kandel, E. R. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1616515114 · Cited by 647 · cited 6×
“…1.53 pmol/mg 1.5 × 10−6 Ma Globus Pallidus (Lateral) Human HPLC (Ebinger et al. 1987) 1.46 pmol/mg 1.5 × 10−6 Ma Globus Pallidus (Medial) Human HPLC (Ebinger et al. 1987) 11 ng/g 7.2 × 10−8 Ma Hippocampus Human HPLC (Musshoff et al. 2000) 0.27 pmol/mg 2.7 × 10−7 Ma Hippocampus Human HPLC (Ebinger…”
InfluentialHernandez, L., & Hoebel, B. G. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90036-7 · Cited by 627
Pivotal role of TLR4 receptors in alcohol-induced neuroinflammation and brain damage
Alfonso-Loeches, S., Pascual-Lucas, M., Blanco, A. M., Sanchez-Vera, I., & Guerri, C. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0976-10.2010 · Cited by 579
Volkow, N. D., Wang, G., Fowler, J. S., Tomasi, D., Telang, F., & Baler, R. (2010) · BioEssays · doi:10.1002/bies.201000042 · Cited by 532
Stahl, S. M., Pradko, J., Haight, B. R., Modell, J. G., Rockett, C. B., & Learned-Coughlin, S. (2004) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v06n0403 · Cited by 495
Valdearcos, M., Douglass, J. D., Robblee, M. M., Dorfman, M. D., Stifler, D. R., Bennett, M. L., Gerritse, I., Fasnacht, R., Barres, B. A., Thaler, J. P., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.015 · Cited by 477
Phagocyte-derived catecholamines enhance acute inflammatory injury
Flierl, M. A., Rittirsch, D., Nadeau, B. A., Chen, A. J., Sarma, J. V., Zetoune, F. S., McGuire, S. R., List, R. P., Day, D. E., Hoesel, L. M., et al. (2007) · Nature · doi:10.1038/nature06185 · Cited by 475
Weiss, F., Parsons, L. H., Schulteis, G., Hyytiä, P., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-10-03474.1996 · Cited by 457
How do immune cells overcome the blood-brain barrier in multiple sclerosis?
Larochelle, C., Alvarez, J. I., & Prat, A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.066 · Cited by 405
Lyte, M. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003726 · Cited by 399
Striatal dopamine neurotransmission: Regulation of release and uptake
Sulzer, D., Cragg, S. J., & Rice, M. E. (2016) · Basal Ganglia · doi:10.1016/j.baga.2016.02.001 · Cited by 382
Innervation Patterns of Autonomic Axons in the Human Endocrine Pancreas
Rodriguez-Diaz, R., Abdulreda, M. H., Formoso, A. L., Gans, I., Ricordi, C., Berggren, P.-O., & Caicedo, A. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.05.008 · Cited by 356
Wahlstrom, D., Collins, P., White, T., & Luciana, M. (2010) · Brain and Cognition · doi:10.1016/j.bandc.2009.10.013 · Cited by 311 · cited 1×
“While this enables a more standardized comparison, it does not account for substantial variability resulting from differences in species, age, cell type or sex (Arvidsson et al. 2014; Bourque et al. 2011; Cosentino et al. 2000; Pilipović et al. 2008; Wahlstrom et al. 2010).”
Pothos, E., Rada, P., Mark, G. P., & Hoebel, B. G. (1991) · Brain Research · doi:10.1016/0006-8993(91)91724-f · Cited by 288
Grundy, D., & Schemann, M. (2007) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3280287a23 · Cited by 283
Activation of the reward system boosts innate and adaptive immunity
Ben-Shaanan, T. L., Azulay-Debby, H., Dubovik, T., Starosvetsky, E., Korin, B., Schiller, M., Green, N. L., Admon, Y., Hakim, F., Shen-Orr, S. S., et al. (2016) · Nature Medicine · doi:10.1038/nm.4133 · Cited by 272
Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse
Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271
Letchworth, S. R., Nader, M. A., Smith, H. R., Friedman, D. P., & Porrino, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-08-02799.2001 · Cited by 239
Stuber, G. D., Roitman, M. F., Phillips, P. E. M., Carelli, R. M., & Wightman, R. M. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300619 · Cited by 217
Morris, D. L., Cho, K. W., DelProposto, J. L., Oatmen, K. E., Geletka, L. M., Martinez-Santibanez, G., Singer, K., & Lumeng, C. N. (2013) · Diabetes · doi:10.2337/db12-1404 · Cited by 217
Brain perivascular macrophages: characterization and functional roles in health and disease
Faraco, G., Park, L., Anrather, J., & Iadecola, C. (2017) · Journal of Molecular Medicine · doi:10.1007/s00109-017-1573-x · Cited by 206
Özoğul, F. (2004) · European Food Research and Technology · doi:10.1007/s00217-004-0988-0 · Cited by 149
Cocaine uptake is decreased in the brain of detoxified cocaine abusers
Volkow, N. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00073-m · Cited by 120
In vivo dynamics of innate immune sentinels in the CNS
Nayak, D., Zinselmeyer, B. H., Corps, K. N., & McGavern, D. B. (2012) · IntraVital · doi:10.4161/intv.22823 · Cited by 109
Dopaminergic effects on in vitro osteogenesis
Lee, D. J., Tseng, H. C., Wong, S. W., Wang, Z., Deng, M., & Ko, C.-C. (2015) · Bone Research · doi:10.1038/boneres.2015.20 · Cited by 101
Dopamine D2 and D4 receptor heteromerization and its allosteric receptor–receptor interactions
Borroto-Escuela, D. O., Craenenbroeck, K. V., Romero-Fernandez, W., Guidolin, D., Woods, A. S., Rivera, A., Haegeman, G., Agnati, L. F., Tarakanov, A. O., & Fuxe, K. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.12.083 · Cited by 98
Differential distribution and activation of microglia in the brain of male C57BL/6J mice
Yang, T.-T., Lin, C., Hsu, C.-T., Wang, T.-F., Ke, F.-Y., & Kuo, Y.-M. (2013) · Brain Structure and Function · doi:10.1007/s00429-012-0446-x · Cited by 92
Cosentino, M., Marino, F., & Maestroni, G. J. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00302 · Cited by 63
Engler, H., Doenlen, R., Riether, C., Engler, A., Niemi, M.-B., Besedovsky, H. O., Rey, A. D., Pacheco-López, G., Feldon, J., & Schedlowski, M. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2009.01.018 · Cited by 59
Carvalho, M. C., Albrechet-Souza, L., Masson, S., & Brandão, M. L. (2005) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2005001200014 · Cited by 41
Male/female differences in neuroprotection and neuromodulation of brain dopamine
Bourque, M. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00035 · Cited by 40
Repurposing dopaminergic drugs for MS — the evidence mounts
Marino, F., & Cosentino, M. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.33 · Cited by 38
Plasma neurotransmitters and cortisol in duodenal ulcer patients: Role of stress
Lechin, F., van der Dijs, B., Rada, I., Jara, H., Lechin, A. E., Cabrera, A., Lechin, M. E., Jimènez, V., Gòmez, F., Villa, S., et al. (1990) · Digestive Diseases and Sciences · doi:10.1007/bf01536734 · Cited by 35
Cited by
Bai, Z., Yang, P., Yu, F., Li, Z., Yao, Z., Martinez, J., Li, M., & Xu, H. (2022) · Cell Death & Disease · doi:10.1038/s41419-022-04562-w · Cited by 43
“In terms of their different functions, the engagement of D1-like DR stimulates cAMP production, while the engagement of D2-like DR inhibits cAMP production [22].”
Background
Metadata
- Authors
- Matt, S. M., & Gaskill, P. J.
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2019-05-11
- Volume
- 15
- Issue
- 1
- Pages
- 114-164
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- OpenAlex
- W2944093217
- Cited by
- 287
- References
- 57
- FWCI
- 6.35
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
