Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder
Abstract
Background The diagnosis of major depression disorder (MDD) and other mental disorders were depended on some subjective survey scales. There are confirmed relationship between the gut flora and the mental states of MDD patients.Methods The V3-V4 region of the 16S rRNA gene was extracted from the fecal microbial communities in MDD patients, PCR amplified and sequenced on the Illumina Miseq platform.Results More phylum Firmicutes, less Bacteroidetes, and more genus Prevotella, Klebsiella, Streptococcus and Clostridium XI were found in MDD patients. The changes of the proportion of Prevotella and Klebsiella were consistent with Hamilton depression rating scale.Limitations The conclusion was limited by small sample sizes and potential uncontrollable influence factors on fecal microbiota.Discussion Prevotella and Klebsiella proportion in fecal microbial communities should be concerned in the diagnosis and therapeutic monitoring of MDD in future.
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Depressed patients display a different gut composition with more bacteria of the phylum Firmicutes, less Bacteroidetes, and more bacteria of the genera Prevotella, Klebsiella, and Streptococcus.
“For example, Lin et al. showed that depressed patients display a different gut composition with more bacteria of the phylum Firmicutes, less Bacteroidetes, and more bacteria of the genera Prevotella, Klebsiella, and Streptococcus [115]”
From Antimicrobial Properties of Antidepressants and Antipsychotics—Possibilities and Implications (2021) · cites this paper as [115]
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Self-citation
- Authors
- Lin, P., Ding, B., Feng, C., Yin, S., Zhang, T., Qi, X., Lv, H., Guo, X., Dong, K., Zhu, Y., & Li, Q.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Li, Qingtian
- Venue
- Journal of Affective Disorders
- Publisher
- Elsevier BV
- Published
- 2017-01
- Volume
- 207
- Pages
- 300-304
- ISSN
- 0165-0327 (ISSN-L)
- OpenAlex
- W2529737593
- Cited by
- 311
- References
- 32
- Citations by year
- 2026: 18 · 2025: 34 · 2024: 45 · 2023: 33 · 2022: 35 · 2021: 43 · 2020: 41 · 2019: 33 · 2018: 23 · 2017: 6
- FWCI
- 10.74
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Affective Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- major depressive disorder, gut microbiota, fecal microbiota, Prevotella, Klebsiella, Firmicutes, Bacteroidetes, Streptococcus, Hamilton Depression Rating Scale, depression diagnosis, therapeutic monitoring
- MeSH terms
- Adult, Aged, Base Sequence, China, Depressive Disorder, Major, Major Depressive Disorder, Feces, Female, Humans, Klebsiella, Middle Aged, RNA, Ribosomal, 16S, Polymerase Chain Reaction, Prevotella, Gastrointestinal Tract, Young Adult, Real-Time Polymerase Chain Reaction, Microbiota
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