Cited by 311Gut microbiota and healthGastrointestinal motility and disordersOral microbiology and periodontitis research

Prevotella and Klebsiella proportions in fecal microbial communities are potential characteristic parameters for patients with major depressive disorder

Lin, Ping, Ding, Bingyu, Feng, Chunyan, Yin, Shuwei, Zhang, Ting, Qi, Xin, Lv, Huiying, Guo, Xiaokui +3 more·2017·Journal of Affective Disorders

Abstract

Background The diagnosis of major depression disorder (MDD) and other mental disorders were depended on some subjective survey scales. There are confirmed relationship between the gut flora and the mental states of MDD patients.Methods The V3-V4 region of the 16S rRNA gene was extracted from the fecal microbial communities in MDD patients, PCR amplified and sequenced on the Illumina Miseq platform.Results More phylum Firmicutes, less Bacteroidetes, and more genus Prevotella, Klebsiella, Streptococcus and Clostridium XI were found in MDD patients. The changes of the proportion of Prevotella and Klebsiella were consistent with Hamilton depression rating scale.Limitations The conclusion was limited by small sample sizes and potential uncontrollable influence factors on fecal microbiota.Discussion Prevotella and Klebsiella proportion in fecal microbial communities should be concerned in the diagnosis and therapeutic monitoring of MDD in future.

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Crossref · 10.1016/j.jad.2016.09.051

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  • Depressed patients display a different gut composition with more bacteria of the phylum Firmicutes, less Bacteroidetes, and more bacteria of the genera Prevotella, Klebsiella, and Streptococcus.

    “For example, Lin et al. showed that depressed patients display a different gut composition with more bacteria of the phylum Firmicutes, less Bacteroidetes, and more bacteria of the genera Prevotella, Klebsiella, and Streptococcus [115]”

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Authors
Lin, P., Ding, B., Feng, C., Yin, S., Zhang, T., Qi, X., Lv, H., Guo, X., Dong, K., Zhu, Y., & Li, Q.
Affiliations
Shanghai Jiao Tong University (CN)
Corresponding author
Li, Qingtian
Venue
Journal of Affective Disorders
Publisher
Elsevier BV
Published
2017-01
Volume
207
Pages
300-304
ISSN
0165-0327 (ISSN-L)
OpenAlex
W2529737593
Cited by
311
References
32
Citations by year
2026: 18 · 2025: 34 · 2024: 45 · 2023: 33 · 2022: 35 · 2021: 43 · 2020: 41 · 2019: 33 · 2018: 23 · 2017: 6
FWCI
10.74
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Affective Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
major depressive disorder, gut microbiota, fecal microbiota, Prevotella, Klebsiella, Firmicutes, Bacteroidetes, Streptococcus, Hamilton Depression Rating Scale, depression diagnosis, therapeutic monitoring
MeSH terms
Adult, Aged, Base Sequence, China, Depressive Disorder, Major, Major Depressive Disorder, Feces, Female, Humans, Klebsiella, Middle Aged, RNA, Ribosomal, 16S, Polymerase Chain Reaction, Prevotella, Gastrointestinal Tract, Young Adult, Real-Time Polymerase Chain Reaction, Microbiota

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