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Stochastic non-enzymatic modification of long-lived macromolecules - A missing hallmark of aging
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“Aging causes numerous damages in the long-lived protein components of the extracellular matrix, including advanced glycation end products (AGE), carbonylation and carbamylation, elastin fragmentation, and collagen crosslinking 244 , thus leading to tissue fibrosis (fibroaging) 245 .”
From Hallmarks of aging: An expanding universe (2023) · cites this paper as [244]
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Metadata
- Authors
- Fedintsev, A., & Moskalev, A.
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2020-09
- Volume
- 62
- Pages
- 101097
- ISSN
- 1568-1637
- Cited by
- 72
- References
- 28
- Language
- en
- Licence
- Funders
- Ministry of Education and Science of the Russian Federation (АААА-А19-119021590022-2)
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