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Cited by 204Child Abuse and TraumaMemory and Neural MechanismsNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

Memory of early maltreatment: Neonatal behavioral and neural correlates of maternal maltreatment within the context of classical conditioning

Roth, Tania L., Sullivan, Regina M.·2005·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.01.032
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Abstract

Background While children form an attachment to their abusive caregiver, they are susceptible to mental illness and brain abnormalities. To understand this important clinical issue, we have developed a rat animal model of abusive attachment where odor paired with shock paradoxically produces an odor preference. Here, we extend this model to a seminaturalistic paradigm using a stressed, "abusive" mother during an odor presentation and assess the underlying learning neural circuit.Methods We used a classical conditioning paradigm pairing a novel odor with a stressed mother that predominantly abused pups to assess olfactory learning in a seminaturalistic environment. Additionally, we used Fos protein immunohistochemistry to assess brain areas involved in learning this pain-induced odor preference within a more controlled maltreatment environment (odor-shock conditioning).Results Odor-maternal maltreatment pairings within a seminatural setting and odor-shock pairings both resulted in paradoxical odor preferences. Learning-induced gene expression was altered in the olfactory bulb and anterior piriform cortex (part of olfactory cortex) but not the amygdala.Conclusions Infants appear to use a unique brain circuit that optimizes learned odor preferences necessary for attachment. A fuller understanding of infant brain function may provide insight into why early maltreatment affects psychiatric well-being.

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Metadata

Authors
Roth, T. L., & Sullivan, R. M.
Affiliations
University of Oklahoma (US)
Corresponding author
Roth, Tania L.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2005-04
Volume
57
Issue
8
Pages
823-831
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.01.032
OpenAlex
W1991479884
Cited by
204
References
129
Citations by year
2026: 10 · 2025: 3 · 2024: 8 · 2023: 8 · 2022: 3 · 2021: 9 · 2020: 8 · 2019: 16 · 2018: 10 · 2017: 13 · 2016: 17 · 2015: 8 · 2014: 12 · 2013: 15 · 2012: 8
FWCI
8.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute on Drug Abuse (F31 DA06082, F31DA006082)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD33402, R01HD033402)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
maternal abuse, odor preference, classical conditioning, olfactory learning, Fos expression, olfactory bulb, anterior piriform cortex, amygdala, infant brain development, rat model
MeSH terms
Animals, Animals, Newborn, Child Abuse, Conditioning, Classical, Disease Models, Animal, Electroshock, Female, Humans, Immunohistochemistry, Infant, Infant, Newborn, Male, Maternal Behavior, Memory, Nerve Net, Odorants, Oncogene Proteins v-fos, Maze Learning, Rats, Long-Evans, Rats

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