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Cited by 56Child Abuse and TraumaMemory and Neural MechanismsStress Responses and Cortisol

Adult depression-like behavior, amygdala and olfactory cortex functions are restored by odor previously paired with shock during infant’s sensitive period attachment learning

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Sevelinges, Yannick, Mouly, Anne-Marie, Raineki, Charlis, Moriceau, Stéphanie, Forest, Christina, Sullivan, Regina M.·2011·Developmental Cognitive Neuroscience
DOI 10.1016/j.dcn.2010.07.005PMC PMC2964861
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Abstract

Maltreatment from the caregiver induces vulnerability to later life psychopathologies, yet attraction and comfort is sometimes provided by cues associated with early life maltreatment. We used a rat model of early life maltreatment with odor-0.5 mA shock conditioning to produce depressive-like behaviors and questioned whether stimuli associated with maltreatment would restore emotional neurobehavioral function to control levels. Pups received daily novel odor-0.5 mA shock conditioning from postnatal day 8 to 12. This procedure produces a new maternal odor that controls pups' attachment behaviors. In adulthood, either with or without the infant odor, animals received a Forced Swim Test, Sucrose Preference Test or assessment of amygdala and olfactory system functioning using field potential signal evoked by olfactory bulb paired-pulse electrical stimulation. Following neonatal odor-shock pairings, but not unpaired controls, adults without the odor present showed increased depression-like behavior in the Forced Swim Test and Sucrose Preference Test and a deficit in paired-pulse inhibition in amygdala and piriform (olfactory) cortex. All effects were brought to control levels when the infant conditioned odor was presented during behavioral and neural tests. The ability of cues associated with early life maltreatment to normalize behavior and amygdala activity suggests these cues provide adaptive value in adulthood.

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  • Amygdala-dependent deficits are task-specific: amygdala hyperactivity underlies decreased social exploration in adolescence and depressive/anxiety-like behavior in adulthood, in parallel with impaired threat aversion learning and blunted amygdala activation during fear conditioning.

    “Amygdala-dependent deficits are expressed in a task-specific manner: amygdala hyperactivity underlies decreased social exploration in adolescence and depressive and anxiety-like behavior in adulthood (Fig. 2), in parallel with impaired ability to learn aversions to threat and blunted amygdala activation during fear conditioning (Raineki et al., 2012, Sevelinges et al., 2007, Sevelinges et al., 201”

    From Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior (2017) · cites this paper as Sevelinges et al., 2011

  • Only early life trauma associated with attachment leads to lifelong amygdala-dependent behavioral deficits, such as poor social behavior (onset prior to weaning) and depressive-like behaviors (onset post-weaning).

    “Testing later in life shows that only the early life trauma associated with attachment will lead to lifelong amygdala-dependent behavioral deficits, such as poor social behavior (onset prior to weaning) and depressive-like behaviors (onset post- weaning (Raineki et al., 2012, Raineki et al., 2010b, Sevelinges et al., 2011, Sullivan et al., 2000a, Sullivan et al., 2000b).”

    From Early life adversity during the infant sensitive period for attachment: Programming of behavioral neurobiology of threat processing and social behavior (2017) · cites this paper as Sevelinges et al., 2011

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Research works printed but not linked: 1

  1. Haberly LB Price JL Association and commissural fiber systems of the olfactory cortex of the rat.II - Systems originating in the olfactory peduncle J. Com. Neurol 1978b 181 781 807 690285

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Authors
Sevelinges, Y., Mouly, A.-M., Raineki, C., Moriceau, S., Forest, C., & Sullivan, R. M.
Affiliations
  • Lyon 1 Université (FR)
  • Nathan Kline Institute for Psychiatric Research (US)
  • University of Oklahoma (US)
Corresponding author
Sullivan, Regina M.
ORCID
Venue
Developmental Cognitive Neuroscience
Publisher
Elsevier BV
Published
2011-01
Volume
1
Issue
1
Pages
77-87
ISSN
1878-9293 (ISSN-L)
DOI
10.1016/j.dcn.2010.07.005
PMC
PMC2964861
OpenAlex
W1966526686
Cited by
56
References
114
Citations by year
2026: 3 · 2025: 1 · 2024: 2 · 2023: 1 · 2022: 1 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 5 · 2016: 9 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 4
FWCI
3.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Developmental Cognitive Neuroscience (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • Agence Nationale de la Recherche
  • National Institutes of Health
  • U.S. Public Health Service (NIHMH091451)
  • National Institute of Mental Health (R01MH091451)
  • National Institute on Deafness and Other Communication Disorders (DC-009910, R01DC009910)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
depression-like behavior, maternal odor, sensitive period, amygdala, piriform cortex, olfactory bulb, paired-pulse inhibition, forced swim test, sucrose preference, rat model
MeSH terms
Age Factors, Amygdala, Animals, Animals, Newborn, Association Learning, Conditioning, Psychological, Depression, Electric Stimulation, Female, Male, Object Attachment, Odorants, Olfactory Pathways, Pregnancy, Rats, Long-Evans, Rats

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