Temporal Lobe Dysfunction in Medication-Naïve Boys With Attention-Deficit/Hyperactivity Disorder During Attention Allocation and Its Relation to Response Variability
Abstract
Background Patients with attention-deficit/hyperactivity disorder (ADHD) typically show fronto-striatal abnormalities during functions of cognitive control. In this study we investigate whether medication-naïve children with ADHD are impaired in temporo-parietal neural networks that mediate purely perceptual attention allocation to a behaviorally neutral oddball task. Furthermore, we explore the relationship between the neural substrates of attention allocation and response variability, typically increased in patients. Method Event-related functional magnetic resonance imaging was used to compare brain activation of 17 medication-naïve boys with ADHD with that of 18 handedness- and IQ-matched healthy comparison boys during a visual oddball task that required the same response to oddball and standard trials. Furthermore, to explore the relationship between behavioral dispersion and attention networks, regression analyses were conducted between response variability and brain activation networks. Results Patients showed significantly reduced brain activation in left and right superior temporal lobes, basal ganglia, and posterior cingulate during the oddball versus standard contrast. The activation differences in superior temporal lobes correlated inversely with response variability in control subjects but not in patients with ADHD. Conclusions Brain abnormalities in patients with ADHD are not confined to fronto-striatal networks mediating executive functions but are also observe…
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On a neural level, RTV has been associated with smaller white matter tracts in the late developing fronto-parietal attention (superior longitudinal fasciculus) and cortico-thalamic cognitive control tracts and reduced activation in fronto-striatal and superior temporal activation in children and adults with ADHD.
“In line with a role in attention and self-control, on a neural level, RTV has been associated with smaller white matter tracts in the late developing fronto-parietal attention (superior longitudinal fasciculus) and cortico-thalamic cognitive control tracts and reduced activation in fronto-striatal and superior temporal activation in children and adults with ADHD (18, 67–70), suggesting an”
From Differential effects of a single dose of Lisdexamfetamine and Guanfacine on cognitive function in children with ADHD (2025) · cites this paper as [69]
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Self-citation
- Authors
- Rubia, K., Smith, A. B., Brammer, M. J., & Taylor, E.
- Affiliations
- King's College London (GB)
- Corresponding author
- Rubia, Katya
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2007-11
- Volume
- 62
- Issue
- 9
- Pages
- 999-1006
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1971144159
- Cited by
- 168
- References
- 6
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 3 · 2022: 8 · 2021: 11 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 8 · 2013: 16 · 2012: 15
- FWCI
- 8.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (053272/Z/98/Z/JRS/JP)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, temporal lobe dysfunction, superior temporal lobe, perceptual attention, oddball paradigm, response variability, posterior cingulate cortex, basal ganglia, fronto-striatal network, children, drug-naive patients
- MeSH terms
- Adolescent, Analysis of Variance, Attention, Attention Deficit Disorder with Hyperactivity, Child, Humans, Image Processing, Computer-Assisted, Judgment, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Photic Stimulation, Psychometrics, Reaction Time, Temporal Lobe, Case-Control Studies
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