The DOI matches its Crossref record; 107 of the 112 references it cites were found in a registry or an index.
Decreased Volume of the Brain Reward System in Alcoholism
Open accessAbstract
Background Reinforcement of behavioral responses involves a complex cerebral circuit engaging specific neuronal networks that are modulated by cortical oversight systems affiliated with emotion, memory, judgment, and decision making (collectively referred to in this study as the "extended reward and oversight system" or "reward network"). We examined whether reward-network brain volumes are reduced in alcoholics and how volumes of subcomponents within this system are correlated with memory and drinking history.Methods Morphometric analysis was performed on magnetic resonance brain scans in 21 abstinent long-term chronic alcoholic men and 21 healthy control men, group-matched on age, verbal IQ, and education. We derived volumes of total brain and volumes of cortical and subcortical reward-related structures including the dorsolateral-prefrontal, orbitofrontal, cingulate cortices, and the insula, as well as the amygdala, hippocampus, nucleus accumbens septi (NAc), and ventral diencephalon.Results Morphometric analyses of reward-related regions revealed decreased total reward-network volume in alcoholic subjects. Volume reduction was most pronounced in right dorsolateral-prefrontal cortex, right anterior insula, and right NAc, as well as left amygdala. In alcoholics, NAc and anterior insula volumes increased with length of abstinence, and total reward-network and amygdala volumes correlated positively with memory scores.Conclusions The observation of decreased reward-network volume suggests that alcoholism is associated with alterations in this neural reward system. These structural reward system deficits and their correlation with memory scores elucidate underlying structural-functional relationships between alcoholism and emotional and cognitive processes.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Additionally, several other studies observed that lower gray matter volumes were associated with higher addictive tendencies [77,78].”
From Addictive Features of Social Media/Messenger Platforms and Freemium Games against the Background of Psychological and Economic Theories (2019) · cites this paper as [77]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The assessment and analysis of handedness: The Edinburgh inventory
Oldfield, R. C. (1971) · Neuropsychologia · doi:10.1016/0028-3932(71)90067-4 · Cited by 35,900
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)
Hu, R. J. (2003) · Elsevier eBooks · doi:10.1016/b0-12-226870-9/01070-4 · Cited by 9,168
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610
Self-citationAutomatically Parcellating the Human Cerebral Cortex
Fischl, B. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg087 · Cited by 4,208
Wechsler Adult Intelligence Scale-III
Ryan, J. J., & Lopez, S. J. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1185-4_2 · Cited by 3,680
The Prefrontal Cortex: Anatomy, Physiology, and Neuropsychology of the Frontal Lobe
Fuster, J. M. (1980) · Cited by 2,367
A simple objective technique for measuring flexibility in thinking
Berg, E. A. (1948) · The Journal of General Psychology · doi:10.1080/00221309.1948.9918159 · Cited by 2,255
Grant, D. A., & Berg, E. (1948) · Journal of Experimental Psychology · doi:10.1037/h0059831 · Cited by 2,244
Fuster, J. M. (1997) · Cited by 2,095
Circuitry of Primate Prefrontal Cortex and Regulation of Behavior by Representational Memory
Goldman‐Rakic, P. S. (1987) · Comprehensive Physiology · doi:10.1002/cphy.cp010509 · Cited by 1,960
Cognitive neuroscience of emotional memory
LaBar, K. S., & Cabeza, R. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1825 · Cited by 1,834 · cited 2×
“Largely through these associations, sensory inputs get transformed into powerful motivational and emotional representations (81).”
Principles of Frontal Lobe Function
Stuss, D. T. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195134971.001.0001 · Cited by 1,731
LeDoux, J., Iwata, J., Cicchetti, P., & Reis, D. (1988) · The Journal of Neuroscience · doi:10.1523/jneurosci.08-07-02517.1988 · Cited by 1,580
Swanson, L. W., & Petrovich, G. D. (1998) · Trends in Neurosciences · doi:10.1016/s0166-2236(98)01265-x · Cited by 1,351
Alheid, G. F., & Heimer, L. (1988) · Neuroscience · doi:10.1016/0306-4522(88)90217-5 · Cited by 1,217
Schmahmann, J. D., & Pandya, D. N. (2006) · doi:10.1093/acprof:oso/9780195104233.001.0001 · Cited by 1,157
Multilingual Aphasia Examination
Patterson, J. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-57111-9_900 · Cited by 1,096
How can drug addiction help us understand obesity?
Volkow, N. D., & Wise, R. A. (2005) · Nature Neuroscience · doi:10.1038/nn1452 · Cited by 1,089
Normal Sexual Dimorphism of the Adult Human Brain Assessed by In Vivo Magnetic Resonance Imaging
Goldstein, J. M. (2001) · Cerebral Cortex · doi:10.1093/cercor/11.6.490 · Cited by 1,052
The Amygdala: a functional analysis
Aggleton, J. P. (2000) · Cited by 966
Orbitofrontal cortex and basolateral amygdala encode expected outcomes during learning
Schoenbaum, G. M., Chiba, A. A., & Gallagher, M. (1998) · Nature Neuroscience · doi:10.1038/407 · Cited by 849
Frazier, J. A., Chiu, S., Breeze, J. L., Makris, N., LANGE, N. D., Kennedy, D. N., Herbert, M. R., Bent, E. K., Koneru, V. K., Dieterich, M., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.7.1256 · Cited by 811
Self-citationPatterns of Hand Preference in a Student Population
Briggs, G. G., & Nebes, R. D. (1975) · Cortex · doi:10.1016/s0010-9452(75)80005-0 · Cited by 786
Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708
Barbas, H. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(99)00245-2 · Cited by 664
The Young Adult Human Brain: An MRI-based Morphometric Analysis
Filipek, P. A., Richelme, C., Kennedy, D. N., & Caviness, V. S. (1994) · Cerebral Cortex · doi:10.1093/cercor/4.4.344 · Cited by 652
Self-citationWikler, A. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750350005001 · Cited by 650
Alcohol: Effects on Neurobehavioral Functions and the Brain
Oscar-Berman, M., & Marinković, K. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9038-6 · Cited by 619
Self-citationCorbit, L. H., & Balleine, B. W. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.4507-04.2005 · Cited by 589
Further contributions to the study of the evolution of the forebrain
Johnston, J. B. (1923) · Journal of Comparative Neurology · doi:10.1002/cne.900350502 · Cited by 575
Principles of frontal lobe function
Jellinger, K. A. (2003) · European Journal of Neurology · doi:10.1046/j.1468-1331.2003.00507_2.x · Cited by 562
FRONTAL LOBE CHANGES IN ALCOHOLISM: A REVIEW OF THE LITERATURE
Moselhy, H. F. (2001) · Alcohol and Alcoholism · doi:10.1093/alcalc/36.5.357 · Cited by 535
The Human Brain Age 7–11 Years: A Volumetric Analysis Based on Magnetic Resonance Images
Caviness, V. S., Kennedy, D. N., Richelme, C., Rademacher, J., & Filipek, P. A. (1996) · Cerebral Cortex · doi:10.1093/cercor/6.5.726 · Cited by 509
Self-citationThe cerebral cortex is damaged in chronic alcoholics
Kril, J. J., Halliday, G. M., Svoboda, M. D., & Cartwright, H. (1997) · Neuroscience · doi:10.1016/s0306-4522(97)00083-3 · Cited by 507
Groenewegen, H. J., Berendse, H. W., Wolters, J. G., & Lohman, A. H. M. (1991) · Progress in brain research · doi:10.1016/s0079-6123(08)62677-1 · Cited by 506
Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys
Herbert, M. R., Ziegler, D. A., Deutsch, C., O’Brien, L. M., LANGE, N. D., Bakardjiev, A. I., Hodgson, J. M., Adrien, K. T., Steele, S., Makris, N., et al. (2003) · Brain · doi:10.1093/brain/awg110 · Cited by 505
Self-citationFrontal Lobe Volume Loss Observed with Magnetic Resonance Imaging in Older Chronic Alcoholics
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., & Lim, K. O. (1997) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1997.tb03798.x · Cited by 492
Horton, A., & Larrabee, G. J. (1999) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/14.5.473 · Cited by 471
Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat
McDonald, A. J. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90247-l · Cited by 463
The D 2 Dopamine Receptor Gene as a Determinant of Reward Deficiency Syndrome
Blum, K., Sheridan, P. J., Wood, R. C., Braverman, E. R., Chen, T. J. H., phd, J. G. C., & Comings, D. E. (1996) · Journal of the Royal Society of Medicine · doi:10.1177/014107689608900711 · Cited by 443
Pfefferbaum, A., Sullivan, E. V., Mathalon, D. H., Shear, P. K., Rosenbloom, M. J., & Lim, K. O. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01598.x · Cited by 420
Prefrontal Cortical Networks Related to Visceral Function and Mood
Price, J. L. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09278.x · Cited by 406
Adolf Pfefferbaum, A., Sullivan, E. V., Rosenbloom, M. J., Mathalon, D. H., & Lim, K. O. (1998) · Archives of General Psychiatry · doi:10.1001/archpsyc.55.10.905 · Cited by 391
Cortical Abnormalities in Schizophrenia Identified by Structural Magnetic Resonance Imaging
Goldstein, J. M. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.6.537 · Cited by 369
The limbic lobe and its output channels: implications for emotional functions and adaptive behavior
Heimer, L., & Van Hoesen, G. W. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.06.006 · Cited by 366
Frontal circuitry degradation marks healthy adult aging: Evidence from diffusion tensor imaging
Adolf Pfefferbaum, A., Elfar Adalsteinsson, A., & Sullivan, E. V. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.02.034 · Cited by 363
Hippocampal Volume in Patients With Alcohol Dependence
Agartz, I., Momenan, R., Rawlings, R. R., Kerich, M. J., & Hommer, D. W. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.4.356 · Cited by 359
The projection field of the stria terminalis in the rat brain. An experimental study
de Olmos, J. S., & Ingram, W. R. (1972) · The Journal of Comparative Neurology · doi:10.1002/cne.901460303 · Cited by 355
Early Asymmetry of Gene Transcription in Embryonic Human Left and Right Cerebral Cortex
Sun, T., Patoine, C., Abu‐Khalil, A., Visvader, J. E., Sum, E. Y. M., Cherry, T. J., Orkin, S. H., Geschwind, D. H., & Walsh, C. A. (2005) · Science · doi:10.1126/science.1110324 · Cited by 352
Anterior Hippocampal Volume Deficits in Nonamnesic, Aging Chronic Alcoholics
Sullivan, E. V., Marsh, L., Mathalon, D. H., Lim, K. O., & Pfefferbaum, A. (1995) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1995.tb01478.x · Cited by 343
Molecular approaches to brain asymmetry and handedness
Sun, T., & Walsh, C. A. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1930 · Cited by 339
Language‐association cortex asymmetry in autism and specific language impairment
De Fossé, L., Hodge, S. M., Makris, N., Kennedy, D. N., Caviness, V. S., McGrath, L., Steele, S., Ziegler, D. A., Herbert, M. R., Frazier, J. A., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20275 · Cited by 339
Self-citationHugdahl, K., & Davidson, R. J. (2003) · Medical Entomology and Zoology · Cited by 329
The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction
Koob, G. F. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09282.x · Cited by 322
Neuroimaging of Gender Differences in Alcohol Dependence: Are Women More Vulnerable?
Mann, K. F., Ackermann, K., Croissant, B., Mundle, G., Nakovics, H., & Diehl, A. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000164376.69978.6b · Cited by 320
Subcortical Correlates of Craving in Recently Abstinent Alcoholic Patients
Schneider, F. W., Habel, U., Wagner, M., Franke, P. E., Salloum, J. B., Shah, N. J., Toni, I., Sulzbach, C., Hönig, K., Maier, W., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.7.1075 · Cited by 319
Relationship between dopaminergic neurotransmission, alcoholism, and reward deficiency syndrome
Bowirrat, A., & Oscar‐Berman, M. (2004) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30080 · Cited by 303
Self-citationCaviness, V. S., Meyer, J. W., Makris, N., & Kennedy, D. N. (1996) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.1996.8.6.566 · Cited by 298
Self-citationCerebellar volume decline in normal aging, alcoholism, and Korsakoff's syndrome: Relation to ataxia.
Sullivan, E. V., Deshmukh, A., Desmond, J. E., Lim, K. O., & Adolf Pfefferbaum, A. (2000) · Neuropsychology · doi:10.1037/0894-4105.14.3.341 · Cited by 290
What Is Inherited in the Predisposition Toward Alcoholism? A Proposed Model
Begleiter, H., & Bernice Porjesz, A. (1999) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1999.tb04269.x · Cited by 288
Heinz, A., Siessmeier, T., Wrase, J., Buchholz, H. G., Gründer, G., Kumakura, Y., Cumming, P., Schreckenberger, M., Smolka, M. N., Rösch, F., et al. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1515 · Cited by 285
The concepts of the ventral striatopallidal system and extended amygdala
DE OLMOS, J. S., & HEIMER, L. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09258.x · Cited by 281
Anatomic segmentation and volumetric calculations in nuclear magnetic resonance imaging
Kennedy, D. N., Filipek, P. A., & Caviness, V. S. (1989) · IEEE Transactions on Medical Imaging · doi:10.1109/42.20356 · Cited by 271
Self-citationThe cognit: A network model of cortical representation
Fuster, J. M. (2006) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2005.12.015 · Cited by 264
LeDoux, J. E., Farb, C. R., & Romanski, L. M. (1991) · Neuroscience Letters · doi:10.1016/0304-3940(91)90526-y · Cited by 264
MRI-Based Topographic Parcellation of Human Cerebral White Matter and Nuclei
Makris, N., Meyer, J. W., Bates, J. F., Yeterian, E. H., Kennedy, D. N., & Caviness, V. S. (1999) · NeuroImage · doi:10.1006/nimg.1998.0384 · Cited by 261
Self-citationAssociation Pathways of the Prefrontal Cortex and Functional Observations
Petrides, M., & Pandya, D. Ν. (2002) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195134971.003.0003 · Cited by 260
Seidman, L. J., Faraone, S. V., Goldstein, J. M., Goodman, J. M., Kremen, W. S., Toomey, R., Tourville, J. A., Kennedy, D. N., Makris, N., Caviness, V. S., et al. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00075-x · Cited by 249
Self-citationfMRI Measurement of Brain Dysfunction in Alcohol-Dependent Young Women
Tapert, S. F., Brown, G. G., Kindermann, S. S., Cheung, E. H., Frank, L. R., & Brown, S. A. (2001) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2001.tb02204.x · Cited by 249
Deformation-based morphometry of brain changes in alcohol dependence and abstinence
Cardenas, V. A., Studholme, C., Gazdzinski, S. P., Durazzo, T. C., & Meyerhoff, D. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.015 · Cited by 237
Dao-Castellana, M. H., Samson, Y., LEGAULT, F., Martinot, J., Aubin, H., Crouzel, C., FELDMAN, L., Barrucand, D., Rancurel, G., Féline, A., et al. (1998) · Psychological Medicine · doi:10.1017/s0033291798006849 · Cited by 214
Harper, C. G., Dixon, G., Sheedy, D. L., & Garrick, T. M. (2003) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(03)00155-6 · Cited by 209
Devlin, J. T., & Poldrack, R. A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.055 · Cited by 195
Hill, S. Y., Bellis, M. D. D., Keshavan, M. S., Lowers, L., Shen, S., Hall, J., & Pitts, T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01088-5 · Cited by 194
Sullivan, E. V., Mathalon, D. H., Zipursky, R. B., Kersteen-Tucker, Z., Knight, R. T., & Pfefferbaum, A. (1993) · Psychiatry Research · doi:10.1016/0165-1781(93)90019-d · Cited by 193
Hemispheric perception of emotional valence from facial expressions.
Adolphs, R., Jansari, A. S., & Tranel, D. (2001) · Neuropsychology · doi:10.1037/0894-4105.15.4.516 · Cited by 191
Fuster, J. M. (2005) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195300840.001.0001 · Cited by 185
Chronic alcoholism and the frontal lobe: which executive functions are imparied?
Ratti, M. T., Bo, P., Giardini, A., & Soragna, D. (2002) · Acta Neurologica Scandinavica · doi:10.1034/j.1600-0404.2002.0o315.x · Cited by 175
Complex Systems Science in Biomedicine
Deisboeck, T. S., & Kresh, J. Y. (2006) · Springer eBooks · doi:10.1007/978-0-387-33532-2 · Cited by 171
The Amygdala and Its Place in the Cerebral Hemisphere
Swanson, L. W. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07081.x · Cited by 161
A volumetric MRI study of the hippocampus in type 1 and 2 alcoholism
Laakso, M. P., Vaurio, O., Savolainen, L., Repo, E., Soininen, H. S., Aronen, H. J., & Tiihonen, J. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00172-2 · Cited by 159
Decreased Absolute Amygdala Volume in Cocaine Addicts
Makris, N., Gasic, G. P., Seidman, L. J., Goldstein, J. M., Gastfriend, D. R., Elman, I., Albaugh, M. D., Hodge, S. M., Ziegler, D. A., Sheahan, F., et al. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.027 · Cited by 159
Self-citationHippocampus Volume Loss Due to Chronic Heavy Drinking
Beresford, T. P., Arciniegas, D. B., Alfers, J., Clapp, L., Martin, B., Du, Y., Liu, D., Shen, D., & Davatzikos, C. (2006) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00223.x · Cited by 158
Alcohol consumption and frontal lobe shrinkage: study of 1432 non-alcoholic subjects
Kubota, M. (2001) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.71.1.104 · Cited by 157
Noel, X. (2002) · Alcohol and Alcoholism · doi:10.1093/alcalc/37.4.347 · Cited by 153
Multiple Affect Adjective Check List
Zuckerman, M., Lubin, B., Vogel, L., & Valerius, E. (1964) · PsycTESTS Dataset · doi:10.1037/t06152-000 · Cited by 140
Striatum gray matter reduction in males with an overactive behavioral activation system
Barrós‐Loscertales, A., Meseguer, V., Sanjuán, A., Belloch, V., Parcet, M. A., Torrúbia, R., & Ávila, C. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05084.x · Cited by 138
Alcoholism, aging, and functional cerebral asymmetries.
Ellis, R. J., & Oscar‐Berman, M. (1989) · Psychological Bulletin · doi:10.1037/0033-2909.106.1.128 · Cited by 131
Self-citationThe molecular foundations of psychiatry
(1993) · Choice Reviews Online · doi:10.5860/choice.30-4099 · Cited by 129
Individual Differences in Amygdala Activity Predict Response Speed during Working Memory
Schaefer, A., Braver, T. S., Reynolds, J. R., Burgess, G. C., Yarkoni, T., & Gray, J. R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2567-06.2006 · Cited by 106
The Neurobehavioral Correlates of Alcoholism
Rourke, S. B., & Løberg, T. (1996) · Oxford University Press eBooks · doi:10.1093/oso/9780195090734.003.0018 · Cited by 103
Genetic and environmental influences on frontal EEG asymmetry: A twin study
Anokhin, A. P., Heath, A. C., & Myers, E. M. (2005) · Biological Psychology · doi:10.1016/j.biopsycho.2005.06.004 · Cited by 100
Processing of Affective Stimuli in Alcoholism
UEKERMANN, J., Daum, I., Schlebusch, P., & Trenckmann, U. (2005) · Cortex · doi:10.1016/s0010-9452(08)70893-1 · Cited by 99
Depression and cognitive functioning in alcoholism
UEKERMANN, J., Daum, I., Schlebusch, P., Wiebel, B., & Trenckmann, U. (2003) · Addiction · doi:10.1046/j.1360-0443.2003.00526.x · Cited by 97
de Olmos, J. S. (2008) · Brain Behavior and Evolution · doi:10.1159/000125825 · Cited by 87
The Molecular Foundations of Psychiatry
Baraban, J. M. (1994) · Journal of Neuropsychiatry · doi:10.1176/jnp.6.1.72 · Cited by 75
Nixon, S. J., & Parsons, O. A. (1990) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.1990.tb01190.x · Cited by 60
Regional cerebral blood flow and neuropsychological functioning in early and late onset alcoholism
Demir, B., Uluğ, B., Ergün, E. L., & Erbaş, B. (2002) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(02)00071-9 · Cited by 59
Rangaswamy, M., Porjesz, B., Ardekani, B. A., Choi, S. J., Tanabe, J., Lim, K. O., & Begleiter, H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.09.018 · Cited by 58
Szabó, Z. R., Owonikoko, T. K., Peyrot, M. F., Varga, J., Mathews, W. B., Ravert, H. T., Dannals, R. F., & Wand, G. S. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.023 · Cited by 51
Genetic influences in emotional dysfunction and alcoholism-related brain damage
Oscar‐Berman, M., & Bowirrat, A. (2005) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.a788 · Cited by 37
Self-citationAsymmetries of Brain Function in Alcoholism: Relationship to Aging
Oscar‐Berman, M., & Schendan, H. E. (2005) · Kluwer Academic Publishers eBooks · doi:10.1007/0-306-46898-0_14 · Cited by 31
Self-citationNeurobiological mechanisms in cocaine and opiate dependence.
Koob, G. F. (1992) · PubMed · Cited by 30
Imaging the Neural Systems for Motivated Behavior and Their Dysfunction in Neuropsychiatric Illness
Breiter, H. C., Gasic, G. P., & Makris, N. (2007) · Springer eBooks · doi:10.1007/978-0-387-33532-2_33 · Cited by 27
Self-citationVolkow, N. D., Wang, G.-J., Begleiter, H., Porjesz, B., Fowler, J. S., Telang, F., Wong, C., Ma, Y., Logan, J., Goldstein, R., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.9.999 · Cited by 2
Cited by
Sorted by citations
Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749
The role of early life stress as a predictor for alcohol and drug dependence
Enoch, M.-A. (2011) · Psychopharmacology · doi:10.1007/s00213-010-1916-6 · Cited by 668
Alcohol: Effects on Neurobehavioral Functions and the Brain
Oscar-Berman, M., & Marinković, K. (2007) · Neuropsychology Review · doi:10.1007/s11065-007-9038-6 · Cited by 619
Self-citationMontag, C., Lachmann, B., Herrlich, M., & Zweig, K. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16142612 · Cited by 387
“Additionally, several other studies observed that lower gray matter volumes were associated with higher addictive tendencies [77,78].”
The insula: a critical neural substrate for craving and drug seeking under conflict and risk
Naqvi, N. H., Gaznick, N., Tranel, D., & Bechara, A. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12415 · Cited by 336
Metadata
- Authors
- Makris, N., Oscar-Berman, M., Jaffin, S. K., Hodge, S. M., Kennedy, D. N., Caviness, V. S., Marinkovic, K., Breiter, H. C., Gasic, G. P., & Harris, G. J.
- Affiliations
- Boston University (US)
- Harvard University (US)
- Massachusetts General Hospital (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 64
- Issue
- 3
- Pages
- 192-202
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2572710
- OpenAlex
- W2003775449
- Cited by
- 372
- References
- 112
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 11 · 2023: 11 · 2022: 16 · 2021: 23 · 2020: 22 · 2019: 26 · 2018: 13 · 2017: 35 · 2016: 25 · 2015: 37 · 2014: 29 · 2013: 27 · 2012: 29
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Alcohol Abuse and Alcoholism (K01AA13402, K01AA013402, R37-AA07112, K05AA00219, R01AA007112, K05AA000219, R37AA007112)
- National Institute on Drug Abuse (P20DA026002)
- National Institute of Neurological Disorders and Stroke (P50NS051343)
- National Center for Research Resources (P41-RR-14075, M01RR001066, P41RR014075)
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- alcoholism, brain reward system, brain atrophy, abstinence, dorsolateral prefrontal cortex, anterior insula, nucleus accumbens, amygdala, memory, brain structural changes, chronic alcohol consumption
- MeSH terms
- Adult, Alcoholism, Brain, Brain Mapping, Educational Status, Humans, Image Processing, Computer-Assisted, Intelligence, Magnetic Resonance Imaging, Male, Middle Aged, Reward, Case-Control Studies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
