Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Cites (333)

Items 201–330 of 330

1. Amyloid-β Dynamics Correlate with Neurological Status in the Injured Human Brain
   Brody, David L., Magnoni, Sandra, Schwetye, Kate E., Spinner, Michael L., Esparza, Thomas J., Stocchetti, Nino, Zipfel, Gregory J., Holtzman, David M. · 2008 · Science
2. Plasma and CSF neurofilament light
   Michelle M. Mielke, Jeremy A. Syrjanen, Kaj Blennow, Henrik Zetterberg, Prashanthi Vemuri, Ingmar Gr. Skoog, Mary M. Machulda, Walter K. Kremers, David S. Knopman, Clifford R. Jack et al. · 2019 · Neurology
3. Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease
   Aschenbrenner, Andrew J., Gordon, Brian A., Benzinger, Tammie L.S., Morris, John C., Hassenstab, Jason J. · 2018 · Neurology
4. A Genome-wide Gene-Expression Analysis and Database in Transgenic Mice during Development of Amyloid or Tau Pathology
   Matarin, Mar, Salih, Dervis A., Yasvoina, Marina, Cummings, Damian M., Guelfi, Sebastian, Liu, Wenfei, Nahaboo Solim, Muzammil A., Moens, Thomas G., Paublete, Rocio Moreno, Ali, Shabinah S. et al. · 2015 · Cell Reports
5. Safety and tolerability of BAN2401 - a clinical study in Alzheimer’s disease with a protofibril selective Aβ antibody
   Veronika Logovinsky, Andrew Satlin, Robert Y. K. Lai, Chad J. Swanson, June M. Kaplow, Gunilla Osswald, Hans Basun, Lars Lannfelt · 2016 · Alzheimer s Research & Therapy
6. Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer’s Disease Brain
   DeVos, Sarah L., Corjuc, Bianca T., Oakley, Derek H., Nobuhara, Chloe K., Bannon, Riley N., Chase, Alison, Commins, Caitlin, Gonzalez, Jose A., Dooley, Patrick M., Frosch, Matthew P. et al. · 2018 · Frontiers in Neuroscience
7. Induction of Tau Pathology by Intracerebral Infusion of Amyloid-β-Containing Brain Extract and by Amyloid-β Deposition in APP × Tau Transgenic Mice
   Bolmont, Tristan, Clavaguera, Florence, Meyer-Luehmann, Melanie, Herzig, Martin C., Radde, Rebecca, Staufenbiel, Matthias, Lewis, Jada, Hutton, Mike, Tolnay, Markus, Jucker, Mathias · 2007 · The American Journal of Pathology
8. Induction of cerebral β-amyloidosis: Intracerebral versus systemic Aβ inoculation
   Eisele, Yvonne S., Bolmont, Tristan, Heikenwalder, Mathias, Langer, Franziska, Jacobson, Laura H., Yan, Zheng-Xin, Roth, Klaus, Aguzzi, Adriano, Staufenbiel, Matthias, Walker, Lary C. et al. · 2009 · Proceedings of the National Academy of Sciences
9. Lessons from a failed γ-secretase Alzheimer trial
   De Strooper, Bart · 2014 · Cell
10. A critique of the drug discovery and phase 3 clinical programs targeting the amyloid hypothesis for Alzheimer disease
    Eric H. Karran, John Hardy · 2014 · Annals of Neurology
11. Human<i>APOE</i>Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice
    Bales, Kelly R., Liu, Feng, Wu, Su, Lin, Suizhen, Koger, Deanna, DeLong, Cynthia, Hansen, Jeffrey C., Sullivan, Patrick M., Paul, Steven M. · 2009 · The Journal of Neuroscience
12. Cerebrovascular Effects of Apolipoprotein E: Implications for Alzheimer Disease
    Zlokovic, Berislav V. · 2013 · JAMA Neurology
13. Long-Term Follow-Up of Patients Immunized with AN1792: Reduced Functional Decline in Antibody Responders
    Bruno J. Vellas, Ronald S. Black, Leon J. Thal, Nick C. Fox, Maki Daniels, G. McLennan, C. Tompkins, Christopher W. Leibman, M. Pomfret, Michael Grundman · 2009 · Current Alzheimer Research
14. A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia
    Pontecorvo, Michael J, Devous, Michael D, Kennedy, Ian, Navitsky, Michael, Lu, Ming, Galante, Nicholas, Salloway, Stephen, Doraiswamy, P Murali, Southekal, Sudeepti, Arora, Anupa K et al. · 2019 · Brain
15. Etanercept in Alzheimer disease
    Joe Butchart, Laura Brook, Vivienne Hopkins, Jessica L. Teeling, Ursula Püntener, David J. Culliford, Richard Sharples, Saif Sharif, Brady McFarlane, Rachel Raybould et al. · 2015 · Neurology
16. Structural Principles of Tau and the Paired Helical Filaments of Alzheimer's Disease
    Mandelkow, Eckhard, Von Bergen, Martin, Biernat, Jacek, Mandelkow, Eva‐Maria · 2007 · Brain Pathology
17. Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease
    TCW, Julia, Goate, Alison M. · 2017 · Cold Spring Harbor Perspectives in Medicine
18. Targeting Prodromal Alzheimer Disease With Avagacestat: A Randomized Clinical Trial
    Coric, Vladimir, Salloway, Stephen, van Dyck, Christopher H., Dubois, Bruno, Andreasen, Niels, Brody, Mark, Curtis, Craig, Soininen, Hilkka, Thein, Stephen, Shiovitz, Thomas et al. · 2015 · JAMA Neurology
19. Structural basis of Notch recognition by human γ-secretase
    Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei, Yigong Shi · 2018 · Nature
20. Shifts in gut microbiota composition in an APP/PSS1 transgenic mouse model of Alzheimer’s disease during lifespan
    Bäuerl, C., Collado, M.C., Diaz Cuevas, A., Viña, J., Pérez Martínez, G. · 2018 · Letters in Applied Microbiology
21. Amyloid accelerates tau propagation and toxicity in a model of early Alzheimer’s disease
    Pooler, Amy M, Polydoro, Manuela, Maury, Eduardo A, Nicholls, Samantha B, Reddy, Snigdha M, Wegmann, Susanne, William, Christopher, Saqran, Lubna, Cagsal-Getkin, Ozge, Pitstick, Rose et al. · 2015 · Acta Neuropathologica Communications
22. Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy
    Sayed, Faten A., Telpoukhovskaia, Maria, Kodama, Lay, Li, Yaqiao, Zhou, Yungui, Le, David, Hauduc, Axel, Ludwig, Connor, Gao, Fuying, Clelland, Claire et al. · 2018 · Proceedings of the National Academy of Sciences
23. Analysis of the relationship between the gut microbiome and dementia: a cross-sectional study conducted in Japan
    Saji, Naoki, Niida, Shumpei, Murotani, Kenta, Hisada, Takayoshi, Tsuduki, Tsuyoshi, Sugimoto, Taiki, Kimura, Ai, Toba, Kenji, Sakurai, Takashi · 2019 · Scientific Reports
24. Conformational Diversity of Wild-type Tau Fibrils Specified by Templated Conformation Change
    Frost, Bess, Ollesch, Julian, Wille, Holger, Diamond, Marc I. · 2009 · Journal of Biological Chemistry
25. Aβ accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model
    Hurtado, David E., Molina-Porcel, Laura, Iba, Michiyo, Aboagye, Awo K., Paul, Steven M., Trojanowski, John Q., Lee, Virginia M.-Y. · 2010 · The American Journal of Pathology
26. ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons<i>In Vivo</i>
    Dumanis, Sonya B., Tesoriero, Joseph A., Babus, Lenard W., Nguyen, Madeline T., Trotter, Justin H., Ladu, Mary Jo, Weeber, Edwin J., Turner, R. Scott, Xu, Baoji, Rebeck, G. William et al. · 2009 · The Journal of Neuroscience
27. Apolipoprotein E and Alzheimer's disease: the influence of apolipoprotein E on amyloid-β and other amyloidogenic proteins
    Huynh, Tien-Phat V., Davis, Albert A., Ulrich, Jason D., Holtzman, David M. · 2017 · Journal of Lipid Research
28. Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
    Huynh, Tien-Phat V., Liao, Fan, Francis, Caroline M., Robinson, Grace O., Serrano, Javier Remolina, Jiang, Hong, Roh, Joseph, Finn, Mary Beth, Sullivan, Patrick M., Esparza, Thomas J. et al. · 2017 · Neuron
29. The viral protein corona directs viral pathogenesis and amyloid aggregation
    Ezzat, Kariem, Pernemalm, Maria, Pålsson, Sandra, Roberts, Thomas C., Järver, Peter, Dondalska, Aleksandra, Bestas, Burcu, Sobkowiak, Michal J., Levänen, Bettina, Sköld, Magnus et al. · 2019 · Nature Communications
30. Alzheimer disease and aducanumab: adjusting our approach
    Selkoe, Dennis J. · 2019 · Nature Reviews Neurology
31. β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1
    Bourgade, Karine, Garneau, Hugo, Giroux, Geneviève, Le Page, Aurélie Y., Bocti, Christian, Dupuis, Gilles, Frost, Eric H., Fülöp, Tamàs · 2015 · Biogerontology
32. Herpes virus in Alzheimer's disease: relation to progression of the disease
    Ilaria Carbone, Tiziana Lazzarotto, Manuela Ianni, Elisa Porcellini, Paola Forti, Eliezer Masliah, Liliana Gabrielli, Federico Licastro · 2013 · Neurobiology of Aging
33. Persistent neuropathological effects 14 years following amyloid-β immunization in Alzheimer’s disease
    James A. R. Nicoll, George R. Buckland, Charlotte H. Harrison, Anton M. Page, Scott Harris, Seth Love, James Neal, Clive Holmes, Delphine Boche · 2019 · Brain
34. Reduced Slow-Wave Sleep Is Associated with High Cerebrospinal Fluid Aβ42 Levels in Cognitively Normal Elderly
    Varga, Andrew W., Wohlleber, Margaret E., Giménez, Sandra, Romero, Sergio, Alonso, Joan F., Ducca, Emma L., Kam, Korey, Lewis, Clifton, Tanzi, Emily B., Tweardy, Samuel et al. · 2016 · SLEEP
35. APOε4 is associated with enhanced in vivo innate immune responses in human subjects
    Gale, Stephen C., Gao, Li, Mikacenic, Carmen, Coyle, Susette M., Rafaels, Nicholas, Murray Dudenkov, Tanda, Madenspacher, Jennifer H., Draper, David W., Ge, William, Aloor, Jim J. et al. · 2014 · Journal of Allergy and Clinical Immunology
36. Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-β Amyloidosis
    Kim, Jungsu, Jiang, Hong, Park, Seonha, Eltorai, Adam E. M., Stewart, Floy R., Yoon, Hyejin, Basak, Jacob M., Finn, Mary Beth, Holtzman, David M. · 2011 · The Journal of Neuroscience
37. Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies
    Conn M. Harrington, Sharon T. Sawchak, Carl Chiang, J. Davies, Carly Donovan, Ann M. Saunders, Michael C. Irizarry, Barbara Jeter, Marina E. Zvartau-Hind, Chris H. van Dyck et al. · 2011 · Current Alzheimer Research
38. Glutamate transmission and toxicity in alzheimer's disease
    J. Timothy Greenamyre, William F. Maragos, Roger L. Albin, John B. Penney, Anne B. Young · 1988 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
39. Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer’s Disease
    Henley, David, Raghavan, Nandini, Sperling, Reisa, Aisen, Paul, Raman, Rema, Romano, Gary · 2019 · New England Journal of Medicine
40. Treatment for Rheumatoid Arthritis and Risk of Alzheimer’s Disease: A Nested Case-Control Analysis
    Chou, Richard C., Kane, Michael, Ghimire, Sanjay, Gautam, Shiva, Gui, Jiang · 2016 · CNS Drugs
41. Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial
    Lawlor, Brian, Segurado, Ricardo, Kennelly, Sean, Olde Rikkert, Marcel G. M., Howard, Robert, Pasquier, Florence, Börjesson-Hanson, Anne, Tsolaki, Magda, Lucca, Ugo, Molloy, D. William et al. · 2018 · PLOS Medicine
42. Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes
    Basak, Jacob M., Verghese, Philip B., Yoon, Hyejin, Kim, Jungsu, Holtzman, David M. · 2012 · Journal of Biological Chemistry
43. Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone
    Purro, Silvia A., Farrow, Mark A., Linehan, Jacqueline, Nazari, Tamsin, Thomas, David X., Chen, Zhicheng, Mengel, David, Saito, Takashi, Saido, Takaomi, Rudge, Peter et al. · 2018 · Nature
44. Image reconstruction of the Alzheimer paired helical filament.
    R. Anthony Crowther, Claude M. Wischik · 1985 · The EMBO Journal
45. Gene Transfer of Human <i>Apoe</i> Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain
    Hudry, Eloise, Dashkoff, Jonathan, Roe, Alysson D., Takeda, Shuko, Koffie, Robert M., Hashimoto, Tadafumi, Scheel, Maria, Spires-Jones, Tara, Arbel-Ornath, Michal, Betensky, Rebecca et al. · 2013 · Science Translational Medicine
46. APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern
    Shannon L. Risacher, Sungeun Kim, Kwangsik T. Nho, Tatiana Foroud, Li Shen, Ronald Carl Petersen, Clifford R. Jack, Laurel A. Beckett, Paul S. S Aisen, Robert A. Koeppe et al. · 2015 · Alzheimer s & Dementia
47. Recognition of the Amyloid Precursor Protein by Human gamma-secretase
    Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi · 2018 · Worldwide Protein Data Bank
48. Anti‐tau antibody reduces insoluble tau and decreases brain atrophy
    Yanamandra, Kiran, Jiang, Hong, Mahan, Thomas E., Maloney, Susan E., Wozniak, David F., Diamond, Marc I., Holtzman, David M. · 2015 · Annals of Clinical and Translational Neurology
49. Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer’s disease
    Najm, Ramsey, Jones, Emily A., Huang, Yadong · 2019 · Molecular Neurodegeneration
50. Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer’s disease-like pathology
    Nuriel, Tal, Angulo, Sergio L., Khan, Usman, Ashok, Archana, Chen, Qiuying, Figueroa, Helen Y., Emrani, Sheina, Liu, Li, Herman, Mathieu, Barrett, Geoffrey et al. · 2017 · Nature Communications
51. Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation
    Liao, Fan, Li, Aimin, Xiong, Monica, Bien-Ly, Nga, Jiang, Hong, Zhang, Yin, Finn, Mary Beth, Hoyle, Rosa, Keyser, Jennifer, Lefton, Katheryn B. et al. · 2018 · Journal of Clinical Investigation
52. Herpes simplex virus type 1 DNA is present in specific regions of brain from aged people with and without senile dementia of the Alzheimer type
    Gordon A. Jamieson, Norman J. Maitland, Gordon Keith Wilcock, Celia M. Yates, Ruth F. Itzhaki · 1992 · The Journal of Pathology
53. Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent Aβ Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice
    Bien-Ly, Nga, Gillespie, Anna K., Walker, David, Yoon, Seo Yeon, Huang, Yadong · 2012 · The Journal of Neuroscience
54. AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease
    Rosenberg, Jonathan B., Kaplitt, Michael G., De, Bishnu P., Chen, Alvin, Flagiello, Thomas, Salami, Christiana, Pey, Eduard, Zhao, Lingzhi, Ricart Arbona, Rodolfo J., Monette, Sebastien et al. · 2018 · Human Gene Therapy Clinical Development
55. Neuropathological correlates and genetic architecture of microglial activation in elderly human brain
    Felsky, Daniel, Roostaei, Tina, Nho, Kwangsik, Risacher, Shannon L., Bradshaw, Elizabeth M., Petyuk, Vlad, Schneider, Julie A., Saykin, Andrew, Bennett, David A., De Jager, Philip L. · 2019 · Nature Communications
56. Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease
    Alireza Atri, Lutz Frölich, Clive G. Ballard, Pierre N. Tariot, José Luís Molinuevo, Neli Boneva, Kristian Windfeld, Lars Lau Rakêt, Jeffrey L. Cummings · 2018 · JAMA
57. Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice
    Hu, Jin, Liu, Chia-Chen, Chen, Xiao-Fen, Zhang, Yun-wu, Xu, Huaxi, Bu, Guojun · 2015 · Molecular Neurodegeneration
58. Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis
    Kim, Jungsu, Eltorai, Adam E.M., Jiang, Hong, Liao, Fan, Verghese, Philip B., Kim, Jaekwang, Stewart, Floy R., Basak, Jacob M., Holtzman, David M. · 2012 · Journal of Experimental Medicine
59. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment
    Sohn, Peter Dongmin, Tracy, Tara E., Son, Hye-In, Zhou, Yungui, Leite, Renata E. P., Miller, Bruce L., Seeley, William W., Grinberg, Lea T., Gan, Li · 2016 · Molecular Neurodegeneration
60. A phase 3 trial of IV immunoglobulin for Alzheimer disease
    Relkin, Norman R., Thomas, Ronald G., Rissman, Robert A., Brewer, James B., Rafii, Michael S., van Dyck, Christopher H., Jack, Clifford R., Sano, Mary, Knopman, David S., Raman, Rema et al. · 2017 · Neurology
61. Low-density lipoprotein receptor overexpression enhances the rate of brain-to-blood Aβ clearance in a mouse model of β-amyloidosis
    Castellano, Joseph M., Deane, Rashid, Gottesdiener, Andrew J., Verghese, Philip B., Stewart, Floy R., West, Tim, Paoletti, Andrew C., Kasper, Tristan R., DeMattos, Ronald B., Zlokovic, Berislav V. et al. · 2012 · Proceedings of the National Academy of Sciences
62. Cryo-EM structure of gamma secretase in complex with a Notch fragment
    Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei, Yigong Shi · 2018 · Worldwide Protein Data Bank
63. Preclinical Assessment of Young Blood Plasma for Alzheimer Disease
    Middeldorp, Jinte, Lehallier, Benoit, Villeda, Saul A., Miedema, Suzanne S. M., Evans, Emily, Czirr, Eva, Zhang, Hui, Luo, Jian, Stan, Trisha, Mosher, Kira I. et al. · 2016 · JAMA Neurology
64. Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype
    Mishra, Shruti, Blazey, Tyler M, Holtzman, David M, Cruchaga, Carlos, Su, Yi, Morris, John C, Benzinger, Tammie L S, Gordon, Brian A · 2018 · Brain
65. No Effect of One-Year Treatment with Indomethacin on Alzheimer's Disease Progression: A Randomized Controlled Trial
    Daniëlle de Jong, R.W.M.M. Jansen, Willibrord H. L. Hoefnagels, Jellesma-Eggenkamp Mj, Marcel M. Verbeek, George F. Borm, Berry P. H. Kremer · 2008 · PLoS ONE
66. Active Aβ immunotherapy CAD106 in Alzheimer's disease: A phase 2b study
    Rik R. Vandenberghe, Marie‐Emmanuelle Riviere, Angelika Caputo, Judit Sóvágó, Ralph Paul Maguire, Martin Rhys Farlow, Giovanni Marotta, Raquel Sánchez‐Valle, Philip Scheltens, J. Michael Ryan et al. · 2016 · Alzheimer s & Dementia Translational Research & Clinical Interventions
67. Aspirin in Alzheimer's disease (AD2000): a randomised open-label trial
    AD Collaborative Group · 2008 · The Lancet Neurology
68. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation
    Crowe, Alex, James, Michael J., Lee, Virginia M.-Y., Smith, Amos B., Trojanowski, John Q., Ballatore, Carlo, Brunden, Kurt R. · 2013 · Journal of Biological Chemistry
69. Herpes Zoster and Dementia: A Nationwide Population-Based Cohort Study
    Chen, Vincent Chin-Hung, Wu, Shu-I, Huang, Kuo-You, Yang, Yao-Hsu, Kuo, Ting-Yu, Liang, Hsin-Yi, Huang, Kuan-Lun, Gossop, Michael · 2018 · The Journal of Clinical Psychiatry
70. APOE ε2 is associated with increased tau pathology in primary tauopathy
    Zhao, Na, Liu, Chia-Chen, Van Ingelgom, Alexandra J., Linares, Cynthia, Kurti, Aishe, Knight, Joshua A., Heckman, Michael G., Diehl, Nancy N., Shinohara, Mitsuru, Martens, Yuka A. et al. · 2018 · Nature Communications
71. Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies.
    Tim West, Y Hu, Philip B. Verghese, Randall John Bateman, Joel B. Braunstein, Ilana Fogelman, K Budur, Hana Florian, N Mendonca, David M. Holtzman · 2017 · PubMed
72. Anti-ApoE Antibody Given after Plaque Onset Decreases Aβ Accumulation and Improves Brain Function in a Mouse Model of Aβ Amyloidosis
    Liao, Fan, Hori, Yukiko, Hudry, Eloise, Bauer, Adam Q., Jiang, Hong, Mahan, Thomas E., Lefton, Katheryn B., Zhang, Tony J., Dearborn, Joshua T., Kim, Jungsu et al. · 2014 · The Journal of Neuroscience
73. The Alzheimer's Prevention Initiative Autosomal‐Dominant Alzheimer's Disease Trial: A study of crenezumab versus placebo in preclinical <i>PSEN1</i> E280A mutation carriers to evaluate efficacy and safety in the treatment of autosomal‐dominant Alzheimer's disease, including a placebo‐treated noncarrier cohort
    Tariot, Pierre N., Lopera, Francisco, Langbaum, Jessica B., Thomas, Ronald G., Hendrix, Suzanne, Schneider, Lon S., Rios‐Romenets, Silvia, Giraldo, Margarita, Acosta, Natalia, Tobon, Carlos et al. · 2018 · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions
74. Amyloidogenic amyloid-β-peptide variants induce microbial agglutination and exert antimicrobial activity
    Spitzer, Philipp, Condic, Mateja, Herrmann, Martin, Oberstein, Timo Jan, Scharin-Mehlmann, Marina, Gilbert, Daniel F., Friedrich, Oliver, Grömer, Teja, Kornhuber, Johannes, Lang, Roland et al. · 2016 · Scientific Reports
75. γ-secretase modulators and presenilin 1 mutants act differently on presenilin/γ-secretase function to cleave Aβ42 and Aβ43
    Okochi, Masayasu, Tagami, Shinji, Yanagida, Kanta, Takami, Mako, Kodama, Takashi S., Mori, Kohji, Nakayama, Taisuke, Ihara, Yasuo, Takeda, Masatoshi · 2013 · Cell Reports
76. Translating the biology of aging into novel therapeutics for Alzheimer disease
    Yuko Hara, Nicholas McKeehan, Howard M. Fillit · 2018 · Neurology
77. A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer’s disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity
    DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank), van der Lee, Sven J., EADB (Alzheimer Disease European DNA biobank), IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium), RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia), Netherlands Brain Bank (NBB), The GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Conway, Olivia J., Jansen, Iris et al. · 2019 · Acta Neuropathologica
78. Sleep deprivation and cerebrospinal fluid biomarkers for Alzheimer’s disease
    Martin A. Olsson, Johan Ärlig, Jan Anders Hedner, Kaj Blennow, Henrik Zetterberg · 2018 · SLEEP
79. The Alzheimer’s Prevention Initiative Generation Program: study design of two randomized controlled trials for individuals at risk for clinical onset of Alzheimer’s disease
    Lopez Lopez, Cristina, Tariot, Pierre N., Caputo, Angelika, Langbaum, Jessica B., Liu, Fonda, Riviere, Marie‐Emmanuelle, Langlois, Carolyn, Rouzade‐Dominguez, Marie‐Laure, Zalesak, Martin, Hendrix, Suzanne et al. · 2019 · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions
80. AADvac1, an Active Immunotherapy for Alzheimer's Disease and Non Alzheimer Tauopathies: An Overview of Preclinical and Clinical Development
    Petr Novák, Norbert Žilka, Monika Žilková, Branislav Kováčech, Rostislav Škrabana, Matej Ondrus, L Fialová, Eva Kontseková, Markus Otto, M Novák · 2019 · The Journal of Prevention of Alzheimer s Disease
81. Safety of the tau-directed monoclonal antibody BIIB092 in progressive supranuclear palsy: a randomised, placebo-controlled, multiple ascending dose phase 1b trial.
    A. Boxer, I. Qureshi, M. Ahlijanian, M. Grundman, L. Golbe, I. Litvan, Lawrence S. Honig, P. Tuite, Nikolaus R. McFarland, P. O'Suilleabhain et al. · 2019 · Lancet Neurology
82. Regional brain hypometabolism is unrelated to regional amyloid plaque burden
    André Altmann, Bernard Ng, Susan M. Landau, William J. Jagust, Michael D. Greicius · 2015 · Brain
83. Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment
    Gan, Kathlyn J., Südhof, Thomas C. · 2019 · Proceedings of the National Academy of Sciences
84. Blood–Brain Barrier Penetrating Biologic TNF-α Inhibitor for Alzheimer’s Disease
    Rudy Chang, Jillian Knox, Jae Hoon Chang, Aram Derbedrossian, Vitaly Vasilevko, David H. Cribbs, Rubén J. Boado, William M. Pardridge, Rachita K. Sumbria · 2017 · Molecular Pharmaceutics
85. INTREPAD: A randomized trial of naproxen to slow progress of presymptomatic Alzheimer disease
    Meyer, Pierre-François, Tremblay-Mercier, Jennifer, Leoutsakos, Jeannie, Madjar, Cécile, Lafaille-Maignan, Marie-Élyse, Savard, Melissa, Rosa-Neto, Pedro, Poirier, Judes, Etienne, Pierre, Breitner, John et al. · 2019 · Neurology
86. Safety, tolerability and immunogenicity of an active anti-Aβ40 vaccine (ABvac40) in patients with Alzheimer’s disease: a randomised, double-blind, placebo-controlled, phase I trial
    Lacosta, Ana-María, Pascual-Lucas, María, Pesini, Pedro, Casabona, Diego, Pérez-Grijalba, Virginia, Marcos-Campos, Iván, Sarasa, Leticia, Canudas, Jesus, Badi, Hassnae, Monleón, Inmaculada et al. · 2018 · Alzheimer's Research &amp; Therapy
87. Safety, Tolerability, and Feasibility of Young Plasma Infusion in the Plasma for Alzheimer Symptom Amelioration Study: A Randomized Clinical Trial
    Sha, Sharon J., Deutsch, Gayle K., Tian, Lu, Richardson, Kara, Coburn, Maria, Gaudioso, Jennifer L., Marcal, Tatiana, Solomon, Ethan, Boumis, Athanasia, Bet, Anthony et al. · 2019 · JAMA Neurology
88. Longitudinal β-Amyloid Deposition and Hippocampal Volume in Preclinical Alzheimer Disease and Suspected Non–Alzheimer Disease Pathophysiology
    Gordon, Brian A., Blazey, Tyler, Su, Yi, Fagan, Anne M., Holtzman, David M., Morris, John C., Benzinger, Tammie L. S. · 2016 · JAMA Neurology
89. Progression of Cerebral Amyloid Load Is Associated with the Apolipoprotein E ε4 Genotype in Alzheimer's Disease
    Timo Grimmer, Susanne Tholen, Behrooz H. Yousefi, Panagiotis Alexopoulos, Annette Förschler, Hans Förstl, Gjermund Henriksen, William Edward Klunk, Chester A. Mathis, Robert Perneczky et al. · 2010 · Biological Psychiatry
90. Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy
    Yanamandra, Kiran, Patel, Tirth K., Jiang, Hong, Schindler, Suzanne, Ulrich, Jason D., Boxer, Adam L., Miller, Bruce L., Kerwin, Diana R., Gallardo, Gilbert, Stewart, Floy et al. · 2017 · Science Translational Medicine
91. BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization
    Hitt, Brian D, Jaramillo, Thomas C, Chetkovich, Dane M, Vassar, Robert · 2010 · Molecular Neurodegeneration
92. The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb
    Tharinda W. Rajapaksha, William A. Eimer, Thomas C. Bozza, Robert J. Vassar · 2011 · Molecular Neurodegeneration
93. Apolipoprotein E4 produced in GABAergic interneurons causes learning and memory deficits in mice
    Knoferle, Johanna, Yoon, Seo Yeon, Walker, David, Leung, Laura, Gillespie, Anna K., Tong, Leslie M., Bien-Ly, Nga, Huang, Yadong · 2014 · The Journal of Neuroscience
94. Axonal organization defects in the hippocampus of adult conditional BACE1 knockout mice
    Ou-Yang, Ming-Hsuan, Kurz, Jonathan E., Nomura, Toshihiro, Popovic, Jelena, Rajapaksha, Tharinda W., Dong, Hongxin, Contractor, Anis, Chetkovich, Dane M., Tourtellotte, Warren G., Vassar, Robert · 2018 · Science Translational Medicine
95. BACE inhibitors in clinical development for the treatment of Alzheimer’s disease
    Panza, Francesco, Lozupone, Madia, Solfrizzi, Vincenzo, Sardone, Rodolfo, Piccininni, Carla, Dibello, Vittorio, Stallone, Roberta, Giannelli, Gianluigi, Bellomo, Antonello, Greco, Antonio et al. · 2018 · Expert Review of Neurotherapeutics
96. Effects of Simvastatin on Cerebrospinal Fluid Biomarkers and Cognition in Middle-Aged Adults at Risk for Alzheimer's Disease
    Cynthia M. Carlsson, Carey Elizabeth Gleason, Timothy Hess, Kimberly A. Moreland, Hanna M. Blazel, Rebecca L. Koscik, Nathan Todd Nelson Schreiber, Sterling C. Johnson, Craig Atwood, Luigi Puglielli et al. · 2008 · Journal of Alzheimer s Disease
97. Plasma exchange for Alzheimer's disease Management by Albumin Replacement (AMBAR) trial: Study design and progress
    Boada, Mercè, López, Oscar, Núñez, Laura, Szczepiorkowski, Zbigniew M., Torres, Mireia, Grifols, Carlota, Páez, Antonio · 2019 · Alzheimer's &amp; Dementia: Translational Research &amp; Clinical Interventions
98. Neuroimaging correlates with neuropathologic schemes in neurodegenerative disease
    Lowe, Val J., Lundt, Emily S., Albertson, Sabrina M., Przybelski, Scott A., Senjem, Matthew L., Parisi, Joseph E., Kantarci, Kejal, Boeve, Bradley, Jones, David T., Knopman, David et al. · 2019 · Alzheimer's &amp; Dementia
99. The Involvement of Post-Translational Modifications in Alzheimer's Disease
    Serena Marcelli, Massimo Corbo, Filomena Iannuzzi, Lucia Negri, Fabio Blandini, Robert Nisticò, Marco Feligioni · 2017 · Current Alzheimer Research
100. Aβ-induced vulnerability propagates via the brain’s default mode network
     Tharick Ali Pascoal, Sulantha Sanjeewa Mathotaarachchi, Min Su Kang, Sara Mohaddes, Monica Shin, Ah Yeon Park, Maxime J. Parent, Andréa Lessa Benedet, Mira Chamoun, Joseph Therriault et al. · 2019 · Nature Communications
101. BACE1 inhibition more effectively suppresses initiation than progression of β-amyloid pathology
     Finn Peters, Hazal Salihoglu, Eva Ferreira Rodrigues, Étienne Herzog, Tanja Blume, Severin Filser, Mario M. Dorostkar, Derya R. Shimshek, Nils Brose, Ulf Neumann et al. · 2018 · Acta Neuropathologica
102. O-GlcNAc Modification Protects against Protein Misfolding and Aggregation in Neurodegenerative Disease
     Philip Ryan, Mingming Xu, Andrew Keith Davey, Jonathan J. Danon, George D. Mellick, Michael Kassiou, Santosh Rudrawar · 2019 · ACS Chemical Neuroscience
103. Follow‐up evaluation of cognitive function in the randomized Alzheimer's Disease Anti‐inflammatory Prevention Trial and its Follow‐up Study
     ADAPT-FS Research Group · 2014 · Alzheimer s & Dementia
104. Cellular Source of Apolipoprotein E4 Determines Neuronal Susceptibility to Excitotoxic Injury in Transgenic Mice
     Buttini, Manuel, Masliah, Eliezer, Yu, Gui-Qiu, Palop, Jorge J., Chang, Shengjun, Bernardo, Aubrey, Lin, Carol, Wyss-Coray, Tony, Huang, Yadong, Mucke, Lennart · 2010 · The American Journal of Pathology
105. NLRP3-dependent synaptic plasticity deficit in an Alzheimer's disease amyloidosis model in vivo
     Yingjie Qi, Igor V. Klyubin, A. Claudio Cuello, Michael J. Rowan · 2018 · Neurobiology of Disease
106. Opposing Synaptic Regulation of Amyloid-β Metabolism by NMDA Receptors <i>In Vivo</i>
     Verges, Deborah K., Restivo, Jessica L., Goebel, Whitney D., Holtzman, David M., Cirrito, John R. · 2011 · The Journal of Neuroscience
107. A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
     Lei Liu, Li Ding, Matteo Rovere, Michael S. Wolfe, Dennis J. Selkoe · 2019 · The Journal of Cell Biology
108. Modulation of γ- and β-secretases as early prevention against Alzheimer's disease
     Voytyuk, Iryna, De Strooper, Bart, Chávez-Gutiérrez, Lucía · 2018 · Biological Psychiatry
109. Cholinesterase Inhibitors May Not Benefit Mild Cognitive Impairment and Mild Alzheimer Disease Dementia
     Jee-Young Han, Lilah M. Besser, Chengjie Xiong, Walter A. Kukull, John C. Morris · 2019 · Alzheimer Disease & Associated Disorders
110. Decreased plasma β‐amyloid in the Alzheimer's disease <scp> <i>APP</i> </scp> <scp>A</scp> 673 <scp>T</scp> variant carriers
     Martiskainen, Henna, Herukka, Sanna‐Kaisa, Stančáková, Alena, Paananen, Jussi, Soininen, Hilkka, Kuusisto, Johanna, Laakso, Markku, Hiltunen, Mikko · 2017 · Annals of Neurology
111. Widespread distribution of tauopathy in preclinical Alzheimer's disease
     Stephanie A. Schultz, Brian Andrew Gordon, Shruti Mishra, Yi Su, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Beau M. Ances, Tammie L.S. Benzinger · 2018 · Neurobiology of Aging
112. Persistence of Aβ seeds in APP null mouse brain
     Lan Ye, Sarah K. Fritschi, Juliane Schelle, Ulrike Obermüller, Karoline Degenhardt, Stephan A. Kaeser, Yvonne S. Eisele, Lary C. Walker, Frank Baumann, Matthias Staufenbiel et al. · 2015 · Nature Neuroscience
113. Elucidating Tau function and dysfunction in the era of cryo-EM
     Guy M. Lippens, Benoı̂t Gigant · 2019 · Journal of Biological Chemistry
114. γ-Secretase and its modulators: Twenty years and beyond
     Xia, Weiming · 2019 · Neuroscience Letters
115. Co-expression of β-amyloid precursor protein (βAPP) and apolipoprotein E in cell culture: analysis of βAPP processing
     Biere, Anja Leona, Ostaszewski, Beth, Zhao, Hongwei, Gillespie, Susan, Younkin, Steven G., Selkoe, Dennis J. · 1995 · Neurobiology of Disease
116. Antibody Therapeutics Targeting Aβ and Tau
     Gilbert Gallardo, David M. Holtzman · 2017 · Cold Spring Harbor Perspectives in Medicine
117. Effects of apolipoprotein E (apoE) isoforms, β-amyloid (Aβ) and apoE/Aβ complexes on Protein Kinase C-α (PKC-α) translocation and amyloid precursor protein (APP) processing in human SH-SY5Y neuroblastoma cells and fibroblasts
     Cedazo-Mı́nguez, Angel, Wiehager, Birgitta, Winblad, Bengt, Hüttinger, Manfred, Cowburn, Richard F. · 2001 · Neurochemistry International
118. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606
     Steven L. Wagner, Kevin D. Rynearson, Steven K. Duddy, Can Martin Zhang, Phuong D. Nguyen, Ann Becker, Uyen Vo, Deborah Masliah, Louise Monte, Justin B. Klee et al. · 2017 · Journal of Pharmacology and Experimental Therapeutics
119. Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice
     Hunter, Jesse M., Cirrito, John R., Restivo, Jessica L., Kinley, Robert D., Sullivan, Patrick M., Holtzman, David M., Koger, Deanna, Delong, Cynthia, Lin, Suizhen, Zhao, Lingzhi et al. · 2012 · Brain Research
120. Effect of Apolipoprotein E4 on clinical, neuroimaging and biomarker measures in non-carrier participants in the Dominantly Inherited Alzheimer Network
     A. Bussy, B. Snider, D. Coble, C. Xiong, A. Fagan, C. Cruchaga, T. Benzinger, B. Gordon, Jason J. Hassenstab, R. Bateman et al. · 2018 · Neurobiology of Aging
121. Evidence for the Efficacy of Latrepirdine (Dimebon) Treatment for Improvement of Cognitive Function: A Meta-Analysis
     Nieves Cano Cuenca, Julián Solís García del Pozo, Joaquı́n Jordán · 2013 · Journal of Alzheimer s Disease
122. No Overt Deficits in Aged Tau-Deficient C57Bl/6.Mapttm1(EGFP)Kit GFP Knockin Mice
     Annika van Hummel, Mian Bi, Stefania Ippati, Julia van der Hoven, Alexander M. Volkerling, Wei S. Lee, Daniel C. S. Tan, André Bongers, Arne Ittner, Yazi Diana Ke et al. · 2016 · PLoS ONE
123. Combination Therapy for Alzheimer's Disease: Perspectives of the EU/US CTAD Task Force
     Serge G. Gauthier, J. Alam, Howard M. Fillit, Takeshi Iwatsubo, H. Liu-Seifert, Marwan Noel Sabbagh, Stephen Salloway, Cristina Sampaio, John Randall Sims, B. K. Sperling et al. · 2019 · The Journal of Prevention of Alzheimer s Disease
124. Charting a path toward combination therapy for Alzheimer’s disease
     Stephenson, Diane, Perry, Dan, Bens, Cynthia, Bain, Lisa J, Berry, Donald, Krams, Michael, Sperling, Reisa, Dilts, David, Luthman, Johan, Hanna, Debra et al. · 2015 · Expert Review of Neurotherapeutics
125. PL‐03‐01: Microinfarcts: Key to prevention of the vascular burden in dementia?
     Geert Jan Biessels · 2015 · Alzheimer s & Dementia
126. N-methyl-D-aspartate receptor encephalitis mediates loss of intrinsic activity measured by functional MRI
     Matthew R. Brier, Gregory Scott Day, Abraham Z. Snyder, Aaron Tanenbaum, Beau M. Ances · 2016 · Journal of Neurology
127. Plasma-Based Strategies for Therapeutic Modulation of Brain Aging
     V. Kheifets, S. Braithwaite · 2019 · Neurotherapeutics
128. Is Now the Time for Combination Therapies for Alzheimer Disease?
     John C. Morris · 2019 · The Journal of Prevention of Alzheimer s Disease
129. Effects of Rofecoxib or Naproxen vs Placebo on Alzheimer Disease Progression: A Randomized Controlled Trial
     Aisen, Paul S., Schafer, Kimberly A., Grundman, Michael, Pfeiffer, Eric, Sano, Mary, Davis, Kenneth L., Farlow, Martin R., Jin, Shelia, Thomas, Ronald G., Thal, Leon J. et al. · 2003 · JAMA
130. Untitled work
     Price · 1999 · 10.1002/1531-8249(199903)45:3