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The Integrative Human Microbiome Project: Dynamic Analysis of Microbiome-Host Omics Profiles during Periods of Human Health and Disease
Open accessAbstract
Much has been learned about the diversity and distribution of human-associated microbial communities, but we still know little about the biology of the microbiome, how it interacts with the host, and how the host responds to its resident microbiota. The Integrative Human Microbiome Project (iHMP, http://hmp2.org), the second phase of the NIH Human Microbiome Project, will study these interactions by analyzing microbiome and host activities in longitudinal studies of disease-specific cohorts and by creating integrated data sets of microbiome and host functional properties. These data sets will serve as experimental test beds to evaluate new models, methods, and analyses on the interactions of host and microbiome. Here we describe the three models of microbiome-associated human conditions, on the dynamics of preterm birth, inflammatory bowel disease, and type 2 diabetes, and their underlying hypotheses, as well as the multi-omic data types to be collected, integrated, and distributed through public repositories as a community resource.
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Metadata
- Venue
- Cell Host & Microbe
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 16
- Issue
- 3
- Pages
- 276-289
- ISSN
- 1931-3128 (ISSN-L)
- PMC
- PMC5109542
- OpenAlex
- W2624135745
- Cited by
- 536
- References
- 80
- Citations by year
- 2026: 34 · 2025: 30 · 2024: 46 · 2023: 46 · 2022: 56 · 2021: 63 · 2020: 64 · 2019: 73 · 2018: 52 · 2017: 30 · 2016: 25 · 2015: 17
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Cell Host & Microbe (publishedVersion, cc-by)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institute on Aging (U19AG063744)
- National Human Genome Research Institute (U01HG004866)
- National Institute of Allergy and Infectious Diseases (UH3AI083263)
- National Institute of Diabetes and Digestive and Kidney Diseases (U54DK102556, U54DK102557)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD080784)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Keywords
- human microbiome, host-microbiome interactions, microbiome dynamics, preterm birth, inflammatory bowel disease, type 2 diabetes, multi-omics integration, longitudinal cohort, public data repositories
- MeSH terms
- Bacteria, Diabetes Mellitus, Type 2, Health, Humans, Inflammatory Bowel Diseases, Bacterial Physiological Phenomena, Premature Birth, Microbiota
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