Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

An obesity-associated gut microbiome with increased capacity for energy harvest

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Dose translation from animal to human studies revisited.

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The gut microbiota as an environmental factor that regulates fat storage

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Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

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Inflammatory Mechanisms in Obesity

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Mechanisms underlying the resistance to diet-induced obesity in germ-free mice

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CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

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Interleukin-1-receptor antagonist in type 2 diabetes mellitus

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The gut-liver axis in liver disease: Pathophysiological basis for therapy

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Inflammation in obesity, diabetes, and related disorders

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The gut-liver axis and the intersection with the microbiome

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The intestinal microbiota fuelling metabolic inflammation

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Triggering and resolution of inflammation in NASH

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Impaired aryl hydrocarbon receptor ligand production by the gut microbiota is a key factor in metabolic syndrome

Natividad, J. M., Agus, A., Planchais, J., Lamas, B., Jarry, A. C., Martin, R., Michel, M.-L., Chong-Nguyen, C., Roussel, R., Straube, M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.001 · Cited by 642

Immune mechanisms linking metabolic injury to inflammation and fibrosis in fatty liver disease – novel insights into cellular communication circuits

Peiseler, M., Schwabe, R., Hampe, J., Kubes, P., Heikenwälder, M., & Tacke, F. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.06.012 · Cited by 564

Tissue Tregs

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Chronic inflammation and the hallmarks of aging

Baechle, J. J., Chen, N., Makhijani, P., Winer, S., Furman, D., & Winer, D. A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101755 · Cited by 471

Global pandemics interconnected — obesity, impaired metabolic health and COVID-19

Stefan, N., Birkenfeld, A. L., & Schulze, M. B. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-00462-1 · Cited by 452

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383

T cell-mediated regulation of the microbiota protects against obesity

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Lipocalin-2: A Master Mediator of Intestinal and Metabolic Inflammation

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Microbiota imbalance induced by dietary sugar disrupts immune-mediated protection from metabolic syndrome

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The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

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Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance

Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2016.29 · Cited by 250

The initiation of metabolic inflammation in childhood obesity

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Type I Interferon Responses Drive Intrahepatic T Cells to Promote Metabolic Syndrome

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Targeting fatty acid metabolism to improve glucose metabolism

Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183

Intestinal Microbiota and Nonalcoholic Steatohepatitis

Brandl, K., & Schnabl, B. (2017) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000349 · Cited by 169

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

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Probiotics as Complementary Treatment for Metabolic Disorders

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The metabolic role of vagal afferent innervation

Waise, T. M. Z., Dranse, H. J., & Lam, T. K. T. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0062-1 · Cited by 140

Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

Wong, C. K., Yusta, B., Koehler, J. A., Baggio, L. L., McLean, B. A., Matthews, D., Seeley, R. J., & Drucker, D. J. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.08.003 · Cited by 138

Circulating NOD1 activators and hematopoietic NOD1 contribute to metabolic inflammation and insulin resistance

Chan, K. L., Tam, T. H., Boroumand, P., Prescott, D., Costford, S. R., Escalante, N. K., Fine, N., Tu, Y., Robertson, S. J., Prabaharan, D., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.02.027 · Cited by 88

Gut microbiota, fatty liver disease, and hepatocellular carcinoma

Chu, H., Williams, B., & Schnabl, B. (2018) · Liver Research · doi:10.1016/j.livres.2017.11.005 · Cited by 84

Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice

Shi, Z., Lei, H., Chen, G., Yuan, P., Cao, Z., Ser, H.-L., Zhu, X., Wu, F., Liu, C., Dong, M., et al. (2021) · mSystems · doi:10.1128/msystems.00985-20 · Cited by 71

Publisher Correction: The gut–liver axis and the intersection with the microbiome

Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0031-8 · Cited by 70

In vivo screening of multiple bacterial strains identifies Lactobacillus rhamnosus Lb102 and Bifidobacterium animalis ssp. lactis Bf141 as probiotics that improve metabolic disorders in a mouse model of obesity

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