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Cited by 607

The DOI matches its Crossref record; 89 of the 89 references it cites were found in a registry or an index.

Managing synchronous liver metastases from colorectal cancer: A multidisciplinary international consensus

Open access
Adam, René, de Gramont, Aimery, Figueras, Joan, Kokudo, Norihiro, Kunstlinger, Francis, Loyer, Evelyne, Poston, Graeme, Rougier, Philippe, Rubbia-Brandt, Laura, Sobrero, Alberto, Teh, Catherine, Tejpar, Sabine, Van Cutsem, Eric, Vauthey, Jean-Nicolas, Påhlman, Lars·2015·Cancer Treatment Reviews
DOI 10.1016/j.ctrv.2015.06.006
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Abstract

An international panel of multidisciplinary experts convened to develop recommendations for managing patients with colorectal cancer (CRC) and synchronous liver metastases (CRCLM). A modified Delphi method was used. CRCLM is defined as liver metastases detected at or before diagnosis of the primary CRC. Early and late metachronous metastases are defined as those detected ⩽12months and >12months after surgery, respectively. To provide information on potential curability, use of high-quality contrast-enhanced computed tomography (CT) before chemotherapy is recommended. Magnetic resonance imaging is increasingly being used preoperatively to aid detection of subcentimetric metastases, and alongside CT in difficult situations. To evaluate operability, radiology should provide information on: nodule size and number, segmental localization and relationship with major vessels, response after neoadjuvant chemotherapy, non-tumoral liver condition and anticipated remnant liver volume. Pathological evaluation should assess response to preoperative chemotherapy for both the primary tumour and metastases, and provide information on the tumour, margin size and micrometastases. Although the treatment strategy depends on the clinical scenario, the consensus was for chemotherapy before surgery in most cases. When the primary CRC is asymptomatic, liver surgery may be performed first (reverse approach). When CRCLM are unresectable, the goal of preoperative chemotherapy is to downsize tumours to allow resection. Hepatic resection should not be denied to patients with stable disease after optimal chemotherapy, provided an adequate liver remnant with inflow and outflow preservation remains. All patients with synchronous CRCLM should be evaluated by a hepatobiliary multidisciplinary team.

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Metadata

Authors
Adam, R., de Gramont, A., Figueras, J., Kokudo, N., Kunstlinger, F., Loyer, E., Poston, G., Rougier, P., Rubbia-Brandt, L., Sobrero, A., Teh, C., Tejpar, S., Van Cutsem, E., Vauthey, J.-N., & Påhlman, L.
Venue
Cancer Treatment Reviews
Publisher
Elsevier BV
Published
2015-11
Volume
41
Issue
9
Pages
729-741
ISSN
0305-7372 (ISSN-L)
DOI
10.1016/j.ctrv.2015.06.006
OpenAlex
W2109248500
Cited by
607
References
89
FWCI
13.26
Type
journal article
Language
en
Open access
hybrid

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