The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Exosome-Mediated Metastasis: Communication from a Distance
Open accessAbstract
Metastasis, a critical phase of tumor progression, remains a primary challenge in treating cancer and a major cause of cancer mortality. Cell-cell communication via extracellular vesicles (exosomes and microvesicles) between primary tumor cells and the microenvironment of distant organs is crucial for pre-metastatic niche (PMN) formation and metastasis. Here, we review work on the contribution of exosome cargo to cancer progression, the role of exosomes in PMN establishment, and the function of exosomes in organotropic metastasis. We also describe the clinical utility of exosomes.
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Metadata
- Authors
- Wortzel, I., Dror, S., Kenific, C. M., & Lyden, D.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 49
- Issue
- 3
- Pages
- 347-360
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2943261504
- Cited by
- 1,285
- References
- 15
- FWCI
- 44.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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