The role of dopamine in alcohol self-administration in humans: individual differences

Barrett, Sean P.; Pihl, Robert O.; Benkelfat, Chawki; Brunelle, Caroline; Young, Simon N.; Leyton, Marco

doi:10.1016/j.euroneuro.2008.01.008

Cited by 92Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and OutcomesNeural and Behavioral Psychology Studies

The role of dopamine in alcohol self-administration in humans: individual differences

Barrett, Sean P., Pihl, Robert O., Benkelfat, Chawki, Brunelle, Caroline, Young, Simon N., Leyton, Marco·2008·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2008.01.008

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Abstract

Objective To clarify dopamine's role in alcohol self-administration in a heterogeneous sample of drinkers using acute phenylalanine/tyrosine depletion (APTD).Methods Sixteen men with variable drinking histories were characterized on their ethanol-induced cardiac response, a marker previously proposed to index dopamine system reactivity and vulnerability to alcohol abuse. During separate sessions participants were administered (i) a nutritionally balanced (BAL) amino acid (AA) mixture, (ii) a mixture lacking the dopamine precursors, phenylalanine and tyrosine, and (iii) APTD followed by the dopamine precursor, L-DOPA. Five hours after AA administration, participants could earn units of alcohol using a progressive ratio breakpoint task.Results Alcohol self-administration was reduced in the APTD and APTD+L-DOPA conditions relative to the BAL condition. In both cases the changes were predicted by ethanol-induced cardiac change.Conclusions The motivation to drink is likely regulated by more than one neurobiological mechanism. Individual differences in cardiac responsivity to ethanol might provide a peripheral marker of responsiveness to pharmacological manipulations of dopamine.

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Haloperidol Reduces Stimulant and Reinforcing Effects of Ethanol in Social Drinkers
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A reward-centred model of anorexia nervosa: A focussed narrative review of the neurological and psychophysiological literature
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Acute phenylalanine/tyrosine depletion reduces motivation to smoke cigarettes across stages of addiction
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Habitual action video game playing is associated with caudate nucleus-dependent navigational strategies.
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Nanomaterials for the sensing of narcotics: Challenges and opportunities
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Neurobiology of Substance Addictions
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Sensitization of Incentive Salience and the Transition to Addiction
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Multiple Memory Systems, Addiction, and Health Habits: New Routes for Translational Science
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Food versus Eating Addictions
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Precision Behavioral Management (PBM): A Novel Genetically Guided Therapy to Combat Reward Deficiency Syndrome (RDS) Relevant to the Opiate Crisis
Blum, K., Roy, A. K., Podesta, A., Modestino, E. J., Steinberg, B., Gondré-Lewis, M. C., Baron, D. A., Thanos, P. K., Lott, L., Badgaiyan, S., et al. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.031 · Cited by 42 · see citing works
Prevention and Treatment of “Food Addiction”
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Human Neurobiological Approaches to Hedonically Motivated Behaviors
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Feedback Models for Gambling Control: The Use and Efficacy of Online Responsible Gambling Tools
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Stimulant and motivational effects of alcohol: Lessons from rodent and primate models
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The Effects of Acute Dopamine Precursor Depletion on the Reinforcing Value of Exercise in Anorexia Nervosa
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Voluntary Intravenous Self‐Administration of Alcohol Detects an Interaction Between GABA ergic Manipulation and GABRG 1 Polymorphism Genotype: A Pilot Study
Plawecki, M. H., Wetherill, L. F., Vitvitskiy, V., Kosobud, A., Zimmermann, U. S., Edenberg, H. J., & O’Connor, S. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01885.x · Cited by 32 · see citing works
Evidence that Illness-Compatible Cues Are Rewarding in Women Recovered from Anorexia Nervosa: A Study of the Effects of Dopamine Depletion on Eye-Blink Startle Responses
O'Hara, C., Keyes, A., Renwick, B., Giel, K. E., Campbell, I. C., & Schmidt, U. H. (2016) · PLoS ONE · doi:10.1371/journal.pone.0165104 · Cited by 27 · see citing works
The Effects of Acute Dopamine Precursor Depletion on the Cognitive Control Functions of Performance Monitoring and Conflict Processing: An Event-Related Potential (ERP) Study
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Acute phenylalanine/tyrosine depletion of phasic dopamine in the rat brain
Shnitko, T. A., Taylor, S. C., Stringfield, S. J., Zandy, S. L., Cofresí, R. U., Doherty, J. M., Lynch, W. B., Boettiger, C. A., Gonzales, R. A., & Robinson, D. L. (2016) · Psychopharmacology · doi:10.1007/s00213-016-4259-0 · Cited by 21 · see citing works
Rat models of reward deficits in psychiatric disorders
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Effects of average reward rate on vigor as a function of individual variation in striatal dopamine
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Altered dopamine transmission as a familial risk trait for addictions
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Appetitive Needs and Addiction
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Amphetamine increases motivation of humans and mice as measured by breakpoint, but does not affect an Electroencephalographic biomarker
Noback, M. N., Bhakta, S. G., Talledo, J., Kotz, J. E., Benster, L. L., Roberts, B. Z., Nungaray, J. A., Light, G. A., Swerdlow, N. R., Brigman, J. L., et al. (2024) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-023-01150-z · Cited by 10 · see citing works
Substance Use and Sexual Behaviour among Female Students in Nigerian Universities
Oye-Adeniran, B., Aina, O. F., Gbadegesin, A., & Ekanem, E. E. (2014) · International Quarterly of Community Health Education · doi:10.2190/iq.35.1.f · Cited by 10 · see citing works
Effects of ethanol on hippocampal neurogenesis depend on the conditioned appetitive response
Tesone-Coelho, C., Varela, P., Escosteguy-Neto, J. C., Cavarsan, C. F., Mello, L. E., & Santos-Junior, J. G. (2012) · Addiction Biology · doi:10.1111/j.1369-1600.2011.00434.x · Cited by 8 · see citing works
Qualitative Approaches to the Study of Substance and Behavioral Addictions
Simpson, K. A., & Bluthenthal, R. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.013 · Cited by 8 · see citing works
Sex moderates effects of alcohol and cannabis co‐use on alcohol and stress reactivity
Claus, E. D., Blaine, S. K., Witkiewitz, K. A., & Ansell, E. B. (2022) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14797 · Cited by 7 · see citing works
The effect of acute tyrosine phenylalanine depletion on emotion-based decision-making in healthy adults
Vrshek‐Schallhorn, S., Wahlstrom, D., White, T. J. H., & Luciana, M. M. (2013) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2013.01.013 · Cited by 7 · see citing works
Dopamine and light: effects on facial emotion recognition
Cawley, E., Tippler, M., Coupland, N. J., Benkelfat, C., Boivin, D. B., Rot, M. A. H., & Leyton, M. (2017) · Journal of Psychopharmacology · doi:10.1177/0269881117711707 · Cited by 7 · see citing works
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The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Stangl, B. L., Byrd, N. D., Soundararajan, S., Plawecki, M. H., O’Connor, S., & Ramchandani, V. A. (2022) · Journal of Visualized Experiments · doi:10.3791/63576 · Cited by 5 · see citing works
Substance and Behavioral Addictions Assessment Instruments
Grigsby, T. J. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.012 · Cited by 5 · see citing works
Prevention and Treatment of Sex Addiction
Reid, R. C., Grubbs, J. B., & Kraus, S. W. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.025 · Cited by 4 · see citing works
Gaming Disorder and Its Treatment
Griffiths, M. D., Kuss, D. J., & Pontes, H. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.029 · Cited by 4 · see citing works
Treatment of Alcohol, Tobacco, and Other Drug (ATOD) Misuse
Sussman, S. Y., & Bolshakova, M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.022 · Cited by 3 · see citing works
The Role of Culture in Addiction
Hoffman, B. R., & Unger, J. B. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.018 · Cited by 3 · see citing works
Translational Neuroimaging
Schwarz, A. J., Plawecki, M. H., McKinzie, D. L., & Wong, C. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-386945-6.00011-1 · Cited by 3 · see citing works
Different Subjective and Objective Responses to Alcohol Among Heavy and Light Drinkers of Han and Uyghur Nationalities in China
Hu, H., Zang, G.-B., Liu, Z.-L., Rueger, S. Y., McNamara, P., King, A. C., & Hao, W. (2015) · Journal of Addictions Nursing · doi:10.1097/jan.0000000000000096 · Cited by 3 · see citing works
Attractiveness and neural processing of infant faces: effects of a facial abnormality but not dopamine
Huffmeijer, R., Barak-Levy, Y., & Rippe, R. C. A. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.112937 · Cited by 3 · see citing works
Passionate Love Addiction: An Evolutionary Survival Mechanism That Can Go Terribly Wrong
Bolshakova, M., Fisher, H. E., Aubin, H., & Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.026 · Cited by 2 · see citing works
Philosophical Issues in the Addictions
Glackin, S. N. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.007 · Cited by 2 · see citing works
Prevention and Treatment
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.020 · Cited by 2 · see citing works
Patterns and Effects of Alcohol and Psychostimulant Co-administration: a Brief Review of Pharmacological Considerations and Subjective Responses
Barrett, S. P., Jemcov, A., & Darredeau, C. (2016) · Current Addiction Reports · doi:10.1007/s40429-016-0080-4 · Cited by 1 · see citing works
Self-citation
Management of alcohol use disorders
Feeney, L. (2009) · Irish Journal of Psychological Medicine · doi:10.1017/s0790966700000781 · Cited by 1 · see citing works
Multiple Memory Systems in Humans and Rodents ☆
White, N. M., & Bohbot, V. D. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809324-5.02801-7 · Cited by 1 · see citing works
Prevention and Treatment of Work Addiction
Quiñones, C., & Griffiths, M. D. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.028 · Cited by 1 · see citing works
Concepts of Addiction
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.003 · Cited by 1 · see citing works
Alcohol
Rassool, G. H. (2011) · doi:10.1007/978-0-230-34456-3_4 · Cited by 1 · see citing works
The Motivation for Alcohol Reward: Predictors of Progressive-Ratio Intravenous Alcohol Self-Administration in Humans
Stangl, B. L., Byrd, N. D., Soundararajan, S., Plawecki, M. H., O’Connor, S., & Ramchandani, V. A. (2022) · Journal of Visualized Experiments · doi:10.3791/63576-v · Cited by 1 · see citing works
Adolescent Drug Misuse Prevention: Challenges in School-Based Programming
Scheier, L. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.021 · Cited by 1 · see citing works
Measurement, Prevention, and Treatment of Exercise Addiction
Hausenblas, H. A., Mann, D. T. Y., & Downs, D. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.036 · Cited by 1 · see citing works
Functional Neuroimaging of the Acute Effects of Drugs of Abuse
Reed, L. J., & Nutt, D. (2011) · doi:10.1002/9781119998938.ch4
Probing mesocorticolimbic dopamine function in alcohol dependence using dextroamphetamine : behavioural and FMRI studies.
Balducci, X. L. (2009) · TSpace (University of Toronto)
An examination of the heart rate and hypothalamic-pituitary-adrenal axis responses to acute ethanol intoxication and stress in two populations at high risk for alcohol misuse
Harrison, J. (2012) · eScholarship@McGill (McGill) · doi:10.82308/17878
Foreword
Compton, W. M., & Blanco, C. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.001
Novel Psychoactive Substances: A New Challenge for Prevention and Treatment
Kapitány‐Fövény, M., Corazza, O., Marrinan, S., & Demetrovics, Z. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.032
Human Laboratory Paradigms in Addictions Research
Morris, V. L., Arshad, F., Balodis, I. M., Reed, D. D., MacKillop, J. M., & Amlung, M. T. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.010
Anhedonia in Addictive Behaviors
Dyer, W. G., Leventhal, A. M., Goldenson, N. I., & Bello, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.039
American Legal Issues in Addiction Treatment and Research
Willick, D. H. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.041
The Physical and Social Environments as Determinants of Health: Implications for Substance and Behavioral Addictions
Strack, R. W., Orsini, M. M., Ewald, D. R., & Scheier, L. M. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.019
Clinical and Research Methods in the Addictions
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.008
Levels of Analysis and Etiology
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.014
Ongoing and Future Research Directions
(2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.030
Preface
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.002
Impaired Physicians
Srivastava, A. B., & Gold, M. S. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.033
Index
Sussman, S. Y. (2020) · Cambridge University Press eBooks · doi:10.1017/9781108632591.042
Intravenous Alcohol Administration Studies in Humans: Investigator-Prescribed and Self-Administration Paradigms
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Authors: Barrett, S. P., Pihl, R. O., Benkelfat, C., Brunelle, C., Young, S. N., & Leyton, M.
Affiliations: McGill University (CA)
Corresponding author: Leyton, Marco
ORCID: Barrett, Sean P.
Brunelle, Caroline
Young, Simon N.
Leyton, Marco
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2008-06
Volume: 18
Issue: 6
Pages: 439-447
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2008.01.008
OpenAlex: W2040500877
Cited by: 92
References: 97
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 45 · 2018: 3 · 2017: 2 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 6 · 2012: 5
FWCI: 1.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: McGill University Health Centre
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: dopamine, alcohol self-administration, L-DOPA, individual differences, dopamine precursor
MeSH terms: Adult, Alcohol Drinking, Ethanol, Amino Acids, Analysis of Variance, Dopamine, Double-Blind Method, Heart Rate, Humans, Individuality, Levodopa, Male, Phenylalanine, Self Administration, Tyrosine, Dopamine Agents

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The role of dopamine in alcohol self-administration in humans: individual differences

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