Skeletal muscle apoptosis, sarcopenia and frailty at old age

Cell Death

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Epidemiology of Sarcopenia among the Elderly in New Mexico

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Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging

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Relationship of Interleukin-6 and Tumor Necrosis Factor- With Muscle Mass and Muscle Strength in Elderly Men and Women: The Health ABC Study

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Longitudinal changes in body composition in older men and women: role of body weight change and physical activity

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Muscle fiber‐specific apoptosis and TNF‐α signaling in sarcopenia are attenuated by life‐long calorie restriction

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Age-related differences in apoptosis with disuse atrophy in soleus muscle

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Aging and lifelong calorie restriction result in adaptations of skeletal muscle apoptosis repressor, apoptosis-inducing factor, X-linked inhibitor of apoptosis, caspase-3, and caspase-12

Dirks, A. J., & Leeuwenburgh, C. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.003 · Cited by 190

Sarcopenia: Aging-Related Loss of Muscle Mass and Function

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Sarcopenia: its assessment, etiology, pathogenesis, consequences and future perspectives

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Sarcopenic obesity: A new category of obesity in the elderly

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Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials

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The roles of vitamin D in skeletal muscle: form, function, and metabolism

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Mitochondrial Aging and Age-Related Dysfunction of Mitochondria

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Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging

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Role of β-Adrenoceptor Signaling in Skeletal Muscle: Implications for Muscle Wasting and Disease

Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410

Skeletal muscle autophagy and apoptosis during aging: Effects of calorie restriction and life-long exercise

Wohlgemuth, S. E., Seo, A. Y., Marzetti, E., Lees, H. A., & Leeuwenburgh, C. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2009.11.002 · Cited by 397

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335

Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy

Calvani, R., Joseph, A.-M., Adhihetty, P. J., Miccheli, A., Bossola, M., Leeuwenburgh, C., Bernabei, R., & Marzetti, E. (2013) · bchm · doi:10.1515/hsz-2012-0247 · Cited by 328

Models of accelerated sarcopenia: critical pieces for solving the puzzle of age-related muscle atrophy

Buford, T. W., Anton, S. D., Judge, A. R., Marzetti, E., Wohlgemuth, S. E., Carter, C. S., Leeuwenburgh, C., Pahor, M., & Manini, T. M. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.04.004 · Cited by 295

Muscle quality in aging: a multi-dimensional approach to muscle functioning with applications for treatment.

Fragala, M. S., Kenny, A. M., & Kuchel, G. A. (2015) · Sports Medicine · doi:10.1007/s40279-015-0305-z · Cited by 246

The clinical implications of ageing for rational drug therapy

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Mechanisms of skeletal muscle aging: insights from Drosophila and mammalian models

Demontis, F., Piccirillo, R., Goldberg, A. L., & Perrimon, N. (2013) · Disease Models & Mechanisms · doi:10.1242/dmm.012559 · Cited by 238

A comparative study of software programmes for cross‐sectional skeletal muscle and adipose tissue measurements on abdominal computed tomography scans of rectal cancer patients

van Vugt, J. L. A., Levolger, S., Gharbharan, A., Koek, M., Niessen, W. J., Burger, J. W. A., Willemsen, S. P., de Bruin, R. W. F., & IJzermans, J. N. M. (2017) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12158 · Cited by 217

Inflammation: roles in aging and sarcopenia

Jensen, G. L. (2008) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607108324585 · Cited by 195

Chronic resistance training activates autophagy and reduces apoptosis of muscle cells by modulating IGF-1 and its receptors, Akt/mTOR and Akt/FOXO3a signaling in aged rats

Luo, L., Lu, A.-M., Wang, Y., Hong, A., Chen, Y., Hu, J., Li, X., & Qin, Z.-H. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.009 · Cited by 192

Wearable sensor-based in-home assessment of gait, balance, and physical activity for discrimination of frailty status: baseline results of the Arizona frailty cohort study

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Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy

Marzetti, E., Hwang, J. C. Y., Lees, H. A., Wohlgemuth, S. E., Dupont-Versteegden, E. E., Carter, C. S., Bernabei, R., & Leeuwenburgh, C. (2010) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.05.007 · Cited by 174

Age-related activation of mitochondrial caspase-independent apoptotic signaling in rat gastrocnemius muscle

Marzetti, E., Wohlgemuth, S. E., Lees, H. A., Chung, H.-Y., Giovannini, S., & Leeuwenburgh, C. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.05.005 · Cited by 172

Age-induced oxidative stress: how does it influence skeletal muscle quantity and quality?

Baumann, C. W., Kwak, D., Liu, H. M., & Thompson, L. V. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00321.2016 · Cited by 169

Attenuation of sarcopenia by dietary restriction in rhesus monkeys

Colman, R. J., Beasley, T. M., Allison, D. B., & Weindruch, R. (2008) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/63.6.556 · Cited by 141

Modulation of age-induced apoptotic signaling and cellular remodeling by exercise and calorie restriction in skeletal muscle

Marzetti, E., Lawler, J. M., Hiona, A., Manini, T., Seo, A. Y., & Leeuwenburgh, C. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.028 · Cited by 113

Changes in IL-15 expression and death-receptor apoptotic signaling in rat gastrocnemius muscle with aging and life-long calorie restriction

Marzetti, E., Carter, C. S., Wohlgemuth, S. E., Lees, H. A., Giovannini, S., Anderson, B., Quinn, L. S., & Leeuwenburgh, C. (2009) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.12.008 · Cited by 113

Sarcopenic obesity: An appraisal of the current status of knowledge and management in elderly people

Molino, S., Dossena, M., Buonocore, D., & Verri, M. (2016) · The Journal of nutrition, health and aging · doi:10.1007/s12603-015-0631-8 · Cited by 91

Physical Activity in Non-Frail and Frail Older Adults

Jansen, F. M., Prins, R. G., Etman, A., van der Ploeg, H. P., de Vries, S. I., van Lenthe, F. J., & Pierik, F. H. (2015) · PLOS ONE · doi:10.1371/journal.pone.0123168 · Cited by 79

Role of PGC-1α in sarcopenia: Etiology and potential intervention—A mini-review

Ji, L. L., & Kang, C. (2015) · Gerontology · doi:10.1159/000365947 · Cited by 77

Optimising nutrition in residential aged care: a narrative review

Agarwal, E., Marshall, S., Miller, M., & Isenring, E. (2016) · Maturitas · doi:10.1016/j.maturitas.2016.06.013 · Cited by 74

Drastic increase of myosin light chain MLC-2 in senescent skeletal muscle indicates fast-to-slow fibre transition in sarcopenia of old age

Gannon, J., Doran, P., Kirwan, A., & Ohlendieck, K. (2009) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2009.06.004 · Cited by 74

Telomerase gene therapy ameliorates the effects of neurodegeneration associated to short telomeres in mice

Whittemore, K., Derevyanko, A., Martinez, P., Serrano, R., Pumarola, M., Bosch, F., & Blasco, M. A. (2019) · Aging · doi:10.18632/aging.101982 · Cited by 69

PGC-1α and Myokines in the Aging Muscle – A Mini-Review

Arnold, A.-S., Egger, A., & Handschin, C. (2011) · Gerontology · doi:10.1159/000281883 · Cited by 65

Metabolic Effects of 20-OH-Ecdysone in Ovariectomized Rats

Seidlova-Wuttke, D., Ehrhardt, C., & Wuttke, W. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2010.01.006 · Cited by 57

Determining the influence of telomere dysfunction and DNA damage on stem and progenitor cell aging: what markers can we use?

Nalapareddy, K., Jiang, H., Gutierrez, L. M. G., & Rudolph, K. L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.09.002 · Cited by 50

Pyropia Yezoensis Peptide PYP1-5 Protects against Dexamethasone-Induced Muscle Atrophy through the Downregulation of Atrogin1/MAFbx and MuRF1 in Mouse C2C12 Myotubes

Lee, M.-K., Kim, Y.-M., Kim, I.-H., Choi, Y.-H., & Nam, T.-J. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.6443 · Cited by 28

Mapping the Immune Cell Microenvironment with Spatial Profiling in Muscle Tissue Injected with the Venom of Daboia russelii

de Oliveira, A. K., Pramoonjago, P., Rucavado, A., Moskaluk, C., Silva, D. T., Escalante, T., Gutiérrez, J. M., & Fox, J. W. (2023) · Toxins · doi:10.3390/toxins15030208 · Cited by 3