Circadian disruption in the pathogenesis of metabolic syndrome

The metabolic syndrome—a new worldwide definition

Alberti, K. G. M., Zimmet, P., & Shaw, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67402-8 · Cited by 9,352 · see citing works

The metabolic syndrome

Eckel, R. H., Alberti, K., Grundy, S. M., & Zimmet, P. (2010) · The Lancet · doi:10.1016/s0140-6736(09)61794-3 · Cited by 6,283 · see citing works

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737 · see citing works

The Metabolic Syndrome and Cardiovascular Risk

Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., Rinfret, S., Schiffrin, E. L., & Eisenberg, M. J. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.05.034 · Cited by 3,009 · see citing works

Obesity and Metabolic Syndrome in Circadian <i>Clock</i> Mutant Mice

Turek, F. W., Joshu, C., Kohsaka, A., Lin, E., Ivanova, G., McDearmon, E., Laposky, A., Losee-Olson, S., Easton, A., Jensen, D. R., et al. (2005) · Science · doi:10.1126/science.1108750 · Cited by 2,485 · see citing works

Adverse metabolic and cardiovascular consequences of circadian misalignment

Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works

Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock

Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,272 · see citing works

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

DIAGRAM Consortium, Dupuis, J., GIANT Consortium, Global BPgen Consortium, Anders Hamsten on behalf of Procardis Consortium, the MAGIC investigators, Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., et al. (2010) · Nature Genetics · doi:10.1038/ng.520 · Cited by 2,166 · see citing works

Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet

Hatori, M., Vollmers, C., Zarrinpar, A., DiTacchio, L., Bushong, E. A., Gill, S., Leblanc, M., Chaix, A., Joens, M., Fitzpatrick, J. A. J., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.019 · Cited by 1,986 · see citing works

NF-κB, Inflammation, and Metabolic Disease

Baker, R. G., Hayden, M. S., & Ghosh, S. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.008 · Cited by 1,952 · see citing works

Mutagenesis and Mapping of a Mouse Gene, <i>Clock</i> , Essential for Circadian Behavior

Vitaterna, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., McDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., & Takahashi, J. S. (1994) · Science · doi:10.1126/science.8171325 · Cited by 1,632 · see citing works

Mop3 is an essential component of the master circadian pacemaker in mammals.

Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works

High-Fat Diet Disrupts Behavioral and Molecular Circadian Rhythms in Mice

Kohsaka, A., Laposky, A. D., Ramsey, K. M., Estrada, C., Joshu, C., Kobayashi, Y., Turek, F. W., & Bass, J. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.006 · Cited by 1,528 · see citing works

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

Marcheva, B., Ramsey, K. M., Buhr, E. D., Kobayashi, Y., Su, H., Ko, C. H., Ivanova, G., Omura, C., Mo, S., Vitaterna, M. H., et al. (2010) · Nature · doi:10.1038/nature09253 · Cited by 1,525 · see citing works

Extensive and divergent circadian gene expression in liver and heart

Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509 · see citing works

Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms

Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402 · see citing works

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

Zhang, X., Zhang, G., Zhang, H., Karin, M., Bai, H., & Cai, D. (2008) · Cell · doi:10.1016/j.cell.2008.07.043 · Cited by 1,350 · see citing works

Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice

Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245 · see citing works

C-reactive protein, fibrinogen, and cardiovascular disease prediction

The Emerging Risk Factors Collaboration (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1107477 · Cited by 1,150 · see citing works

BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis

Rudic, R. D., McNamara, P., Curtis, A.-M., Boston, R. C., Panda, S., Hogenesch, J. B., & FitzGerald, G. A. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020377 · Cited by 1,059 · see citing works

Physiological significance of a peripheral tissue circadian clock

Lamia, K. A., Storch, K.-F., & Weitz, C. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806717105 · Cited by 1,048 · see citing works

Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037 · see citing works

Circadian timing of food intake contributes to weight gain

Arble, D. M., Bass, J., Laposky, A. D., Vitaterna, M. H., & Turek, F. W. (2009) · Obesity · doi:10.1038/oby.2009.264 · Cited by 953 · see citing works

The metabolic syndrome: a global public health problem and a new definition.

Zimmet, P., Magliano, D., Matsuzawa, Y., Alberti, G., & Shaw, J. (2005) · Journal of atherosclerosis and thrombosis · doi:10.5551/jat.12.295 · Cited by 925 · see citing works

Effects of poor and short sleep on glucose metabolism and obesity risk

Spiegel, K., Tasali, E., Leproult, R., & Van Cauter, E. (2009) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2009.23 · Cited by 857 · see citing works

A circadian clock in macrophages controls inflammatory immune responses

Keller, M., Mazuch, J., Abraham, U., Eom, G. D., Herzog, E. D., Volk, H.-D., Kramer, A., & Maier, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906361106 · Cited by 843 · see citing works

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Solt, L. A., Wang, Y., Banerjee, S., Hughes, T., Kojetin, D. J., Lundåsen, T., Shin, Y., Liu, J., Cameron, M. D., Noël, R., et al. (2012) · Nature · doi:10.1038/nature11030 · Cited by 835 · see citing works

Rotating Night Shift Work and Risk of Type 2 Diabetes: Two Prospective Cohort Studies in Women

Pan, A., Schernhammer, E. S., Sun, Q., & Hu, F. B. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001141 · Cited by 805 · cited 2× · see citing works

Light at night increases body mass by shifting the time of food intake

Fonken, L. K., Workman, J. L., Walton, J. C., Weil, Z. M., Morris, J. S., Haim, A., & Nelson, R. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008734107 · Cited by 796 · see citing works

Sleep duration as a risk factor for the development of type 2 diabetes

Yaggi, H. K., Araujo, A. B., & McKinlay, J. B. (2006) · Diabetes Care · doi:10.2337/diacare.29.03.06.dc05-0879 · Cited by 790 · see citing works

The mPer2 gene encodes a functional component of the mammalian circadian clock

Zheng, B., Larkin, D. W., Albrecht, U., Sun, Z. S., Sage, M., Eichele, G., Lee, C. C., & Bradley, A. (1999) · Nature · doi:10.1038/22118 · Cited by 718 · see citing works

A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism

Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701 · see citing works

Differential regulation of mammalian <i>Period</i> genes and circadian rhythmicity by cryptochromes 1 and 2

Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12114 · Cited by 690 · see citing works

The nuclear receptor REV-ERBα mediates circadian regulation of innate immunity through selective regulation of inflammatory cytokines

Gibbs, J. E., Blaikley, J., Beesley, S., Matthews, L. C., Simpson, K. D., Boyce, S., Farrow, S. N., Else, K. J., Singh, D., Ray, D. W., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106750109 · Cited by 671 · see citing works

The National Cholesterol Education Program–Adult Treatment Panel III, International Diabetes Federation, and World Health Organization Definitions of the Metabolic Syndrome as Predictors of Incident Cardiovascular Disease and Diabetes

Lorenzo, C., Williams, K., Hunt, K. J., & Haffner, S. M. (2006) · Diabetes Care · doi:10.2337/dc06-1414 · Cited by 660 · see citing works

Circadian Gene Bmal1 Regulates Diurnal Oscillations of Ly6C hi Inflammatory Monocytes

Nguyen, K. D., Fentress, S. J., Qiu, Y., Yun, K., Cox, J. S., & Chawla, A. (2013) · Science · doi:10.1126/science.1240636 · Cited by 647 · see citing works

Timing of food intake predicts weight loss effectiveness

Garaulet, M., Gómez-Abellán, P., Alburquerque-Béjar, J. J., Lee, Y.-C., Ordovás, J. M., & Scheer, F. A. J. L. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.229 · Cited by 639 · see citing works

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance

Forouhi, N. G., Luan, J., Cooper, A., Boucher, B. J., & Wareham, N. J. (2008) · Diabetes · doi:10.2337/db08-0593 · Cited by 613 · see citing works

Circadian topology of metabolism

Bass, J. T. (2012) · Nature · doi:10.1038/nature11704 · Cited by 610 · see citing works

Cryptochromes mediate rhythmic repression of the glucocorticoid receptor

Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590 · see citing works

Genetics of Circadian Rhythms in Mammalian Model Organisms

Lowrey, P. L., & Takahashi, J. S. (2011) · Advances in genetics · doi:10.1016/b978-0-12-387690-4.00006-4 · Cited by 578 · see citing works

Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome

Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576 · see citing works

Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis

Zhang, E. E., Liu, Y., Dentin, R., Pongsawakul, P. Y., Liu, A. C., Hirota, T., Nusinow, D. A., Sun, X., Landais, S., Kodama, Y., et al. (2010) · Nature Medicine · doi:10.1038/nm.2214 · Cited by 567 · see citing works

The human circadian metabolome

Dallmann, R., Viola, A. U., Tarokh, L., Cajochen, C., & Brown, S. A. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1114410109 · Cited by 566 · see citing works

Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs

Mukherji, A., Kobiita, A., Ye, T., & Chambon, P. (2013) · Cell · doi:10.1016/j.cell.2013.04.020 · Cited by 560 · see citing works

Rev-Erbs repress macrophage gene expression by inhibiting enhancer-directed transcription

Lam, M. T. Y., Cho, H., Lesch, H. P., Gosselin, D., Heinz, S., Tanaka-Oishi, Y., Benner, C., Kaikkonen, M. U., Kim, A. S., Kosaka, M., et al. (2013) · Nature · doi:10.1038/nature12209 · Cited by 548 · see citing works

Disruption of circadian clocks has ramifications for metabolism, brain, and behavior

Karatsoreos, I. N., Bhagat, S., Bloss, E. B., Morrison, J. H., & McEwen, B. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018375108 · Cited by 547 · see citing works

Brain and muscle Arnt-like protein-1 (BMAL1), a component of the molecular clock, regulates adipogenesis

Shimba, S., Ishii, N., Ohta, Y., Ohno, T., Watabe, Y., Hayashi, M., Wada, T., Aoyagi, T., & Tezuka, M. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502383102 · Cited by 536 · see citing works

PAI‐1 and atherothrombosis

Vaughan, D. E. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01420.x · Cited by 508 · see citing works

Identification of Small Molecule Activators of Cryptochrome

Hirota, T., Lee, J. W., John, P. C. S., Sawa, M., Iwaisako, K., Noguchi, T., Pongsawakul, P. Y., Sonntag, T., Welsh, D. K., Brenner, D. A., et al. (2012) · Science · doi:10.1126/science.1223710 · Cited by 500 · see citing works

Obesity in mice with adipocyte-specific deletion of clock component Arntl

Paschos, G. K., Ibrahim, S., Song, W.-L., Kunieda, T., Grant, G., Reyes, T. M., Bradfield, C. A., Vaughan, C. H., Eiden, M., Masoodi, M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2979 · Cited by 465 · see citing works

Rev-erb-α modulates skeletal muscle oxidative capacity by regulating mitochondrial biogenesis and autophagy

Woldt, E., Sebti, Y., Solt, L. A., Duhem, C., Lancel, S., Eeckhoute, J., Hesselink, M. K. C., Paquet, C., Delhaye, S., Shin, Y., et al. (2013) · Nature Medicine · doi:10.1038/nm.3213 · Cited by 454 · see citing works

Circadian Disruption Leads to Insulin Resistance and Obesity

Shi, S.-Q., Ansari, T. S., McGuinness, O. P., Wasserman, D. H., & Johnson, C. H. (2013) · Current Biology · doi:10.1016/j.cub.2013.01.048 · Cited by 452 · see citing works

REV-ERBα Participates in Circadian SREBP Signaling and Bile Acid Homeostasis

Martelot, G. L., Claudel, T., Gatfield, D., Schaad, O., Kornmann, B., Sasso, G. L., Moschetta, A., & Schibler, U. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000181 · Cited by 448 · see citing works

Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6

Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431 · see citing works

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

Narasimamurthy, R., Hatori, M., Nayak, S. K., Liu, F., Panda, S., & Verma, I. M. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209965109 · Cited by 421 · see citing works

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes

Woon, P. Y., Kaisaki, P. J., Bragança, J., Bihoreau, M., Lévy, J., Farrall, M., & Gauguier, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703247104 · Cited by 410 · see citing works

Circadian variation of blood pressure and the vascular response to asynchronous stress

Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 401 · see citing works

CLOCK and BMAL1 regulate <i>MyoD</i> and are necessary for maintenance of skeletal muscle phenotype and function

Andrews, J. L., Zhang, X., McCarthy, J. J., McDearmon, E. L., Hornberger, T. A., Russell, B., Campbell, K. S., Arbogast, S., Reid, M. B., Walker, J. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1014523107 · Cited by 389 · cited 3× · see citing works

Waist Circumference and Cardiometabolic Risk

Klein, S., Allison, D. B., Heymsfield, S. B., Kelley, D. E., Leibel, R. L., Nonas, C., & Kahn, R. (2007) · Diabetes Care · doi:10.2337/dc07-9921 · Cited by 387 · see citing works

Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression

Bray, M. S., Shaw, C. A., Moore, M. W. S., Garcia, R. A. P., Zanquetta, M. M., Durgan, D. J., Jeong, W. J., Tsai, J.-Y., Bugger, H., Zhang, D., et al. (2008) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2007 · Cited by 384 · see citing works

Timed high-fat diet resets circadian metabolism and prevents obesity

Sherman, H., Genzer, Y., Cohen, R., Chapnik, N., Madar, Z., & Froy, O. (2012) · The FASEB Journal · doi:10.1096/fj.12-208868 · Cited by 360 · see citing works

Vitamin D Status and Cardiometabolic Risk Factors in the United States Adolescent Population

Reis, J. P., von Mühlen, D. G., Miller, E. R., Michos, E. D., & Appel, L. J. (2009) · PEDIATRICS · doi:10.1542/peds.2009-0213 · Cited by 359 · see citing works

Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man

SCOTT, E. M., Carter, A. M., & Grant, P. J. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803778 · Cited by 344 · see citing works

A Daily Rhythm in Glucose Tolerance

la Fleur, S. E., Kalsbeek, A., Wortel, J., Fekkes, M. L., & Buijs, R. M. (2001) · Diabetes · doi:10.2337/diabetes.50.6.1237 · Cited by 337 · see citing works

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

Sun, Z., Miller, R. A., Patel, R. T., Chen, J., Dhir, R., Wang, H., Zhang, D., Graham, M. J., Unterman, T. G., Shulman, G. I., et al. (2012) · Nature Medicine · doi:10.1038/nm.2744 · Cited by 335 · see citing works

Core circadian protein CLOCK is a positive regulator of NF-κB–mediated transcription

Spengler, M. L., Kuropatwinski, K. K., Comas, M., Gasparian, A. V., Fedtsova, N. G., Gleiberman, A. S., Gitlin, I. I., Artemicheva, N. M., Deluca, K. A., Gudkov, A. V., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1206274109 · Cited by 331 · see citing works

Circadian Programs of Transcriptional Activation, Signaling, and Protein Turnover Revealed by Microarray Analysis of Mammalian Cells

Duffield, G. E., Best, J. D., Meurers, B. H., Bittner, A., Loros, J., & Dunlap, J. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00765-0 · Cited by 329 · see citing works

The Number of X Chromosomes Causes Sex Differences in Adiposity in Mice

Chen, X., McClusky, R., Chen, J., Beaven, S. W., Tontonoz, P., Arnold, A. P., & Reue, K. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002709 · Cited by 326 · see citing works

Food intake during the normal activity phase prevents obesity and circadian desynchrony in a rat model of night work

Salgado-Delgado, R., Angeles-Castellanos, M., Saderi, N., Buijs, R. M., & Escobar, C. (2010) · Endocrinology · doi:10.1210/en.2009-0864 · Cited by 323 · see citing works

Dissecting the Functions of the Mammalian Clock Protein BMAL1 by Tissue-Specific Rescue in Mice

McDearmon, E. L., Patel, K., Ko, C. H., Walisser, J. A., Schook, A. C., Chong, J. L., Wilsbacher, L. D., Song, E. J., Hong, H., Bradfield, C. A., et al. (2006) · Science · doi:10.1126/science.1132430 · Cited by 321 · see citing works

An intrinsic circadian clock of the pancreas is required for normal insulin release and glucose homeostasis in mice

Sadacca, L. A., Lamia, K. A., deLemos, A. S., Blum, B., & Weitz, C. J. (2011) · Diabetologia · doi:10.1007/s00125-010-1920-8 · Cited by 314 · see citing works

Rotating Night Shift Work and the Risk of Ischemic Stroke

Brown, D. L., Feskanich, D., Sanchez, B. N., Rexrode, K. M., Schernhammer, E. S., & Lisabeth, L. D. (2009) · American Journal of Epidemiology · doi:10.1093/aje/kwp056 · Cited by 297 · see citing works

Untitled work

Zheng (1999) · doi:10.1038/22659 · Cited by 293 · see citing works

Vascular Disease in Mice With a Dysfunctional Circadian Clock

Anea, C. B., Zhang, M., Stepp, D. W., Simkins, G. B., Reed, G. L., Fulton, D. J., & Rudic, R. D. (2009) · Circulation · doi:10.1161/circulationaha.108.827477 · Cited by 292 · see citing works

Synchronicity of frequently sampled, 24-h concentrations of circulating leptin, luteinizing hormone, and estradiol in healthy women

Licinio, J., Negrão, A. B., Mantzoros, C., Kaklamani, V., Wong, M.-L., Bongiorno, P. B., Mulla, A., Cearnal, L., Veldhuis, J. D., Flier, J. S., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2541 · Cited by 287 · see citing works

The Cardiomyocyte Circadian Clock: Emerging Roles in Health and Disease

Durgan, D. J., & Young, M. E. (2010) · Circulation Research · doi:10.1161/circresaha.109.209957 · Cited by 277 · see citing works

Molecular clock is involved in predictive circadian adjustment of renal function

Zuber, A. M., Centeno, G., Pradervand, S., Nikolaeva, S., Maquelin, L., Cardinaux, L., Bonny, O., & Firsov, D. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904890106 · Cited by 274 · see citing works

The role of mPer2 clock gene in glucocorticoid and feeding rhythms

Yang, S., Liu, A., Weidenhammer, A., Cooksey, R. C., McClain, D., Kim, M. K., Aguilera, G., Abel, E. D., & Chung, J. H. (2009) · Endocrinology · doi:10.1210/en.2008-0705 · Cited by 263 · see citing works

Genetic variants of Clock transcription factor are associated with individual susceptibility to obesity

Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Castaño, G. O., & Pirola, C. J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1606 · Cited by 262 · see citing works

Evidence for a circadian rhythm of insulin secretion

Boden, G., Ruiz, J., Urbain, J. L., & Chen, X. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.271.2.e246 · Cited by 261 · see citing works

Circadian clock regulates the host response to Salmonella

Bellet, M. M., Deriu, E., Liu, J. Z., Grimaldi, B., Blaschitz, C., Zeller, M., Edwards, R. A., Sahar, S., Dandekar, S., Baldi, P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120636110 · Cited by 260 · see citing works

A longitudinal study on the effect of shift work on weight gain in male Japanese workers.

Suwazono, Y., Dochi, M., Sakata, K., Okubo, Y., Oishi, M., Tanaka, K., Kobayashi, E., Kido, T., & Nogawa, K. (2008) · Obesity · doi:10.1038/oby.2008.298 · Cited by 259 · see citing works

Low Serum 25-Hydroxyvitamin D Is Associated with Increased Risk of the Development of the Metabolic Syndrome at Five Years: Results from a National, Population-Based Prospective Study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab)

Gagnon, C., Lu, Z. X., Magliano, D. J., Dunstan, D. W., Shaw, J. E., Zimmet, P., Sikaris, K. A., Ebeling, P. R., & Daly, R. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-3187 · Cited by 255 · see citing works

Circadian regulation of lipid mobilization in white adipose tissues

Shostak, A., Meyer-Kovac, J., & Oster, H. (2013) · Diabetes · doi:10.2337/db12-1449 · Cited by 243 · see citing works

Vascular PPARγ Controls Circadian Variation in Blood Pressure and Heart Rate through Bmal1

Wang, N., Yang, G., Jia, Z., Zhang, H. E., Aoyagi, T., Soodvilai, S., Symons, J. D., Schnermann, J. B., Gonzalez, F. J., Litwin, S. E., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.10.009 · Cited by 240 · see citing works

Clock is important for food and circadian regulation of macronutrient absorption in mice

Pan, X., & Hussain, M. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900085-jlr200 · Cited by 226 · see citing works

Bmal1 and β-Cell Clock Are Required for Adaptation to Circadian Disruption, and Their Loss of Function Leads to Oxidative Stress-Induced β-Cell Failure in Mice

Lee, J., Moulik, M., Fang, Z., Saha, P., Zou, F., Xu, Y., Nelson, D. L., Ma, K., Moore, D. D., & Yechoor, V. K. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01421-12 · Cited by 224 · see citing works

The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice

Gumz, M. L., Stow, L. R., Lynch, I. J., Greenlee, M. M., Rudin, A., Cain, B. D., Weaver, D. R., & Wingo, C. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci36908 · Cited by 216 · see citing works

Regulation of Bile Acid Synthesis by the Nuclear Receptor Rev-erbα

Duez, H., van der Veen, J. N., Duhem, C., Pourcet, B., Touvier, T., Fontaine, C., Derudas, B., Baugé, E., Havinga, R., Bloks, V. W., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.05.035 · Cited by 212 · see citing works

Progressive arthropathy in mice with a targeted disruption of theMop3/Bmal-1 locus

Bunger, M. K., Walisser, J. A., Sullivan, R., Manley, P. A., Moran, S. M., Kalscheur, V. L., Colman, R. J., & Bradfield, C. A. (2005) · genesis · doi:10.1002/gene.20102 · Cited by 207 · see citing works

Involvement of Hypothalamic Histamine H1 Receptor in the Regulation of Feeding Rhythm and Obesity

Masaki, T., Chiba, S., Yasuda, T., Noguchi, H., Kakuma, T., Watanabe, T., Sakata, T., & Yoshimatsu, H. (2004) · Diabetes · doi:10.2337/diabetes.53.9.2250 · Cited by 203 · see citing works

Diurnal Regulation of MTP and Plasma Triglyceride by CLOCK Is Mediated by SHP

Pan, X., Zhang, Y., Wang, L., & Hussain, M. M. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.014 · Cited by 180 · see citing works

Shifts to and from Daylight Saving Time and Incidence of Myocardial Infarction

Janszky, I., & Ljung, R. (2008) · New England Journal of Medicine · doi:10.1056/nejmc0807104 · Cited by 178 · see citing works

CLOCK genetic variation and metabolic syndrome risk: modulation by monounsaturated fatty acids

Garaulet, M., Lee, Y.-C., Shen, J., Parnell, L. D., Arnett, D. K., Tsai, M. Y., Lai, C.-Q., & Ordovas, J. M. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27536 · Cited by 172 · see citing works

Disrupted fat absorption attenuates obesity induced by a high‐fat diet in <i>Clock</i> mutant mice

Oishi, K., Atsumi, G.-I., Sugiyama, S., Kodomari, I., Kasamatsu, M., Machida, K., & Ishida, N. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.11.063 · Cited by 166 · see citing works

Blood-Borne Circadian Signal Stimulates Daily Oscillations in Actin Dynamics and SRF Activity

Gerber, A., Esnault, C., Aubert, G., Treisman, R., Pralong, F., & Schibler, U. (2013) · Cell · doi:10.1016/j.cell.2012.12.027 · Cited by 160 · see citing works

Genetic Components of the Circadian Clock Regulate Thrombogenesis In Vivo

Westgate, E. J., Cheng, Y., Reilly, D. F., Price, T. S., Walisser, J. A., Bradfield, C. A., & FitzGerald, G. A. (2008) · Circulation · doi:10.1161/circulationaha.107.739227 · Cited by 155 · see citing works

NPAS2 and PER2 are linked to risk factors of the metabolic syndrome

Englund, A., Kovanen, L., Saarikoski, S. T., Haukka, J. K., Reunanen, A., Aromaa, A., Lönnqvist, J. K., & Partonen, T. (2009) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-7-5 · Cited by 148 · see citing works

Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

Doi, M., Ishida, A., Miyake, A., Sato, M., Komatsu, R., Yamazaki, F., Kimura, I., Tsuchiya, S., Kori, H., Seo, K., et al. (2011) · Nature Communications · doi:10.1038/ncomms1316 · Cited by 143 · see citing works

Serum 25-hydroxyvitamin D concentrations in relation to cardiometabolic risk factors and metabolic syndrome in postmenopausal women

Chacko, S. A., Song, Y., Manson, J. E., Horn, L. V., Eaton, C. B., Martin, L. W., McTiernan, A., Curb, J. D., Wylie‐Rosett, J., Phillips, L. S., et al. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010272 · Cited by 136 · see citing works

Increased Superoxide and Endothelial NO Synthase Uncoupling in Blood Vessels of Bmal1-Knockout Mice

Anea, C. B., Cheng, B., Sharma, S., Kumar, S., Caldwell, R. W., Yao, L., Ali, M. I., Merloiu, A. M., Stepp, D. W., Black, S. M., et al. (2012) · Circulation Research · doi:10.1161/circresaha.111.261750 · Cited by 122 · see citing works

PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity

Garaulet, M., Corbalán-Tutau, M. D., Madrid, J. A., Baraza, J. C., Parnell, L. D., Lee, Y.-C., & Ordovas, J. M. (2010) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2010.03.017 · Cited by 111 · see citing works

Shift work as a risk factor for future type 2 diabetes: evidence, mechanisms, implications, and future research directions

Kivimäki, M., Batty, G. D., & Hublin, C. (2011) · PLoS Medicine · doi:10.1371/journal.pmed.1001138 · Cited by 110 · see citing works

Immunity's fourth dimension: approaching the circadian–immune connection

Arjona, A., Silver, A. C., Walker, W. E., & Fikrig, E. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.08.007 · Cited by 109 · see citing works

The hypothalamic clock and its control of glucose homeostasis

Kalsbeek, A., Yi, C., la Fleur, S. E., & Fliers, E. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.02.005 · Cited by 106 · see citing works

Nutrient sensing and the circadian clock

Peek, C. B., Ramsey, K. M., Marcheva, B., & Bass, J. T. (2012) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2012.02.003 · Cited by 103 · see citing works

Circadian Expression of Adiponectin and Its Receptors in Human Adipose Tissue

Gómez-Abellán, P., Gómez‐Santos, C., Madrid, J. A., Milagro, F. I., Campión, J., Martínez, J. A., Ordovás, J. M., & Garaulet, M. (2009) · Endocrinology · doi:10.1210/en.2009-0647 · Cited by 93 · see citing works

Suprachiasmatic Nucleus Clock Time in the Mammalian Circadian SystemPreprint

Okamura, H. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.033 · Cited by 87 · see citing works

Assessing prediction of diabetes in older adults using different adiposity measures: a 7 year prospective study in 6,923 older men and women

Wannamethee, S. G., Papacosta, O., Whincup, P. H., Carson, C., Thomas, M. C., Lawlor, D. A., Ebrahim, S. B. J., & Sattar, N. A. (2010) · Diabetologia · doi:10.1007/s00125-010-1670-7 · Cited by 76 · see citing works

Melatonin and activity rhythm responses to light pulses in mice with theClockmutation

Kennaway, D. J., Voultsios, A., Varcoe, T. J., & Moyer, R. W. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00697.2002 · Cited by 50 · see citing works

Diurnal Variation in Vascular and Metabolic Function in Diet-Induced Obesity

Prasai, M., Mughal, R. S., Wheatcroft, S. B., Kearney, M. T., Grant, P. J., & SCOTT, E. M. (2013) · Diabetes · doi:10.2337/db11-1740 · Cited by 47 · see citing works

Effect of Obesity on Growth‐related Oncogene Factor‐α, Thrombopoietin, and Tissue Inhibitor Metalloproteinase‐1 Serum Levels

Maury, E., Brichard, S. M., Pataky, Z., Carpentier, A., Golay, A., & Bobbioni‐Harsch, E. (2009) · Obesity · doi:10.1038/oby.2009.464 · Cited by 44 · see citing works

Circadian Rhythm of Glucose Uptake in Cultures of Skeletal Muscle Cells and Adipocytes in Wistar-Kyoto, Wistar, Goto-Kakizaki, and Spontaneously Hypertensive Rats

Feneberg, R., & Lemmer, B. (2004) · Chronobiology International · doi:10.1081/cbi-200026958 · Cited by 40 · see citing works

Thrombopoietin as Biomarker and Mediator of Cardiovascular Damage in Critical Diseases

Lupia, E., Goffi, A., Bosco, O., & Montrucchio, G. (2012) · Mediators of Inflammation · doi:10.1155/2012/390892 · Cited by 38 · see citing works

Circadian Feeding Drive of Metabolic Activity in Adipose Tissue and not Hyperphagia Triggers Overweight in Mice: Is There a Role of the Pentose-Phosphate Pathway?

Stucchi, P., Gil‐Ortega, M., Merino, B., et al. (2011) · Endocrinology · doi:10.1210/en.2011-1023 · Cited by 38 · see citing works

Vitamin D and Type 2 Diabetes

Scragg, R. K. R. (2008) · Diabetes · doi:10.2337/db08-0879 · Cited by 34 · see citing works

Clock regulation of dietary lipid absorption

Hussain, M. M., & Pan, X. (2012) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3283548629 · Cited by 28 · see citing works

Light Pulse‐Induced Heme and Iron‐Associated Transcripts in Mouse Brain: A Microarray Analysis

Ben‐Shlomo, R., Akhtar, R. A., Collins, B. H., Judah, D. J., Davies, R., & Kyriacou, C. P. (2005) · Chronobiology International · doi:10.1081/cbi-200062353 · Cited by 25 · see citing works

Diurnal expression of the thrombopoietin gene is regulated by CLOCK

Tracey, C., Pan, X., Catterson, J. H., Harmar, A. J., Hussain, M. M., & Hartley, P. S. (2012) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2012.04643.x · Cited by 18 · see citing works

Chronobiological Aspects of Weight Loss in Obesity: Effects of Different Meal Timing Regimens

Sensi, S., & Capani, F. (1987) · Chronobiology International · doi:10.3109/07420528709078532 · Cited by 17 · see citing works

NAD+ and sirtuins in aging and disease

Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.002 · Cited by 1,481 · see citing works

The Sleep-Immune Crosstalk in Health and Disease

Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works

Circadian Rhythms, Sleep, and Disorders of Aging

Mattis, J., & Sehgal, A. (2016) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2016.02.003 · Cited by 369 · see citing works

Chronotype and circadian rhythm in bipolar disorder: A systematic review

Melo, M. C. A., Abreu, R. L. C., Linhares Neto, V. B., de Bruin, P. F. C., & de Bruin, V. M. S. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.06.007 · Cited by 324 · see citing works

Circadian timing of metabolism in animal models and humans

Dibner, C., & Schibler, U. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12347 · Cited by 237 · see citing works

Circadian disruption: New clinical perspective of disease pathology and basis for chronotherapeutic intervention

Smolensky, M. H., Hermida, R. C., Reinberg, A., Sackett-Lundeen, L., & Portaluppi, F. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1184678 · Cited by 197 · see citing works

Sleep restriction increases free fatty acids in healthy men

Broussard, J. L., Chapotot, F., Abraham, V., Day, A., Delebecque, F., Whitmore, H. R., & Tasali, E. (2015) · Diabetologia · doi:10.1007/s00125-015-3500-4 · Cited by 156 · see citing works

Mammalian circadian systems: Organization and modern life challenges

Finger, A., & Kramer, A. (2021) · Acta Physiologica · doi:10.1111/apha.13548 · Cited by 117 · see citing works

Circadian depression: A mood disorder phenotype

Carpenter, J. S., Crouse, J. J., Scott, E. M., Naismith, S. L., Wilson, C., Scott, J., Merikangas, K. R., & Hickie, I. B. (2021) · Neuroscience &amp; Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.045 · Cited by 114 · see citing works

Temperature as a circadian marker in older human subjects: relationship to metabolic syndrome and diabetes

Harfmann, B. D., Schroder, E. A., England, J. H., Senn, N. J., Westgate, P. M., Esser, K. A., & Kern, P. A. (2017) · Journal of the Endocrine Society · doi:10.1210/js.2017-00086 · Cited by 16 · see citing works

Interactions between the circadian clock and metabolism: there are good times and bad times

Shi, M., & Zheng, X. (2012) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gms110 · Cited by 22 · see citing works

Keeping time in the dark: Potato diel and circadian rhythmic gene expression reveals tissue‐specific circadian clocks

Hoopes, G. M., Zarka, D. G., Feke, A., Acheson, K., Hamilton, J. P., Douches, D. S., Buell, C. R., & Farré, E. M. (2022) · Plant Direct · doi:10.1002/pld3.425 · Cited by 19 · see citing works

A circadian clock in macrophages controls inflammatory immune responses

Keller, M., Mazuch, J., Abraham, U., Eom, G. D., Herzog, E. D., Volk, H.-D., Kramer, A., & Maier, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906361106 · Cited by 843 · see citing works

Magnesium maintains the length of the circadian period in Arabidopsis

de Melo, J. R. F., Gutsch, A., Caluwé, T. D., et al. (2021) · PLANT PHYSIOLOGY · doi:10.1093/plphys/kiaa042 · Cited by 38 · see citing works

Circadian expression of clock genes in human peripheral leukocytes

Fukuya, H., Emoto, N., Nonaka, H., Yagita, K., Okamura, H., & Yokoyama, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.063 · Cited by 72 · see citing works