The DOI matches its Crossref record; 48 of the 52 references it cites were found in a registry or an index; none of the 41 sources its claims cite is checked for support yet.
Quantification of the impact of endometriosis symptoms on health-related quality of life and work productivity
Open accessAbstract
OBJECTIVE To quantify the impact of endometriosis-related symptoms on physical and mental health status, health-related quality of life (HRQoL), and work-related aspects (absenteeism, presenteeism, work productivity, activity impairment). DESIGN Cross-sectional quantitative study. SETTING Academic and research institution. PATIENT(S) Women (n=193) with self-reported surgically diagnosed endometriosis from the Endometriosis Patient Registry at Ponce School of Medicine and Health Sciences (PSMHS). INTERVENTION(S) Patients completed an anonymous questionnaire divided into three sections consisting of questions from the Patient Health Survey (SF-12®), the Endometriosis Health Profile (EHP-5), and the Work Productivity and Activity Impairment Survey (WPAI). MAIN OUTCOME MEASURE(S) Impact of endometriosis symptoms on physical and mental health status, health-related quality of life (HRQoL), absenteeism, presenteeism, work productivity and activity impairment was quantified. RESULTS Patients had SF-12 scores denoting significant disability in the phyisical and mental health components. They also reported an average of 7.41 hrs (approximately one working day) of work time loss during the week the symptoms are worse. In addition, WPAI scores show high impact on work-related domains: 13% of average loss in work time (absenteeism), 65% of their work was impaired (presenteeism), 64% loss in efficiency levels (work productivity loss), and 60% of daily activities perturbed (activity impairment). CONCLUSION Endometriosis symptoms such as chronic, incapacitating pelvic pain and infertility negatively and substantially impact the physical and mental health status, HRQoL, and productivity at work of patients with endometriosis.
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A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Also, feeling depressed due to the possibility of not being able to conceive was commonly reported as a major distress.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passes- Rests on an assumption: The Spanish version of EHP-5 used in this study was valid for measuring endometriosis-related HRQoL despite not having been formally translated and validated in Spanish.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“EHP-5 results further demonstrated that endometriosis symptoms negatively affect many aspects of a substantial proportion of patients’ physical and mental health, including sexual relations, treatment expectations, and maternity issues.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The Spanish version of EHP-5 used in this study was valid for measuring endometriosis-related HRQoL despite not having been formally translated and validated in Spanish.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“101 participants reported missing work in the past week due to their health problem (mean loss in work time = 7.41 hrs; SD±8.97 hrs) during those seven days when symptoms were worse.”
- Also stated in: § RESULTS · plain
“They also reported an average of 7.41 hrs (approximately one working day) of work time loss during the week the symptoms are worse.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Results > WPAI: Work Productivity and Activity Impairment Survey Results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: Self-reported surgically diagnosed endometriosis in the registry accurately identifies women who have endometriosis.
- Rests on an assumption: The WPAI instrument is valid for measuring endometriosis-related work productivity in this population.
- Rests on an assumption: The week of the last menstrual period or when symptoms were worse is representative of the typical impact of endometriosis symptoms on work and daily activities.
- Rests on an assumption: The 40% response rate did not introduce non-response bias that would alter the findings.
- Also stated in: § RESULTS · plain
In the paper
“The Work Productivity and Activity Impairment Questionnaire (WPAI) is a validated instrument that measures the effect of both general and specific symptoms on work productivity and daily tasks (34).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Introduction
What the sources say
- Not checked yetcites [34] Reilly, 2004, The validity and accuracy of the Work Productivity and Activity Impairment questionnaire—irritable bowel syndrome version (WPAI: IBS), Aliment Pharmacol Ther source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesNone of the sources cited for this claim have been checked yet.
In the paper
“To date, the only validated endometriosis-specific HRQoL instruments are EHP-30 and its shorter version, EHP-5 (25-29).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Introduction
What the sources say
- Not checked yetcites [25] Jenkinson, 2008, Evaluation of the American version of the 30-item Endometriosis Health Profile (EHP-30), Qual Life Res source
- Not checked yetcites [26] Jones, 2004, Evaluating the responsiveness of the Endometriosis Health Profile Questionnaire: the EHP-30, Qual Life Res source
- Not checked yetcites [27] Jones, 2001, Development of an endometriosis quality-of-life instrument: the Endometriosis Health Profile-30, Obstet Gynecol
- Not checked yetcites [28] Khong, 2010, Is the 30-item Endometriosis Health Profile (EHP-30) suitable as a self-report health status instrument for clinical trials?, Fertil Steril source
- Not checked yetcites [29] Jones, 2004, Development of the Short Form Endometriosis Health Profile Questionnaire: the EHP-5, Qual Life Res source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“It is noteworthy that disease severity defined by the patient does not necessarily correlate with physician-rated severity scores, as shown in other diseases such as ulcerative colitis, in which endoscopy severity scores had limited value in estimating HRQoL (48).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
What the sources say
- Not checked yetcites [48]
Load-bearingStrength:hedged· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesA conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Endometriosis symptoms such as chronic, incapacitating pelvic pain and infertility negatively and substantially impact the physical and mental health status, HRQoL, and productivity at work of patients with endometriosis.”
- Also stated in: § Discussion · hedged
“This cross-sectional study on 193 Puerto Rican women with endometriosis supports the evidence gathered by qualitative studies conducted in other populations indicating that endometriosis-related symptoms have a negative impact on QoL, HRQoL, and work productivity.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Abstract > CONCLUSION
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: Self-reported surgically diagnosed endometriosis in the registry accurately identifies women who have endometriosis.
- Rests on an assumption: The Spanish version of EHP-5 used in this study was valid for measuring endometriosis-related HRQoL despite not having been formally translated and validated in Spanish.
- Rests on an assumption: The sample of 193 women from the PSMHS registry is representative of women with endometriosis in Puerto Rico or more broadly.
- Rests on an assumption: The WPAI instrument is valid for measuring endometriosis-related work productivity in this population.
- Rests on an assumption: The week of the last menstrual period or when symptoms were worse is representative of the typical impact of endometriosis symptoms on work and daily activities.
- Rests on an assumption: The 40% response rate did not introduce non-response bias that would alter the findings.
- Also stated in: § Discussion · hedged
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“This study is limited in that we did not obtain information about disease severity.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIn the paper
“It is well recognized that endometriosis causes severe and incapacitating painful symptoms including chronic pelvic pain, dysmenorrhea, and dyspareunia (1).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Introduction
What the sources say
- Not checked yetcites [1] Bulun, 2009, Endometriosis, N Engl J Med source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIn the paper
“These data suggest that endometriosis negatively impacts HRQoL across populations (37).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
What the sources say
- Not checked yetcites [37] Wilhelm, 2008, What can alert the general practitioner to people whose common mental health problems are unrecognised?, Med J Aust source
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passes- Rests on an assumption: The sample of 193 women from the PSMHS registry is representative of women with endometriosis in Puerto Rico or more broadly.
- It may state two separate claims as one. 12
- The quote only partly states this claim. 1
- Probably not a substantial claim. 5
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The SF-12® PCS and MCS scores were 38.4±6.7 and 39.5±6.2, respectively, indicating substantial disability.”
- Also stated in: § RESULTS · plain
“Patients had SF-12 scores denoting significant disability in the phyisical and mental health components.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Results > SF-12® Health Survey Results
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Self-reported surgically diagnosed endometriosis in the registry accurately identifies women who have endometriosis.
- Rests on an assumption: The 40% response rate did not introduce non-response bias that would alter the findings.
- Also stated in: § RESULTS · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“We observed that, indeed, patients categorized as “high impact” had significantly higher WPAI Presenteeism, Work productivity loss and Activity impairment scores indicating greater impairment and less productivity (Table 4).”
- Also stated in: § Discussion · plain
“Also, except for absenteeism, we observed statistically significant differences between patients reporting high vs low impact on EHP-5 domains in all WPAI dimensions.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Results > Comparison between EHP-5 and WPAI results
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: Self-reported surgically diagnosed endometriosis in the registry accurately identifies women who have endometriosis.
- Rests on an assumption: The Spanish version of EHP-5 used in this study was valid for measuring endometriosis-related HRQoL despite not having been formally translated and validated in Spanish.
- Rests on an assumption: The WPAI instrument is valid for measuring endometriosis-related work productivity in this population.
- Rests on an assumption: The 40% response rate did not introduce non-response bias that would alter the findings.
- Also stated in: § Discussion · plain
In the paper
“Compared to patients with rheumatoid arthritis, patients in this study reported worse WPAI outcomes in all domains measured except for absenteeism (13% vs. 46%) (47).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
What the sources say
- Not checked yetcites [47] Poole, 2010, A comparison of physician-rated disease severity and patient reported outcomes in mild to moderately active ulcerative colitis, J Crohns Colitis source
Strength:plain· not yet calibratedCausal:correlational· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The WPAI instrument is valid for measuring endometriosis-related work productivity in this population.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Patients reported a substantial impact of symptoms in both work productivity (moderately affected) and daily life activities (extremely affected).”
- Also stated in: § WPAI: Work Productivity and Activity Impairment Survey Results · plain
“Based on this scale, loss of productivity had a median of 6.0 (moderately affected) and daily life activities a median of 7.0 (extremely affected).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one. The quote only partly states this claim.
- Rests on an assumption: The WPAI instrument is valid for measuring endometriosis-related work productivity in this population.
- Rests on an assumption: The week of the last menstrual period or when symptoms were worse is representative of the typical impact of endometriosis symptoms on work and daily activities.
- Also stated in: § WPAI: Work Productivity and Activity Impairment Survey Results · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Among QoL domains most commonly affected were changes in mood, and perceptions that no one understands, which were reported by more than half of respondents.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The Spanish version of EHP-5 used in this study was valid for measuring endometriosis-related HRQoL despite not having been formally translated and validated in Spanish.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The only significant difference observed between these two groups was age: patients who responded by regular mail were older than those who responded electronically.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The 40% response rate did not introduce non-response bias that would alter the findings.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“The questionnaire was completed by 193 women, for a response rate of 40%.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Results
Strength:plain· not yet calibratedn = 193Tests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
- Rests on an assumption: The 40% response rate did not introduce non-response bias that would alter the findings.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Moreover, we observed an association between EHP-5 and WPAI results, supporting the use of EHP-5 as a tool to predict work-related problems in these patients.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
Tests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
- Rests on an assumption: The Spanish version of EHP-5 used in this study was valid for measuring endometriosis-related HRQoL despite not having been formally translated and validated in Spanish.
- Rests on an assumption: The WPAI instrument is valid for measuring endometriosis-related work productivity in this population.
None of the sources cited for this claim have been checked yet.
In the paper
“WPAI and SF-12® have been translated to Spanish and validated previously (38, 39).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
What the sources say
- Not checked yetcites [38] Rodriguez-Merchan, 2003, Health outcome assessment: SF-36 in English and Spanish, Haemophilia source
- Not checked yetcites [39] Vergara, 2009, Validation of the Spanish Work Productivity and Activity impairment questionnaire: Crohn’s disease version, Eur J Gastroenterol Hepatol source
Load-bearingStrength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✓ Load-bearing: passes✓ Based: passesIt may state two separate claims as one.
In the paper
“Thus, SF-12® scores ≥50 represent above average health status and scores of ≤40 have been used as determinant of significant disability (37).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Materials and Methods > Study Questionnaires
What the sources say
- Not checked yetcites [37] Wilhelm, 2008, What can alert the general practitioner to people whose common mental health problems are unrecognised?, Med J Aust source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Such studies have also shown that endometriosis symptoms negatively impact patients’ social wellbeing, affecting relationships, lowering self-esteem, and leading to a feeling of loss of control (3, 22, 23).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Introduction
What the sources say
- Not checked yetcites [3] Jones, 2004, The impact of endometriosis upon quality of life: a qualitative analysis, J Psychosom Obstet Gynaecol source
- Not checked yetcites [22] Lewis, 1987, Bipolar mood disorder and endometriosis: preliminary findings, Am J Psychiatry source
- Not checked yetcites [23] Low, 1993, A psychological profile of endometriosis patients in comparison to patients with pelvic pain of other origins, J Psychosom Res source
Strength:plain· not yet calibratedCausal:direct· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes? Load-bearing: unclear✓ Based: passesIt may state two separate claims as one.
In the paper
“The endometriosis-specific EHP-5 survey was developed and validated in an effort to have a condensed HRQoL instrument that could be used in a time-effective manner during a clinical consult and/or encounters with researchers (29).”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Materials and Methods > Study Questionnaires
What the sources say
- Not checked yetcites [29] Jones, 2004, Development of the Short Form Endometriosis Health Profile Questionnaire: the EHP-5, Qual Life Res source
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Initials, date of birth, and surgeon’s name were used to warrant that participants completed the questionnaire only once.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Materials and Methods > Study Population
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“The endometriosis-specific surveys EHP-30/EHP-5 have been translated and validated in several populations (25, 30, 31, 44); however, these valuable instruments have not been widely used.”
§ Quantification of the Impact of Endometriosis Symptoms on Health Related Quality of Life and Work Productivity > Discussion
What the sources say
- Not checked yetcites [25] Jenkinson, 2008, Evaluation of the American version of the 30-item Endometriosis Health Profile (EHP-30), Qual Life Res source
- Not checked yetcites [30] Renouvel, 2009, Linguistic adaptation of the endometriosis health profile 5: EHP 5 [in French], J Gynecol Obstet Biol Reprod (Paris) source
- Not checked yetcites [31] Mengarda, 2008, Validation of Brazilian Portuguese version of quality of life questionnaire for women with endometriosis (Endometriosis Health Profile Questionnaire—EHP-30) [in Portugese], Rev Bras Ginecol Obstet source
- Not checked yetcites [44] Choi, 2005, Influencing factors of depression in women with endometriosis [in Korean], Taehan Kanho Hakhoe Chi
Strength:plain· not yet calibratedTests✓ Asserted: passes✓ Checkable: passes✗ Load-bearing: fails✓ Based: passesProbably not a substantial claim. The paper’s conclusions may not depend on it.
The paper relies on this without support.
Before this study, the effect of endometriosis symptoms on work productivity had not been measured with standardized instruments.
“One important aspect of QoL is work productivity; however, the impact of endometriosis symptoms on this particular area has not been quantified to date using standardized instruments.”
“To our knowledge, WPAI has not been used before to quantify the impact of endometriosis symptoms on work aspects.”
The paper relies on this without support.
Self-reported surgically diagnosed endometriosis in the registry accurately identifies women who have endometriosis.
“Women (n=193) with self-reported surgically diagnosed endometriosis from the Endometriosis Patient Registry at Ponce School of Medicine and Health Sciences (PSMHS).”
“patients with self-reported surgically diagnosed of endometriosis (n=715) and controls (n=246)”
The paper relies on this without support.
The Spanish version of EHP-5 used in this study was valid for measuring endometriosis-related HRQoL despite not having been formally translated and validated in Spanish.
“EHP-5 had not been translated to Spanish, although its questions were derived from SF-36, which has been previously translated to Spanish.”
The paper relies on this without support.
The sample of 193 women from the PSMHS registry is representative of women with endometriosis in Puerto Rico or more broadly.
“This cross-sectional study on 193 Puerto Rican women with endometriosis supports the evidence gathered by qualitative studies conducted in other populations indicating that endometriosis-related symptoms have a negative impact on QoL, HRQoL, and work productivity.”
The paper relies on this without support.
The WPAI instrument is valid for measuring endometriosis-related work productivity in this population.
“to our knowledge, this is the first time WPAI has been applied to an endometriosis patient population.”
“The Work Productivity and Activity Impairment Questionnaire (WPAI) is a validated instrument that measures the effect of both general and specific symptoms on work productivity and daily tasks (34).”
The paper relies on this without support.
The week of the last menstrual period or when symptoms were worse is representative of the typical impact of endometriosis symptoms on work and daily activities.
“Patients were instructed to respond these questions according to how they felt during the week of their last menstrual period (when exacerbation of symptoms most commonly occurs) or during the week of the month when symptoms were worse.”
The paper relies on this without support.
The 40% response rate did not introduce non-response bias that would alter the findings.
“The questionnaire was completed by 193 women, for a response rate of 40%.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The impacts of disease extent, duration and fertility status upon HRQoL were inconsistent.”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [17]
In the citing paper
“Findings showed that endometriosis impaired women’s HRQoL.”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [17]
In the citing paper
“It was also reported that endometriosis was associated with greater losses in work productivity [3,4,13,17] and increased sexual dysfunction [13].”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [17]
In the citing paper
“Infertility significantly impaired the physical and mental status in endometriosis [17].”
From Health-related quality of life in women with endometriosis: a systematic review (2012) · cites this paper as [17]
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“Impact on health, work productivity, and daily life activities has been already described by qualitative studies (16-20) and costs of productivity loss has been estimated (21).”
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“Impact on health, work productivity, and daily life activities has been already described by qualitative studies (16-20) and costs of productivity loss has been estimated (21).”
Background
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4 of the 52 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Rethinking mechanisms, diagnosis and management of endometriosis
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“Overall, the weight of the evidence points to higher rates of depression, anxiety and emotional distress than control groups and the general population (Low et al., 1993; Peveler et al., 1996; Lemaire, 2004; Lorençatto et al., 2006; Petrelluzzi et al., 2008; Siedentopf et al., 2008; Sepulcri and do Amaral, 2009; Fourq…”
BackgroundInfluentialImpact of endometriosis on women’s lives: a qualitative study
Moradi, M., Parker, M. A., Sneddon, A., López, V., & Ellwood, D. A. (2014) · BMC Women s Health · doi:10.1186/1472-6874-14-123 · Cited by 525
“Quantitative studies have reported that endometriosis leads to a poor or impaired quality of life [9,36-39].”
BackgroundPrevalence of Chronic Pelvic Pain Among Women: An Updated Review
Ahangari, A. (2014) · Pain Physician · doi:10.36076/ppj.2014/17/e141 · Cited by 437
Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management
Abrao, M. S., Petraglia, F., Falcone, T., Keckstein, J., Osuga, Y., & Chapron, C. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv003 · Cited by 398
“The bowel disease affects patient quality of life as it can increase the number of evacuations or cause progressive constipation leading to bowel obstruction (Bailey et al., 1994; Garry et al., 2000; Redwine and Wright 2001; Darai et al., 2007a; Dousset et al., 2010; Fourquet et al., 2011).”
BackgroundDiagnosis and management of endometriosis
Allaire, C., Bedaiwy, M. A., & Yong, P. J. (2023) · Canadian Medical Association Journal · doi:10.1503/cmaj.220637 · Cited by 363
Schoep, M. E., Adang, E., Maas, J. W. M., Bie, B. D., Aarts, J. W. M., & Nieboer, T. E. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026186 · Cited by 335
“Absenteeism and presenteeism due to endometriosis in other studies was greater than in our study, which was not surprising.(9) 14 30 However, some interesting parallels can be drawn to findings from a recent study by Soliman et al.”
ResultWomen's experiences of endometriosis: a systematic review and synthesis of qualitative research
Young, K., Fisher, J., & Kirkman, M. (2014) · Journal of Family Planning and Reproductive Health Care · doi:10.1136/jfprhc-2013-100853 · Cited by 241
“For example, Simoens et al. 39 estimated that a woman with endometriosis living in Europe or America experiences an average annual loss of productivity cost of € 6298, while Fourquet et al. 37 reported that women lose approximately one working day per week when their symptoms are “ prevalent ” .”
BackgroundResultImpact of Endometriosis on Life-Course Potential: A Narrative Review
Missmer, S. A., Tu, F. F., Agarwal, S. K., Chapron, C., Soliman, A. M., Chiuve, S. E., Eichner, S. F., Flores, I., Horne, A. W., Kimball, A. B., et al. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s261139 · Cited by 222
“In a second survey within this population, women with endometriosis (n=193) reported an average of 7.41 hours per week of missed work when symptoms were at their worst, and work-related losses of 13% due to absenteeism, 65% due to presenteeism, and 64% from decreased work productivity, as measured on the Work Producti…”
BackgroundMethodInfluentialSelf-citationSoliman, A. M., Coyne, K. S., Zaiser, E., Castelli-Haley, J., & Fuldeore, M. J. (2017) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2017.1289512 · Cited by 166
“[10] each reported that endometriosis had affected work and relationships of approximately half of the women in their studies.”
BackgroundThe Effect of Endometriosis Symptoms on Absenteeism and Presenteeism in the Workplace and at Home
Soliman, A. M., Coyne, K. S., Gries, K. S., Castelli‐Haley, J., Snabes, M. C., & Surrey, E. S. (2017) · Journal of Managed Care & Specialty Pharmacy · doi:10.18553/jmcp.2017.23.7.745 · Cited by 160
Fatigue – a symptom in endometriosis
Ramin-Wright, A., Schwartz, A. S. K., Geraedts, K., Rauchfuss, M., Wölfler, M. M., Haeberlin, F., von Orelli, S., Eberhard, M., Imthurn, B., Imesch, P., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey115 · Cited by 147
Quality of Life in Women with Endometriosis: An Integrative Review
Marinho, M. C. P., de Magalhães, T. F., Fernandes, L. F. C., Augusto, K. L., Brilhante, A. V. M., & Bezerra, L. R. P. S. (2017) · Journal of Women s Health · doi:10.1089/jwh.2017.6397 · Cited by 149
Sims, O. T., Gupta, J., Missmer, S. A., & Aninye, I. O. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18158210 · Cited by 185
Laganà, A. S., Condemi, I., Retto, G., Muscatello, M. R. A., Bruno, A., Zoccali, R. A., Triolo, O., & Cedro, C. (2015) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2015.08.015 · Cited by 144
“Our findings are congruent with literature data showing higher rates of depression, anxiety, and emotional distress in endometriotic patients than in the general population [15–17].”
ResultRetractedThe Impact of Endometriosis on Quality of Life in Adolescents
Gallagher, J. S., DiVasta, A. D., Vitonis, A. F., Sarda, V., Laufer, M. R., & Missmer, S. A. (2018) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2018.06.027 · Cited by 143
Systematic review of quality of life measures in patients with endometriosis
Bourdel, N., Chauvet, P., Billone, V., Douridas, G., Fauconnier, A., Gerbaud, L., & Canis, M. J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0208464 · Cited by 139
Yoo, J., Kim, T. H., Fazleabas, A. T., Palomino, W. A., Ahn, S. H., Tayade, C., Schammel, D. P., Young, S. L., Jeong, J., & Lessey, B. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-04577-w · Cited by 140
Health-related quality of life in women with endometriosis: a systematic review
Jia, S.-Z., Leng, J.-H., Shi, J.-H., Sun, P.-R., & Lang, J.-H. (2012) · Journal of Ovarian Research · doi:10.1186/1757-2215-5-29 · Cited by 132
“With respect to infertility, no consistent conclusion could be made [3,16,17].”
BackgroundInfluentialTherapeutic Affordances of Online Support Group Use in Women With Endometriosis
Shoebotham, A., & Coulson, N. S. (2016) · Journal of Medical Internet Research · doi:10.2196/jmir.5548 · Cited by 99
“Endometriosis can negatively affect social life, work, and daily activities [15-17] as well as education, finances, life opportunities [18], personal relationship quality [8], and physical intimacy [19].”
Montanari, G., Donato, N. D., Benfenati, A., Giovanardi, G., Zannoni, L., Vicenzi, C., Solfrini, S., Mignemi, G., Villa, G., Mabrouk, M., et al. (2013) · The Journal of Sexual Medicine · doi:10.1111/jsm.12133 · Cited by 96
Szypłowska, M., Tarkowski, R., & Kułak, K. (2023) · Frontiers in Public Health · doi:10.3389/fpubh.2023.1230303 · Cited by 103
“Six other studies found significantly reduced physical HRQoL in affected women (32, 36, 37, 39, 42, 45).”
BackgroundResultInfluentialPsychosocial impact of endometriosis: From co-morbidity to intervention
Aerts, L., Grangier, L., Streuli, I., Dällenbach, P., Marci, R., Wenger, J., & Pluchino, N. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.008 · Cited by 92
Strowitzki, T., Marr, J., Gerlinger, C., Faustmann, T. A., & Seitz, C. (2012) · International Journal of Gynecology & Obstetrics · doi:10.1016/j.ijgo.2012.01.009 · Cited by 90
“The relevance of QoL outcomes is indicated by a recent study quantifying the impact of endometriosis symptoms on QoL, in which there was a 13% average loss in work time (absenteeism), 65% work impairment (presenteeism), 64% loss in work productivity, and 60% impairment in daily activities [20].”
MethodWomen with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome
Conti, N., Cevenini, G., Vannuccini, S., Orlandini, C., Valensise, H. C. C., Gervasi, M. T., Ghezzi, F., Tommaso, M. D., Severi, F. M., & Petraglia, F. (2014) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.3109/14767058.2014.968843 · Cited by 90
“metrial tissue outside uterus causes two main symptoms, pain and infertility, but endometriosis is associated with significant deterioration of quality of life and represents a significant public health issue [2].”
BackgroundStress Exacerbates Endometriosis Manifestations and Inflammatory Parameters in an Animal Model
Cuevas, M., Flores, I., Thompson, K. J., Ramos‐Ortolaza, D. L., Torres-Reverón, A., & Appleyard, C. B. (2012) · Reproductive Sciences · doi:10.1177/1933719112438443 · Cited by 91
“In addition, there is ample evidence from qualitative and quantitative studies that document the significant negative impact on quality of life in patients with endometriosis.(10,11) Taken together, data from both animal models and human studies strongly suggest that stress does play a role in endometriosis.”
BackgroundSelf-citationExamining subjective wellbeing and health-related quality of life in women with endometriosis
Rush, G., & Misajon, R. (2017) · Health Care For Women International · doi:10.1080/07399332.2017.1397671 · Cited by 83
Quality of life outcomes in women with endometriosis are highly influenced by recruitment strategies
de Graaff, A. A., Dirksen, C. D., Simoens, S., Bie, B. D., Hummelshøj, L., D’Hooghe, T. M., & Dunselman, G. A. J. (2015) · Human Reproduction · doi:10.1093/humrep/dev084 · Cited by 85
Hansen, K. E., Kesmodel, U. S., Baldursson, E. B., Schultz, R., & Forman, A. (2013) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2013.03.008 · Cited by 87
Santulli, P., Bourdon, M., Presse, M., Gayet, V., Marcellin, L., Prunet, C., de Ziegler, D., & Chapron, C. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.12.006 · Cited by 82
Hudson, N., Culley, L. A., Law, C., Mitchell, H., Denny, E., & Raine‐Fenning, N. (2015) · Sociology of Health & Illness · doi:10.1111/1467-9566.12392 · Cited by 83
Quality of life in women with endometriosis: a narrative overview
Rosa, V. L. L., FRANCISCIS, P. D., Barra, F., Schiattarella, A., Török, P., Shah, M., Karaman, E., Cerentini, T. M., Guardo, F. D., Gullo, G., et al. (2020) · Minerva Medica · doi:10.23736/s0026-4806.19.06298-0 · Cited by 82
Impact of coping strategies on quality of life of adolescents and young women with endometriosis
González-Echevarría, A. M., Rosario, E., Acevedo, S. F., & Flores, I. (2018) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2018.1450384 · Cited by 90
“These findings are in accord to previous studies showing that patients with endometriosis feel lack of support from others, lose the ability to perform at work, and have limitations in day-to-day activities, reducing their QoL [3,9,10,15].”
BackgroundResultSelf-citationSalient aspects of quality of life among women diagnosed with endometriosis: A qualitative study
Roomaney, R., & Kagee, A. (2016) · Journal of Health Psychology · doi:10.1177/1359105316643069 · Cited by 76
“Other studies also found that endometriosis impacted women’s ability to work (Fourquet et al., 2011; Gilmour et al., 2008; Nnoaham et al., 2011; Seear, 2009c).”
ResultHang, Y., Tan, L. H., Chen, Q., Qiaoli, L., & Jin, Y. (2021) · Cell Biology International · doi:10.1002/cbin.11592 · Cited by 72
“Endometriosis refers to the abnormal growth of endometrial tissues outside the endometrium and myometrium of the uterus, which subsequently causes symptoms including pain and infertility affecting the quality of life of 10% of child‐bearing women (Fourquet et al., 2011; Wang et al., 2020).”
BackgroundAge-Related Differences in Quality of Life in Swedish Women with Endometriosis
Lövkvist, L., Boström, P., Edlund, M., & Olovsson, M. (2016) · Journal of Women s Health · doi:10.1089/jwh.2015.5403 · Cited by 73
Quality of life in women with endometriosis: a cross-sectional survey
Bień, A., Rzońca, E., Zarajczyk, M., Wilkosz, K., Wdowiak, A., & Iwanowicz-Palus, G. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02515-4 · Cited by 70
Bush, D., Brick, E., East, M. C., & Johnson, N. (2017) · Australian and New Zealand Journal of Obstetrics and Gynaecology · doi:10.1111/ajo.12614 · Cited by 70
Sperschneider, M. L., Hengartner, M. P., Schwartz, A. K., Geraedts, K., Rauchfuß, M., Woelfler, M. M., Haeberlin, F., von Orelli, S., Eberhard, M., Maurer, F., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2017-019570 · Cited by 70
“4 hours.(13) 14 In our study, chronic pain, frequency of pain, fatigue and psychological symptoms, such as self-reported depression and anxiety, were significantly—but with modest effect sizes—related to taking more sick leave (table 4).”
BackgroundChronic stress accelerates the development of endometriosis in mouse through adrenergic receptor β2
Long, Q., Liu, X., Qi, Q.-M., & Guo, S. (2016) · Human Reproduction · doi:10.1093/humrep/dew237 · Cited by 68
Elagolix, an Oral GnRH Antagonist for Endometriosis-Associated Pain: A Randomized Controlled Study
Carr, B. R., Giudice, L. C., Dmowski, W. P., O’Brien, C., Jiang, P. X., Burke, J., Jimenez, R., Hass, S., Fuldeore, M. J., & Chwalisż, K. (2013) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000157 · Cited by 64
“In addition, the pain related to endometriosis has been shown to impair both workrelated and non-work-related daily activities (4-6).”
BackgroundAnxiety, coping skills and hypothalamus-pituitary-adrenal (HPA) axis in patients with endometriosis
Quiñones, M., Urrutia, R., Torres-Reverón, A., Vincent, K., & Flores, I. (2015) · Journal of Reproductive Biology and Health · doi:10.7243/2054-0841-3-2 · Cited by 60
“Pain, especially when chronic in nature, is considered a major cause of physical, psychosocial, and emotional impairment [18,19].”
BackgroundSelf-citationDelanerolle, G., Ramakrishnan, R., Hapangama, D. K., Zeng, Y., Shetty, A., Elneil, S., Chong, S., Hirsch, M., Oyewole, M., Phiri, P., et al. (2021) · Women s Health · doi:10.1177/17455065211019717 · Cited by 61
“Es que tú eres una changa”: stigma experiences among Latina women living with endometriosis
Matías-González, Y., Sánchez-Galarza, A. N., Flores, I., & Rivera-Segarra, E. (2020) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2020.1822807 · Cited by 54
Self-citationRodrigues, M. P. D. F., Vilariño, F. L., Munhoz, A. D. S. B., Paiva, L. D. S., Sousa, L. V. D. A., Zaia, V., & Barbosa, C. P. (2020) · BMC Women s Health · doi:10.1186/s12905-020-00987-7 · Cited by 53
Endometriosis and Sexual Quality of Life
van Poll, M., van Barneveld, E., Aerts, L., Maas, J. W. M., Lim, A., de Greef, B. T. A., Bongers, M. Y., & van Hanegem, N. (2020) · Sexual Medicine · doi:10.1016/j.esxm.2020.06.004 · Cited by 54
“Menstruation-related symptoms in general and endometriosis in particular have a high impact onworkrelated domains such as absenteeism, presenteeism, and loss in efficiency and productivity of work.(32,33)We can theorize that women with endometriosis who are unable to work due to health complaints encounter more severe…”
BackgroundColón-Caraballo, M., García, M., Mendoza, A., & Flores, I. (2018) · Applied immunohistochemistry & molecular morphology · doi:10.1097/pai.0000000000000663 · Cited by 52
“Peritoneal endometriosis (5) showed a tendency for lower levels of ESR1 than the other receptors that can be attributed to the menstrual phase (secretory).”
Self-citationEndometriosis and autoimmunity: Can autoantibodies be used as a non-invasive early diagnostic tool?
Greenbaum, H., Galper, B.-E. L., Decter, D. H., & Eisenberg, V. H. (2021) · Autoimmunity Reviews · doi:10.1016/j.autrev.2021.102795 · Cited by 53
Apers, S., Dancet, E. A. F., Aarts, J. W. M., Kluivers, K. B., D’Hooghe, T. M., & Nelen, W. L. D. M. (2017) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2017.10.106 · Cited by 52
Dysregulation of Lysyl Oxidase Expression in Lesions and Endometrium of Women With Endometriosis
Ruiz, L. A., Báez, P., Ruiz, A., Peterse, D., Monteiro, J. B., Bracero, N. J., Beauchamp, P. J., Fazleabas, A. T., & Flores, I. (2015) · Reproductive Sciences · doi:10.1177/1933719115585144 · Cited by 49
Self-citationLaganà, A. S., Sturlese, E., Retto, G., Sofo, V., & Triolo, O. (2013) · Obstetrics and Gynecology International · doi:10.1155/2013/527041 · Cited by 53
“…Simone Laganà,1 Emanuele Sturlese,1 Giovanni Retto,1 Vincenza Sofo,2 and Onofrio Triolo1 1 Department of Pediatric, Gynecological, Microbiological and Biomedical Sciences, University of Messina, Via C. Valeria 1, 98125 Messina, Italy 2 Department of Environmental Sciences, Safety,…”
BackgroundInfluentialTouboul, C., Ballester, M., Dubernard, G., Zilberman, S., Thomin, A., & Daraï, É. (2014) · Surgical Endoscopy · doi:10.1007/s00464-014-3880-4 · Cited by 46
As‐Sanie, S., Laufer, M. R., Missmer, S. A., Murji, A., Vincent, K., Eichner, S. F., Cross, S. J., Soliman, A. M., & Tu, F. F. (2021) · Current Medical Research and Opinion · doi:10.1080/03007995.2021.1929896 · Cited by 46
Patient Quality of Life and Symptoms after Surgical Treatment for Endometriosis
Comptour, A., Chauvet, P., Canis, M. J., Grémeau, A., Pouly, J. L., Rabischong, B., Pereira, B., & Bourdel, N. (2018) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2018.08.005 · Cited by 43
Does minimally invasive surgery for endometriosis improve pelvic symptoms and quality of life?
Deguara, C. S., Pepas, L. P., & Davis, C. (2012) · Current Opinion in Obstetrics & Gynecology · doi:10.1097/gco.0b013e328355626f · Cited by 47
Soliman, A. M., Rahal, Y., Robert, C., Defoy, I., Nisbet, P., Leyland, N. A., & Singh, S. S. (2020) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2020.06.022 · Cited by 44
The Link Between Stress and Endometriosis: from Animal Models to the Clinical Scenario
Appleyard, C. B., Flores, I., & Torres-Reverón, A. (2020) · Reproductive Sciences · doi:10.1007/s43032-020-00205-7 · Cited by 49
Self-citationFourquet, J., Zavala, D. E., Missmer, S. A., Bracero, N. J., Romaguera, J., & Flores, I. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.06.020 · Cited by 45
Self-citationMeyer, T. K., Hu, A. C., & Hıllel, A. D. (2013) · The Laryngoscope · doi:10.1002/lary.24292 · Cited by 47
Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain
Escudero-Lara, A., Argerich, J., Cabañero, D., & Maldonado, R. J. (2020) · eLife · doi:10.7554/elife.50356 · Cited by 42
“It is characterized by the growth of endometrium in extrauterine locations, chronic pain in the pelvis and the lower abdomen, infertility, emotional distress and loss of working ability (Fourquet et al., 2011; Márki et al., 2017; Zondervan et al., 2019).”
BackgroundJones, G. L., Budds, K., Taylor-Phillips, F., Musson, D., Raymer, J., Churchman, D., Kennedy, S., & Jenkinson, C. (2023) · Human Reproduction Update · doi:10.1093/humupd/dmad029 · Cited by 51
“…2018; van Aken et al. , 2018; Gonz � alez-Echevarr � ıa et al. , 2019; Roomaney et al. , 2020; � Skegro et al. , 2021); work/productivity (n ¼ 2) (Fourquet et al. , 2011; Hansen et al. , 2013); pain (n ¼ 5) (Hansen et al. , 2014; Stratton et al. , 2015; van Aken et al. , 2017; de Freitas Fonseca…”
Path to diagnosis and women’s perspectives on the impact of endometriosis pain
Lamvu, G., Flores, O. A., Orady, M. E., & Schneider, B. (2020) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.1177/2284026520903214 · Cited by 42
Preliminary insights on the relation between endometriosis, pelvic pain, and employment
Facchin, F., Buggio, L., Ottolini, F. L., Barbàra, G., Saita, E., & Vercellini, P. (2018) · Gynecologic and Obstetric Investigation · doi:10.1159/000494254 · Cited by 43
Communicating endometriosis with young women to decrease diagnosis time
Shadbolt, N. A., Parker, M. A., & Orthia, L. A. (2013) · Health Promotion Journal of Australia · doi:10.1071/he12915 · Cited by 41
Aubry, G., Panel, P., Thiollier, G., Huchon, C., & Fauconnier, A. (2017) · Human Reproduction · doi:10.1093/humrep/dex057 · Cited by 40
“The associated symptoms, dominated by severe pelvic pains and infertility, the chronicity, side effects of treatment and lack of understanding by other people, can have an impact on the personal, psychological and social aspects of patients’ daily life (Fourquet et al., 2011; De Graaff et al., 2013).”
BackgroundThe Role of mTOR and eIF Signaling in Benign Endometrial Diseases
Driva, T. S., Schatz, C., Sobočan, M., & Haybaeck, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073416 · Cited by 44
Social psychogenic stress promotes the development of endometriosis in mouse
Guo, S., Zhang, Q., & Liu, X. (2016) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2016.11.012 · Cited by 40
“…that endometriosis impacts negatively on women’s quality of life, work productivity, sexual relationship and self-esteem, mainly because of chronic, incapacitating pain and infertility (Culley et al., 2013; Denny and Mann, 2007; Fourquet et al., 2011; Lovkvist et al., 2016; Nnoaham et al, 2011).”
BackgroundMousa, M., Al‐Jefout, M., AlSafar, H. S., Becker, C. M., Zondervan, K. T., & Rahmioğlu, N. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.708410 · Cited by 38
“Presence and severity of multiple pelvic pain symptoms are the major drivers of work productivity loss in endometriosis (5, 85, 86).”
BackgroundFarshi, N., Hasanpour, S., Mirghafourvand, M., & Esmaeilpour, K. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02795-7 · Cited by 49
“Other endometriosis-associated symptoms including dysuria, dysmenorrhea, dyspareunia, and pelvic pain alleviate the mental health of patients [21, 22].”
BackgroundChronic Pelvic Pain and Quality of Life in Women with and without Endometriosis
Centini, G., Lazzeri, L., Dores, D., Pianigiani, L., Iannone, P., Luisi, S. V., Petraglia, F., & Zupi, E. (2013) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/je.5000148 · Cited by 38
Álvarez-Salvago, F., Lara-Ramos, A., Cantarero-Villanueva, I., Mazheika, M., Mundo-López, A., Galiano-Castillo, N., Fernández-Lao, C., Arroyo-Morales, M., Ocón-Hernández, O., & Artacho-Cordón, F. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17103610 · Cited by 38
Timing, delays and pathways to diagnosis of endometriosis: a scoping review protocol
Cromeens, M. G., Carey, E. T., Robinson, W. R., Knafl, K. A., & Thoyre, S. M. (2021) · BMJ Open · doi:10.1136/bmjopen-2021-049390 · Cited by 41
Nocturia Work Productivity and Activity Impairment Compared with Other Common Chronic Diseases
Miller, P. S. J., Hill, H. R., & Andersson, F. (2016) · PharmacoEconomics · doi:10.1007/s40273-016-0441-9 · Cited by 36
“We included 84 studies in the review: three nocturia studies [20–22], five OAB studies [23–27], 14 IBS/constipation studies [28–41], 13 GERD studies [42–54], 11 asthma/allergies studies [55–65], seven COPD studies [66–72], three sleep studies [73–75], 13 arthritis studies [76–88], nine pain studies [89–97], four depre…”
BackgroundThree-Dimensional Biofabrication Models of Endometriosis and the Endometriotic Microenvironment
Wendel, J. R. H., Wang, X., Smith, L. J., & Hawkins, S. M. (2020) · Biomedicines · doi:10.3390/biomedicines8110525 · Cited by 35
“Endometriosis often results in decreased quality of life, as measured by the Endometriosis Health Profile-30 (EHP-30) [4–8].”
Gupta, J., Cardoso, L., Harris, C., Dance, A. D., Seckin, T. A., Baker, N., & Ferguson, Y. O. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-020657 · Cited by 45
“Lost wages, coupled with healthcare expenses, result in a substantial economic burden on women.(18) Diagnostic delays, stigma and lack of support collectively contribute to the toll endometriosis has on quality of life and social, emotional and economic well-being.”
BackgroundEvaluation of sexual function in women with deep infiltrating endometriosis
Cozzolino, M., Malosso, E. R. M., Tofani, L., & Coccia, M. E. (2018) · Sexual & Reproductive Healthcare · doi:10.1016/j.srhc.2017.12.005 · Cited by 37
Quality of life of the woman carrier of endometriosis: systematized review
Ferreira, A. L. L., Bessa, M. M. M., Drezett, J., & de Abreu, L. C. (2016) · Reprodução & Climatério · doi:10.1016/j.recli.2015.12.002 · Cited by 37
Hutton, D. W., Mustafa, A., Patil, S., Rathod, S., Shrikhande, G., Advincula, A. P., Drummond, J., Gregersen, P. K., Hall, J. F., Metz, C. N., et al. (2023) · PLoS ONE · doi:10.1371/journal.pone.0269828 · Cited by 38
Giuliani, N., Cosmi, V., Pierleoni, L., Recine, A., Pieroni, M., Ticino, A., Porpora, M. G., & Simonelli, C. (2015) · Sexologies · doi:10.1016/j.sexol.2015.03.004 · Cited by 35
“…the ability to work and daily life, and can be associated with mood and anxiety disorders (Denny and Mann, 2007a, 2007b; Sepulcri and doAmaral, 2009; Fourquet et al., 2010, 2011; Nnoaham et al., 2011; Tripoli et al., 2011; Montanari et al., 2013; Cavaggioni et al., 2014; Fritzer et al., 2014).”
BackgroundMissmer, S. A., Tu, F. F., Soliman, A. M., Chiuve, S. E., Cross, S. J., Eichner, S. F., Flores, O. A., Horne, A. W., Schneider, B., & As‐Sanie, S. (2022) · BMJ Open · doi:10.1136/bmjopen-2021-052765 · Cited by 40
Olliges, E., Bobinger, A., Weber, A., Hoffmann, V. S., Schmitz, T., Popovici, R. M., & Meißner, K. (2021) · Frontiers in Global Women s Health · doi:10.3389/fgwh.2021.767114 · Cited by 32
“Several studies have reported reduced quality of life in women with endometriosis, characterized by constraining physical conditions as well as negative emotions such as uncertainty, anxiety, or depressive symptoms (14, 16, 18, 24).”
BackgroundEffects of histone methyltransferase inhibition in endometriosis†
Colón-Caraballo, M., Torres-Reverón, A., Soto-Vargas, J. L., Young, S. L., Lessey, B. A., Mendoza, A., Urrutia, R. A., & Flores, I. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy030 · Cited by 32
“The main clinical manifestations of women with endometriosis include dysmenorrhea, dyspareunia, chronic pelvic pain, and often infertility, which negatively impact their quality of life (QoL) [2, 3].”
BackgroundSelf-citationValidação da Versão Portuguesa do Questionário EHP-30 (The Endometriosis Health Profile-30)
Nogueira‐Silva, C., Costa, P., Martins, C. F. P., Barata, S., Alho, C., Calhaz–Jorge, C., & Osório, F. (2015) · Acta Médica Portuguesa · doi:10.20344/amp.5778 · Cited by 32
Evaluation of quality of life in fertile Turkish women with severe endometriosis
Altınbaş, Ş. K., Tekın, Y. B., Dilbaz, B., & Dilbaz, S. (2014) · Journal of Obstetrics and Gynaecology · doi:10.3109/01443615.2014.930110 · Cited by 29
“…is a major problem leading to pain-related symptoms that have a considerable negative impact on the physical, emotional and social wellbeing of patients, resulting in poor quality of life (QoL) (Simoens et al. 2012; Jones et al. 2004; Denny and Khan 2006; Fourquet et al. 2011; Ferrero et al. 2005).”
BackgroundHow Women Suffering from Endometriosis Disclose about their Disorder at Work
Krsmanovic, A., & Dean, M. (2021) · Health Communication · doi:10.1080/10410236.2021.1880053 · Cited by 30
“The nature and severity of endometriosis symptoms have been demonstrated to affect women’s on-the-job productivity (Fourquet et al., 2011; Soliman et al., 2018).”
BackgroundMick, I., Freger, S., van Keizerswaard, J., Gholiof, M., & Leonardi, M. (2024) · Therapeutic Advances in Reproductive Health · doi:10.1177/26334941241277759 · Cited by 40
Ensari, I., Pichon, A., Gorman, S. L., Henry, S. B., & Elhadad, N. (2020) · Applied Clinical Informatics · doi:10.1055/s-0040-1718755 · Cited by 30
Alcalde, A. M., Martínez‐Zamora, M. Á., Gràcia, M., Ros, C., Rius, M., Nicolás, I., & Carmona, F. (2021) · Journal of Women s Health · doi:10.1089/jwh.2020.8789 · Cited by 27
“This may explain why WPAI:GH outcomes in our study were better compared to those in patients with endometriosis reported by Fourquet et al. 24 These authors assessed WPAI:GH outcomes according to how patients felt during the week of their last menstrual period (when exacerbation of symptoms most commonly occurs) or du…”
Araújo, R. S. D. C., Ribeiro, H. S. A. A., Sekula, V. G., Porto, B. T. D. C., & Ribeiro, P. A. (2014) · Journal of Minimally Invasive Gynecology · doi:10.1016/j.jmig.2014.02.005 · Cited by 27
“Furthermore, bowel endometriosis increases the number of evacuations or progressive constipation leading to bowel obstruction, which substantially alters patient quality of life (QoL) [12,16–21].”
BackgroundResultAwareness of Endometriosis Symptoms—A Cross Sectional Survey among Polish Women
Kotowska, M., Urbaniak, J., Falęcki, W. J., Łazarewicz, P., Masiak, M., & Szymusik, I. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189919 · Cited by 26
“4 h), 64% reported loss of productivity at work and 60% impaired daily functioning [7].”
BackgroundVitale, S. G., Rosa, V. L. L., Vitagliano, A., Noventa, M., Laganà, F. M., Ardizzone, A., Rapisarda, A. M. C., Terzić, M., Terzic, S., & Laganà, A. S. (2017) · Journal of Endometriosis and Pelvic Pain Disorders · doi:10.5301/jeppd.5000303 · Cited by 25
“Indeed, women frequently report lack of energy and strength to carry out any activity that would normally take place, including taking care of the house and the children (21, 22).”
BackgroundHealth-related quality of life improvements in patients with endometriosis treated with elagolix
Taylor, H. S., Soliman, A. M., Johns, B., Pokrzywinski, R. M., Snabes, M., & Coyne, K. S. (2020) · Obstetrics & Gynecology · doi:10.1097/aog.0000000000003917 · Cited by 25
Soliman, A. M., Singh, S. S., Rahal, Y., Robert, C., Defoy, I., Nisbet, P., & Leyland, N. A. (2020) · Journal of Obstetrics and Gynaecology Canada · doi:10.1016/j.jogc.2020.04.013 · Cited by 24
Cunnington, S., Cunnington, A., & Hirose, A. (2024) · Journal of Endometriosis and Uterine Disorders · doi:10.1016/j.jeud.2024.100087 · Cited by 25
Mehdizadehkashi, A., Moradi, Y., Chaichian, S., Najmi, Z., Mansori, K., Salehin, F., Rastgar, A., & Khateri, S. (2018) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2018.61.5.598 · Cited by 24
“Additionally, previous studies reported from other countries have described that endometriosis causes severe pain and symptoms that affect healthrelated QOL [24-26], which concurs with the results of the present study (the lowest mean score was observed in the physical health domain).”
ResultLee, D., Park, H. G., Yoon, B.-K., & Choi, D. (2016) · Obstetrics & Gynecology Science · doi:10.5468/ogs.2016.59.1.32 · Cited by 21
“Only a few studies have assessed how endometriosis-related symptoms reduce quality of life and affect socio-economic burden [6-8,15]: one previous study compared the effects of GnRH agonists and other hormonal treatments on quality of life, including pain, sleep disturbance, and anxiety-depression in women with pelvic…”
BackgroundSupporting and Inhibiting Factors When Coping with Endometriosis From the Patientsʼ Perspective
Kundu, S., Wildgrube, J., Schippert, C., Hillemanns, P., & Brandes, I. (2015) · Geburtshilfe und Frauenheilkunde · doi:10.1055/s-0035-1546052 · Cited by 34
Arena, A., Orsini, B., Esposti, E. D., Manzara, F., Ambrosio, M., Raimondo, D., Lenzi, J., Casadio, P., & Seracchioli, R. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110512 · Cited by 21
Wu, M., Su, P.-F., Chu, W.-Y., Lin, C.-W., Huey, N. G., Lin, C., & Ou, H. (2020) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2020.1758659 · Cited by 22
Metadata
- Authors
- Fourquet, J., Báez, L., Figueroa, M., Iriarte, R. I., & Flores, I.
- Affiliations
- Ponce Health Sciences University (PR)
- Corresponding author
- Flores, Idhaliz
- ORCID
- Flores, Idhaliz
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 96
- Issue
- 1
- Pages
- 107-112
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC3129383
- OpenAlex
- W1964830755
- Semantic Scholar
- 79811ffdaea9ba8942ee7a3f3519d6c7ea661b5a
- Cited by
- 262
- References
- 52
- Citations by year
- 2026: 13 · 2025: 24 · 2024: 21 · 2023: 17 · 2022: 16 · 2021: 31 · 2020: 28 · 2019: 9 · 2018: 23 · 2017: 18 · 2016: 14 · 2015: 16 · 2014: 12 · 2013: 12 · 2012: 8
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (5s06gm008239-23)
- National Institute of General Medical Sciences (S06 GM-08239, S06-GM 008239)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD050559)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Health Professions › Physical Therapy, Sports Therapy and Rehabilitation › Musculoskeletal pain and rehabilitation
- Keywords
- endometriosis, endometriosis symptoms, health-related quality of life, labor productivity, absenteeism, presenteeism, activity impairment, physical and mental health, pelvic pain, infertility, women's health
- MeSH terms
- Activities of Daily Living, Adolescent, Adult, Cross-Sectional Studies, Efficiency, Endometriosis, Female, Health Status Indicators, Health Surveys, Humans, Middle Aged, Quality of Life, Young Adult
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