Cited by 1,372

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HIF-1: upstream and downstream of cancer metabolism

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Semenza, Gregg L·2010·Current Opinion in Genetics & Development

DOI 10.1016/j.gde.2009.10.009

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Abstract

Summary Hypoxia-inducible factor 1 (HIF-1) plays a key role in the reprogramming of cancer metabolism by activating transcription of genes encoding glucose transporters and glycolytic enzymes, which take up glucose and convert it to lactate; pyruvate dehydrogenase kinase 1, which shunts pyruvate away from the mitochondria; and BNIP3, which triggers selective mitochondrial autophagy. The shift from oxidative to glycolytic metabolism allows maintenance of redox homeostasis and cell survival under conditions of prolonged hypoxia. Many metabolic abnormalities in cancer cells increase HIF-1 activity. As a result, a feed-forward mechanism can be activated that drives HIF-1 activation and may promote tumor progression.

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Authors: Semenza, G. L.
Venue: Current Opinion in Genetics & Development
Publisher: Elsevier BV
Published: 2010-02
Volume: 20
Issue: 1
Pages: 51-56
ISSN: 0959-437X (ISSN-L)
DOI: 10.1016/j.gde.2009.10.009
OpenAlex: W2035983112
Cited by: 1,372
References: 21
FWCI: 2.38
Type: journal article
Language: en
Open access: green

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HIF-1: upstream and downstream of cancer metabolism

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