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Mechanisms of SARS-CoV-2 Transmission and Pathogenesis
Open accessAbstract
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) marks the third highly pathogenic coronavirus to spill over into the human population. SARS-CoV-2 is highly transmissible with a broad tissue tropism that is likely perpetuating the pandemic. However, important questions remain regarding its transmissibility and pathogenesis. In this review, we summarize current SARS-CoV-2 research, with an emphasis on transmission, tissue tropism, viral pathogenesis, and immune antagonism. We further present advances in animal models that are important for understanding the pathogenesis of SARS-CoV-2, vaccine development, and therapeutic testing. When necessary, comparisons are made from studies with SARS to provide further perspectives on coronavirus infectious disease 2019 (COVID-19), as well as draw inferences for future investigations.
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Metadata
- Authors
- Harrison, A. G., Lin, T., & Wang, P.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 41
- Issue
- 12
- Pages
- 1100-1115
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W3093061534
- Cited by
- 1,186
- References
- 47
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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