Diet, inflammation and the gut microbiome: mechanisms for obesity-associated cognitive impairment
Open accessAbstract
Poor diet and obesity are associated with cognitive impairment throughout adulthood, and increased dementia risk in aging. Here we review the current literature interrogating the mechanisms by which diets high in fat, or fat and sugar lead to cognitive impairment, focusing on changes to gut microbiome composition, inflammatory signalling and blood-brain barrier integrity. Preclinical studies indicate weight gain is not necessary for diet-induced cognitive impairment. Rather, gut microbiome composition, and systemic and central inflammatory processes appear to contribute to diet-induced cognitive impairment. While both obese humans and rodents exhibit reduced blood-brain barrier integrity, cognitive impairments precede these changes, suggesting other mechanisms may underly diet-induced cognitive changes. Other potential candidates include hormone, glucoregulatory and cardiovascular changes. Poor diet and obesity act through multiple mechanisms to affect cognitive health and the challenge for future research is to identify key processes that can be reversed to improve cognition and quality of life.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A poor diet and obesity are associated with GM alterations, cognitive dysfunction, and an increased risk for dementia.
“Conversely, a poor diet and obesity are associated with GM alterations, cognitive dysfunction, and an increased risk for dementia [reviewed in (511)].”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [511]
Proposed mechanisms linking poor diet and obesity to cognitive dysfunction include changes in GM composition and function, alterations in microbial metabolites, compromised barrier integrity, peripheral and central inflammatory processes, and hormonal, glucoregulatory, and cardiovascular changes.
“Proposed mechanisms include changes in GM composition and function, alterations in microbial metabolites, compromised barrier integrity, and peripheral and central inflammatory processes, as well as hormonal, glucoregulatory, and cardiovascular changes (502, 511, 512).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [511]
The effect of SCFAs on inflammation can be mediated by improvement of the intestinal barrier, potentially preventing immune molecules and bacterial LPS from translocating into the periphery and thus reducing systemic inflammation and ultimately neuroinflammation.
“The effect of SCFAs on inflammation can be mediated by improvement of the intestinal barrier (361), thereby potentially preventing immune molecules and bacterial LPS translocating into the periphery and thus reducing systemic inflammation and ultimately neuroinflammation (362).”
From Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health (2021) · cites this paper as [362]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Diet rapidly and reproducibly alters the human gut microbiome
David, L. A., Maurice, C. F., Carmody, R. N., Gootenberg, D. B., Button, J. E., Wolfe, B. E., Ling, A. V., Devlin, A. S., Varma, Y., Fischbach, M. A., et al. (2014) · Nature · doi:10.1038/nature12820 · Cited by 10,100 · see citing works
Human gut microbes associated with obesity
Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works
Health effects of overweight and obesity in 195 countries over 25 years
Collaborators, T. G. 2. O. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1614362 · Cited by 7,918 · see citing works
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
Cani, P. D., Amar, J., Iglesias, M. A., Poggi, M., Knauf, C., Bastelica, D., Neyrinck, A. M., Fava, F., Tuohy, K. M., Chabo, C., et al. (2007) · Diabetes · doi:10.2337/db06-1491 · Cited by 6,638 · see citing works
Obesity alters gut microbial ecology
Ley, R. E., Bäckhed, F., Turnbaugh, P., Lozupone, C. A., Knight, R. D., & Gordon, J. I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504978102 · Cited by 6,176 · see citing works
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413 · see citing works
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice
Ridaura, V. K., Faith, J. J., Rey, F. E., Cheng, J., Duncan, A. E., Kau, A. L., Griffin, N. W., Lombard, V., Henrissat, B., Bain, J. R., et al. (2013) · Science · doi:10.1126/science.1241214 · Cited by 3,788 · see citing works
Host microbiota constantly control maturation and function of microglia in the CNS
Erny, D., Hrabě de Angelis, A. L., Jaitin, D., Wieghofer, P., Staszewski, O., David, E., Keren-Shaul, H., Mahlakoiv, T., Jakobshagen, K., Buch, T., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4030 · Cited by 3,569 · see citing works
Hsiao, E. Y., McBride, S. W., Hsien, S., Sharon, G., Hyde, E. R., McCue, T., Codelli, J. A., Chow, J., Reisman, S. E., Petrosino, J. F., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.024 · Cited by 3,283 · see citing works
Designing and developing a literature-derived, population-based dietary inflammatory index
Shivappa, N., Steck, S. E., Hurley, T. G., Hussey, J. R., & Hébert, J. R. (2014) · Public Health Nutrition · doi:10.1017/s1368980013002115 · Cited by 2,731 · see citing works
The gut microbiota influences blood-brain barrier permeability in mice
Braniste, V., Al-Asmakh, M., Kowal, C., Anuar, F., Abbaspour, A., Tóth, M., Korecka, A., Bakocevic, N., Ng, L. G., Kundu, P., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009759 · Cited by 2,530 · see citing works
The neuroactive potential of the human gut microbiota in quality of life and depression
Valles-Colomer, M., Falony, G., Darzi, Y., Tigchelaar, E. F., Wang, J., Tito, R. Y., Schiweck, C., Kurilshikov, A., Joossens, M., Wijmenga, C., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0337-x · Cited by 1,963 · see citing works
Dietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
The interplay between the intestinal microbiota and the brain
Collins, S. M., Surette, M., & Bercik, P. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2876 · Cited by 1,611 · see citing works
Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States
Mattson, M. P., & Arumugam, T. V. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.05.011 · Cited by 1,242 · see citing works
Adapting to obesity with adipose tissue inflammation
Reilly, S. M., & Saltiel, A. R. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2017.90 · Cited by 1,204 · see citing works
Kim, K., Gu, W., Lee, I., Joh, E., & Kim, D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047713 · Cited by 1,184 · see citing works
Diet dominates host genotype in shaping the murine gut microbiota
Carmody, R. N., Gerber, G. K., Luevano, J. M., Gatti, D. M., Somes, L., Svenson, K. L., & Turnbaugh, P. J. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2014.11.010 · Cited by 1,103 · see citing works
Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,102 · see citing works
Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection
Thaiss, C. A., Levy, M., Grosheva, I., Zheng, D., Soffer, E., Blacher, E., Braverman, S., Tengeler, A. C., Barak, O., Elazar, M., et al. (2018) · Science · doi:10.1126/science.aar3318 · Cited by 942 · see citing works
Impaired Recognition Memory in Rats after Damage to the Hippocampus
Clark, R. E., Zola, S. M., & Squire, L. R. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-23-08853.2000 · Cited by 740 · see citing works
Fröhlich, E. E., Farzi, A., Mayerhofer, R., Reichmann, F., Jačan, A., Wagner, B., Zinser, E., Bordag, N., Magnes, C., Fröhlich, E., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.020 · Cited by 720 · see citing works
MahmoudianDehkordi, S., Arnold, M., Nho, K., Ahmad, S., Jia, W., Xie, G., Louie, G., Kueider‐Paisley, A., Moseley, M. A., Thompson, J. W., et al. (2019) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.07.217 · Cited by 706 · see citing works
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
Wernstedt Asterholm, I., Tao, C., Morley, T. S., Wang, Q. A., Delgado-Lopez, F., Wang, Z. V., & Scherer, P. E. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.05.005 · Cited by 668 · see citing works
Cavicchia, P. P., Steck, S. E., Hurley, T. G., Hussey, J. R., Ma, Y., Ockene, I. S., & Hébert, J. R. (2009) · Journal of Nutrition · doi:10.3945/jn.109.114025 · Cited by 632 · see citing works
Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota
Sérino, M., Luche, É., Grès, S., Baylac, A., Bergé, M., Cénac, C., Waget, A., Klopp, P., Iacovoni, J. S., Klopp, C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301012 · Cited by 621 · see citing works
Cognitive impairment following high fat diet consumption is associated with brain inflammation
Pistell, P. J., Morrison, C. D., Gupta, S., Knight, A. G., Keller, J. N., Ingram, D. K., & Bruce‐Keller, A. J. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.11.010 · Cited by 594 · see citing works
Obese-type gut microbiota induce neurobehavioral changes in the absence of obesity
Bruce-Keller, A. J., Salbaum, J. M., Luo, M., Blanchard, E., Taylor, C. M., Welsh, D. A., & Berthoud, H.-R. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.012 · Cited by 563 · see citing works
A high-fat diet is associated with endotoxemia that originates from the gut
Pendyala, S., Walker, J. M., & Holt, P. R. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.01.034 · Cited by 546 · see citing works
Association between dietary inflammatory index and inflammatory markers in the HELENA study
Shivappa, N., Hébert, J. R., Marcos, A., Díaz, L. E., Gómez‐Martínez, S., Nova, E., Michels, N., Arouca, A. B., González‐Gil, E. M., Gottrand, F., et al. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600707 · Cited by 543 · see citing works
Neurological consequences of obesity
O’Brien, P. D., Hinder, L. M., Callaghan, B. C., & Feldman, E. L. (2017) · The Lancet Neurology · doi:10.1016/s1474-4422(17)30084-4 · Cited by 535 · see citing works
What cognitive abilities are involved in trail-making performance?
Salthouse, T. A. (2011) · Intelligence · doi:10.1016/j.intell.2011.03.001 · Cited by 513 · see citing works
Persistent microbiome alterations modulate the rate of post-dieting weight regain
Thaiss, C. A., Itav, S., Rothschild, D., Meijer, M. T., Levy, M., Moresi, C., Dohnalová, L., Braverman, S., Rozin, S., Malitsky, S., et al. (2016) · Nature · doi:10.1038/nature20796 · Cited by 471 · see citing works
Toll-Like Receptor SignalingPreprint
Lim, K., & Staudt, L. M. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011247 · Cited by 470 · see citing works
Associations between dietary inflammatory index and inflammatory markers in the Asklepios Study
Shivappa, N., Hébert, J. R., Rietzschel, E. R., Buyzere, M. D., Langlois, M. R., Debruyne, E., Marcos, A., & Huybrechts, I. (2015) · British Journal Of Nutrition · doi:10.1017/s000711451400395x · Cited by 454 · see citing works
Body mass index and risk of dementia: analysis of individual-level data from 1·3 million individuals
Kivimäki, M., Luukkonen, R., Batty, G. D., Ferrie, J. E., Pentti, J., Nyberg, S. T., Shipley, M. J., Alfredsson, L., Fransson, E. I., Goldberg, M., et al. (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2017.09.016 · Cited by 440 · see citing works
Responses of gut microbiota to diet composition and weight loss in lean and obese mice
Ravussin, Y., Koren, O., Spor, A., LeDuc, C., Gutman, R., Stombaugh, J., Knight, R., Ley, R. E., & Leibel, R. L. (2012) · Obesity · doi:10.1038/oby.2011.111 · Cited by 406 · see citing works
Bifidobacteria modulate cognitive processes in an anxious mouse strain
Savignac, H. M., Tramullas, M., Kiely, B., Dinan, T. G., & Cryan, J. F. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.02.044 · Cited by 365 · see citing works
MyD88 Signaling in T Cells Directs IgA-Mediated Control of the Microbiota to Promote Health
Kubinak, J. L., Petersen, C., Stephens, W. Z., Soto, R., Bake, E., O’Connell, R. M., & Round, J. L. (2015) · Cell Host & Microbe · doi:10.1016/j.chom.2014.12.009 · Cited by 328 · see citing works
Kanoski, S. E., Zhang, Y., Zheng, W., & Davidson, T. L. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091414 · Cited by 324 · see citing works
Fat intake at midlife and cognitive impairment later in life: a population‐based CAIDE study
Eskelinen, M. H., Ngandu, T., Helkala, E., Tuomilehto, J., Nissinen, A., Soininen, H., & Kivipelto, M. (2008) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1969 · Cited by 321 · see citing works
Arnold, S., Lucki, I., Brookshire, B. R., Carlson, G., Browne, C., Kazi, H., Bang, S., Choi, B.-R., Chen, Y., McMullen, M. F., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.03.011 · Cited by 309 · see citing works
Western diet is associated with a smaller hippocampus: a longitudinal investigation
Jacka, F. N., Cherbuin, N., Anstey, K. J., Sachdev, P. S., & Butterworth, P. (2015) · BMC Medicine · doi:10.1186/s12916-015-0461-x · Cited by 292 · see citing works
Obesity Elicits Interleukin 1-Mediated Deficits in Hippocampal Synaptic Plasticity
Erion, J., Wosiski‐Kuhn, M., Dey, A., Hao, S., Davis, C. L., Pollock, N. K., & Stranahan, A. M. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4200-13.2014 · Cited by 279 · see citing works
Chunchai, T., Thunapong, W., Yasom, S., Wanchai, K., Eaimworawuthikul, S., Metzler, G., Lungkaphin, A., Pongchaidecha, A., Sirilun, S., Chaiyasut, C., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1055-2 · Cited by 273 · see citing works
Boitard, C., Etchamendy, N., Sauvant, J., Aubert, A., Tronel, S., Marighetto, A., Layé, S., & Ferreira, G. (2012) · Hippocampus · doi:10.1002/hipo.22032 · Cited by 258 · see citing works
Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity
Jaïs, A., Solas, M., Backes, H., Chaurasia, B., Kleinridders, A., Theurich, S., Mauer, J., Steculorum, S. M., Hampel, B., Goldau, J., et al. (2016) · Cell · doi:10.1016/j.cell.2016.03.033 · Cited by 253 · see citing works
Obesity diminishes synaptic markers, alters microglial morphology, and impairs cognitive function
Bocarsly, M. E., Fasolino, M., Kane, G. A., LaMarca, E. A., Kirschen, G. W., Karatsoreos, I. N., McEwen, B. S., & Gould, E. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1511593112 · Cited by 250 · see citing works
Fitzpatrick, S., Gilbert, S. J., & Serpell, L. (2013) · Neuropsychology Review · doi:10.1007/s11065-013-9224-7 · Cited by 247 · see citing works
Li, W., Dowd, S. E., Scurlock, B., Acosta-Martinez, V., & Lyte, M. (2009) · Physiology & Behavior · doi:10.1016/j.physbeh.2008.12.004 · Cited by 246 · see citing works
Beilharz, J. E., Maniam, J., & Morris, M. J. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.11.016 · Cited by 234 · see citing works
Self-citationObesity Is Associated With Reduced White Matter Integrity in Otherwise Healthy Adults*
Stanek, K. M., Grieve, S. M., Brickman, A. M., Korgaonkar, M. S., Paul, R. H., Cohen, R. A., & Gunstad, J. (2010) · Obesity · doi:10.1038/oby.2010.312 · Cited by 231 · see citing works
Relationships between diet-related changes in the gut microbiome and cognitive flexibility
Magnusson, K. R., Hauck, L., Jeffrey, B. M., Elias, V., Humphrey, A., Nath, R., Perrone, A., & Bermudez, L. E. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.016 · Cited by 225 · see citing works
Hsu, T. M., Konanur, V. R., Taing, L., Usui, R., Kayser, B. D., Goran, M. I., & Kanoski, S. E. (2015) · Hippocampus · doi:10.1002/hipo.22368 · Cited by 217 · see citing works
Diet, cognition, and alzheimer’s disease: food for thought
Otaegui-Arrazola, A., Amiano, P., Elbusto, A., Urdaneta, E., & Martínez-Lage, P. (2014) · European Journal of Nutrition · doi:10.1007/s00394-013-0561-3 · Cited by 214 · see citing works
Spencer, S. J., D’Angelo, H. M., Soch, A., Watkins, L. R., Maier, S. F., & Barrientos, R. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.014 · Cited by 213 · see citing works
In Vivo Imaging of Human Neuroinflammation
Albrecht, D., Granziera, C., Hooker, J. M., & Loggia, M. L. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00056 · Cited by 207 · see citing works
Davidson, T. L., Monnot, A. D., Neal, A. U., Martin, A., Horton, J., & Zheng, W. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.05.015 · Cited by 202 · see citing works
Siervo, M., Arnold, R. J., Wells, J. C. K., Tagliabue, A., Colantuoni, A., Albanese, E., Brayne, C., & Stephan, B. C. M. (2011) · Obesity Reviews · doi:10.1111/j.1467-789x.2011.00903.x · Cited by 198 · see citing works
Sripetchwandee, J., Chattipakorn, N., & Chattipakorn, S. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00496 · Cited by 196 · see citing works
Francis, H., & Stevenson, R. J. (2011) · Behavioral Neuroscience · doi:10.1037/a0025998 · Cited by 190 · see citing works
Kanoski, S. E., & Davidson, T. L. (2010) · Journal of Experimental Psychology Animal Behavior Processes · doi:10.1037/a0017228 · Cited by 185 · see citing works
Leptin regulation of neuronal excitability and cognitive function
Harvey, J. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.006 · Cited by 184 · see citing works
The impact of diabetes on cognition: What can be learned from rodent models?
Biessels, G. J., & Gispen, W. H. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.08.015 · Cited by 172 · see citing works
Inter-relationships among diet, obesity and hippocampal-dependent cognitive function
Davidson, T. L., Hargrave, S. L., Swithers, S. E., Sample, C. H., Fu, X., Kinzig, K. P., & Zheng, W. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.044 · Cited by 171 · see citing works
Beilharz, J. E., Maniam, J., & Morris, M. J. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.018 · Cited by 169 · see citing works
Self-citationHolloway, C., Cochlin, L., Emmanuel, Y., Murray, A., Codreanu, I., Edwards, L., Szmigielski, C., Tyler, D., Knight, N. S., Saxby, B., et al. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002758 · Cited by 166 · see citing works
Heyward, F. D., Walton, R. G., Carle, M. S., Coleman, M. A., Garvey, W. T., & Sweatt, J. D. (2012) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2012.04.005 · Cited by 165 · see citing works
Dietary pattern, inflammation and cognitive decline: The Whitehall II prospective cohort study
Ozawa, M., Shipley, M. J., Mika Kivimaki, B., Singh‐Manoux, A., & Brunner, E. J. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.01.013 · Cited by 165 · see citing works
Sobesky, J. L., Barrientos, R. M., May, H. S. D., Thompson, B. M., Weber, M. D., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.017 · Cited by 160 · see citing works
A high fructose diet impairs spatial memory in male rats
Ross, A. P., Bartness, T. J., Mielke, J. G., & Parent, M. B. (2009) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2009.05.007 · Cited by 154 · see citing works
Blood-Brain Barriers in Obesity
Rhea, E. M., Salameh, T. S., Logsdon, A. F., Hanson, A. J., Erickson, M. A., & Banks, W. A. (2017) · The AAPS Journal · doi:10.1208/s12248-017-0079-3 · Cited by 152 · see citing works
Gut microbiota, dietary intakes and intestinal permeability reflected by serum zonulin in women
Mörkl, S., Lackner, S., Meinitzer, A., Mangge, H., Lehofer, M., Halwachs, B., Gorkiewicz, G., Kashofer, K., Painold, A., Holl, A. K., et al. (2018) · European Journal of Nutrition · doi:10.1007/s00394-018-1784-0 · Cited by 151 · see citing works
Samieri, C., Okereke, O. I., Devore, E. E., & Grodstein, F. (2013) · Journal of Nutrition · doi:10.3945/jn.112.169896 · Cited by 150 · see citing works
Midlife systemic inflammatory markers are associated with late-life brain volume: The ARIC study
Walker, K. A., Hoogeveen, R. C., Folsom, A. R., Ballantyne, C. M., Knopman, D. S., Windham, B. G., Jack, C. R., & Gottesman, R. F. (2017) · Neurology · doi:10.1212/wnl.0000000000004688 · Cited by 150 · see citing works
Porter, D. W., Kerr, B. D., Flatt, P. R., Hölscher, C., & Gault, V. A. (2010) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01259.x · Cited by 148 · see citing works
Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness
Staubo, S. C., Aakre, J. A., Vemuri, P., Syrjanen, J. A., Mielke, M. M., Geda, Y. E., Kremers, W. K., Machulda, M. M., Knopman, D. S., Petersen, R. C., et al. (2017) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.06.2359 · Cited by 147 · see citing works
Attuquayefio, T., Stevenson, R. J., Oaten, M., & Francis, H. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172645 · Cited by 147 · see citing works
Diet, gut microbiota and cognition
Proctor, C., Thiennimitr, P., Chattipakorn, N., & Chattipakorn, S. C. (2017) · Metabolic Brain Disease · doi:10.1007/s11011-016-9917-8 · Cited by 144 · see citing works
Almeida-Suhett, C. P., Graham, A. M., Chen, Y., & Deuster, P. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.016 · Cited by 142 · see citing works
Wu, J., Song, X., Chen, G., Neelakantan, N., van Dam, R. M., Feng, L., Yuan, J., Pan, A., & Koh, W. (2019) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqz150 · Cited by 134 · see citing works
Cross-sectional and longitudinal association of body mass index and brain volume
Bobb, J. F., Schwartz, B. S., Davatzikos, C. A., & Caffo, B. C. (2012) · Human Brain Mapping · doi:10.1002/hbm.22159 · Cited by 130 · see citing works
Cheke, L. G., Bonnici, H. M., Clayton, N. S., & Simons, J. S. (2017) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2017.01.013 · Cited by 130 · see citing works
Edwards, L. M., Murray, A. J., Holloway, C. J., Carter, E. E., Kemp, G. J., Codreanu, I., Brooker, H. J., Tyler, D. J., Robbins, P. A., & Clarke, K. (2010) · The FASEB Journal · doi:10.1096/fj.10-171983 · Cited by 127 · see citing works
Manderino, L., Carroll, I., Azcarate-Peril, M. A., Rochette, A., Heinberg, L., Peat, C., Steffen, K., Mitchell, J., & Gunstad, J. (2017) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617717000492 · Cited by 125 · see citing works
Sa‐nguanmoo, P., Tanajak, P., Kerdphoo, S., Satjaritanun, P., Wang, X., Liang, G., Li, X., Jiang, C., Pratchayasakul, W., Chattipakorn, N., et al. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.08.006 · Cited by 122 · see citing works
Bradburn, S., Sarginson, J. E., & Murgatroyd, C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00438 · Cited by 120 · see citing works
TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse
Prieto, G. A., Tong, L., Smith, E. D., & Cotman, C. W. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2517-8 · Cited by 118 · see citing works
Beilharz, J. E., Kaakoush, N. O., Maniam, J., & Morris, M. J. (2018) · Molecular Psychiatry · doi:10.1038/mp.2017.38 · Cited by 116 · see citing works
Effects of adiposity and metabolic dysfunction on cognition: A review
Farruggia, M. C., & Small, D. M. (2019) · Physiology & Behavior · doi:10.1016/j.physbeh.2019.112578 · Cited by 112 · see citing works
Saiyasit, N., Chunchai, T., Prus, D., Suparan, K., Pittayapong, P., Apaijai, N., Pratchayasakul, W., Sripetchwandee, J., Chattipakorn, N., & Chattipakorn, S. C. (2019) · Nutrition · doi:10.1016/j.nut.2019.110576 · Cited by 109 · see citing works
Frith, E., Shivappa, N., Mann, J. R., Hébert, J. R., Wirth, M. D., & Loprinzi, P. D. (2018) · British Journal Of Nutrition · doi:10.1017/s0007114517003804 · Cited by 105 · see citing works
Western diets induce blood-brain barrier leakage and alter spatial strategies in rats.
Hargrave, S. L., Davidson, T. L., Zheng, W., & Kinzig, K. P. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000110 · Cited by 103 · see citing works
Probiotics and Prebiotics as a Therapeutic Strategy to Improve Memory in a Model of Middle-Aged Rats
Romo‐Araiza, A., Gutiérrez-Salmeán, G., Galván, E. J., Hernández‐Frausto, M., Herrera‐López, G., Parra, H. R., García-Contreras, V., Fernández-Presas, A. M., Jasso‐Chávez, R., Borlongan, C. V., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00416 · Cited by 103 · see citing works
Effect of western and high fat diets on memory and cholinergic measures in the rat
Kosari, S., Badoer, E., Nguyen, J. C. D., Killcross, S., & Jenkins, T. A. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.017 · Cited by 101 · see citing works
Pratchayasakul, W., Sa‐nguanmoo, P., Sivasinprasasn, S., Pintana, H., Tawinvisan, R., Sripetchwandee, J., Kumfu, S., Chattipakorn, N., & Chattipakorn, S. C. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.04.023 · Cited by 94 · see citing works
Cognitive training on eating behaviour and weight loss: A meta‐analysis and systematic review
Yang, Y., Shields, G. S., Wu, Q., Liu, Y., Chen, H., & Guo, C. (2019) · Obesity Reviews · doi:10.1111/obr.12916 · Cited by 94 · see citing works
Gault, V. A., Porter, W. D., Flatt, P. R., & Hölscher, C. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.59 · Cited by 93 · see citing works
Beilharz, J. E., Kaakoush, N. O., Maniam, J., & Morris, M. J. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.07.151 · Cited by 93 · see citing works
SONIC Study Group, Okubo, H., Inagaki, H., Gondo, Y., Kamide, K., Ikebe, K., Masui, Y., Arai, Y., Ishizaki, T., Sasaki, S., et al. (2017) · Nutrition Journal · doi:10.1186/s12937-017-0273-2 · Cited by 85 · see citing works
Rapid and reversible impairment of episodic memory by a high-fat diet in mice
McLean, F. H., Grant, C., Morris, A. C., Horgan, G. W., Polanski, A. J., Allan, K., Campbell, F., Langston, R. F., & Williams, L. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-30265-4 · Cited by 85 · see citing works
Fructose consumption reduces hippocampal synaptic plasticity underlying cognitive performance
Cisternas, P., Salazar, P. L., Serrano, F. G., Montecinos-Oliva, C., Arredondo, S. B., Varela‐Nallar, L., Salesa Barja, Y., Vio, C. P., Gómez‐Pinilla, F., & Inestrosa, N. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.08.016 · Cited by 83 · see citing works
Reorganization of brain connectivity in obesity
Geha, P., Cecchi, G., Constable, R. T., Abdallah, C. G., & Small, D. M. (2016) · Human Brain Mapping · doi:10.1002/hbm.23462 · Cited by 83 · see citing works
The outward spiral: a vicious cycle model of obesity and cognitive dysfunction
Hargrave, S. L., Jones, S., & Davidson, T. L. (2015) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2015.12.001 · Cited by 81 · see citing works
Glutamate interactions with obesity, insulin resistance, cognition and gut microbiota composition
Palomo-Buitrago, M. E., Sabater, M., Moreno‐Navarrete, J. M., Caballano‐Infantes, E., Arnoriaga‐Rodríguez, M., Coll, C., Ramió, L., Palomino‐Schätzlein, M., Gutiérrez-Carcedo, P., Pérez‐Brocal, V., et al. (2019) · Acta Diabetologica · doi:10.1007/s00592-019-01313-w · Cited by 76 · see citing works
Johnson, L. A., Zuloaga, K. L., Kugelman, T., Mader, K. S., Morré, J. T., Zuloaga, D. G., Weber, S. J., Marzulla, T., Mulford, A., Button, D. A., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.12.008 · Cited by 73 · see citing works
Attuquayefio, T., Stevenson, R. J., Boakes, R. A., Oaten, M., Yeomans, M. R., Mahmut, M. K., & Francis, H. (2016) · Journal of Experimental Psychology Animal Learning and Cognition · doi:10.1037/xan0000118 · Cited by 69 · see citing works
Cognitive and neuronal systems underlying obesity
Kanoski, S. E. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2012.01.007 · Cited by 66 · see citing works
Denver, P., Gault, V. A., & McClean, P. L. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13210 · Cited by 66 · see citing works
Schüler, R., Seebeck, N., Osterhoff, M. A., Witte, A. V., Flöel, A., Busjahn, A., Jaïs, A., Brüning, J. C., Frahnow, T., Kabisch, S., et al. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.02.004 · Cited by 65 · see citing works
Johnston, J. M., Hu, W. T., Fardo, D. W., Greco, S. J., Perry, G. L., Montine, T. J., Trojanowski, J. Q., Shaw, L. M. J., Ashford, J. W., & Tezapsidis, N. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131212114156 · Cited by 64 · see citing works
Moreno‐Navarrete, J. M., Blasco, G., Puig, J., Biarnés, C., Rivero, M., Gich, J., Fernández‐Aranda, F., Garre‐Olmo, J., Ramió‐Torrentà, L., Alberich‐Bayarri, Á., et al. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.162 · Cited by 63 · see citing works
Obesity and episodic memory function
Loprinzi, P. D., & Frith, E. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0612-x · Cited by 63 · see citing works
TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity
Moser, V. A., Uchoa, M. F., & Pike, C. J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1340-0 · Cited by 63 · see citing works
Rutkowsky, J. M., Lee, L. L., Puchowicz, M., Golub, M. S., Befroy, D. E., Wilson, D. W., Anderson, S., Cline, G. W., Bini, J., Borkowski, K., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0191909 · Cited by 60 · see citing works
Gut barrier impairment by high-fat diet in mice depends on housing conditions.
Müller, V. M., Zietek, T., Rohm, F., Fiamoncini, J., Lagkouvardos, I., Haller, D., Clavel, T., & Daniel, H. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500775 · Cited by 57 · see citing works
Cafeteria-diet induced obesity results in impaired cognitive functioning in a rodent model
Lewis, A. R., Singh, S., & Youssef, F. F. (2019) · Heliyon · doi:10.1016/j.heliyon.2019.e01412 · Cited by 55 · see citing works
Wang, S., Huang, X., Zhang, P., Newell, K. A., Wang, H., Zheng, K., & Yu, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-12156-2 · Cited by 54 · see citing works
Plasma leptin levels are not predictive of dementia in patients with mild cognitive impairment
Oania, R., & McEvoy, L. K. (2014) · Age and Ageing · doi:10.1093/ageing/afu160 · Cited by 52 · see citing works
FGF21 and DPP-4 inhibitor equally prevents cognitive decline in obese rats
Sa‐nguanmoo, P., Tanajak, P., Kerdphoo, S., Jaiwongkam, T., Wang, X., Liang, G., Li, X., Jiang, C., Pratchayasakul, W., Chattipakorn, N., et al. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.12.021 · Cited by 48 · see citing works
Beyer, F., Masouleh, S. K., Kratzsch, J., Schroeter, M. L., Röhr, S., Riedel-Heller, S. G., Villringer, A., & Witte, A. V. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00202 · Cited by 48 · see citing works
Gonzales, M. M., Tarumi, T., Eagan, D. E., Tanaka, H., Vaghasia, M., & Haley, A. P. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31825ff1de · Cited by 46 · see citing works
Measures of obesity are associated with MRI markers of brain aging
Caunca, M. R., Gardener, H. E., Simonetto, M., Cheung, Y. K., Alperin, N. J., Yoshita, M., DeCarli, C. S., Elkind, M. S. V., Sacco, R. L., Wright, C. B., et al. (2019) · Neurology · doi:10.1212/wnl.0000000000007966 · Cited by 45 · see citing works
Brain and behavioral perturbations in rats following Western diet access
Hargrave, S. L., Davidson, T. L., Lee, T.-J., & Kinzig, K. P. (2015) · Appetite · doi:10.1016/j.appet.2015.03.037 · Cited by 43 · see citing works
Leigh, S.-J., Lee, F., & Morris, M. J. (2018) · Current Obesity Reports · doi:10.1007/s13679-018-0292-0 · Cited by 43 · see citing works
Self-citationCaloric Intake, Aging, and Mild Cognitive Impairment: A Population-Based Study
Geda, Y. E., Ragossnig, M., Roberts, L. A., Roberts, R. O., Pankratz, V. S., Christianson, T. J. H., Mielke, M. M., Levine, J. A., Boeve, B. F., Sochor, O., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121270 · Cited by 41 · see citing works
Cifre, M., Palou, A., & Oliver, P. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0246-8 · Cited by 40 · see citing works
Attuquayefio, T., & Stevenson, R. J. (2015) · Appetite · doi:10.1016/j.appet.2015.08.023 · Cited by 38 · see citing works
Executive functions predict weight loss in a medically supervised weight loss programme
Galioto, R., Bond, D. S., Gunstad, J., Pera, V., Rathier, L. A., & Tremont, G. N. (2016) · Obesity Science & Practice · doi:10.1002/osp4.70 · Cited by 37 · see citing works
Deshpande, N. G., Saxena, J., Pesaresi, T., Carrell, C. D., Ashby, G. B., Liao, M.-K., & Freeman, L. R. (2019) · PLoS ONE · doi:10.1371/journal.pone.0217553 · Cited by 35 · see citing works
Gladding, J. M., Abbott, K. N., Antoniadis, C. P., Stuart, A., & Begg, D. P. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00752 · Cited by 34 · see citing works
The relationship of CRP and cognition in cognitively normal older Mexican Americans
Vintimilla, R., Hall, J. R., Johnson, L. A., & O’Bryant, S. E. (2019) · Medicine · doi:10.1097/md.0000000000015605 · Cited by 33 · see citing works
Sulfate-reducing bacteria impairs working memory in mice
Ritz, N. L., Burnett, B. J., Setty, P., Reinhart, K. M., Wilson, M. R., Alcock, J., Singh, S., Barton, L. L., & Lin, H. C. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.01.023 · Cited by 32 · see citing works
Lauridsen, J. K., Olesen, R. H., Vendelbo, J. H., Hyde, T. M., Kleinman, J. E., Bibby, B. M., Brock, B., Rungby, J., & Larsen, A. (2017) · Translational Psychiatry · doi:10.1038/tp.2016.259 · Cited by 32 · see citing works
Wu, S., Fisher‐Hoch, S. P., Reininger, B. M., & McCormick, J. B. (2018) · Health Psychology · doi:10.1037/hea0000646 · Cited by 32 · see citing works
Corem, N., Anzi, S., Gelb, S., & Ben‐Zvi, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-39230-1 · Cited by 31 · see citing works
Ishikawa, R., Fukushima, H., Nakakita, Y., Kado, H., & Kida, S. (2019) · Neuropsychopharmacology Reports · doi:10.1002/npr2.12054 · Cited by 25 · see citing works
Mäe, M. A., Tian, L., Bertuzzi, G., Raschperger, E., Vanlandewijck, M., He, L., Nahar, K., Dalheim, A. V., Hofmann, J. J., Laviña, B., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-35576-0 · Cited by 23 · see citing works
Moser, V., Christensen, A., Liu, J., Zhou, A.-J., Yagi, S., Beam, C. R., Galea, L., & Pike, C. J. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.016 · Cited by 19 · see citing works
To What Extent Memory Could Contribute to Impaired Food Valuation and Choices in Obesity?
Zhang, Z., & Coppin, G. (2018) · Frontiers in Psychology · doi:10.3389/fpsyg.2018.02523 · Cited by 16 · see citing works
Rijnsburger, M., Unmehopa, U. A., Eggels, L., et al. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1418727 · Cited by 15 · see citing works
Food Selection of Cafeteria Diet Affects Memory Dysfunction Related to Obesity
Feijó, G. D. S., de Oliveira, S., Thoen, R. U., Schaab, E. E., de Moura, A. C., Franco, F. B., Giovenardi, M., Porawski, M., & Guedes, R. P. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02821-5 · Cited by 14 · see citing works
Cognitive Impairment Among Elderly Individuals in Shanghai Suburb, China
Chen, J., Cui, G.-H., Jiang, G., Xu, R.-F., Tang, H., Wang, G., Chen, S., & Cheng, Q. (2014) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317514534758 · Cited by 12 · see citing works
Annweiler, C., Duval, G. T., Cheng, C., Wong, T. Y., Lamoureux, E. L., Miléa, D., & Sabanayagam, C. (2019) · Nutrients · doi:10.3390/nu11030660 · Cited by 12 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Diet and the Microbiota–Gut–Brain Axis: Sowing the Seeds of Good Mental Health
Berding, K., Vlckova, K., Marx, W., Schellekens, H., Stanton, C., Clarke, G., Jacka, F., Dinan, T. G., & Cryan, J. F. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa181 · Cited by 451 · see citing works
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415 · see citing works
Więckowska-Gacek, A., Mietelska-Porowska, A., Wydrych, M., & Wojda, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101397 · Cited by 343 · see citing works
Benedé-Ubieto, R., Cubero, F. J., & Nevzorova, Y. A. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2331460 · Cited by 242 · see citing works
Bhargava, A., Arnold, A. P., Bangasser, D. A., Denton, K. M., Gupta, A., Hilliard Krause, L. M., Mayer, E. A., McCarthy, M., Miller, W. L., Raznahan, A., et al. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnaa034 · Cited by 130 · see citing works
Going with the grain: Fiber, cognition, and the microbiota-gut-brain-axis
Berding, K., Carbia, C., & Cryan, J. F. (2021) · Experimental Biology and Medicine · doi:10.1177/1535370221995785 · Cited by 100 · see citing works
- Authors
- Leigh, S.-J., & Morris, M. J.
- Affiliations
- UNSW Sydney (AU)
- Corresponding author
- Morris, Margaret J.
- Venue
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- Publisher
- Elsevier BV
- Published
- 2020-06
- Volume
- 1866
- Issue
- 6
- Pages
- 165767
- ISSN
- 0925-4439 (ISSN-L)
- OpenAlex
- W3011638844
- Cited by
- 221
- References
- 145
- Citations by year
- 2026: 20 · 2025: 44 · 2024: 41 · 2023: 50 · 2022: 35 · 2021: 24 · 2020: 7
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Health and Medical Research Council (1126929)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Keywords
- obesity, cognitive impairment, high-fat diet, high-fat high-sugar diet, gut microbiota, inflammation, blood-brain barrier integrity, dementia risk, weight gain, glucoregulation, cardiovascular changes
- MeSH terms
- Gastrointestinal Microbiome, Blood-Brain Barrier, Humans, Inflammation, Obesity, Quality of Life, Weight Gain, Diet, High-Fat, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
