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Frailty Consensus: A Call to Action
Open accessAbstract
Frailty is a clinical state in which there is an increase in an individual’s vulnerability for developing increased dependency and/or mortality when exposed to a stressor. Frailty can occur as the result of a range of diseases and medical conditions. A consensus group consisting of delegates from 6 major international, European, and US societies created 4 major consensus points on a specific form of frailty: physical frailty. Physical frailty is an important medical syndrome. The group defined physical frailty as “a medical syndrome with multiple causes and contributors that is characterized by diminished strength, endurance, and reduced physiologic function that increases an individual’s vulnerability for developing increased dependency and/or death.” Physical frailty can potentially be prevented or treated with specific modalities, such as exercise, protein-calorie supplementation, vitamin D, and reduction of polypharmacy. Simple, rapid screening tests have been developed and validated, such as the simple FRAIL scale, to allow physicians to objectively recognize frail persons. For the purposes of optimally managing individuals with physical frailty, all persons older than 70 years and all individuals with significant weight loss (≥5%) due to chronic disease should be screened for frailty.
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Cites
Frailty in Older Adults: Evidence for a Phenotype
Fried, L. P., Tangen, C. M., Walston, J., Newman, A. B., Hirsch, C., Gottdiener, J., Seeman, T., Tracy, R., Kop, W. J., Burke, G., et al. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.3.m146 · Cited by 24,907
Self-citationSarcopenia: European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Baeyens, J. P., Bauer, J. M., Boirie, Y., Cederholm, T., Landi, F., Martin, F. C., Michel, J.-P., Rolland, Y., Schneider, S. M., et al. (2010) · Age and Ageing · doi:10.1093/ageing/afq034 · Cited by 11,601
Self-citationA global clinical measure of fitness and frailty in elderly people
Rockwood, K. (2005) · Canadian Medical Association Journal · doi:10.1503/cmaj.050051 · Cited by 8,968
Self-citationInterventions for preventing falls in older people living in the community
Gillespie, L. D., Robertson, M. C., Gillespie, W. J., Sherrington, C., Gates, S., Clemson, L., & Lamb, S. E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007146.pub3 · Cited by 3,966
Fielding, R. A., Vellas, B., Evans, W. J., Bhasin, S., Morley, J. E., Newman, A. B., Abellan van Kan, G., Andrieu, S., Bauer, J., Breuille, D., et al. (2011) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2011.01.003 · Cited by 3,256
Self-citationMuscaritoli, M., Anker, S. D., Argilés, J., Aversa, Z., Bauer, J. M., Biolo, G., Boirie, Y., Bosaeus, I., Cederholm, T., Costelli, P., et al. (2010) · Clinical Nutrition · doi:10.1016/j.clnu.2009.12.004 · Cited by 1,732
Self-citationWalston, J., Hadley, E. C., Ferrucci, L., Guralnik, J. M., Newman, A. B., Studenski, S. A., Ershler, W. B., Harris, T., & Fried, L. P. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00745.x · Cited by 1,605
Self-citationProtein and energy supplementation in elderly people at risk from malnutrition
Milne, A. C., Potter, J., Vivanti, A., & Avenell, A. (2009) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003288.pub3 · Cited by 849
Nutritional recommendations for the management of sarcopenia
Morley, J. E., Argiles, J. M., Evans, W. J., Bhasin, S., Cella, D., Deutz, N. E. P., Doehner, W., Fearon, K. C. H., Ferrucci, L., Hellerstein, M. K., et al. (2010) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2010.04.014 · Cited by 664
Self-citationTieland, M., Dirks, M. L., van der Zwaluw, N., Verdijk, L. B., van de Rest, O., de Groot, L. C. P. G. M., & van Loon, L. J. C. (2012) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2012.05.020 · Cited by 556
Cited by
Sarcopenia: revised European consensus on definition and diagnosis
Cruz-Jentoft, A. J., Bahat, G., Bauer, J., Boirie, Y., Bruyère, O., Cederholm, T., Cooper, C., Landi, F., Rolland, Y., Sayer, A. A., et al. (2019) · Age and Ageing · doi:10.1093/ageing/afy169 · Cited by 13,818
Self-citationSARC-F: A simple questionnaire to rapidly diagnose sarcopenia
Malmstrom, T. K., & Morley, J. E. (2013) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2013.05.018 · Cited by 1,319
Self-citationManagement of Depression in Older Adults: A Review
Kok, R. M., & Reynolds, C. F. (2017) · JAMA · doi:10.1001/jama.2017.5706 · Cited by 890
Frailty in older adults: a nationally representative profile in the United States
Bandeen-Roche, K., Seplaki, C. L., Huang, J., Buta, B., Kalyani, R. R., Varadhan, R., Xue, Q.-L., Walston, J. D., & Kasper, J. D. (2015) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv133 · Cited by 800
Self-citationEvidence for the Domains Supporting the Construct of Intrinsic Capacity
Cesari, M., Araujo de Carvalho, I., Amuthavalli Thiyagarajan, J., Cooper, C., Martin, F. C., Reginster, J.-Y., Vellas, B., & Beard, J. R. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly011 · Cited by 745
Self-citationLai, J. C., Tandon, P., Bernal, W., Tapper, E. B., Ekong, U., Dasarathy, S., & Carey, E. J. (2021) · Hepatology · doi:10.1002/hep.32049 · Cited by 742
Bauer, J. M., Verlaan, S., Bautmans, I., Brandt, K., Donini, L. M., Maggio, M., McMurdo, M. E. T., Mets, T., Seal, C., Wijers, S. L., et al. (2015) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2015.05.021 · Cited by 670
Self-citationBeiderbeck, D., Frevel, N., von der Gracht, H. A., Schmidt, S. L., & Schweitzer, V. M. (2021) · MethodsX · doi:10.1016/j.mex.2021.101401 · Cited by 642
Gale, C. R., Westbury, L., & Cooper, C. (2018) · Age and Ageing · doi:10.1093/ageing/afx188 · Cited by 590
“definition of frailty inherent in the cumulative deficit model which describes the general state or condition of an individual rather than a specific medical syndrome [30].”
BackgroundAdverse drug reactions in special populations – the elderly
Davies, E. A., & O'Mahony, M. S. (2015) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12596 · Cited by 604
Frailty and sarcopenia: The potential role of an aged immune system
Wilson, D., Jackson, T., Sapey, E., & Lord, J. M. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.01.006 · Cited by 573
Carli, F., Bousquet-Dion, G., Awasthi, R., Elsherbini, N., Liberman, S., Boutros, M., Stein, B., Charlebois, P., Ghitulescu, G., Morin, N., et al. (2020) · JAMA Surgery · doi:10.1001/jamasurg.2019.5474 · Cited by 537
Nutrition, frailty, and sarcopenia
Cruz-Jentoft, A. J., Kiesswetter, E., Drey, M., & Sieber, C. C. (2017) · Aging Clinical and Experimental Research · doi:10.1007/s40520-016-0709-0 · Cited by 488
Sarcopenia and Physical Frailty: Two Sides of the Same Coin
Cesari, M., Landi, F., Vellas, B., Bernabei, R., & Marzetti, E. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00192 · Cited by 468
Self-citationCao, L., & Morley, J. E. (2016) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.06.001 · Cited by 424
Self-citationESPEN guidelines on nutrition in dementia
Volkert, D., Chourdakis, M., Faxen-Irving, G., Frühwald, T., Landi, F., Suominen, M. H., Vandewoude, M., Wirth, R., & Schneider, S. M. (2015) · Clinical Nutrition · doi:10.1016/j.clnu.2015.09.004 · Cited by 442
Self-citationClegg, A., Rogers, L., & Young, J. (2015) · Age and Ageing · doi:10.1093/ageing/afu157 · Cited by 380
Sarcopenia, frailty and their prevention by exercise
Nascimento, C. M., Ingles, M., Salvador-Pascual, A., Cominetti, M. R., Gomez-Cabrera, M. C., & Viña, J. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.08.035 · Cited by 396
Yoshimura, Y., Wakabayashi, H., Yamada, M., Kim, H., Harada, A., & Arai, H. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.03.019 · Cited by 365
Oblak, A. L., Lin, P. B., Kotredes, K. P., Pandey, R. S., Garceau, D., Williams, H. M., Uyar, A., O’Rourke, R., O’Rourke, S., Ingraham, C., et al. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.713726 · Cited by 325
Frailty for Surgeons: Review of a National Institute on Aging Conference on Frailty for Specialists
Robinson, T. N., Walston, J. D., Brummel, N. E., Deiner, S., Brown, C. H., Kennedy, M., & Hurria, A. (2015) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2015.08.428 · Cited by 304
Self-citationSarcopenia as the biological substrate of physical frailty
Landi, F., Calvani, R., Cesari, M., Tosato, M., Martone, A. M., Bernabei, R., Onder, G., & Marzetti, E. (2015) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2015.04.005 · Cited by 288
Self-citationFrailty, Sarcopenia and Diabetes
Morley, J. E., Malmstrom, T. K., Rodriguez-Mañas, L., & Sinclair, A. J. (2014) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2014.10.001 · Cited by 277
Self-citationThe hallmarks of fibroblast ageing
Tigges, J., Krutmann, J., Fritsche, E., Haendeler, J., Schaal, H., Fischer, J. W., Kalfalah, F., Reinke, H., Reifenberger, G., Stühler, K., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.03.004 · Cited by 250
Verlaan, S., Ligthart-Melis, G. C., Wijers, S. L. J., Cederholm, T., Maier, A. B., & de van der Schueren, M. A. E. (2017) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2016.12.074 · Cited by 246
Billot, M., Calvani, R., Urtamo, A., Sánchez-Sánchez, J. L., Ciccolari-Micaldi, C., Chang, M., Roller-Wirnsberger, R., Wirnsberger, G., Sinclair, A., Vaquero-Pinto, M. N., et al. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s253535 · Cited by 242
The relationship between depression and frailty syndrome: a systematic review
Buigues, C., Padilla-Sánchez, C., Garrido, J. F., Navarro-Martínez, R., Ruiz-Ros, V., & Cauli, O. (2015) · Aging & Mental Health · doi:10.1080/13607863.2014.967174 · Cited by 235
Pharmacologic Options for the Treatment of Sarcopenia
Morley, J. E. (2016) · Calcified Tissue International · doi:10.1007/s00223-015-0022-5 · Cited by 225
Self-citationEffect of a Prebiotic Formulation on Frailty Syndrome: A Randomized, Double-Blind Clinical Trial
Buigues, C., Fernández-Garrido, J., Pruimboom, L., Hoogland, A., Navarro-Martínez, R., Martínez-Martínez, M., Verdejo, Y., Mascarós, M., Peris, C., & Cauli, O. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060932 · Cited by 222
Biological aging and the human gut microbiota
Maffei, V. J., Kim, S., Blanchard, E., Luo, M., Jazwinski, S. M., Taylor, C. M., & Welsh, D. A. (2017) · The Journals of Gerontology Series A · doi:10.1093/gerona/glx042 · Cited by 219
Tompkins, B. A., DiFede, D. L., Khan, A., Landin, A. M., Schulman, I. H., Pujol, M. V., Heldman, A. W., Miki, R., Goldschmidt-Clermont, P. J., Goldstein, B. J., et al. (2017) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx137 · Cited by 169
Physical Exercise in the Oldest Old
Valenzuela, P. L., Castillo‐García, A., Morales, J. S., Izquierdo, M., Serra‐Rexach, J. A., Santos‐Lozano, A., & Lucia, A. (2019) · Comprehensive Physiology · doi:10.1002/cphy.c190002 · Cited by 152
Chaabene, H., Prieske, O., Herz, M., Moran, J., Höhne, J., Kliegl, R., Ramirez-Campillo, R., Behm, D. G., Hortobágyi, T., & Granacher, U. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101265 · Cited by 146
Agostini, D., Donati Zeppa, S., Lucertini, F., Annibalini, G., Gervasi, M., Ferri Marini, C., Piccoli, G., Stocchi, V., Barbieri, E., & Sestili, P. (2018) · Nutrients · doi:10.3390/nu10081103 · Cited by 151
Lozano-Montoya, I., Correa-Pérez, A., Abraha, I., Soiza, R. L., Cherubini, A., O'Mahony, D., & Cruz-Jentoft, A. J. (2017) · Clinical Interventions in Aging · doi:10.2147/cia.s132496 · Cited by 130
Screening for frailty in Canada’s health care system: A time for action
Muscedere, J., Andrew, M. K., Bagshaw, S. M., Estabrooks, C., Hogan, D., Holroyd-Leduc, J., Howlett, S., Lahey, W., Maxwell, C., McNally, M., et al. (2016) · Canadian Journal on Aging / La Revue canadienne du vieillissement · doi:10.1017/s0714980816000301 · Cited by 112
Precarity in late life: rethinking dementia as a ‘frailed’ old age
Grenier, A., Lloyd, L., & Phillipson, C. (2017) · Sociology of Health & Illness · doi:10.1111/1467-9566.12476 · Cited by 110
Wang, H., Huang, W. Y., & Zhao, Y. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19138212 · Cited by 99
Izquierdo, M., & Cadore, E. L. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.908175 · Cited by 97
Adherence to Mediterranean Diet and Frailty
Ntanasi, E., Yannakoulia, M., Kosmidis, M.-H., Anastasiou, C. A., Dardiotis, E., Hadjigeorgiou, G., Sakka, P., & Scarmeas, N. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2017.11.005 · Cited by 94
Ambagtsheer, R. C., Beilby, J. J., Visvanathan, R., Dent, E., Yu, S., & Braunack-Mayer, A. J. (2019) · Preventive Medicine · doi:10.1016/j.ypmed.2018.12.020 · Cited by 95
Relationship between frailty and Alzheimer's disease biomarkers: a scoping review
Wallace, L., Theou, O., Rockwood, K., & Andrew, M. K. (2018) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1016/j.dadm.2018.05.002 · Cited by 72
Self-citationLazarus, N. R., Izquierdo, M., Higginson, I. J., & Harridge, S. D. R. (2018) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2018.04.014 · Cited by 63
Comparing the prognostic value of geriatric health indicators: a population-based study
Zucchelli, A., Vetrano, D. L., Grande, G., Calderón-Larrañaga, A., Fratiglioni, L., Marengoni, A., & Rizzuto, D. (2019) · BMC Medicine · doi:10.1186/s12916-019-1418-2 · Cited by 55
Type 2 diabetes and impaired physical function: a growing problem
Ahmad, E., Sargeant, J. A., Yates, T., Webb, D. R., & Davies, M. J. (2022) · Diabetology · doi:10.3390/diabetology3010003 · Cited by 52
Baldwin, M. R., Singer, J. P., Huang, D., Sell, J., Gonzalez, W. C., Pollack, L. R., Maurer, M. S., D’Ovidio, F. F., Bacchetta, M., Sonett, J. R., et al. (2017) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201612-1008oc · Cited by 45
Self-citationEnergetics of aging and frailty: the FRADEA study
Abizanda, P., Romero, L., Sánchez-Jurado, P. M., Ruano, T. F., Ríos, S. S., & Sánchez, M. F. (2016) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glv182 · Cited by 44
Telomere length and frailty in older adults-a systematic review and meta-analysis
Araújo Carvalho, A. C., Tavares Mendes, M. L., da Silva Reis, M. C., Santos, V. S., Tanajura, D. M., & Martins-Filho, P. R. S. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100914 · Cited by 44
Gondal, A. B., Hsu, C.-H., Zeeshan, M., Hamidi, M., Joseph, B., & Ghaderi, I. (2019) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2019.06.028 · Cited by 46
Fragility Fracture Nursing: Holistic Care and Management of the Orthogeriatric Patient
(2018) · Perspectives in Nursing Management and Care for Older Adults · doi:10.1007/978-3-319-76681-2 · Cited by 40
To what extent will blockchain drive the machine economy? Perspectives from a prospective study
Schweizer, A., Knoll, P., Urbach, N., von der Gracht, H. A., & Hardjono, T. (2020) · IEEE Transactions on Engineering Management · doi:10.1109/tem.2020.2979286 · Cited by 39
Association of shorter leucocyte telomere length with risk of frailty
Bountziouka, V., Nelson, C. P., Codd, V., Wang, Q., Musicha, C., Allara, E., Kaptoge, S., Di Angelantonio, E., Butterworth, A. S., Thompson, J. R., et al. (2022) · Journal of Cachexia, Sarcopenia and Muscle · doi:10.1002/jcsm.12971 · Cited by 36
Weersink, R. A., Alvarez‐Alvarez, I., Medina‐Cáliz, I., Sanabria‐Cabrera, J., Robles‐Díaz, M., Ortega‐Alonso, A., García‐Cortés, M., Bonilla, E., Niu, H., Soriano, G., et al. (2021) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt.2108 · Cited by 29
Morrison, R. T., Taylor, S., Buckley, J., Twist, C., & Kite, C. (2023) · Journal of Physiotherapy · doi:10.1016/j.jphys.2023.05.018 · Cited by 11
“Because functional decline falls under the physical domain of frailty syndrome,(6) functional trajectories influence frailty risk, making people more vulnerable to negative health outcomes.(7) Whilst acute functional decline can be caused by a medical event, progressive functional decline is often latent and can begin…”
BackgroundZhou, W., Qiao, X., Liu, T., Wen, L., Gao, H., Wang, C., Jin, Y., Si, H., Bian, Y., Liu, Q., et al. (2024) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2024.08.029 · Cited by 8
Kamper, R. S., Nygaard, H., Ekmann, A., Schultz, M., Hansen, S. K., Hansen, P., Pressel, E., Rasmussen, J., & Suetta, C. (2023) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2023.07.002 · Cited by 6
González-Martin, A. M., Limón-Villegas, E. S., Reyes-Castillo, Z., Esparza-Ros, F., Hernández-Palma, L. A., Santillán-Rivera, M. S., Herrera-Amante, C. A., Ramos-García, C. O., & Righini, N. (2025) · Journal of Functional Morphology and Kinesiology · doi:10.3390/jfmk10030276 · Cited by 4
Metadata
- Authors
- Morley, J. E., Vellas, B., Abellan van Kan, G., Anker, S. D., Bauer, J. M., Bernabei, R., Cesari, M., Chumlea, W. C., Doehner, W., Evans, J., Fried, L. P., Guralnik, J. M., Katz, P. R., Malmstrom, T. K., McCarter, R. J., Gutierrez Robledo, L. M., Rockwood, K., von Haehling, S., Vandewoude, M. F., & Walston, J.
- Venue
- Journal of the American Medical Directors Association
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 14
- Issue
- 6
- Pages
- 392-397
- ISSN
- 1525-8610 (ISSN-L)
- OpenAlex
- W2092170177
- Cited by
- 4,043
- References
- 16
- FWCI
- 78.71
- Type
- journal article
- Language
- en
- Open access
- green
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