The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Chronic glucocorticoid treatment induced circadian clock disorder leads to lipid metabolism and gut microbiota alterations in rats
Abstract
Aim Glucocorticoids (GCs), steroid hormones synthetized by the adrenal gland, are regulated by circadian cycles, and dysregulation of GC signaling can lead to the development of metabolic syndrome. The effects and potential mechanism of GCs in physiology were investigated in the present study.Main methods Male Wistar rats were orally administered dexamethasone sodium phosphate (DEX, 0.01 and 0.05mg/kg body weight per day) for 7weeks.Key finding DEX treatment attenuated body weight gain and reduced food intake, whereas it induced the accumulation of fat. Administration of DEX induced dysregulation of the expression of lipogenic genes in both fat and liver. Moreover, the mRNA levels of genes related to mitochondrial biogenesis and function were significantly downregulated in the liver and fat of DEX-treated rats. Furthermore, DEX treatment caused a significant reduction in the richness and diversity of the microbiota in the colon, as assessed using high-throughput sequencing of the 16s rRNA gene V3-V4 region, an increase in inflammatory cell infiltration, and a decrease in mucus secretion in the colon. Additionally, DEX administration induced phase shift or loss of circadian rhythmicity of clock-related genes in peripheral tissues. These results were associated with higher serum corticosterone levels and upregulation of GC receptor (GR) expression in peripheral tissues.Significance Our findings indicate that long-term administration of GC caused lipid accumulation, changes in the structure of the intestinal flora, and reduced colonic mucus secretion in vivo. The mechanism of these physiological changes may involve a circadian rhythm disorder and dysregulation of GR expression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Experimental administration of glucocorticoid synchronizes the peripheral clocks located in liver, muscle, and adipose tissue which are the major storage sites for glycogen, protein, and fat, respectively, as well as other metabolically relevant organs such as pancreas and gut [60–63].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [61]
In the citing paper
“This rhythm is important for its action because cortisol, not melatonin, is recognized to be the key metabolic central synchronizing signal [60–62].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [61]
In the citing paper
“Regarding the effects of glucocorticoids on the composition and functioning of the microbiota, some studies have indicated microbiota disruption, while others have shown beneficial effects, which likely depend on the degree of exposure (dose and period) and the type of glucocorticoid studied (434–437)”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [434]
Citations
Cites
The gut microbiota shapes intestinal immune responses during health and disease
Round, J. L., & Mazmanian, S. K. (2009) · Nature Reviews Immunology · doi:10.1038/nri2515 · Cited by 5,029
Loss of a circadian adrenal corticosterone rhythm following suprachiasmatic lesions in the rat
Moore, R. Y., & Eichler, V. B. (1972) · Brain Research · doi:10.1016/0006-8993(72)90054-6 · Cited by 2,135
Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5
Vijay-Kumar, M., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., Sitaraman, S. V., Knight, R., Ley, R. E., & Gewirtz, A. T. (2010) · Science · doi:10.1126/science.1179721 · Cited by 2,068
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
Devkota, S., Wang, Y., Musch, M. W., Leone, V., Fehlner-Peach, H., Nadimpalli, A., Antonopoulos, D. A., Jabri, B., & Chang, E. B. (2012) · Nature · doi:10.1038/nature11225 · Cited by 1,904
Van der Sluis, M., De Koning, B. A. E., De Bruijn, A. C. J. M., Velcich, A., Meijerink, J. P. P., Van Goudoever, J. B., Büller, H. A., Dekker, J., Van Seuningen, I., Renes, I. B., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.04.020 · Cited by 1,684
Anti-inflammatory Actions of Glucocorticoids: Molecular Mechanisms
Barnes, P. J. (1998) · Clinical Science · doi:10.1042/cs0940557 · Cited by 1,591
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949
IBD—what role do Proteobacteria play?
Mukhopadhya, I., Hansen, R., El-Omar, E. M., & Hold, G. L. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.14 · Cited by 810
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738
Bloom, S. M., Bijanki, V. N., Nava, G. M., Sun, L., Malvin, N. P., Donermeyer, D. L., Dunne, W. M., Allen, P. M., & Stappenbeck, T. S. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.04.009 · Cited by 488
Genome-scale analyses of health-promoting bacteria: probiogenomics
Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., van Sinderen, D., & O'Toole, P. W. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2047 · Cited by 471
The intestinal microbiota regulates body composition through NFIL3 and the circadian clock
Wang, Y., Kuang, Z., Yu, X., Ruhn, K. A., Kubo, M., & Hooper, L. V. (2017) · Science · doi:10.1126/science.aan0677 · Cited by 456
Interactions of the circadian CLOCK system and the HPA-axis
Nader, N., Chrousos, G. P., & Kino, T. (2010) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2009.12.011 · Cited by 449
Regulation of CLOCK and MOP4 by Nuclear Hormone Receptors in the Vasculature
McNamara, P., Seo, S., Rudic, R. D., Sehgal, A., Chakravarti, D., & FitzGerald, G. A. (2001) · Cell · doi:10.1016/s0092-8674(01)00401-9 · Cited by 445
Intracellular Receptor Concentration Limits Glucocorticoid-Dependent Enhancer Activity*
Vanderbilt, J. N., Miesfeld, R. L., Maler, B. A., & Yamamoto, K. R. (1987) · Molecular Endocrinology · doi:10.1210/mend-1-1-68 · Cited by 349
The Human Gut Microbiome and Body Metabolism: Implications for Obesity and Diabetes
Devaraj, S., Hemarajata, P., & Versalovic, J. (2013) · Clinical Chemistry · doi:10.1373/clinchem.2012.187617 · Cited by 321
Direct Effect of Glucocorticoids on Lipolysis in Adipocytes
Xu, C., He, J., Jiang, H., Zu, L., Zhai, W., Pu, S., & Xu, G. (2009) · Molecular Endocrinology · doi:10.1210/me.2008-0464 · Cited by 291
Glucocorticoids: exemplars of multi-tasking
Buckingham, J. C. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706456 · Cited by 276
Adverse effects of corticosteroids on the cardiovascular system.
De, S., & Armstrong, P. W. (2000) · PubMed · Cited by 264
Leleu, X. P., Attal, M., Arnulf, B., Moreau, P., Traullé, C., Marit, G., Mathiot, C., Petillon, M. O., Macro, M., Roussel, M., et al. (2013) · Blood · doi:10.1182/blood-2012-09-452375 · Cited by 206
Abnormal Cortisol Metabolism and Tissue Sensitivity to Cortisol in Patients with Glucose Intolerance
Andrews, R. C., Herlihy, O., Livingstone, D. E. W., Andrew, R., & Walker, B. R. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2002-020048 · Cited by 199
Circadian regulation of lipid metabolism
Gooley, J. J. (2016) · Proceedings of The Nutrition Society · doi:10.1017/s0029665116000288 · Cited by 194
The Metabolic Syndrome and Cardiovascular Risk in Cushing's Syndrome
Pivonello, R., Faggiano, A., Lombardi, G., & Colao, A. (2005) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2005.01.010 · Cited by 173
Jin, Y., Zeng, Z., Wu, Y., Zhang, S., & Fu, Z. (2015) · Toxicological Sciences · doi:10.1093/toxsci/kfv115 · Cited by 152
Self-citationFRIEDMAN, T. C., MASTORAKOS, G., NEWMAN, T. D., MULLEN, N. M., HORTON, E. G., COSTELLO, R., PAPADOPOULOS, N. M., & CHROUSOS, G. P. (1996) · Endocrine Journal · doi:10.1507/endocrj.43.645 · Cited by 145
Bhandari, R., Juluri, K. R., Resnick, A. C., & Snyder, S. H. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712227105 · Cited by 145
On communication between gut microbes and the brain
Forsythe, P., Kunze, W. A., & Bienenstock, J. (2012) · Current Opinion in Gastroenterology · doi:10.1097/mog.0b013e3283572ffa · Cited by 137
Demonacos, C., Djordjevic-Markovic, R., Tsawdaroglou, N., & Sekeris, C. E. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00159-w · Cited by 131
Insulin action and signalling in fat and muscle from dexamethasone-treated rats
Burén, J., Lai, Y. C., Lundgren, M., Eriksson, J. W., & Jensen, J. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.02.034 · Cited by 125
Peripheral Circadian Oscillators in Mammals
Brown, S. A., & Azzi, A. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_3 · Cited by 124
Das, I., Png, C. W., Oancea, I., Hasnain, S. Z., Lourie, R., Proctor, M. A., Eri, R. D., Sheng, Y., Crane, D. I., Florin, T. H., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121268 · Cited by 117
Fatty Acid Oxidation in Zebrafish Adipose Tissue Is Promoted by 1α,25(OH)2D3
Peng, X., Shang, G., Wang, W., Chen, X., Lou, Q., Zhai, G., Li, D., Du, Z., Ye, Y., Jin, X., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.04.066 · Cited by 114
Glucocorticoid hormones and energy homeostasis
de Guia, R. M., Rose, A. J., & Herzig, S. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0021 · Cited by 93
Jiang, W., Li, S., Zhou, S., Sun, Y., Shi, J., & Lü, L. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.001 · Cited by 85
Hoskins, L. C. (1993) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199304000-00004 · Cited by 69 · cited 1×
“Changes in mucus secretion will lead directly to changes in the bacterial structure [38].”
Tonsfeldt, K. J., & Chappell, P. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.003 · Cited by 66
Tsiriyotis, C., Spandidos, D. A., & Sekeris, C. E. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6787 · Cited by 61
Abad, V., Chrousos, G. P., Reynolds, J. C., Nieman, L. K., Hill, S. C., Weinstein, R. S., & Leong, G. M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1879 · Cited by 57
Glucocorticoid Regulation of Clock Gene Expression in the Mammalian Limbic Forebrain
Segall, L. A., & Amir, S. (2010) · Journal of Molecular Neuroscience · doi:10.1007/s12031-010-9341-1 · Cited by 45
Li, Z., Fan, M.-B., Zhang, S.-L., Qu, Y., Zheng, S., Song, J., & Miao, C. (2016) · Acta Pharmacologica Sinica · doi:10.1038/aps.2016.70 · Cited by 44
Mitophagy and Mitoptosis in Disease Processes
Mijaljica, D., Prescott, M., & Devenish, R. J. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-756-3_6 · Cited by 38
Light and food signals cooperate to entrain the rat pineal circadian system
Wu, T., Jin, Y., Kato, H., & Fu, Z. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21769 · Cited by 34
Self-citationl-Carnitine intake prevents irregular feeding-induced obesity and lipid metabolism disorder
Wu, T., Guo, A., Shu, Q., Qi, Y., Kong, Y., Sun, Z., Sun, S., & Fu, Z. (2014) · Gene · doi:10.1016/j.gene.2014.10.040 · Cited by 34
Self-citationLee, K., Youm, J., Lee, W. J., Kang, S., & Kim, Y. J. (2017) · Experimental Dermatology · doi:10.1111/exd.13319 · Cited by 33
Priyadarshini, E., & Anuradha, C. V. (2016) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2016.06.003 · Cited by 27
1H NMR-based metabonomic study on the effects of Epimedium on glucocorticoid-induced osteoporosis
Pan, S., Chen, A., Han, Z., Wang, Y., Lu, X., & Yang, Y. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.10.015 · Cited by 27
Self-citation3 Rationale for treatment and therapeutic options in Cushing's disease
Stewart, P. M., & Petersenn, S. (2009) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/s1521-690x(09)70004-1 · Cited by 26
Wu, T., Jiang, J., Yang, L., Li, H., Zhang, W., Chen, Y., Zhao, B., Kong, B., Lü, P., Zhao, Z., et al. (2016) · Chronobiology International · doi:10.1080/07420528.2016.1238831 · Cited by 25
Self-citationEffects of Glucocorticoids on Bone: What we can Learn from Pediatric Endogenous Cushing’s Syndrome
Tack, L. J. W., Tatsi, C., Stratakis, C. A., & Lodish, M. B. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-117721 · Cited by 22
Minami, I., Tateno, T., Yoshimoto, T., Doi, M., Izumiyama, H., Akashi, T., & Hirata, Y. (2006) · Internal Medicine · doi:10.2169/internalmedicine.45.1809 · Cited by 15
Research works printed but not linked: 1
- Bloom, 2011, Commensal Bacteroides species induce colitis in host-genotype-specific fashion in a mouse model of inflammatory bowel disease, Cell Host Microbe, 9, 390, 10.1016/j.chom.2011.04.009 · DOI · Paper page
Cited by
Sorted by citations
Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis
Rusch, J. A., Layden, B. T., & Dugas, L. R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1130689 · Cited by 415
The Role of Microbiome in Insomnia, Circadian Disturbance and Depression
Li, Y., Hao, Y., Fan, F., & Zhang, B. (2018) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00669 · Cited by 296
Cortellini, A., Tucci, M., Adamo, V., Stucci, L. S., Russo, A., Tanda, E. T., Spagnolo, F., Rastelli, F., Bisonni, R., Santini, D., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-001361 · Cited by 275
Dysbiosis of microbiome and probiotic treatment in a genetic model of autism spectrum disorders
Tabouy, L., Getselter, D., Ziv, O., Karpuj, M., Tabouy, T., Lukic, I., Maayouf, R., Werbner, N., Ben-Amram, H., Nuriel-Ohayon, M., et al. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.05.015 · Cited by 214
A Review of Microbiota and Irritable Bowel Syndrome: Future in Therapies
Rodiño‐Janeiro, B. K., Vicario, M., Alonso, C., Pascua-García, R., & Santos, J. (2018) · Advances in Therapy · doi:10.1007/s12325-018-0673-5 · Cited by 223
Metadata
- Authors
- Wu, T., Yang, L., Jiang, J., Ni, Y., Zhu, J., Zheng, X., Wang, Q., Lu, X., & Fu, Z.
- Affiliations
- Zhejiang University of Technology (CN)
- Corresponding author
- Fu, Zhengwei
- Venue
- Life Sciences
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 192
- Pages
- 173-182
- ISSN
- 0024-3205 (ISSN-L)
- OpenAlex
- W2775302672
- Cited by
- 126
- References
- 53
- Citations by year
- 2026: 7 · 2025: 14 · 2024: 22 · 2023: 15 · 2022: 15 · 2021: 14 · 2020: 14 · 2019: 13 · 2018: 12
- FWCI
- 6.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Life Sciences (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31200890)
- Open Research Fund Program of the Collaborative Innovation Center of Membrane Separation and Water Treatment, Zhejiang Province Public Welfare Research Project (2015C33178)
- Scientific Innovation Program for University Students in Zhejiang Province (2014R403060)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- glucocorticoids, dexamethasone, circadian clock, circadian rhythm disorders, lipid metabolism, gut microbiota, metabolic syndrome, lipogenic genes, mitochondrial biogenesis, colonic inflammation, corticosterone, glucocorticoid receptor, adipose tissue, liver
- MeSH terms
- Gastrointestinal Microbiome, Adipose Tissue, Animals, Cecum, Colon, Corticosterone, Dexamethasone, Eating, Glucose Tolerance Test, Glycolipids, Liver, Male, Mitochondria, Receptors, Glucocorticoid, Weight Gain, Rats, Wistar, Lipid Metabolism, Rats, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
