Cited by 355Regulation of Appetite and ObesityGenetic Associations and EpidemiologyNutrition, Genetics, and Disease

The DOI matches its Crossref record; 152 of the 154 references it cites were found in a registry or an index.

Genetics and epigenetics in obesity

Open access

Rohde, Kerstin, Keller, Maria, la Cour Poulsen, Lars, Blüher, Matthias, Kovacs, Peter, Böttcher, Yvonne·2019·Metabolism

DOI 10.1016/j.metabol.2018.10.007

Open this paper in CoChat — free account

Abstract

Obesity is among the most threatening health burdens worldwide and its prevalence has markedly increased over the last decades. Obesity maybe considered a heritable trait. Identifications of rare cases of monogenic obesity unveiled that hypothalamic circuits and the brain-adipose axis play an important role in the regulation of energy homeostasis, appetite, hunger and satiety. For example, mutations in the leptin gene cause obesity through almost unsuppressed overeating. Common (multifactorial) obesity, most likely resulting from a concerted interplay of genetic, epigenetic and environmental factors, is clearly linked to genetic predisposition by multiple risk variants, which, however only account for a minor part of the general BMI variability. Although GWAS opened new avenues in elucidating the complex genetics behind common obesity, understanding the biological mechanisms relative to the specific risk contributing to obesity remains poorly understood. Non-genetic factors such as eating behavior or physical activity strongly modulate the individual risk for developing obesity. These factors may interact with genetic predisposition for obesity through epigenetic mechanisms. Thus, here, we review the current knowledge about monogenic and common (multifactorial) obesity highlighting the important recent advances in our knowledge on how epigenetic regulation is involved in the etiology of obesity.

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2018.10.007

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Positional cloning of the mouse obese gene and its human homologue
Zhang, Y., Proenca, R., Maffei, M., Barone, M., Leopold, L., & Friedman, J. M. (1994) · Nature · doi:10.1038/372425a0 · Cited by 13,419
Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013
Ng, M., Fleming, T., Robinson, M., Thomson, B., Graetz, N., Margono, C., Mullany, E. C., Biryukov, S., Abbafati, C., Abera, S. F., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60460-8 · Cited by 11,952
A New Initiative on Precision Medicine
Collins, F. S., & Varmus, H. (2015) · New England Journal of Medicine · doi:10.1056/nejmp1500523 · Cited by 5,202
Genetic studies of body mass index yield new insights for obesity biology
Study, T. L. C., Locke, A. E., The ADIPOGen Consortium, The AGEN-BMI Working Group, The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The, G. L. G. C., The, I. C. B. P., The MAGIC Investigators, The MuTHER Consortium, et al. (2015) · Nature · doi:10.1038/nature14177 · Cited by 4,534
Self-citation
A Common Variant in the FTO Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity
Frayling, T. M., Timpson, N. J., Weedon, M. N., Zeggini, E., Freathy, R. M., Lindgren, C. M., Perry, J. R. B., Elliott, K. S., Lango, H., Rayner, N. W., et al. (2007) · Science · doi:10.1126/science.1141634 · Cited by 4,531
Abdominal obesity and metabolic syndrome
Després, J.-P., & Lemieux, I. (2006) · Nature · doi:10.1038/nature05488 · Cited by 4,354
CpG islands and the regulation of transcription
Deaton, A. M., & Bird, A. (2011) · Genes & Development · doi:10.1101/gad.2037511 · Cited by 3,187
Years of Life Lost Due to Obesity
Fontaine, K. R., Redden, D. T., Wang, C., Westfall, A. O., & Allison, D. B. (2003) · JAMA · doi:10.1001/jama.289.2.187 · Cited by 2,551
Meta-analysis of genome-wide association studies for height and body mass index in ∼700000 individuals of European ancestry
Yengo, L., Sidorenko, J., Kemper, K. E., Zheng, Z., Wood, A. R., Weedon, M. N., Frayling, T. M., Hirschhorn, J. N., Yang, J., & Visscher, P. M. (2018) · Human Molecular Genetics · doi:10.1093/hmg/ddy271 · Cited by 2,393
Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
Farooqi, I. S., Jebb, S. A., Langmack, G., Lawrence, E., Cheetham, C. H., Prentice, A. M., Hughes, I. A., McCamish, M. A., & O'Rahilly, S. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411204 · Cited by 1,998
Clinical Spectrum of Obesity and Mutations in the Melanocortin 4 Receptor Gene
Farooqi, I. S., Keogh, J. M., Yeo, G. S. H., Lank, E. J., Cheetham, T., & O'Rahilly, S. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022050 · Cited by 1,778
Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans
Krude, H., Biebermann, H., Luck, W., Horn, R., Brabant, G. E., & Grüters, A. (1998) · Nature Genetics · doi:10.1038/509 · Cited by 1,769
New genetic loci link adipose and insulin biology to body fat distribution
The ADIPOGen Consortium, Shungin, D., The CARDIOGRAMplusC4D Consortium, The CKDGen Consortium, The GEFOS Consortium, The GENIE Consortium, The, G. L. G. C., The, I. C. B. P., The International Endogene Consortium, Study, T. L. C., et al. (2015) · Nature · doi:10.1038/nature14132 · Cited by 1,580
Self-citation
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15693 · Cited by 1,374
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Claussnitzer, M., Dankel, S. N., Kim, K.-H., Quon, G., Meuleman, W., Haugen, C., Glunk, V., Sousa, I. S., Beaudry, J. L., Puviindran, V., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1502214 · Cited by 1,332
Common variants near MC4R are associated with fat mass, weight and risk of obesity
The Prostate, L., Loos, R. J. F., KORA, Study, N. H., Initiative, D. G., Study, T. S., The Wellcome Trust Case Control Consortium, FUSION, Lindgren, C. M., Li, S., et al. (2008) · Nature Genetics · doi:10.1038/ng.140 · Cited by 1,325
An Adoption Study of Human Obesity
Stunkard, A. J., Sørensen, T. I. A., Hanis, C., Teasdale, T. W., Chakraborty, R., Schull, W. J., & Schulsinger, F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198601233140401 · Cited by 1,318
The Body-Mass Index of Twins Who Have Been Reared Apart
Stunkard, A. J., Harris, J. R., Pedersen, N. L., & McClearn, G. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005243222102 · Cited by 1,286
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
Jackson, R. S., Creemers, J. W. M., Ohagi, S., Raffin-Sanson, M.-L., Sanders, L., Montague, C. T., Hutton, J. C., & O'Rahilly, S. (1997) · Nature Genetics · doi:10.1038/ng0797-303 · Cited by 1,153
Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency
Farooqi, I. S., Matarese, G., Lord, G. M., Keogh, J. M., Lawrence, E., Agwu, C., Sanna, V., Jebb, S. A., Perna, F., Fontana, S., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215693 · Cited by 1,105
Acute Exercise Remodels Promoter Methylation in Human Skeletal Muscle
Barrès, R., Yan, J., Egan, B., Treebak, J. T., Rasmussen, M., Fritz, T., Caidahl, K., Krook, A., O'Gorman, D. J., & Zierath, J. R. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.001 · Cited by 965
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P.-C., Ried, J. S., Zhang, W., Yang, Y., et al. (2017) · Nature · doi:10.1038/nature20784 · Cited by 945
A Twin Study of Human Obesity
Stunkard, A. J. (1986) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1986.03380010055024 · Cited by 912
Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity
Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., & Froguel, P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9238 · Cited by 897
Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency
Farooqi, I. S., Yeo, G. S. H., Keogh, J. M., Aminian, S., Jebb, S. A., Butler, G. E., Cheetham, T. D., & O’Rahilly, S. (2000) · Journal of Clinical Investigation · doi:10.1172/jci9397 · Cited by 801
DNA methylation and body-mass index: a genome-wide analysis
Dick, K. J., Nelson, C. P., Tsaprouni, L., Sandling, J. K., Aïssi, D., Wahl, S., Meduri, E., Morange, P.-E., Gagnon, F., Grallert, H., et al. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62674-4 · Cited by 778
Neurobiology of food intake in health and disease
Morton, G. J., Meek, T. H., & Schwartz, M. W. (2014) · Nature Reviews Neuroscience · doi:10.1038/nrn3745 · Cited by 748
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index
Study, T. L. C., Yang, J., Bakshi, A., Zhu, Z., Hemani, G., Vinkhuyzen, A. A. E., Lee, S. H., Robinson, M. R., Perry, J. R. B., Nolte, I. M., et al. (2015) · Nature Genetics · doi:10.1038/ng.3390 · Cited by 745
Self-citation
Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects
Ozata, M., Ozdemir, I. C., & Licinio, J. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.10.5999 · Cited by 739
A personal view on systems medicine and the emergence of proactive P4 medicine: predictive, preventive, personalized and participatory
Hood, L., & Flores, M. (2012) · New Biotechnology · doi:10.1016/j.nbt.2012.03.004 · Cited by 648
A Six Months Exercise Intervention Influences the Genome-wide DNA Methylation Pattern in Human Adipose Tissue
Rönn, T., Volkov, P., Davegårdh, C., Dayeh, T., Hall, E., Olsson, A. H., Nilsson, E., Tornberg, Å. B., Nitert, M. D., Eriksson, K., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003572 · Cited by 637
Sugar-Sweetened Beverages and Genetic Risk of Obesity
Qi, Q., Chu, A. Y., Kang, J., Jensen, M. K., Curhan, G. C., Pasquale, L. R., Ridker, P. M., Hunter, D. J., Willett, W. C., Rimm, E. B., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1203039 · Cited by 609
Genes, Genetics, and Epigenetics: A Correspondence
Wu, C.-T., & Morris, J. R. (2001) · Science · doi:10.1126/science.293.5532.1103 · Cited by 577
From big data analysis to personalized medicine for all: challenges and opportunities
Alyass, A., Turcotte, M., & Meyre, D. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0108-y · Cited by 575
Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans
Donkin, I., Versteyhe, S., Ingerslev, L. R., Qian, K., Mechta, M., Nordkap, L., Mortensen, B., Appel, E. V. R., Jørgensen, N., Kristiansen, V. B., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.11.004 · Cited by 549
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
Licinio, J., Caglayan, S., Ozata, M., Yildiz, B. O., de Miranda, P. B., O'Kirwan, F., Whitby, R., Liang, L., Cohen, P., Bhasin, S., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308767101 · Cited by 505
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist
Kühnen, P., Clément, K., Wiegand, S., Blankenstein, O., Gottesdiener, K., Martini, L. L., Mai, K., Blume-Peytavi, U., Grüters, A., & Krude, H. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1512693 · Cited by 485
Low Physical Activity Accentuates the Effect of the FTO rs9939609 Polymorphism on Body Fat Accumulation
Andreasen, C. H., Stender-Petersen, K. L., Mogensen, M. S., Torekov, S. S., Wegner, L., Andersen, G., Nielsen, A. L., Albrechtsen, A., Borch-Johnsen, K., Rasmussen, S. S., et al. (2008) · Diabetes · doi:10.2337/db07-0910 · Cited by 476
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population
Akiyama, M., Okada, Y., Kanai, M., Takahashi, A., Momozawa, Y., Ikeda, M., Iwata, N., Ikegawa, S., Hirata, M., Matsuda, K., et al. (2017) · Nature Genetics · doi:10.1038/ng.3951 · Cited by 455
THE NHLBI TWIN STUDY OF CARDIOVASCULAR DISEASE RISK FACTORS: METHODOLOGY AND SUMMARY OF RESULTS
Feinleib, M., Garrison, R. J., Fabsitz, R. R., Christian, J. C., Hrubec, Z., Borhani, N. O., Kannel, W. B., Rosenman, R. H., Schwartz, J. T., & Wagner, J. O. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112464 · Cited by 449
Recent progress in genetics, epigenetics and metagenomics unveils the pathophysiology of human obesity
Pigeyre, M., Yazdi, F., Kaur, Y., & Meyre, D. (2016) · Clinical Science · doi:10.1042/cs20160136 · Cited by 422
The heritability of body mass index among an international sample of monozygotic twins reared apart.
Allison, D. B., Kaprio, J. A., Korkeila, M., Koskenvuo, M. J., Neale, M. C., & Hayakawa, K. (1996) · PubMed · Cited by 420
Genomic patterns of DNA methylation: targets and function of an epigenetic mark
Weber, M., & Schübeler, D. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.04.011 · Cited by 410
Impact of common genetic determinants of hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Wheeler, E., Leong, A., Liu, C.-T., Hivert, M.-F., Strawbridge, R. J., Podmore, C., Li, M., Yao, J., Sim, X., Hong, J., et al. (2017) · PLOS Medicine · doi:10.1371/journal.pmed.1002383 · Cited by 408
Self-citation
Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes
Nilsson, E., Jansson, P. A., Perfilyev, A., Volkov, P., Pedersen, M., Svensson, M. K. E., Poulsen, P., Ribel‐Madsen, R., Pedersen, N. L., Almgren, P., et al. (2014) · Diabetes · doi:10.2337/db13-1459 · Cited by 407
Profound obesity associated with a balanced translocation that disrupts the SIM1 gene
L., J., Jr. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.1.101 · Cited by 405
Global analysis of DNA methylation variation in adipose tissue from twins reveals links to disease-associated variants in distal regulatory elements
Grundberg, E., Meduri, E., Sandling, J. K., Hedman, Å. K., Keildson, S., Buil, A., Busche, S., Yuan, W., Nisbet, J., Sekowska, M., et al. (2013) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2013.10.004 · Cited by 370
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach
Mendelson, M., Marioni, R. E., Joehanes, R., Liu, C., Hedman, Å. K., Aslibekyan, S. W., Demerath, E. W., Guan, W., Zhi, D., Yao, C., et al. (2017) · PLoS Medicine · doi:10.1371/journal.pmed.1002215 · Cited by 353
The role of proopiomelanocortin (POMC) neurones in feeding behaviour
Millington, G. W. (2007) · Nutrition & Metabolism · doi:10.1186/1743-7075-4-18 · Cited by 345
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen, T. O., Zillikens, M. C., Stančákova, A., Finucane, F. M., Ried, J. S., Langenberg, C., Zhang, W., Beckmann, J. S., Luan, J., Vandenput, L., et al. (2011) · Nature Genetics · doi:10.1038/ng.866 · Cited by 335
MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency
Clément, K., Biebermann, H., Farooqi, I. S., der Ploeg, L. H. T. V., Wolters, B., Poitou, C., Puder, L., Fiedorek, F. T., Gottesdiener, K. M., Kleinau, G., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0015-9 · Cited by 325
Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity
Pritchard, L. E., Turnbull, A. V., & White, A. E. (2002) · Journal of Endocrinology · doi:10.1677/joe.0.1720411 · Cited by 309
Rare Genetic Forms of Obesity: Clinical Approach and Current Treatments in 2016
Huvenne, H., Dubern, B., Clément, K., & Poitou, C. (2016) · Obesity Facts · doi:10.1159/000445061 · Cited by 302
Common nonsynonymous variants in PCSK1 confer risk of obesity
Benzinou, M., Creemers, J. W. M., Choquet, H., Lobbens, S., Christian Dina, C., Durand, E., Guérardel, A., Boutin, P., Jouret, B., Heude, B., et al. (2008) · Nature Genetics · doi:10.1038/ng.177 · Cited by 299
Self-citation
Physical Activity Attenuates the Genetic Predisposition to Obesity in 20,000 Men and Women from EPIC-Norfolk Prospective Population Study
Li, S., Zhao, J. H., Luan, J., Ekelund, U., Luben, R., Khaw, K., Wareham, N. J., & Loos, R. J. F. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000332 · Cited by 293
Weight Loss after Gastric Bypass Surgery in Human Obesity Remodels Promoter Methylation
Barrès, R., Kirchner, H., Rasmussen, M., Yan, J., Kantor, F. R., Krook, A., Näslund, E. B., & Zierath, J. R. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.018 · Cited by 287
An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss
Benton, M. C., Johnstone, A. C., Eccles, D., Harmon, B. T., Hayes, M. T., Lea, R. A., Griffiths, L. R., Hoffman, E. P., Stubbs, R. S., & Macartney-Coxson, D. P. (2015) · Genome biology · doi:10.1186/s13059-014-0569-x · Cited by 281
Adipose tissue inflammation: a cause or consequence of obesity-related insulin resistance?
Blüher, M. (2016) · Clinical Science · doi:10.1042/cs20160005 · Cited by 273
Self-citation
Impact of age, BMI and HbA1c levels on the genome-wide DNA methylation and mRNA expression patterns in human adipose tissue and identification of epigenetic biomarkers in blood
Ronn, T., Volkov, P., Gillberg, L., Kokosar, M., Perfilyev, A., Jacobsen, A. L., Jorgensen, S. W., Brons, C., Jansson, P.-A., Eriksson, K.-F., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv124 · Cited by 270
Integrated Genetic and Epigenetic Analysis Identifies Haplotype-Specific Methylation in the FTO Type 2 Diabetes and Obesity Susceptibility Locus
Bell, C. G., Finer, S., Lindgren, C. M., Wilson, G. A., Rakyan, V. K., Teschendorff, A. E., Akan, P., Stupka, E., Down, T. A., Prokopenko, I., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014040 · Cited by 260
Genetic determinants of common obesity and their value in prediction
Loos, R. J. F. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2011.11.003 · Cited by 256
Impaired Processing of Prohormones Associated with Abnormalities of Glucose Homeostasis and Adrenal Function
O'Rahilly, S., Gray, H., Humphreys, P. J., Krook, A., Polonsky, K. S., White, A., Gibson, S., Taylor, K., & Carr, C. (1995) · New England Journal of Medicine · doi:10.1056/nejm199511233332104 · Cited by 237
Epigenome-wide study identifies novel methylation loci associated with body mass index and waist circumference
Aslibekyan, S. W., Demerath, E. W., Mendelson, M., Zhi, D., Guan, W., Liang, L., Sha, J., Pankow, J. S., Liu, C., Irvin, M. R., et al. (2015) · Obesity · doi:10.1002/oby.21111 · Cited by 214
Impact of polyunsaturated and saturated fat overfeeding on the DNA-methylation pattern in human adipose tissue: a randomized controlled trial1–3
Perfilyev, A., Dahlman, I. A., Gillberg, L., Rosqvist, F., Iggman, D., Volkov, P., Nilsson, E., Risérus, U., & Ling, C. (2017) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.143164 · Cited by 205
DNA methylation of loci within ABCG1 and PHOSPHO1 in blood DNA is associated with future type 2 diabetes risk
Dayeh, T., Tuomilehto, J., Almgren, P., Perfilyev, A., Jansson, P., de Mello, V. D., Pihlajamäki, J., Vaag, A. A., Groop, L., Nilsson, E., et al. (2016) · Epigenetics · doi:10.1080/15592294.2016.1178418 · Cited by 204
A systematic review of genetic syndromes with obesity
Kaur, Y., de Souza, R. J., Gibson, W. T., & Meyre, D. (2017) · Obesity Reviews · doi:10.1111/obr.12531 · Cited by 203
DNA Methylation of Lipid-Related Genes Affects Blood Lipid Levels
Pfeiffer, L., Wahl, S., Pilling, L. C., Reischl, E., Sandling, J. K., Kunze, S., Holdt, L. M., Kretschmer, A., Schramm, K., Adamski, J., et al. (2015) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.114.000804 · Cited by 197
CLOCK, PER2 and BMAL1 DNA Methylation: Association with Obesity and Metabolic Syndrome Characteristics and Monounsaturated Fat Intake
Milagro, F., Gómez-Abellán, P., Campión, J., Martinez, J., Ordovás, J. M., & Garaulet, M. (2012) · Chronobiology International · doi:10.3109/07420528.2012.719967 · Cited by 191
Blood lipids influence DNA methylation in circulating cells
Dekkers, K. F., van Iterson, M., Slieker, R. C., Moed, M. H., Bonder, M. J., van Galen, M., Mei, H., Zhernakova, D. V., van den Berg, L. H., Deelen, J., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1000-6 · Cited by 190
An Alu Element–Associated Hypermethylation Variant of the POMC Gene Is Associated with Childhood Obesity
Kühnen, P., Mischke, M., Wiegand, S., Sers, C., Horsthemke, B., Lau, S., Keil, T. O. P., Lee, Y., Grueters, A., & Krude, H. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002543 · Cited by 182
Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers
Voisin, S. A. C., Almén, M. S., Zheleznyakova, G. Y., Lundberg, L., Zarei, S., Castillo, S., Eriksson, F. E., Nilsson, E., Blüher, M., Böttcher, Y., et al. (2015) · Genome Medicine · doi:10.1186/s13073-015-0225-4 · Cited by 175
Self-citation
Rare variants in single-minded 1 (SIM1) are associated with severe obesity
Ramachandrappa, S., Raimondo, A., Cali, A. M. G., Keogh, J. M., Henning, E., Saeed, S., Thompson, A., Garg, S., Bochukova, E. G., Brage, S., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68016 · Cited by 172
FTO Genotype and 2-Year Change in Body Composition and Fat Distribution in Response to Weight-Loss Diets
Zhang, X., Qi, Q., Zhang, C., Smith, S. R., Hu, F. B., Sacks, F. M., Bray, G. A., & Qi, L. (2012) · Diabetes · doi:10.2337/db11-1799 · Cited by 170
Lifestyle Intervention in Obese Children With Variations in the Melanocortin 4 Receptor Gene
Reinehr, T., Hebebrand, J., Friedel, S., Toschke, A. M., Brumm, H., Biebermann, H., & Hinney, A. (2009) · Obesity · doi:10.1038/oby.2008.422 · Cited by 166
Distribution and heritability of BMI in Finnish adolescents aged 16 y and 17 y: A study of 4884 twins and 2509 singletons
Pietiläinen, K. H., Kaprio, J. A., Rissanen, A., Winter, T., Rimpelä, A., Viken, R. J., & Rose, R. J. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800767 · Cited by 166
Leptin and adiponectin DNA methylation levels in adipose tissues and blood cells are associated with BMI, waist girth and LDL-cholesterol levels in severely obese men and women
Houde, A.-A., Légaré, C., Biron, S., Lescelleur, O., Biertho, L. D., Marceau, S., Tchernof, A., Vohl, M., Hivert, M., & Bouchard, L. (2015) · BMC Medical Genetics · doi:10.1186/s12881-015-0174-1 · Cited by 152
Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi–like features
Bonnefond, A., Raimondo, A., Stutzmann, F., Ghoussaini, M., Ramachandrappa, S., Bersten, D. C., Durand, E., Vatin, V., Balkau, B., Lantieri, O., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci68035 · Cited by 152
Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity
Keller, M., Hopp, L., Liu, X., Wohland, T., Rohde, K., Cancello, R., Klös, M., Bacos, K., Kern, M., Eichelmann, F., et al. (2016) · Molecular Metabolism · doi:10.1016/j.molmet.2016.11.003 · Cited by 140
Self-citation
Epigenome-wide association study (EWAS) on lipids: the Rotterdam Study
Braun, K. V. E., Dhana, K., de Vries, P. S., Voortman, T., van Meurs, J. B. J., Uitterlinden, A. G., Albert Hofman, D., Hu, F. B., Franco, O. H., & Dehghan, A. (2017) · Clinical Epigenetics · doi:10.1186/s13148-016-0304-4 · Cited by 140
An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth
Drake, A. J., McPherson, R. C., Godfrey, K. M., Cooper, C. C., Lillycrop, K. A., Hanson, M. A., Meehan, R. R., Seckl, J. R., & Reynolds, R. M. (2012) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2012.04453.x · Cited by 137
Interindividual Variation in DNA Methylation at a Putative POMC Metastable Epiallele Is Associated with Obesity
Kühnen, P., Handke, D., Waterland, R. A., Hennig, B. J., Silver, M. J., Fulford, A. J., Domínguez-Salas, P., Moore, S. E., Prentice, A. M., Spranger, J., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.001 · Cited by 136
A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits
Volkov, P., Olsson, A. H., Gillberg, L., Jørgensen, S. W., Brøns, C., Eriksson, K., Groop, L., Jansson, P., Nilsson, E., Rönn, T., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157776 · Cited by 129
Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots
Ingerslev, L. R., Donkin, I., Fabre, O., Versteyhe, S., Mechta, M., Pattamaprapanont, P., Mortensen, B., Krarup, N. T., & Barrès, R. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0446-7 · Cited by 124
Association of weight regain with specific methylation levels in the NPY and POMC promoters in leukocytes of obese men: A translational study
Crujeiras, A. B., Campión, J., Díaz‐Lagares, Á., Milagro, F. I., Goyenechea, E., Abete, I., Casanueva, F. F., & Martínez, J. A. (2013) · Regulatory Peptides · doi:10.1016/j.regpep.2013.06.012 · Cited by 121
Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium
Ng, M. C. Y., Graff, M., Lu, Y., Justice, A. E., Mudgal, P., Liu, C., Young, K. L., Yanek, L. R., Feitosa, M. F., Wojczynski, M. K., et al. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006719 · Cited by 119
Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants
Allum, F., Shao, X., Guénard, F., Simon, M.-M., Busche, S., Caron, M., Lambourne, J. J., Lessard, J., Tandre, K., Hedman, Å. K., et al. (2015) · Nature Communications · doi:10.1038/ncomms8211 · Cited by 118
Inclusion of Gene-Gene and Gene-Environment Interactions Unlikely to Dramatically Improve Risk Prediction for Complex Diseases
Aschard, H., Chen, J., Cornelis, M. C., Chibnik, L. B., Karlson, E. W., & Kraft, P. L. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.04.017 · Cited by 111
Duration of breastfeeding and gender are associated with methylation of the LEPTIN gene in very young children
Obermann-Borst, S. A., Eilers, P. H. C., Tobi, E. W., de Jong, F. H., Slagboom, P. E., Heijmans, B. T., & Steegers‐Theunissen, R. P. M. (2013) · Pediatric Research · doi:10.1038/pr.2013.95 · Cited by 110
The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes
Dahlman, I. A., Sinha, I., Gao, H., Brodin, D., Thorell, A., Rydén, M., Andersson, D. P., Henriksson, J., Perfilyev, A., Ling, C., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.31 · Cited by 107
Molecular Basis of Obesity: Current Status and Future Prospects
Choquet, H., & Meyre, D. (2011) · Current Genomics · doi:10.2174/138920211795677921 · Cited by 106
Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance
Johansson, L. E., Danielsson, A. P., Parikh, H. M., Klintenberg, M., Norström, F., Groop, L., & Ridderstråle, M. (2012) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.020578 · Cited by 103
Gene-environment interactions and obesity: recent developments and future directions
Huang, T., & Hu, F. B. (2015) · BMC Medical Genomics · doi:10.1186/1755-8794-8-s1-s2 · Cited by 98
DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework
Richmond, R. C., Sharp, G. C., Ward, M. E., Fraser, A., Lyttleton, O., McArdle, W. L., Ring, S. M., Gaunt, T. R., Lawlor, D. A., Smith, G. D., et al. (2016) · Diabetes · doi:10.2337/db15-0996 · Cited by 97
Lifestyle Interaction With Fat Mass and Obesity-Associated (FTO) Genotype and Risk of Obesity in Apparently Healthy U.S. Women
Ahmad, T., Lee, I.-M. M., Paré, G., Chasman, D. I., Rose, L. M., Ridker, P. M., & Mora, S. (2011) · Diabetes Care · doi:10.2337/dc10-0948 · Cited by 93
TNF-alpha promoter methylation in peripheral white blood cells: Relationship with circulating TNFα, truncal fat and n-6 PUFA intake in young women
Hermsdorff, H. H. M., Mansego, M. L., Campión, J., Milagro, F. I., Zulet, M. Á., & Martínez, J. A. (2013) · Cytokine · doi:10.1016/j.cyto.2013.05.028 · Cited by 91
Promoter methylation of serotonin transporter gene is associated with obesity measures: a monozygotic twin study
Zhao, J., Goldberg, J. H., & Vaccarino, V. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.8 · Cited by 88
Effect of Bariatric Surgery-Induced Weight Loss on SR-BI-, ABCG1-, and ABCA1-Mediated Cellular Cholesterol Efflux in Obese Women
Aron‐Wisnewsky, J., Julia, Z., Poitou, C., Bouillot, J., Basdevant, A., Chapman, M. J., Clément, K., & Guérin, M. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-2378 · Cited by 87
DNA methylation of the IGF2/H19 imprinting control region and adiposity distribution in young adults
Huang, R., Galati, J. C., Burrows, S., Beilin, L. J., Li, X., Pennell, C. E., van Eekelen, J., Mori, T. A., Adams, L. A., & Craig, J. M. (2012) · Clinical Epigenetics · doi:10.1186/1868-7083-4-21 · Cited by 86
Human Genetics of Obesity and Type 2 Diabetes Mellitus
Ingelsson, E., & McCarthy, M. I. (2018) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.118.002090 · Cited by 86
A genetic analysis of weight and overweight in 4-year-old twin pairs
Koeppen-Schomerus, G., Wardle, J., & Plomin, R. J. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801589 · Cited by 84
The role of obesity in oesophageal cancer development
Long, E., & Beales, I. (2014) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x14538689 · Cited by 81
Genetic risk factors for BMI and obesity in an ethnically diverse population: Results from the population architecture using genomics and epidemiology (PAGE) study
Fesinmeyer, M. D., North, K. E., Ritchie, M. D., Lim, U., Franceschini, N., Wilkens, L. R., Gross, M. D., Bůžková, P., Glenn, K., Quibrera, P. M., et al. (2013) · Obesity · doi:10.1002/oby.20268 · Cited by 80
HIF3A DNA Methylation Is Associated with Childhood Obesity and ALT
Wang, S., Song, J., Yang, Y., Zhang, Y., Wang, H., & Ma, J. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145944 · Cited by 76
Acetylsalicylic acid, aging and coronary artery disease are associated with ABCA1 DNA methylation in men
Guay, S., Légaré, C., Houde, A., Mathieu, P., Bossé, Y., & Bouchard, L. (2014) · Clinical Epigenetics · doi:10.1186/1868-7083-6-14 · Cited by 75
The Mystique of Epigenetics
Lewin, B. (1998) · Cell · doi:10.1016/s0092-8674(00)81154-x · Cited by 74
Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass
Kirchner, H., Nylén, C., Laber, S., Barrès, R., Yan, J., Krook, A., Zierath, J. R., & Näslund, E. B. (2014) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2013.12.019 · Cited by 72
Hypoxia-inducible factor 3A gene expression and methylation in adipose tissue is related to adipose tissue dysfunction
Pfeiffer, S., Krüger, J., Maierhofer, A., Böttcher, Y., Klöting, N., Hajj, N. E., Schleinitz, D., Schön, M. R., Dietrich, A., Faßhauer, M., et al. (2016) · Scientific Reports · doi:10.1038/srep27969 · Cited by 72
Self-citation
Exercise training alters the genomic response to acute exercise in human adipose tissue
Fabre, O., Ingerslev, L., Garde, C., Donkin, I., Simar, D., & Barrès, R. (2018) · Epigenomics · doi:10.2217/epi-2018-0039 · Cited by 71
Common Variants in FTO, MC4R, TMEM18, PRL, AIF1, and PCSK1 Show Evidence of Association With Adult Obesity in the Greek Population
Rouskas, K., Kouvatsi, A., Paletas, K., Papazoglou, D., Τσάπας, Α., Lobbens, S., Vatin, V., Durand, E., Labrune, Y., Delplanque, J., et al. (2011) · Obesity · doi:10.1038/oby.2011.177 · Cited by 68
Nutritional State Affects the Expression of the Obesity‐Associated Genes Etv5, Faim2, Fto, and Negr1
Boender, A. J., van Rozen, A. J., & Adan, R. A. H. (2012) · Obesity · doi:10.1038/oby.2012.128 · Cited by 67
The epigenetic signature of subcutaneous fat cells is linked to altered expression of genes implicated in lipid metabolism in obese women
Arner, P., Sinha, I., Thorell, A., Rydén, M., Dahlman‐Wright, K., & Dahlman, I. A. (2015) · Clinical Epigenetics · doi:10.1186/s13148-015-0126-9 · Cited by 62
Common Genetic Variation near MC4R Has a Sex-Specific Impact on Human Brain Structure and Eating Behavior
Horstmann, A., Kovacs, P. L., Kabisch, S., Boettcher, Y., Schloegl, H., Tönjes, A., Stümvoll, M., Pleger, B., & Villringer, A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074362 · Cited by 62
Self-citation
36 h fasting of young men influences adipose tissue DNA methylation of LEP and ADIPOQ in a birth weight-dependent manner
Hjort, L., Jørgensen, S. W., Gillberg, L., Hall, E., Brøns, C., Frystyk, J., Vaag, A. A., & Ling, C. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0340-8 · Cited by 61
Skeletal Muscle PGC1α −1 Nucleosome Position and −260 nt DNA Methylation Determine Exercise Response and Prevent Ectopic Lipid Accumulation in Men
Bajpeyi, S., Covington, J. D., Taylor, E. M., Stewart, L. K., Galgani, J. E., & Henagan, T. M. (2017) · Endocrinology · doi:10.1210/en.2017-00051 · Cited by 60
Translational approaches: from fatty liver to non-alcoholic steatohepatitis.
Rosso, N., Chávez-Tapia, N. C., Tiribelli, C., & Bellentani, S. (2014) · PubMed Central · doi:10.3748/wjg.v20.i27.9038 · Cited by 57
Allele-Specific, Age-Dependent and BMI-Associated DNA Methylation of Human MCHR1
Stepanow, S., Reichwald, K., Huse, K., Gausmann, U., Nebel, A., Rosenstiel, P., Wabitsch, M., Fischer-Posovszky, P., & Platzer, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017711 · Cited by 57
Twins and the mystery of missing heritability: the contribution of gene–environment interactions
Kaprio, J. A. (2012) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2012.02587.x · Cited by 56
Sim2 Mutants Have Developmental Defects Not Overlapping with Those of Sim1 Mutants
Goshu, E., Jin, H., Fasnacht, R., Sepenski, M., Michaud, J. L., & Fan, C. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.12.4147-4157.2002 · Cited by 55
Familial Risk of Overweight and Obesity in the Canadian Population using the WHO/NIH Criteria
Katzmarzyk, P. T., Përusse, L., Rao, D. C., & Bouchard, C. (2000) · Obesity Research · doi:10.1038/oby.2000.21 · Cited by 55
Blood triglyceride levels are associated with DNA methylation at the serine metabolism gene PHGDH
Trương, V., Huang, S., Dennis, J. K., Lemire, M., Zwingerman, N., Aïssi, D., Kassam, I., Perret, C., Wells, P., Morange, P., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-09552-z · Cited by 55
Differential methylation in inflammation and type 2 diabetes genes in siblings born before and after maternal bariatric surgery
Berglind, D., Müller, P., Willmer, M., Sinha, I., Tynelius, P., Näslund, E. B., Dahlman‐Wright, K., & Rasmussen, F. E. (2015) · Obesity · doi:10.1002/oby.21340 · Cited by 54
Genetics of Obesity in Consanguineous Populations: Toward Precision Medicine and the Discovery of Novel Obesity Genes
Saeed, S., Arslan, M., & Froguel, P. (2018) · Obesity · doi:10.1002/oby.22064 · Cited by 54
DNA Methylation of the LY86 Gene is Associated With Obesity, Insulin Resistance, and Inflammation
Su, S., Zhu, H., Xu, X., Wang, X., Dong, Y., Kapuku, G. K., Treiber, F. A., Gutin, B., Harshfield, G., Snieder, H., et al. (2014) · Twin Research and Human Genetics · doi:10.1017/thg.2014.22 · Cited by 51
Activity-Based Anorexia Alters the Expression of BDNF Transcripts in the Mesocorticolimbic Reward Circuit
Ho, E. V., Klenotich, S. J., McMurray, M. S., & Dulawa, S. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0166756 · Cited by 51
Cardiometabolic risk markers, adipocyte fatty acid binding protein (aFABP) and the impact of high-intensity interval training (HIIT) in obese adolescents.
Blüher, S., Käpplinger, J., Herget, S., Reichardt, S., Böttcher, Y., Grimm, A., Kratzsch, J., & Petroff, D. (2017) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2016.11.015 · Cited by 51
Self-citation
Circadian gene methylation profiles are associated with obesity, metabolic disturbances and carbohydrate intake
Ramos-López, O., Samblas, M., Milagro, F. I., Riezu‐Boj, J. I., Crujeiras, A. B., Martínez, J. A., & MENA Project (2018) · Chronobiology International · doi:10.1080/07420528.2018.1446021 · Cited by 51
DNA methylation of candidate genes in peripheral blood from patients with type 2 diabetes or the metabolic syndrome
van Otterdijk, S. D., Binder, A. M., Szic, K. S. V., Schwald, J., & Michels, K. B. (2017) · PLoS ONE · doi:10.1371/journal.pone.0180955 · Cited by 48
Genome-wide DNA methylation analysis reveals loci that distinguish different types of adipose tissue in obese individuals
Macartney-Coxson, D. P., Benton, M. C., Blick, R. A. J., Stubbs, R. S., Hagan, R. D., & Langston, M. A. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0344-4 · Cited by 47
Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis
Keller, M., Kralisch, S., Rohde, K., Schleinitz, D., Dietrich, A., Schön, M., Gärtner, D., Lohmann, T., Dressler, M., Tönjes, A., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3356-z · Cited by 46
Self-citation
Evaluation of weight loss and adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variant
de Luis, D. A., Aller, R., Izaola, O., de la Fuente, B., Conde, R., Sagrado, M. G., & Primo, D. (2012) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2323 · Cited by 45
Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances
Guénard, F., Tchernof, A., Deshaies, Y., Përusse, L., Biron, S., Lescelleur, O., Biertho, L. D., Marceau, S., & Vohl, M. (2014) · Physiological Genomics · doi:10.1152/physiolgenomics.00160.2013 · Cited by 45
Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism
Lund, J., Rustan, A. C., Løvsletten, N. G., Mudry, J. M., Langleite, T. M., Feng, Y., Stensrud, C., Brubak, M. G., Drevon, C. A., Birkeland, K. I., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0175441 · Cited by 44
PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome‐wide methylation analysis
Samblas, M., Milagro, F. I., Mansego, M. L., Martí, A., Martínez, J. A., & members, G. (2017) · Pediatric Obesity · doi:10.1111/ijpo.12224 · Cited by 43
DNA methylation and gene expression of HIF3A: cross-tissue validation and associations with BMI and insulin resistance
Main, A. M., Gillberg, L., Jacobsen, A. L., Nilsson, E., Gjesing, A. P., Hansen, T. F., Pedersen, O. B., Ribel‐Madsen, R., & Vaag, A. A. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0258-6 · Cited by 42
Genomics, Personalized Medicine, and Pediatrics
Feero, W. G., & Guttmacher, A. E. (2013) · Academic Pediatrics · doi:10.1016/j.acap.2013.06.008 · Cited by 41
Contribution of Common PCSK1 Genetic Variants to Obesity in 8,359 Subjects from Multi-Ethnic American Population
Choquet, H., Kasberger, J., Hamidovic, A., & Jorgenson, E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057857 · Cited by 37
Higher chylomicron remnants and LDL particle numbers associate with CD36 SNPs and DNA methylation sites that reduce CD36
Love-Gregory, L. D., Kraja, A. T., Allum, F., Aslibekyan, S. W., Hedman, Å. K., Duan, Y., Borecki, I. B., Arnett, D. K., McCarthy, M. I., Deloukas, P., et al. (2016) · Journal of Lipid Research · doi:10.1194/jlr.p065250 · Cited by 37
Weight loss in obese children carrying the proopiomelanocortin R236G variant
Santoro, N., Perrone, L., Cirillo, G., Raimondo, P., Amato, A., Coppola, F., Santarpia, M., D’Aniello, A., & del Giudice, E. M. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03345544 · Cited by 35
Longitudinal genome-wide methylation study of Roux-en-Y gastric bypass patients reveals novel CpG sites associated with essential hypertension
Boström, A. E. D., Mwinyi, J., Voisin, S. A. C., Wu, W., Schultes, B., Zhang, K., & Schiöth, H. B. (2016) · BMC Medical Genomics · doi:10.1186/s12920-016-0180-y · Cited by 34
IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits
Rohde, K., Klös, M., Hopp, L., Liu, X., Keller, M., Stümvoll, M., Dietrich, A., Schön, M. R., Gärtner, D., Lohmann, T., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12393-5 · Cited by 33
Self-citation
Serotonin transporter gene promoter methylation status correlates with in vivo prefrontal 5-HTT availability and reward function in human obesity
Drabe, M., Rullmann, M., Luthardt, J., Boettcher, Y., Regenthal, R., Ploetz, T., Becker, G. A., Patt, M., Schinke, C., Bergh, F. T., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.133 · Cited by 32
Effect of a diet containing folate and hazelnut oil capsule on the methylation level of the ADRB3 gene, lipid profile and oxidative stress in overweight or obese women
Lima, R. P. A., do Nascimento, R. A. F., Luna, R. C. P., Persuhn, D. C., Silva, A. S., Gonçalves, M. D. C. R., de Almeida, A. T. C., de Moraes, R. M., Verly, E., Meugnier, E., et al. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0407-6 · Cited by 31
DNA methylation and gene expression of TXNIP in adult offspring of women with diabetes in pregnancy
Houshmand‐Oeregaard, A. S., Hjort, L., Kelstrup, L., Hansen, N. S., Broholm, C., Gillberg, L., Clausen, T. D., Mathiesen, E. R., Damm, P., & Vaag, A. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187038 · Cited by 29
Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery
Day, S. E., Garcia, L. A., Coletta, R. L., Campbell, L. E., Benjamin, T. R., Filippis, E. A. D., Madura, J. A., Mandarino, L. J., Roust, L. R., & Coletta, D. K. (2017) · Clinical Epigenetics · doi:10.1186/s13148-017-0396-5 · Cited by 28
Regional distribution of body fat in relation to DNA methylation within the LPL, ADIPOQ and PPARγ promoters in subcutaneous adipose tissue
Drogan, D., Boeing, H., Janke, J., Schmitt, B. A., Zhou, Y., Walter, J., Pischon, T., & Tierling, S. (2015) · Nutrition and Diabetes · doi:10.1038/nutd.2015.19 · Cited by 24
Adipose tissue depot specific promoter methylation of TMEM18
Rohde, K., Keller, M., Klös, M., Schleinitz, D., Dietrich, A., Schön, M. R., Gärtner, D., Lohmann, T., Dreßler, M., Stümvoll, M., et al. (2014) · Journal of Molecular Medicine · doi:10.1007/s00109-014-1154-1 · Cited by 23
Self-citation
Changes in SCD gene DNA methylation after bariatric surgery in morbidly obese patients are associated with free fatty acids
Morcillo, S., Martín‐Núñez, G. M., García‐Serrano, S., Gutiérrez‐Repiso, C., Rodríguez‐Pacheco, F., Valdés, S., Gonzalo, M., Rojo‐Martínez, G., Moreno‐Ruiz, F. J., Rodríguez‐Cañete, A., et al. (2017) · Scientific Reports · doi:10.1038/srep46292 · Cited by 19
Network analysis identifies common genes associated with obesity in six obesity-related diseases
Su, L., Wang, Y.-B., Wnag, C.-G., & Wei, H. (2017) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1600454 · Cited by 18
Genetic regulation of differentially methylated genes in visceral adipose tissue of severely obese men discordant for the metabolic syndrome
Guénard, F., Tchernof, A., Deshaies, Y., Biron, S., Lescelleur, O., Biertho, L., Marceau, S., Pérusse, L., & Vohl, M. (2017) · Translational research : the journal of laboratory and clinical medicine · doi:10.1016/j.trsl.2017.01.002 · Cited by 16
Is Genetic Testing of Value in Predicting and Treating Obesity?
Ng, M. C. Y., & Bowden, D. W. (2013) · North Carolina Medical Journal · doi:10.18043/ncm.74.6.530 · Cited by 16
Methylation quantitative trait loci within the TOMM20 gene are associated with metabolic syndrome-related lipid alterations in severely obese subjects
de Toro‐Martín, J., Guénard, F., Tchernof, A., Deshaies, Y., Përusse, L., Hould, F., Lebel, S., Marceau, P., & Vohl, M. (2016) · Diabetology & Metabolic Syndrome · doi:10.1186/s13098-016-0171-3 · Cited by 13
DNA methylation of SSPN is linked to adipose tissue distribution and glucose metabolism
Keller, M., Klös, M., Rohde, K., Krüger, J., Kurze, T., Dietrich, A., Schön, M. R., Gärtner, D., Lohmann, T., Dreßler, M., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800528r · Cited by 12
Self-citation

Sorted by citations

Obesity: global epidemiology and pathogenesis
Blüher, M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-019-0176-8 · Cited by 5,126
Self-citation
Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Wu, Y., Lin, Z., Li, C., Lin, X. J., Shan, S., Guo, B., Zheng, M.-H., Li, F., Yuan, L., & Li, Z. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01333-7 · Cited by 549
Advantages and Limitations of the Body Mass Index (BMI) to Assess Adult Obesity
Wu, Y., Li, D., & Vermund, S. H. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21060757 · Cited by 332
“However, the genetics of obesity are not sufﬁcient to account for the variability of BMI [20,21].”
Background
Weight bias among health care professionals: A systematic review and meta‐analysis
Lawrence, B. J., Kerr, D., Pollard, C. M., Theophilus, M., Alexander, E., Haywood, D., & O’Connor, M. (2021) · Obesity · doi:10.1002/oby.23266 · Cited by 283
Arcuate Nucleus-Dependent Regulation of Metabolism—Pathways to Obesity and Diabetes Mellitus
Jaïs, A., & Brüning, J. C. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab025 · Cited by 298

See all 355

Authors: Rohde, K., Keller, M., la Cour Poulsen, L., Blüher, M., Kovacs, P., & Böttcher, Y.
Affiliations: University of Oslo (NO)
IFB Adiposity Diseases (DE)
Leipzig University (DE)
Corresponding author: Rohde, Kerstin
Keller, Maria
Blüher, Matthias
Kovacs, Peter
Böttcher, Yvonne
ORCID: Rohde, Kerstin
Keller, Maria
Blüher, Matthias
Kovacs, Peter
Böttcher, Yvonne
Venue: Metabolism
Publisher: Elsevier BV
Published: 2019-03
Volume: 92
Pages: 37-50
ISSN: 0026-0495 (ISSN-L)
DOI: 10.1016/j.metabol.2018.10.007
OpenAlex: W2898859410
Cited by: 355
References: 154
Citations by year: 2026: 13 · 2025: 43 · 2024: 38 · 2023: 52 · 2022: 61 · 2021: 82 · 2020: 45 · 2019: 21
FWCI: 5.21
Type: journal article
Language: en
Open access: green
hdl.handle.net
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Metabolism (publishedVersion)
PubMed (publishedVersion)
NORA - Norwegian Open Research Archives (submittedVersion, cc-by-nc-nd)
Funders: BMBF (FKZ: 01EO1501)
European Union Seventh Framework Programme (FP7-PEOPLE-2013-COFUND)
Helse Sør-Øst
Deutsche Forschungsgemeinschaft
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Keywords: obesity, monogenic obesity, epigenetics, genetic susceptibility, leptin, hypothalamic circuits, energy homeostasis, appetite and satiety, genetic risk variants, dietary habits, physical activity, gene-environment interaction
MeSH terms: Humans, Obesity, Genetic Predisposition to Disease, Epigenesis, Genetic, Precision Medicine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Genetics and epigenetics in obesity

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks