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Colonic bacterial metabolites and human health
Abstract
The influence of the microbial-mammalian metabolic axis is becoming increasingly important for human health. Bacterial fermentation of carbohydrates (CHOs) and proteins produces short-chain fatty acids (SCFA) and a range of other metabolites including those from aromatic amino acid (AAA) fermentation. SCFA influence host health as energy sources and via multiple signalling mechanisms. Bacterial transformation of fibre-related phytochemicals is associated with a reduced incidence of several chronic diseases. The 'gut-liver axis' is an emerging area of study. Microbial deconjugation of xenobiotics and release of aromatic moieties into the colon can have a wide range of physiological consequences. In addition, the role of the gut microbiota in choline deficiency in non-alcoholic fatty liver disease (NAFLD) and insulin resistance is receiving increased attention.
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Metadata
- Authors
- Russell, W. R., Hoyles, L., Flint, H. J., & Dumas, M.-E.
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 16
- Issue
- 3
- Pages
- 246-254
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2076500913
- Cited by
- 350
- References
- 15
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
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