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Fractional anisotropy of water diffusion in cerebral white matter across the lifespan

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Kochunov, P., Williamson, D.E., Lancaster, J., Fox, P., Cornell, J., Blangero, J., Glahn, D.C.·2012·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2010.01.014
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Abstract

Determining the time of peak of cerebral maturation is vital for our understanding of when cerebral maturation ceases and the cerebral degeneration in healthy aging begins. We carefully mapped changes in fractional anisotropy (FA) of water diffusion for eleven major cerebral white matter tracts in a large group (831) of healthy human subjects aged 11–90. FA is a neuroimaging index of micro-structural white matter integrity, sensitive to age-related changes in cerebral myelin levels, measured using diffusion tensor imaging. The average FA values of cerebral white matter (WM) reached peak at the age 32±6 years. FA measurements for all but one major cortical white matter tract (cortico-spinal) reached peaks between 23 and 39 years of age. The maturation rates, prior to age-of-peak were significantly correlated (r=0.74; p=.01) with the rates of decline, past age-of-peak. Regional analysis of corpus callosum (CC) showed that thinly-myelinated, densely packed fibers in the genu, that connect pre-frontal areas, maturated later and showed higher decline in aging than the more thickly myelinated motor and sensory areas in the body and splenium of CC. Our findings can be summarized as: associative, cerebral WM tracts that reach their peak FA values later in life also show progressively higher age-related decline than earlier maturing motor and sensory tracts. These findings carry multiple and diverse implications for both theoretical studies of the neurobiology of maturation and aging and for the clinical studies of neuropsychiatric disorders.

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Cited by

Metadata

Authors
Kochunov, P., Williamson, D. E., Lancaster, J., Fox, P., Cornell, J., Blangero, J., & Glahn, D. C.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2012-01
Volume
33
Issue
1
Pages
9-20
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2010.01.014
OpenAlex
W2031157309
Cited by
365
References
13
FWCI
13.50
Type
journal article
Language
en
Open access
green
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
  • National Institute of Biomedical Imaging and Bioengineering (K01 EB006395)
  • the National Institute on Alcohol Abuse and Alcoholism (R01AA016274)
  • the National Institute of Mental Health (MH078111, MH0708143 and MH083824)
  • NIMH and NIDA (P20 MH/DA52176)
  • General Clinical Research Core (HSC19940074H)

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