Disrupted Sleep: From Molecules to Cognition
Open accessAbstract
Although the functions of sleep remain to be fully elucidated, it is clear that there are far-reaching effects of its disruption, whether by curtailment for a single night, by a few hours each night over a long period, or by disruption in sleep continuity. Epidemiological and experimental studies of these different forms of sleep disruption show deranged physiology from subcellular levels to complex affective behavior. In keeping with the multifaceted influence of sleep on health and well-being, we illustrate how the duration of sleep, its timing, and continuity can affect cellular ultrastructure, gene expression, metabolic and hormone regulation, mood, and vigilance. Recent brain imaging studies provide some clues on mechanisms underlying the most common cause of disrupted sleep (insomnia). These insights should ultimately result in adequate interventions to prevent and treat sleep disruption because of their high relevance to our most prevalent health problems. SIGNIFICANCE STATEMENT Disruption of the duration, timing, and continuity of sleep affects cellular ultrastructure, gene expression, appetite regulation, hormone production, vigilance, and reward functions.
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Altered stressor responses affecting sleep quality may be a critical mediator of emotion regulation, stress resilience, and tolerance for shift work.
“In fact, the impact of altered stressor responses on the quality of sleep may be a critical mediator of emotion regulation [97], resilience to stress [98], and ultimately tolerance for shift work [1].”
From Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being (2017) · cites this paper as [97]
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- Authors
- Van Someren, E. J. W., Cirelli, C., Dijk, D.-J., Van Cauter, E., Schwartz, S., & Chee, M. W. L.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Surrey (GB)
- University of Geneva (CH)
- National University of Singapore (SG)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-10-14
- Volume
- 35
- Issue
- 41
- Pages
- 13889-13895
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4604227
- OpenAlex
- W2172778146
- Cited by
- 127
- References
- 84
- Citations by year
- 2026: 3 · 2025: 13 · 2024: 9 · 2023: 13 · 2022: 6 · 2021: 13 · 2020: 11 · 2019: 11 · 2018: 17 · 2017: 21 · 2016: 9 · 2015: 1
- FWCI
- 9.62
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion, other-oa)
- VU Research Portal (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Open Research (University of Surrey) (submittedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- National Science Foundation (51NF40-104897)
- Royal Society
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (104897, 51NF40, 135653, 320030)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (453.07.001, VICI-453.07.001)
- National Institutes of Health (5p01ns083514-05, PO1 AG 11412)
- Directorate for Biological Sciences
- Medical Research Council
- Biotechnology and Biological Sciences Research Council (BB/F022883)
- National Medical Research Council
- National Institute on Aging (P01-AG11412., P01AG011412)
- National Institute of Mental Health (R01MH099231)
- National Institute of Neurological Disorders and Stroke (P01 NS-083514)
- National Institute for Occupational Safety and Health (R01-OH009482)
- H2020 European Research Council (671084)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- sleep disruption, insomnia, sleep duration, sleep timing, sleep continuity, cell ultrastructure, gene expression, metabolic regulation, hormonal regulation, appetite regulation, mood, sustained attention, reward, sleep deprivation
- MeSH terms
- Affect, Brain, Cognition Disorders, Humans, Sleep Wake Disorders
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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