Cited by 116Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

The impact of in-scanner head motion on structural connectivity derived from diffusion MRI

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Baum, Graham L., Roalf, David R., Cook, Philip A., Ciric, Rastko, Rosen, Adon F.G., Xia, Cedric, Elliott, Mark A., Ruparel, Kosha +6 more·2018·NeuroImage

Abstract

Multiple studies have shown that data quality is a critical confound in the construction of brain networks derived from functional MRI. This problem is particularly relevant for studies of human brain development where important variables (such as participant age) are correlated with data quality. Nevertheless, the impact of head motion on estimates of structural connectivity derived from diffusion tractography methods remains poorly characterized. Here, we evaluated the impact of in-scanner head motion on structural connectivity using a sample of 949 participants (ages 8-23 years old) who passed a rigorous quality assessment protocol for diffusion magnetic resonance imaging (dMRI) acquired as part of the Philadelphia Neurodevelopmental Cohort. Structural brain networks were constructed for each participant using both deterministic and probabilistic tractography. We hypothesized that subtle variation in head motion would systematically bias estimates of structural connectivity and confound developmental inference, as observed in previous studies of functional connectivity. Even following quality assurance and retrospective correction for head motion, eddy currents, and field distortions, in-scanner head motion significantly impacted the strength of structural connectivity in a consistency- and length-dependent manner. Specifically, increased head motion was associated with reduced estimates of structural connectivity for network edges with high inter-subject consistency, which included both short- and long-range connections. In contrast, motion inflated estimates of structural connectivity for low-consistency network edges that were primarily shorter-range. Finally, we demonstrate that age-related differences in head motion can both inflate and obscure developmental inferences on structural connectivity. Taken together, these data delineate the systematic impact of head motion on structural connectivity, and provide a critical context for identifying motion-related confounds in studies of structural brain network development.

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Crossref · 10.1016/j.neuroimage.2018.02.041

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  1. Fischl B 2012 FreeSurfer Neuroimage 62 774 781 22248573 PMC3685476
  2. Jenkinson M Beckmann CF Behrens TE Woolrich MW Smith SM 2012 Fsl Neuroimage 62 782 790 21979382

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Authors
Baum, G. L., Roalf, D. R., Cook, P. A., Ciric, R., Rosen, A. F. G., Xia, C., Elliott, M. A., Ruparel, K., Verma, R., Tunç, B., Gur, R. C., Gur, R. E., Bassett, D. S., & Satterthwaite, T. D.
Affiliations
University of Pennsylvania (US)
Corresponding author
Satterthwaite, Theodore D.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2018-06
Volume
173
Pages
275-286
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2790978796
Cited by
116
References
113
Citations by year
2026: 6 · 2025: 11 · 2024: 17 · 2023: 15 · 2022: 15 · 2021: 15 · 2020: 13 · 2019: 15 · 2018: 9
FWCI
8.98
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (acceptedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Army Research Office (W911NF-14-1-0679, W911NF-16-1-0474)
  • National Institutes of Health (2-R01-DC-009209-11, R01MH109520, 1R01HD086888-01, 1R01NS099348)
  • Army Research Laboratory (W911NF-10-2-0022)
  • National Institute of Mental Health (K01MH102609, MH089924, P50MH096891, MH089983, R01NS085211, R01MH107235, R01-MH107703, R21-M MH-106799, R01MH112847)
  • Alfred P. Sloan Foundation
  • John D. and Catherine T. MacArthur Foundation
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
structural connectivity, diffusion MRI, deterministic tractography, probabilistic tractography, brain network development, age differences, Philadelphia Neurodevelopmental Cohort, motion correction
MeSH terms
Adolescent, Brain, Child, Female, Head, Humans, Image Interpretation, Computer-Assisted, Male, Motion, Neural Pathways, Artifacts, Diffusion Magnetic Resonance Imaging, Young Adult, Neuroimaging

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