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Postsynaptic Positioning of Endocytic Zones and AMPA Receptor Cycling by Physical Coupling of Dynamin-3 to Homer
Open accessAbstract
Endocytosis of AMPA receptors and other postsynaptic cargo occurs at endocytic zones (EZs), stably positioned sites of clathrin adjacent to the postsynaptic density (PSD). The tight localization of postsynaptic endocytosis is thought to control spine composition and regulate synaptic transmission. However, the mechanisms that situate the EZ near the PSD and the role of spine endocytosis in synaptic transmission are unknown. Here, we report that a physical link between dynamin-3 and the postsynaptic adaptor Homer positions the EZ near the PSD. Disruption of dynamin-3 or its interaction with Homer uncouples the PSD from the EZ, resulting in synapses lacking postsynaptic clathrin. Loss of the EZ leads to a loss of synaptic AMPA receptors and reduced excitatory synaptic transmission that corresponds with impaired synaptic recycling. Thus, a physical link between the PSD and the EZ ensures localized endocytosis and recycling by recapturing and maintaining a proximate pool of cycling AMPA receptors.
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“DNM3 participates in the morphogenesis of the postsynaptic density and excitatory synaptic transmission24”
From Locus for severity implicates CNS resilience in progression of multiple sclerosis (2023) · cites this paper as [24]
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Cites
The dynamin superfamily: universal membrane tubulation and fission molecules?
Praefcke, G. J. K., & McMahon, H. T. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1313 · Cited by 1,370
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
Reinsertion or Degradation of AMPA Receptors Determined by Activity-Dependent Endocytic Sorting
Ehlers, M. D. (2000) · Neuron · doi:10.1016/s0896-6273(00)00129-x · Cited by 1,096
Self-citationCoupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
Tu, J. C., Xiao, B., Naisbitt, S. R., Yuan, J. P., Petralia, R. S., Brakeman, P., Doan, A., Aakalu, V. K., Lanahan, A. A., Sheng, M., et al. (1999) · Neuron · doi:10.1016/s0896-6273(00)80810-7 · Cited by 1,079
Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009
Self-citationThe Postsynaptic Architecture of Excitatory Synapses: A More Quantitative View
Sheng, M., & Hoogenraad, C. C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.060805.160029 · Cited by 1,003
Tu, J. C., Xiao, B., Yuan, J. P., Lanahan, A. A., Leoffert, K., Li, M., Linden, D. J., & Worley, P. F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80589-9 · Cited by 862
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779
Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730
Self-citationRegulation of Dendritic Spine Morphology and Synaptic Function by Shank and Homer
Sala, C., Piëch, V., Wilson, N. R., Passafaro, M., Liu, G., & Sheng, M. (2001) · Neuron · doi:10.1016/s0896-6273(01)00339-7 · Cited by 716
Regulatory mechanisms of AMPA receptors in synaptic plasticity
Derkach, V. A., Oh, M. C., Guire, E. S., & Soderling, T. R. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2055 · Cited by 708
Harnessing actin dynamics for clathrin-mediated endocytosis
Kaksonen, M., Toret, C. P., & Drubin, D. G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1940 · Cited by 706
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692
Activity-Dependent Modulation of Synaptic AMPA Receptor Accumulation
O’Brien, R. J., Kamboj, S., Ehlers, M. D., Rosen, K. R., Fischbach, G. D., & Huganir, R. L. (1998) · Neuron · doi:10.1016/s0896-6273(00)80624-8 · Cited by 688
Self-citationA Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis
Ferguson, S. M., Brasnjo, G., Hayashi, M., Wölfel, M., Collesi, C., Giovedì, S., Raimondi, A., Gong, L., Ariel, P., Paradise, S., et al. (2007) · Science · doi:10.1126/science.1140621 · Cited by 516
Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
Park, M., Salgado, J. M., Ostroff, L., Helton, T. D., Robinson, C. G., Harris, K. M., & Ehlers, M. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.040 · Cited by 493
Self-citationSpatial control of coated-pit dynamics in living cells
Gaidarov, I., Santini, F., Warren, R. A., & Keen, J. H. (1999) · Nature Cell Biology · doi:10.1038/8971 · Cited by 427
Dynamin-dependent endocytosis of ionotropic glutamate receptors
Carroll, R. C., Beattie, E. C., Xia, H., Lüscher, C., Altschuler, Y., Nicoll, R. A., Malenka, R. C., & von Zastrow, M. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.24.14112 · Cited by 423
Differential Distribution of Dynamin Isoforms in Mammalian Cells
Cao, H., Garcı́a, F., & McNiven, M. A. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.9.2595 · Cited by 409
Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines
Blanpied, T. A., Scott, D. B., & Ehlers, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00979-0 · Cited by 392
Self-citationDirect imaging of lateral movements of AMPA receptors inside synapses
Tardin, C., Cognet, L., Bats, C., Lounis, B., & Choquet, D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg463 · Cited by 384
ORGANELLES AND TRAFFICKING MACHINERY FOR POSTSYNAPTIC PLASTICITY
Kennedy, M. J., & Ehlers, M. D. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112808 · Cited by 346
Self-citationRole of Phosphorylation in Regulation of the Assembly of Endocytic Coat Complexes
Slepnev, V. I., Ochoa, G.-C., Butler, M. H., Grabs, D., & Camilli, P. V. D. (1998) · Science · doi:10.1126/science.281.5378.821 · Cited by 311
Ashby, M. C., Maier, S. R., Nishimune, A., & Henley, J. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1235-06.2006 · Cited by 302
Laminar Organization of the NMDA Receptor Complex within the Postsynaptic Density
Valtschanoff, J. G., & Weinberg, R. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-04-01211.2001 · Cited by 301
Self-citationDiffusional trapping of GluR1 AMPA receptors by input-specific synaptic activity
Ehlers, M. D., Heine, M., Groc, L., Lee, M.-C., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.04.010 · Cited by 300
Self-citationAn Architectural Framework That May Lie at the Core of the Postsynaptic Density
Baron, M. K., Boeckers, T. M., Vaida, B., Faham, S., Gingery, M., Sawaya, M. R., Salyer, D., Gundelfinger, E. D., & Bowie, J. U. (2006) · Science · doi:10.1126/science.1118995 · Cited by 292
Sala, C., Futai, K., Yamamoto, K., Worley, P. F., Hayashi, Y., & Sheng, M. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-15-06327.2003 · Cited by 288
Surface trafficking of receptors between synaptic and extrasynaptic membranes: and yet they do move!
Triller, A., & Choquet, D. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.001 · Cited by 285
Calcium triggers calcineurin-dependent synaptic vesicle recycling in mammalian nerve terminals
Marks, B., & McMahon, H. T. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70297-0 · Cited by 271
Gardner, S. M., Takamiya, K., Xia, J., Suh, J., Johnson, R. C., Yu, S., & Huganir, R. L. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.026 · Cited by 245
Ashby, M. C., De La Rue, S. A., Ralph, G. S., Uney, J., Collingridge, G. L., & Henley, J. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1042-04.2004 · Cited by 244
Lateral organization of endocytic machinery in dendritic spines
Rácz, B., Blanpied, T. A., Ehlers, M., & Weinberg, R. J. (2004) · Nature Neuroscience · doi:10.1038/nn1303 · Cited by 236
Self-citationBrown, T. C., Tran, I. C., Backos, D. S., & Esteban, J. A. (2005) · Neuron · doi:10.1016/j.neuron.2004.12.023 · Cited by 234
Endocytosis Optimizes the Dynamic Localization of Membrane Proteins that Regulate Cortical Polarity
Marco, E., Wedlich‐Söldner, R., Li, R., Altschuler, S. J., & Wu, L. F. (2007) · Cell · doi:10.1016/j.cell.2007.02.043 · Cited by 221
A Preformed Complex of Postsynaptic Proteins Is Involved in Excitatory Synapse Development
Gerrow, K., Romorini, S., Nabi, S., Colicos, M. A., Sala, C., & El-Husseini, A. (2006) · Neuron · doi:10.1016/j.neuron.2006.01.015 · Cited by 211
Identification of dynamin 2, an isoform ubiquitously expressed in rat tissues.
Cook, T. A., Urrutia, R. A., & McNiven, M. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.2.644 · Cited by 187
Cycling of NMDA Receptors during Trafficking in Neurons before Synapse Formation
Washbourne, P., Liu, X.-B., Jones, E. G., & McAllister, A. K. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.2555-04.2004 · Cited by 167
Regulating Actin Dynamics at Membranes: A Focus on Dynamin
Schafer, D. A. (2004) · Traffic · doi:10.1111/j.1600-0854.2004.00199.x · Cited by 150
Dynamin 3 is a component of the postsynapse, where it interacts with mGluR5 and Homer
Gray, N. W., Fourgeaud, L., Huang, B., Chen, J., Cao, H., Oswald, B. J., Hémar, A., & McNiven, M. A. (2003) · Current Biology · doi:10.1016/s0960-9822(03)00136-2 · Cited by 143
Endocytosis and Degradative Sorting of NMDA Receptors by Conserved Membrane-Proximal Signals
Scott, D. B., Michailidis, I. E., Mu, Y., Logothetis, D. E., & Ehlers, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0780-04.2004 · Cited by 130
Self-citationEps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development
Koh, T., Korolchuk, V. I., Wairkar, Y. P., Jiao, W., Evergren, E., Pan, H., Zhou, Y., Venken, K. J. T., Shupliakov, O., Robinson, I. M., et al. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200701030 · Cited by 129
Dynamin as a mover and pincher during cell migration and invasion
Kruchten, A. E., & McNiven, M. A. (2006) · Journal of Cell Science · doi:10.1242/jcs.02963 · Cited by 123
Cottrell, J. R., Borók, E., Horváth, T. L., & Nedivi, E. (2004) · Neuron · doi:10.1016/j.neuron.2004.10.025 · Cited by 111
Tetrameric Hub Structure of Postsynaptic Scaffolding Protein Homer
Hayashi, M. K., Ames, H. M., & Hayashi, Y. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2731-06.2006 · Cited by 101
Predominant and developmentally regulated expression of dynamin in neurons
Nakatax, T., Iwamoto, A., Noda, Y., Takemura, R., Yoshikura, H., & Hirokawa, N. (1991) · Neuron · doi:10.1016/0896-6273(91)90298-e · Cited by 101
G protein–coupled receptor/arrestin3 modulation of the endocytic machinery
Santini, F., Gaidarov, I., & Keen, J. H. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200110132 · Cited by 96
Okamoto, P. M., Gamby, C., Wells, D. G., Fallon, J. R., & Vallee, R. B. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m104927200 · Cited by 81
Multiple Distinct Coiled-coils Are Involved in Dynamin Self-assembly
Okamoto, P. M., Tripet, B., Litowski, J. R., Hodges, R. S., & Vallée, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.15.10277 · Cited by 73
Gray, N. W., Kruchten, A. E., Chen, J., & McNiven, M. A. (2005) · Journal of Cell Science · doi:10.1242/jcs.01711 · Cited by 64
Research works printed but not linked: 1
- Cottrell, 2004, CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors, Neuron, 44, 677
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Actin in dendritic spines: connecting dynamics to function
Hotulainen, P., & Hoogenraad, C. C. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201003008 · Cited by 815
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels
Hansen, K. B., Wollmuth, L. P., Bowie, D., Furukawa, H., Menniti, F. S., Sobolevsky, A. I., Swanson, G. T., Swanger, S. A., Greger, I. H., Nakagawa, T., et al. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000131 · Cited by 686
Seminars in Cell & Developmental Biology
Lee, H., & Kirkwood, A. (2011) · Cited by 692
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Sheng, M., & Kim, E. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005678 · Cited by 603
Metadata
- Authors
- Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D.
- Affiliations
- Duke Medical Center (US)
- University of North Carolina at Chapel Hill (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Ehlers, Michael D.
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2007-09
- Volume
- 55
- Issue
- 6
- Pages
- 874-889
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC2597538
- OpenAlex
- W1997282555
- Cited by
- 273
- References
- 51
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 8 · 2022: 10 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 19 · 2017: 11 · 2016: 8 · 2015: 16 · 2014: 15 · 2013: 21 · 2012: 18
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2146 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- UNC Libraries
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- DNM3, Homer, postsynaptic density, clathrin, synaptic transmission, dendritic spine morphology, excitatory synapses, receptor recycling, protein-protein interaction
- MeSH terms
- Homer Scaffolding Proteins, Animals, Carrier Proteins, Clathrin, DNA, Electrophysiology, Humans, Immunohistochemistry, Microscopy, Electron, Synaptic Transmission, Neurons, Receptors, AMPA, Patch-Clamp Techniques, Microscopy, Confocal, GTP Phosphohydrolases, Transport Vesicles, Dynamin III, RNA Interference, Lipid Metabolism
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